American Peptide Company (APC) is a peptide manufacturing company founded in 1987 that offers catalog peptides, custom peptide synthesis, and cGMP manufacturing of pharmaceutical peptides. APC has expanded its facilities over the years and currently has a headquarters in Sunnyvale, CA and a cGMP manufacturing facility in Vista, CA. APC aims to be the industry leader in peptide process development by providing high quality peptides and services from early research to commercial quantities.

1. APC Overview American Peptide Company, Inc. :your strategic partner forpeptide manufacturing and services © Copyright 2010 American Peptide Company Inc., All Rights Reserved 2010 – v3.01

2. APC Corporate Facts and History 1987 1994 1998 2002 2005 2003 2007 2008 - GMP License - Ito Life Sciences Founded - GMP facility expansion - Founded - New GMP facility in Vista (30,000sq.) Itoham Foods, Japan - Acquisition by Otsuka Chemical - Launch website - FDA inspected GMP facility - 2 -

3. APC Organization CEO Seiji Sato, Ph.D. President & COO Hiro (Takahiro) Ogata GMP Manufacturing VP Jianjun (JJ) Jiang, Ph.D. Quality, VP Shawn Shirzadi Research & Production, VP Baosheng Liu, Ph.D. Sales & Marketing VP Gary Hu Finance & Administration, VP David Godkin Research & Production V.P. Director, GMP Manufacturing Patricia Haller, Ph.D. Director, GMP Quality Control Scott Caton Finance Director, Sales Firuz Shakoori Synthesis Purification Sales Accounting & Finance Quality Control Synthesis Marketing Process Development Administration Material Management Purification Customer Service Quality Control Human Resource Process Development Quality Assurance Project/Product Management Purchasing Shipping - 3 -

4. APC Company Overview We offer a comprehensive selection of pre-manufactured catalog peptides in convenient aliquots, a spectrum of custom synthesis services from array screens to mg to kg of research-grade peptide, and full-scale cGMP manufacturing of pharmaceutical-grade peptides. APC is dedicated to delivering high-quality peptides to pharmaceutical and biotech companies. - 4 -

5. APC Facilities Headquarters 777 East Evelyn Ave. Sunnyvale, CA 94086 USA Tel: 408-733-7604 or 1-800-926-8272 Fax: 408-733-7603 or 1-888-670-0070 © Copyright 2010 American Peptide Company Inc., All Rights Reserved cGMP Manufacturing Facility 1271 Avenida Chelsea Vista, CA 92081 USA Tel: 760-597-8820 Fax: 760-597-8816 - 5 -

6. Our Mission To be the industry leader in peptide process development by providing high quality compounds and services coupled with knowledgeable customer support from early stage research to downstream commercial grade quantities. © Copyright 2010 American Peptide Company Inc., All Rights Reserved - 6 -

7. © Copyright 2010 American Peptide Company Inc., All Rights Reserved Research & Process Development GMP Manufacturing Our Capabilities Discovery Technology Transfer Process Development Pilot Scale-up Production Campaign Clinical Batches - 7 -

8. Manage & Support © Copyright 2010 American Peptide Company Inc., All Rights Reserved Preclinical Phase 1 Phase 2 Phase 3 NDA Process Development Analytical Qualification Analytical Validation Analytical Development Supportive Stability Studies Process Qualification Process Validation Scale-up - 8 -

9. Products and Services Custom Synthesis cGMP - Active Pharmaceutical Ingredients Catalog Peptide - 9 -

11. Bioactive Peptides

12. Substrate & Inhibitors

13. Fluorescent Materials

14. Quick Label DerivativecGMP - Active Pharmaceutical Ingredients Catalog Peptide - 10 -

16. Peptide Arrays

17. Organic Synthesis

18. Process Development

19. Contract Manufacturing

20. New ProductscGMP - Active Pharmaceutical Ingredients Catalog Peptide Custom Synthesis - 11 -

22. Glucagon, human

23. Leuprolide

24. Octreotide

25. Fertirelin

26. Calcitonin, salmon

27. CRF, human, rat

28. Brain Natriuretic Peptide, human

29. Thymopentin (TP-5)

30. ACTH (corticotropin)

31. Elcatonin

32. Beta Amyloid (1-42), human

33. Triptorelin

34. Buserelin

35. Thymosin a-1

36. Somatostatin 14

37. Exendin (9-39)cGMP - Active Pharmaceutical Ingredients Catalog Peptide Custom Synthesis - 12 -

39. 5-lodoacetamido Fluorescein

40. AFC

41. AMC

42. Biotin

43. Bodipy

44. BSA/KLH Conjugation

45. Coumarin

46. Cyclic peptide

47. Cy3 and Cy5

48. Dabcyl

49. Dansyl

50. Ser (octanoic acid)

51. Stearic acid modification

53. Sulfated peptide [Tyr(SO3)]

54. EDANS

55. Farnesyl

56. FITC

57. MAPS

58. MCA

59. Palmitoyl

60. PEGylation

61. Phosphorylation

62. PNA

63. Rhodamine 110

64. Rhodamine B- 13 -

65. © Copyright 2010 American Peptide Company Inc., All Rights Reserved Our Customers (to name a few) - 14 -

66. Distributors © Copyright 2010 American Peptide Company Inc., All Rights Reserved - 15 -

68. Biotechs

69. AcademicsUSA,Canada,Japan,Europe,Korea,China,India,South Africa,Australia, Netherlands - 16 -

70. Project Management © Copyright 2010 American Peptide Company Inc., All Rights Reserved Customer Account Manager Project Manager Quality Business Development Manufacturing - 17 -

71. Synthesis of the Starting Material Peptide Process Sequential Additional of Derivatized Amino Acids Equipment and Area Preparation Qualification of Raw Materials Cleavage Peptide from the Support Resin In process test Reverse Phase and Ion Exchange Column Purification of the Peptide In process test Final Lyophilization of the Peptide Product In process test Move to Class 10 K clean room packaging room In process test Packaging and Labeling Final QC Testing QA Review and Release Label Issuance and Preparation - 18 - © Copyright 2010 American Peptide Company Inc., All Rights Reserved

73. Solution Phase

74. Combination

75. Common Strategies Analysis: - Purity - Identity - Content Purification: - Method & Tools - 19 -

77. Solution Phase

78. Combination

79. Common Strategies

80. Strategy: Boc, Fmoc, Cbz

81. Current capacity: up to 80L (solid), 200L (solution) reaction volume

82. Batch Size: up to 2Kg per batch of synthetic peptides depending on the sequence

83. Expansion: 3X current capacity, 10Kg per batch depending on sequence- 20 -

85. ion exchange

86. SEC

87. Gel Chromatography- 21 -

89. MS, IR, NMR*, UV

90. Chiral analysis

91. AAA

92. Elemental analysis*

93. Heavy metals*

94. Bioburden

95. Endotoxin

96. Residual Solvents *

98. final productsAnalysis: - Purity - Identity - Content - 22 -

101. UPLC (analysis for HPLC, LCMS, AAA)

102. TOC (Total organic carbon analyzer)50 L lyophilizer - 23-

106. Conjugation & PEGylation experience

107. Creating long-term business relations

108. Growth potential- 25 -

109. Total Peptide Management™ is to bring our product portfolio and customer support capabilities to each individual client with efficient, high quality and cost effective peptide management solutions. - 26 -