Dyslipidemia refers to abnormalities in serum lipid levels, including high or low levels of total cholesterol, triglycerides, LDL cholesterol, and HDL cholesterol. These abnormalities can be inherited, acquired, or secondary to other primary conditions. Dyslipidemias are classified based on the pattern of lipoproteins in electrophoresis or ultracentrifugation testing.
1. Dyslipidemia
Abnormalities in the serum levels of LIPIDS, including
Hyperlipidaemia
overproduction or deficiency. Abnormal serum lipid Conditions with abnormally elevated levels of
profiles may include high total CHOLESTEROL, high
LIPOPROTEINS in the blood. They may be inherited,
TRIGLYCERIDES, low HIGH DENSITY LIPOPROTEIN
acquired, primary, or secondary. Hyperlipoproteinemias are
CHOLESTEROL, and elevated LOW DENSITY LIPOPROTEIN
classified according to the pattern of lipoproteins on
CHOLESTEROL
electrophoresis or ultracentrifugation
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2. Endocrine conditions
Hyperlipidaemia may be caused by or feature of the
Cushing syndrome
following ... (sorted by category). Pituitary tumour (growth hormone secreting)
Biochemical abnormalities Iatrogenic conditions
High density lipoprotein levels raised (plasma) Parenteral nutrition
(Specific kind of Hyperlipidaemia) Shortcut to causes
Hypercholesterolaemia Drugs, hormones and mediators
(Specific kind of Hyperlipidaemia) Shortcut to
causes Cyclopenthiazide
Hypertriglyceridaemia Danazol
(Specific kind of Hyperlipidaemia)Shortcut to causes Etretinate
o Gestrinone
Lipoprotein(a) levels raised (plasma or serum) Isotretinoin
Nelfinavir
(Specific kind of Hyperlipidaemia) Shortcut to Tobacco smoking
causes
Low density lipoprotein levels raised (serum or
plasma)
(Specific kind of Hyperlipidaemia) Shortcut to
causes
Very low density lipoprotein levels raised
(plasma or serum)
(Specific kind of Hyperlipidaemia) Shortcut to
causes
Symptoms and Signs
Obesity
Biochemical abnormalities
Cholestasis, intrahepatic
Autosomal recessive conditions
Fructose-1, 6-diphosphatase deficiency
Smith-Lemli-Opitz syndrome
3. Familial mixed hyperlipidaemia Hyperlipoproteinemia, familial type 5
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A severe type of hyperlipidemia, sometimes familial, that it is
A type of familial lipid metabolism disorder characterized by a
characterized by the elevation of both plasma CHYLOMICRONS
variable pattern of elevated plasma CHOLESTEROL and/or
and TRIGLYCERIDES contained in VERY-LOW-DENSITY
TRIGLYCERIDES. Multiple genes on different chromosomes may
LIPOPROTEINS. Type V hyperlipoproteinemia is often
be involved, such as the major late transcription factor
associated with DIABETES MELLITUS and is not caused by
(UPSTREAM STIMULATORY FACTORS) on CHROMOSOME 1
reduced LIPOPROTEIN LIPASE activity as in
HYPERLIPOPROTEINEMIA TYPE I
4. Hypoprebetalipoproteinemia
A condition with abnormally low levels of PREBETA-
HARP syndrome
LIPOPROTEINS in the blood Links :
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m
5. Hypolipidemia Hypocholesterolaemia
abnormally decreased amount of fat in the blood