Metabolomics is the newest hype in the 'omics' family. Although defined as highly important to recent biological research, the analytical science applied is far from acceptable for the majority of publications that appear nowadays. Take a look at our approach to tackle the metabolomics issue, which remains a new name for an old science.

1. METABOLOMICS A strategic approach for GC amenable compounds Interscience Expert Center www.is-x.be

2. Analysis of small-molecule metabolites formed by the cell in association with its metabolism. “

3. Accurate reflection of changes in cell functions taking genotype and phenotype into account.

4. Bacteria Food quality assessment Environmental remediation Antibiotics discovery

5. Plants Stress assessment studies Identification of gene function Cultivar differentiation

6. Mammals Health status assessment Prediction of clinical outcomes Patient classification

8. Renewed hype for an ‘old science’ Classical biochemical concepts Classical analytical techniques

13. Approximately 85% of the articles published in ‘Metabolomics’ apply non-target screening. Carolyn Honour, Editorial Director ‘Metabolomics’ (Springer)

14. Unfortunately, the non-target screening approach suffers from some serious drawbacks.

16. Target analysis Profiling Screening “ Accuracy Scope

20. Go for automated solutions that apply ‘ state-of-the-art’ sampler robotics.

22. Go for GC in combination with the selectivity of MS/MS in h-SRM mode.

24. Conclusion

25. Expert chromatographic knowledge is mandatory for you to decide which strategy to apply so you can be sure that the results you report are scientifically correct. Visit www.is-x.be for more details.