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What Rash is that?
Is it Infectious?
By Kane Guthrie
Learning Points
• General assessment of rashes
• Describing rashes
• When to Isolate
• Pearls & Pitfalls
• Case studies
Rashes
• Most are not evidence of serious illness
• Frequently alarm patients/parents
• Rashes are one of the top 20 presentations to ED
• Often anxiety provoking to health care providers
Rashes!
“Recognition is 99% of the problem;
treatment/advice is usually simple”
Describing a Rash
• It’s a little tricky
• Keep it simple
• Pattern recognition!
http://www.ausmed.com.au/blog/entry/how-to-describe-a-rash
http://www.ausmed.com.au/blog/entry/how-to-describe-a-rash
http://www.ausmed.com.au/blog/entry/how-to-describe-a-rash
History Taking
• When did it start?
• How quickly did it progress?
Pearl:
• The more lethal – the more rapid progression!
History Taking
• Has the rash changed over time?
• Where did it start & progress to?
• Is the lesion pruritic?
– Allergic response!
History Taking
• Recent travel?
– In the last month!
• PMHx:
– Immunocompromised, asplenia, cancer, DM, ETOH
• Occupation
– Child care, student, military, aid workers
• Medications
Physical Exam
• Get them undressed!
Check:
• Oral cavity
• Adenopathy
• Hepatosplenomegaly
• Genitals
• Nails & fingers
Skin Exam
• Characterise type of lesion
• Shape of individual lesion
• Arrangement of multiple lesions
– Linear, annular, disseminated
• Pattern of rash
– Sun exposed areas, flexor/extensor surfaces
Case 1
• 10 year old girl
• Coryza, conjunctivitis, cough, fever
• Maculopapular rash, starts behind ears
• Descends onto upper torso
http://scghed.com/
Koplik’s Spots
• Manifest 2-3 days before measles rash
• Cluster lesions buccal mucosa
http://en.wikipedia.org/wiki/Koplik%27s_spots
Measles
• Acute viral disease
• Incubation period 10-14 days
• Highly contagious – airborne route
– Airborne precautions needed!
• Non-immune @ high risk!
Early Symptoms
• Fever
• Tiredness
• Cough
• Sore throat
• Runny nose
• Sore eyes
• Photophobia
http://www.nevdgp.org.au/info/murtagh/Childrens/measles.htm
The Rash
• Symptoms usually worsen over 3-5 days
• Blotchy rash begins on the head
• Spreads to rest of body over 1-2days
• Rash last 4-7 days
Measles Complications
• Middle ear infection 7% of cases
• Bacterial pneumonia 6% of cases
• 1:1000 cases encephalitis occurs
– Results in death, permanent disability
http://www.abc.net.au/news/2014-07-31/health-department-warns-of-surge-in-measles-cases-in-wa/5639558
Measles Management
• Vaccination is the best treatment
• Supportive care
• Treat complications with AB’s
Case 2
• 4 year male
• C/O headache, fever, then rash develops
• Explosion of lesions: 1st to face/scalp, then
trunk & limbs
• No rash soles or palms!
The Rash
• Many papules
• Become vesicles
http://bit.ly/1zL2y5E
Chicken Pox
• Acute generalised viral infection
• Incubation period 11-17 days
• Highly contagious
• Transmission direct contact/airborne
– Use airborne precautions
Shingles
• Blistering rash – dermatome distribution
• Increased age
• Immunosupression
• Stress
http://1.usa.gov/1yBhN0c
Varicella Zoster Complications
Chicken pox:
• Pneumonia, congenital varicella, neonatal
varicella
Shingles:
• Post-herpetic neuralgia, zoster keratitis, motor
nerve paralysis
Varicella Management
• Prevention –imunisation
• Supportive care
• Pneumonia – give AB’s
Shingles:
• Commence acyclovir ASAP
– Limits post-herpetic neuralgia
Case 3
• 17 female
• S/B GP c/o fever, headaches & muscle pain
– Dx: viral illness – sent home to rest
• 12 hours later develops peticial > purpuric
rash
• Arrives in ED shocked!
The Rash
Non-Blanching Rashes!
Meningococcal Septicaemia
• Acute Bacterial Infection
• Mainly affects young children/adolescents
• Transmission by direct contact Resp secretions
– Droplet precautions
– AB’s for staff if exposed to resp secretions
• Incubation period 2-4 days
Meningitis Complications
• Abscess
• Cerebritis
• Deafness
• Cognitive impairment
• Hydrocephalus
• Death
Meningitis Management
• AB’s within 30mins of recognition
– Broad spectrum (Ceftriaxone)
– Immunocompromised add (Vancomycin)
• Haemodynamic support
• Dexamethasone 0.15mg/kg Q6 hourly
Case 5
http://scghed.com/2013/11/cme-141113-paediatric-rashes/
http://scghed.com/2013/11/cme-141113-paediatric-rashes/
Hand Foot & Mouth Disease
• Coxsackie virus
• Common in kids- can affect all age groups
• Low grade fever, anorexia, sore mouth
• Oral lesions develop
– Vesicles/erythematous base – painful
• Hand/foot lesions – red papules
• Symptomatic care- mouth wash/analgesia
Case 6
• 28 male
• Hx epilepsy, on phenytoin
• Presents: Shocked
• Severe mouth ulcers
• Maculopapular rash
Stevens Johnson Syndrome
Toxic Epidermal Necrosis
• SJS <10% BSA, TEN >30% BSA
• Dermatological emergency
• Causes:
– Drugs: anticonvulsants, NSAIDs, antiviral, allopurinal
– Malignancy: lymphoma
– Idiopathic
– Infectious
Clinical Features
• Prodrome: fever, URTI, malaise
• Macular rash develops:
– Starts centrally – spreads peripherally
– May be painful
– Nikolsky’s sign (skin separation via blisters)
• Mucous membranes severely affected
Management
• Removing inciting cause
• Airway support
• Fluid replacements – follow burns protocol
• Wound care
• AB’s if infection
• Consider but controversial:
– IVIG, plasmapharesis, corticosteroids
Case 7
• 4 year boy
• Hx of ^ red spots to legs over past 6/7
• Now spread to legs, buttock
• Not responding to cream
• Systemically well
Henoch-Schonlein Purpura
• HSP- autoimmune, self limiting,
– IgA-mediated small vessel vasculitis
• Affects children 2-8 years old
Diagnosis triad:
1. Purpuric rash on lower limbs/buttock
2. Joint pain/swelling
3. Abdominal pain
Complications
Management
• Check renal function
• Give analgesia
• Consider Prednisolone 1mg/kg - 2/52
• Abdo pain last <72 hours
• Joint pain last <48 hours
• Rash resolves 4-6 weeks
Case 8
• 18 male
• Eating kebab after night out
• Develops erythematous rash and SOB
Anaphylaxis
• IgE mediated hypersensitivity reaction
• Leads to profound:
– Histamine & serotonin release
Urticaria Vs Anaphylaxis
• Urticaria: hives, weals, nettle rash
• May occur alone or R/T allergic reaction
• Histamine release
Anaphylaxis Pearls
• Forget about the rash!
– Focus hypotension, bronchospasm
• Give adrenaline – its only thing that works!
– Adult 0.5mg IMI, Child 0.3mg IMI
• Fluid bolus
• Ranitidine
• Steroid
• D/C Epipen
Diagnosis?
http://scghed.com/2013/11/cme-141113-paediatric-rashes/
Scabies
• Skin infestation scabie mite
• 4-6 wk incubation period
• Not a reflection of poor hygiene!
• General eruption: linear burrows, papules,
pustules
• Treatment: Permethrin 5% all family members
http://www.wikem.org/wiki/File:ScabiesD08.JPG
The Algorithms
Erythematous Rash
http://bit.ly/1xf8rVH
Maculopapular Rash
http://bit.ly/1xf8rVH
Petechial/Purpuric Rash
http://bit.ly/1xf8rVH
Vesiculobullous Rash
http://bit.ly/1xf8rVH
There’s an App!
Take Home Points
• Pattern recognition is everything
• Always take a good history
• Isolate if unsure
• Look for:
– Fever, toxicity, distribution, specific signs
• Management is generally simple
What's Rash is that!

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