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Gigantis
                       m

47 unique logo. (2011,
febr 09). Retrieved from   Table 4
                           Kevin Knox, Kaley
http://www.bore-           Miller, Hailey Ray, Ashley
list.com/2011/02/47-       Spaulding
unique-logo.html
W, J. (2009, Janu 21). Double vision. Retrieved from http://www.jeffreymd.com/2009/01/31/double-vision/




       Symptoms
    • Pretty big people (usually two
      standard deviations above
      normal height should be)

    • Delayed puberty                                                                                     Vos, A., & Barnes, K.
                                                                                                          (2011). Gigantism.
                                                                                                          Retrieved from

    • Double vision or difficulty                                                                         http://misskay03.edu.gl
                                                                                                          ogster.com/gigantism
                                                                                                          /
      with side vision
                                                                                                              W, J. (2009, Janu
                                                                                                              21). Double vision.
                                                                                                              Retrieved from
                                                                                                              http://www.jeffrey
                                                                                                              md.com/2009/01/3
                                                                                                              1/double-vision/
britishpathe. (2011, july                                 keane, C. (2006, Octo 9). At 7-foot-9,
20). The british pathe                                    chinese man hopes to play in nba.
blog. Retrieved from
http://britishpathe.wordp   • Headaches                   Retrieved from
                                                          http://forums.about.com/n/pfx/forum.a
ress.com/2011/07/20/the
-long-and-short-of-it/
                            • Increased sweating          spx/forum
                                                          /i620.aspx?tsn=1&nav=messages&webta
                                                          g=ab-racerelation&tid=9276
                            • Irregular periods
                              (females)
                            • Large hands and feet with
                              large fingers and toes
• Release of breast milk
• Thickening of facial
  features
                    Eckman, S. (2009, 11
                    23). Gigantism.
                    Retrieved from
                    http://www.ncbi.nl


• Weakness
                    m.nih.gov/pubmedh
                    ealth/PMH0002157/
                    Encyclopædia
                    Britannica Online

• Bulging forehead  School Edition, s.v.
                    "drug," accessed
                    February
                    23, 2012, http://scho
                    ol.eb.com/eb/article-
                    10969.


                    acromegaly. (
                    2012). In
                    Encyclopædia
                    Britannica.
                    Retrieved from
                    http://school.eb.com
                    /eb/article-9003588



                    Big Head.
                    (2011, febr 09).
                    Retrieved from
                    http://www.wik
                    ipediat.com/20
                    11/02/47-baby-
                    head.html
Causes
• ***Excess of growth
  hormone ***(Acromegaly)
• Most commonly:
  Noncancerous(adenoma)
  tumor of the pituitary gland

pituitary toumors. (2012). Retrieved from
http://www.riversideonline.com/health_r
eference/Disease-
Conditions/DS00533.cfm
• Carney complex




                   Characteristics of
                   carney complex.
                   (n.d.). Retrieved
                   from
                   http://www.mayoc
                   linic.org/medicalp
                   rofs/enlargeimage
                   5833.html
Possible solutions

• Medications that
  reduce growth
  hormone release
  such as somatostain
  analogs (growth
  inhibiting
  hormones)
• Dopamine agonoists
  but they are the
  least effective       Vos, A., & Barnes, K. (2011). Gigantism.
                        Retrieved from
                        http://misskay03.edu.glogster.com/giganti
Radiation
                                therapy can be
                                used to bring the
                                growth hormone
                                level back to
                                normal but it
                                take 5 to 10 years
                                to take full effect
                                and often effects
                                other pituitary
                                hormones
Radiation. (2012). Retrieved from
http://www.riversideonline.com/health_r
eference/Disease-
Conditions/DS00687975333.cfm
• Removal of tumor on pituitary through
  endonasal surgery (through nose)



                                          Nose Surgery.
                                          (2009, Janu
                                          21).
                                          endoscpoic.
                                          Retrieved
                                          from
                                          http://www.je
                                          ffreymd.com/
                                          2009/01/31/a
                                          cromegaly/
Exams and Tests
• CT or MRI scans
-CT uses x-rays
-MRI uses magnets to align
  protons and take an MDM
  vector (fancy picture)




                             These sources are
                             getting old… I
                             give up- Kevin
                             Knox
Exams and Tests
• CT or MRI scans
-CT uses x-rays
-MRI uses magnets to align
  protons and take an MDM
  vector (fancy picture)     CT


                  MRI
• Failure to suppress serum growth hormone
  (GH) levels after an oral glucose challenge
  (maximum 75g)

• Fancy way of saying they get you hopped up on
  sugar and see if your body can suppress growth
  hormone like a normal person would
Miscellaneous
• Female to male ratio
  of 1:2 (twice as
  common in males)
• Commonly occurs
  with Acromegaly
Fact Sources
• acromegaly. ( 2012). In Encyclopædia Britannica.
  Retrieved from http://school.eb.com/eb/article-9003588
• drug 2012. Encyclopædia Britannica Online School Edition.
  Retrieved 23 February 2012, from
  http://school.eb.com/eb/article-10969
• Eckman, S. (2009, 11 23). Gigantism. Retrieved from
  http://www.ncbi.nlm.nih.gov/pubmedhealth/PMH0002157/
  Encyclopædia Britannica Online School Edition, s.v. "drug,"
  accessed February 23, 2012, http://school.eb.com/eb/article-
  10969.
• gigantism 2012. Encyclopædia Britannica Online School
  Edition. Retrieved 23 February 2012, from
  http://school.eb.com/eb/article-9036788
• Goyal, S. (n.d.). Gigantism. Retrieved from
  http://www.hxbenefit.com/gigantism-definition-symptoms-
  causes-treatment-and-acromegaly.html

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Gigantism 120223070434-phpapp01

  • 1. Gigantis m 47 unique logo. (2011, febr 09). Retrieved from Table 4 Kevin Knox, Kaley http://www.bore- Miller, Hailey Ray, Ashley list.com/2011/02/47- Spaulding unique-logo.html
  • 2. W, J. (2009, Janu 21). Double vision. Retrieved from http://www.jeffreymd.com/2009/01/31/double-vision/ Symptoms • Pretty big people (usually two standard deviations above normal height should be) • Delayed puberty Vos, A., & Barnes, K. (2011). Gigantism. Retrieved from • Double vision or difficulty http://misskay03.edu.gl ogster.com/gigantism / with side vision W, J. (2009, Janu 21). Double vision. Retrieved from http://www.jeffrey md.com/2009/01/3 1/double-vision/
  • 3. britishpathe. (2011, july keane, C. (2006, Octo 9). At 7-foot-9, 20). The british pathe chinese man hopes to play in nba. blog. Retrieved from http://britishpathe.wordp • Headaches Retrieved from http://forums.about.com/n/pfx/forum.a ress.com/2011/07/20/the -long-and-short-of-it/ • Increased sweating spx/forum /i620.aspx?tsn=1&nav=messages&webta g=ab-racerelation&tid=9276 • Irregular periods (females) • Large hands and feet with large fingers and toes
  • 4. • Release of breast milk • Thickening of facial features Eckman, S. (2009, 11 23). Gigantism. Retrieved from http://www.ncbi.nl • Weakness m.nih.gov/pubmedh ealth/PMH0002157/ Encyclopædia Britannica Online • Bulging forehead School Edition, s.v. "drug," accessed February 23, 2012, http://scho ol.eb.com/eb/article- 10969. acromegaly. ( 2012). In Encyclopædia Britannica. Retrieved from http://school.eb.com /eb/article-9003588 Big Head. (2011, febr 09). Retrieved from http://www.wik ipediat.com/20 11/02/47-baby- head.html
  • 5. Causes • ***Excess of growth hormone ***(Acromegaly) • Most commonly: Noncancerous(adenoma) tumor of the pituitary gland pituitary toumors. (2012). Retrieved from http://www.riversideonline.com/health_r eference/Disease- Conditions/DS00533.cfm
  • 6. • Carney complex Characteristics of carney complex. (n.d.). Retrieved from http://www.mayoc linic.org/medicalp rofs/enlargeimage 5833.html
  • 7. Possible solutions • Medications that reduce growth hormone release such as somatostain analogs (growth inhibiting hormones) • Dopamine agonoists but they are the least effective Vos, A., & Barnes, K. (2011). Gigantism. Retrieved from http://misskay03.edu.glogster.com/giganti
  • 8. Radiation therapy can be used to bring the growth hormone level back to normal but it take 5 to 10 years to take full effect and often effects other pituitary hormones Radiation. (2012). Retrieved from http://www.riversideonline.com/health_r eference/Disease- Conditions/DS00687975333.cfm
  • 9. • Removal of tumor on pituitary through endonasal surgery (through nose) Nose Surgery. (2009, Janu 21). endoscpoic. Retrieved from http://www.je ffreymd.com/ 2009/01/31/a cromegaly/
  • 10. Exams and Tests • CT or MRI scans -CT uses x-rays -MRI uses magnets to align protons and take an MDM vector (fancy picture) These sources are getting old… I give up- Kevin Knox
  • 11. Exams and Tests • CT or MRI scans -CT uses x-rays -MRI uses magnets to align protons and take an MDM vector (fancy picture) CT MRI
  • 12. • Failure to suppress serum growth hormone (GH) levels after an oral glucose challenge (maximum 75g) • Fancy way of saying they get you hopped up on sugar and see if your body can suppress growth hormone like a normal person would
  • 13. Miscellaneous • Female to male ratio of 1:2 (twice as common in males) • Commonly occurs with Acromegaly
  • 14. Fact Sources • acromegaly. ( 2012). In Encyclopædia Britannica. Retrieved from http://school.eb.com/eb/article-9003588 • drug 2012. Encyclopædia Britannica Online School Edition. Retrieved 23 February 2012, from http://school.eb.com/eb/article-10969 • Eckman, S. (2009, 11 23). Gigantism. Retrieved from http://www.ncbi.nlm.nih.gov/pubmedhealth/PMH0002157/ Encyclopædia Britannica Online School Edition, s.v. "drug," accessed February 23, 2012, http://school.eb.com/eb/article- 10969. • gigantism 2012. Encyclopædia Britannica Online School Edition. Retrieved 23 February 2012, from http://school.eb.com/eb/article-9036788 • Goyal, S. (n.d.). Gigantism. Retrieved from http://www.hxbenefit.com/gigantism-definition-symptoms- causes-treatment-and-acromegaly.html