Arvo 2010 Final
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Presentation given at ARVO 2010 conference.
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Arvo 2010 Final
- 1. Does the Posterior Corneal Elevation Provide the First Indication of Keratoconus? K.C. Baker, Y.-L.Chen, L.Shi, J.W. L. Lewis, L.Kugler, M.Wang. Wang Vision Institute, Nashville, TN; Center for Laser Applications, University of Tennessee Space Institute, Tullahoma, TN; Department of Ophthalmology, University of Tennessee, Memphis, TN Program # 4963 Poster # D759
- 10. Results : FFKC and KC Classification KC sensitivity at 100% specificity KC area under ROC curve FFKC sensitivity at 100% specificity FFKC area under ROC curve Anterior 5mm 70% 0.92 38% 0.67 Posterior 5mm 90% 0.99 38% 0.66 Difference 5mm 100% 1.00 38% 0.68 Anterior 6mm 80% 0.94 38% 0.69 Posterior 6mm 90% 0.98 38% 0.68 Difference 6mm 90% 0.97 38% 0.64 Anterior 7mm 80% 0.93 38% 0.75 Posterior 7mm 80% 0.97 63% 0.84 Difference 7mm 90% 0.95 63% 0.81
Notas do Editor
- These view graphs were to presented to ARVO 2010 meeting by WVI CLA, UTSI, If you find any mistakes in the slides, please inform me. Kevin Baker, Email: dr.kevin.charles.baker@gmail.com, Phone: (office) 610-217-9141
- We included Pentacam data of 18 KC and 22 astigmatic eyes in this study. Within the KC eyes, 8 are mild with manifest best corrected visual acuity (BCVA) of 20/25 or better. The FFKC diagnosis relied on the other eye's condition from the same subject, other KC indications, and family history. The remaining KC eyes are comprised of 5 moderate with a BCVA of 20/30-20/40, and 5 that are worse than 20/40. The 22 astigmatic eyes all had a BCVA of 20/25 or better. The posterior and anterior elevation maps are decomposed into Zernike polynomials to obtain the root mean squared error (RMSE) above the 2 nd order that represents high-order complex patterns. The difference between the 2 RMSE values is used as a third indicator. The extreme RMSE values of the astigmatic eyes are used as the screening criteria (i.e. 100% specificity).
- We included Pentacam data of 18 KC and 22 astigmatic eyes in this study. Within the KC eyes, 8 are mild with manifest best corrected visual acuity (BCVA) of 20/25 or better. The FFKC diagnosis relied on the other eye's condition from the same subject, other KC indications, and family history. The remaining KC eyes are comprised of 5 moderate with a BCVA of 20/30-20/40, and 5 that are worse than 20/40. The 22 astigmatic eyes all had a BCVA of 20/25 or better. The posterior and anterior elevation maps are decomposed into Zernike polynomials to obtain the root mean squared error (RMSE) above the 2 nd order that represents high-order complex patterns. The difference between the 2 RMSE values is used as a third indicator. The extreme RMSE values of the astigmatic eyes are used as the screening criteria (i.e. 100% specificity).
- AUC is equal to the probability that a classifier will rank a randomly chosen positive instance higher than a randomly chosen negative one
- 1. The posterior cornea surface alone provides more significant indication of keratoconus than the anterior surface. 2. Analysis with a larger cornea area improves detection sensitivity. 3. Either anterior or posterior cornea irregularity is a sufficient indicator of early KC, but sometimes additional information is required to clinically diagnose FFKC.