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Welcome toINTERPHEX 2011
Spraying Systems Co. US Facilities Corporate Headquarters Wheaton, Illinois East Coast Facility Hudson, New Hampshire
Global Manufacturing and Service Spraying Systems Co. corporate headquarters is located in Wheaton, IL, just outside of Chicago. With 10 manufacturing facilities and 85 sales engineering offices located in North and South America, Europe, and Asia, we are able to provide hands-on assistance and quickly deliver our products to customers anywhere in the world.
Fluid Air Division Specializing In:  Fluid bed processing   High-shear granulation/one pot processing  Size reduction   Material handling  Process automation   Engineering services  Retrofits: Fluid Air & non-Fluid Air
Fluid Bed Dryers, Granulators, and Coaters Phase III: Production Scale Phase II: Pilot Scale Phase I: R&D Scale
R&D/Pilot Scale Fluid Beds
Production Scale Fluid Beds
Predictable Scale-Up
Conical Expansion Chamber ,[object Object]
Less filter pressure or plugging
Fines stay below spray nozzles when granulating
Less fines in finished batch increasing yields
No need for different chamber pieces used by competitors, taking up a smaller amount of bowl volume and reducing construction costs,[object Object]
Fluid Bed Process Overview ,[object Object]
Fluid bed granulation isan extension of the drying process where a binder solution is top-sprayed onto dry suspended fine particles to bind them into granules which are then dried in the same vessel
InWurster coating, also known as air suspension coating, theproduct particles are first separated from one another in an air (gas) stream. The desired coating formulation is then sprayed from a bottom-mounted spray nozzle onto the particles while they are suspended,[object Object]
R&D Scale Size Reduction Systems
Production Scale Size Reduction Systems
Flexible Containment for High Potency Compounds in R & D Applications • Flexible enclosure set-up allows for use in both containment and non-containment applications, eliminating the need to purchase a second machine solely for containment use • Capable of meeting an OEB5  classification • Achievable containment level of 1.0 μg/m3 on a task basis
Particle Size Reduction Process Overview ,[object Object]
 A typical Fluid Air milling system consists of an inlet, chamber with rotor, screen, and an outlet
 The particle size distribution generated is dependent upon the speed of the rotor, rotor type, screen hole size and the feed rate of the product
 As both a screen mill and an impact mill in one machine, GRANUMILL ® systems offer two applications to suit differentprocessing needsLarge agglomerates (before milling) Granules  (after milling)
PHARMX® High-Shear Granulators Phase III: Production Scale Phase II: Pilot Scale Phase I: R&D Scale
R&D/Pilot Scale Granulators
One Pot Processors
Production Scale Granulators
Impeller and Chopper
High-Shear Granulation Process Overview High-shear granulation effectively turns powders into dense granules for tableting or coating  A large impeller located in the bowl bottom blends the product while liquid is added A chopper located in the bowl shears the granules until desired size and density is achieved
Process Controls ,[object Object]
Manual equipment controls
Batch Architect Pro™
Fully automated 21 CFR Part 11 capable controlsTypical through-the-wall control panel  with touch screen control
Batch Architect™ Process Control Software Flexible solution for controlling lab scale and portable equipment  Compatible with virtually any batch-type processing equipment, including: coating pans, pellet-making process trains, and liquid delivery systems Equipped with a graphical user interface (GUI) which provides users with current status information of critical machine functions through animation and text Recipe editor feature allows batches to be reproduced with minimal user intervention Offers convenient electronic batch record data logging and report creation services CFR 21 Part 11 FDA capable (Batch Architect ProTM)
                 Virtualization Technology and Disaster Recovery  Batch Architect Pro operates in a virtualized control environment, which allows multiple simulated "virtual" computers to run on a single host computer.  This enables multiple systems to be configured in a distributed architecture to provide cost savings and simplified administration.  Once a control system is in place and operational, virtualization technology helps to simplify disaster recovery procedures. By accessing a copy of the virtual machine, software engineers are able to restore the end user’s malfunctioning control system to an operational state, greatly reducing downtime in the event of system failure.  Virtualization also enables end users to meet federal regulations for data retention; a virtual system that has been removed or replaced can easily be copied to another computer to maintain data access after it is decommissioned.
Graphical User Interface Screen
Recipe Editor for Automated Processing
Tablet Coating Solutions  for the  Pharmaceutical Market
Understanding the Coating Process
Mode of Processing
Atomization ,[object Object]
Therefore energy is needed to break up the droplets (i.e., larger surface area)
As energy dissipates, droplets coalesce
Better nozzle designs will result in less localized over-wetting
Nozzle design must be improved in the larger equipment in order to maintain the same coating time while maintaining the same coating uniformity,[object Object]
4 gun manifold with Teflon spacer weights 13.5lb (6.14kg)Benefits of lighter weight: ,[object Object]
Easier to maintain,[object Object],[object Object]
Excellent surface finish both internal and external
Manufacturing and quality systems meeting cGMP requirements
Design meeting ASME BPE requirements
Complete turnover package ships with every productImprove Spray Performance: ,[object Object]
Lower air consumption and pressure leading to a more stable environment in the coater and less bearding
Self locating spray setup feature (new!),[object Object]
Strong ability to resist staining
Excellent finish for both internal and external surfaces
Extended needle assembly to ease its removal from the nozzle body (new!)
Easy to switch spray setups – captured O-ringAdvantages: ,[object Object]
We can develop brackets to fit your needs and retrofit exiting coaters
We offer a unique design for both continuous and batch coaters,[object Object]
Automatic gun, air actuated (cylinder air)

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Pharmaceutical Tradeshow Interphex Presentation

Notas do Editor

  1. Spraying Systems Co corporate headquarters is in Wheaton IL right outside of Chicago. With 10 manufacturing facilities located in North and South America, Europe and Asia, we can quickly deliver our products to customers anywhere in the world. And with 85 sales engineering offices around the world, there is a local representative you can call on to provide hands on assistance with your application. For instance we have Mathieu located right here at Lachute, Quebec.
  2. We can have vessels reviewed and modeled by our engineering staff to utilize custom spray ball patterns specific to that vessel. This shows a custom spray pattern in the works. Baffles, agitators, spargers, critical vessel areas can all be taken in to consideration when a custom spray pattern is used. This also allows greater efficiency of available resources….purified water…chemicals…etc.