2017 is on track to be the biggest year yet for digital health funding, with almost $2.4B in deals in Q3 alone, according to StartUp Health Insights’ 2016 Q3 Report. With a record quarter on the books and no signs of funding slowing down, join the Director of StartUp Health Academy as she shares the latest market trends and advances in digital health technology and what’s in store over the next quarter, next year, and 10+ years from now.

1. BETTING BIG BUSINESS ON
DIGITAL HEALTH
January 7th, 2017
JOIN THE HEALTH TRANSFORMER MOVEMENT ™ & © 2017 StartUp Health Holdings, Inc. All rights reserved.
Polina Hanin
Academy Director
@polinahanin @startuphealth

2. ORGANIZING AND SUPPORTING A
GLOBAL ARMY OF HEALTH
TRANSFORMERS
To improve the health and wellbeing of everyone in the world
JOIN THE HEALTH TRANSFORMER MOVEMENT ™ & © 2017 StartUp Health Holdings, Inc. All rights reserved.

3. 3JOIN THE HEALTH TRANSFORMER MOVEMENT
THE IDEAL OUTCOME
Achieve 100 Years of Progress in 25 Years
™ & © 2017 StartUp Health Holdings, Inc. All rights reserved.

4. 3JOIN THE HEALTH TRANSFORMER MOVEMENT
2011
LAUNCH
100
YEARS
THE IDEAL OUTCOME
Achieve 100 Years of Progress in 25 Years
™ & © 2017 StartUp Health Holdings, Inc. All rights reserved.

5. 3JOIN THE HEALTH TRANSFORMER MOVEMENT
2011
LAUNCH
100
YEARS
2017
THE IDEAL OUTCOME
Achieve 100 Years of Progress in 25 Years
™ & © 2017 StartUp Health Holdings, Inc. All rights reserved.

6. 3JOIN THE HEALTH TRANSFORMER MOVEMENT
25
YEARS
2011
LAUNCH
100
YEARS
2017
THE IDEAL OUTCOME
Achieve 100 Years of Progress in 25 Years
™ & © 2017 StartUp Health Holdings, Inc. All rights reserved.

7. Conditions Are Aligned for the Reimagination of Healthcare
A ONCE-IN-A-LIFETIME MOMENT
JOIN THE HEALTH TRANSFORMER MOVEMENT ™ & © 2017 StartUp Health Holdings, Inc. All rights reserved.

8. A NEW MODEL FOR TRANSFORMING HEALTH
JOIN THE HEALTH TRANSFORMER MOVEMENT
Based on The Health Transformer Mindset™
™ & © 2017 StartUp Health Holdings, Inc. All rights reserved.

9. A NEW MODEL FOR TRANSFORMING HEALTH
GLOBAL
ARMY
JOIN THE HEALTH TRANSFORMER MOVEMENT
Based on The Health Transformer Mindset™
™ & © 2017 StartUp Health Holdings, Inc. All rights reserved.

10. A NEW MODEL FOR TRANSFORMING HEALTH
GLOBAL
ARMY
LIFETIME
COACHING
JOIN THE HEALTH TRANSFORMER MOVEMENT
Based on The Health Transformer Mindset™
™ & © 2017 StartUp Health Holdings, Inc. All rights reserved.

11. A NEW MODEL FOR TRANSFORMING HEALTH
GLOBAL
ARMY
LIFETIME
COACHING
PARTNER
ACCESS
JOIN THE HEALTH TRANSFORMER MOVEMENT
Based on The Health Transformer Mindset™
™ & © 2017 StartUp Health Holdings, Inc. All rights reserved.

12. A NEW MODEL FOR TRANSFORMING HEALTH
GLOBAL
ARMY
LIFETIME
COACHING
PARTNER
ACCESS
MEDIA
PLATFORM
JOIN THE HEALTH TRANSFORMER MOVEMENT
Based on The Health Transformer Mindset™
™ & © 2017 StartUp Health Holdings, Inc. All rights reserved.

13. A NEW MODEL FOR TRANSFORMING HEALTH
GLOBAL
ARMY
LIFETIME
COACHING
PARTNER
ACCESS
MEDIA
PLATFORM
DATA-DRIVEN TECH PLATFORM
JOIN THE HEALTH TRANSFORMER MOVEMENT
Based on The Health Transformer Mindset™
™ & © 2017 StartUp Health Holdings, Inc. All rights reserved.

14. A NEW MODEL FOR TRANSFORMING HEALTH
GLOBAL
ARMY
LIFETIME
COACHING
PARTNER
ACCESS
MEDIA
PLATFORM
DATA-DRIVEN TECH PLATFORM
COACHING FROM “UNIQUE ABILITY” TEAM
JOIN THE HEALTH TRANSFORMER MOVEMENT
Based on The Health Transformer Mindset™
™ & © 2017 StartUp Health Holdings, Inc. All rights reserved.

15. HEALTH TRANSFORMER SHOWCASE
The World’s Largest Portfolio of Digital Health Companies
JOIN THE HEALTH TRANSFORMER MOVEMENT ™ & © 2017 StartUp Health Holdings, Inc. All rights reserved.

16. 2010 2011 2012 2013 2014 2015 2016
Q1 Q2 Q3 Q4
159
298
498
670
590
527
599
Deal Count
$1.3B
$1.7B
$1.7B
$611M
$590M
$494M
$274M
$8.1B
$5.9B
$7.1B
$2.9B
$2.4B
$1.9B
$1.1B
DIGITAL HEALTH FUNDING SNAPSHOT: YEAR OVER YEAR
Source: StartUp Health Insights | startuphealth.com/insights Note: Report based on public data on seed, venture, corporate venture and private equity funding only. © 2017 StartUp Health LLC
Over $8B have fueled new business models, increased demand, spurred a digital health revolution, and globalized what is
now possible.
DEALS & FUNDING GEOGRAPHY INVESTORS

17. DEALS & FUNDING
$0B
$0.2B
$0.4B
$0.6B
$0.8B
$1B
$1.2B
Jan Feb Mar Apr May Jun Jul Aug Sep Oct Nov Dec
2013 2014 2015 2016
In comparing monthly funding over the last four years, May and October are both breakout months for digital health funding, while
June is the least active month on average.
DIGITAL HEALTH FUNDING SNAPSHOT: MONTH OVER MONTH
GEOGRAPHY INVESTORS
Source: StartUp Health Insights | startuphealth.com/insights Note: Report based on public data on seed, venture, corporate venture and private equity funding only. © 2017 StartUp Health LLC

18. Company $ Invested Subsector Notable Investor
1 $500M Patient/Consumer Experience
1 $500M Patient/Consumer Experience Undisclosed
3 $448M Patient/Consumer Experience
4 $400M Wellness
5 $220M Personalized Health
6 $160M Wellness
7 $151M Patient/Consumer Experience
8 $145M Big Data/Analytics
9 $120M Patient/Consumer Experience
10 $100M Medical Device Undisclosed
10 $100M Medical Device
10 $100M Personalized Health
THE TOP 10 LARGEST DEALS OF 2016
Three of the top five deals in record were signed this year, demonstrating international commitment to supporting paradigm
shifting ideas in digital health.
DEALS & FUNDING GEOGRAPHY INVESTORS
Source: StartUp Health Insights | startuphealth.com/insights Note: Report based on public data on seed, venture, corporate venture and private equity funding only. © 2017 StartUp Health LLC

19. Patient/consumer experience was the most funded sector in digital health even the excluding the $1B funding raised by
Onduo and Good Doctor’s. Even after excluding these two deals, it is still the most funded sector in Digital Health.
Subsector Total Raised YTD Deal Count Avg. Deal Size
1 Patient/Consumer Experience $2.8B 163 $17M
2 Wellness $1.0B 45 $23M
3 Personalized Health/ Quantified-Self $765M 47 $16M
4 Medical Device $713M 53 $13M
5 Workflow $593M 89 $7M
6 Big Data/Analytics $562M 54 $10M
7 Population Health $436M 52 $8M
8 Clinical Decision Support $332M 22 $15M
9 Research $280M 28 $10M
10 E-commerce $277M 17 $16M
THE TOP 10 MOST ACTIVE MARKETS OF 2016
DEALS & FUNDING GEOGRAPHY INVESTORS
Source: StartUp Health Insights | startuphealth.com/insights Note: Report based on public data on seed, venture, corporate venture and private equity funding only. © 2017 StartUp Health LLC

20. We saw consistent market maturity in the patient/consumer experience, workflow, and personalized health markets, with the
latter having the most late-stage deals. There were few clinical decision support, EMR, and e-commerce deals at the early
stage.
47%
Patient/Consumer Experience
Wellness
Personalized Health/Quantified-Self
Big Data/Analytics
Medical Devices
Clinical Decision
Support
E-Commerce
32 32 21 4 4
15 15 11 5 1
9 12 13 0 1
11 11 5 2 0
11 10 5 6 0
11 9 6 3 5
7 11 2 0 0
8 6 6 2 4
1 3 4 3 0
0 4 2 0 1
2 0 0 0 0
0 1 1 1 0
Workflow
Research
Population
Health
EHR
Education/Training
Seed Series A Series B Series C Series D-H
MARKET MATURITY MAP 2016
More funding activity Less funding activity
DEALS & FUNDING GEOGRAPHY INVESTORS
Source: StartUp Health Insights | startuphealth.com/insights Note: Report based on public data on seed, venture, corporate venture and private equity funding only. © 2017 StartUp Health LLC

21. 2010
2011
2012
2013
2014
2015
2016
0% 25% 50% 75% 100%
Seed Series A Series B Series C Series D Series E Series F + G + H
31% 33% 7%22% 3%
*Deal count only includes Seed though Series G rounds. Does not include venture rounds or growth equity.
Deal Count*
124
237
304
450
391
300
344
2013 remains the year with the most early-stage investments at 74% or 331 deals. The last three years have remained strong
with 2/3 of all deals being Seed or A Rounds. Steady Seed Round & Series A funding in 2016 was an encouraging sign that
capital is still being distributed among early-stage digital health companies.
DEAL ACTIVITY BY STAGE
DEALS & FUNDING GEOGRAPHY INVESTORS
Source: StartUp Health Insights | startuphealth.com/insights Note: Report based on public data on seed, venture, corporate venture and private equity funding only. © 2017 StartUp Health LLC

22. Region
1 SF Bay Area
2 Boston Metro
3 New York Metro
4 San Diego
5 Los Angeles
6 Minneapolis/St. Paul
7 Philadelphia
8 Chicago
9 Salt Lake City
10 Washington, DC
Funding continues to be significant in the Bay Area and in the Northeast. In 2016, the metro regions of Boston and New York
City yielded 208 deals (47% of all deals) and approximately $3.4B in funding (54% of all funding).
THE MOST ACTIVE US METRO AREAS OF 2016
$105M
$928M
$970M
$710M
$1.5B
San Francisco Bay
Area
Salt Lake City
San Diego Metro
New York City Metro
Boston Metro
$180M
Chicago Metro
$216M
Minneapolis / St.
Paul Metro
$200M
Philadelphia
Metro
(8 Deals)
(7 Deals)
(116 Deals)
(15 Deals)
(15 Deals)
(17 Deals)
(60 Deals)
(35 Deals)
Los Angeles
Metro
$468M
(29 Deals)
Washington,
DC Metro
$97M
(9 Deals)
DEALS & FUNDING GEOGRAPHY INVESTORS
Source: StartUp Health Insights | startuphealth.com/insights Note: Report based on public data on seed, venture, corporate venture and private equity funding only. © 2017 StartUp Health LLC

23. Firm 2016 YTD Deals 2015 Deals Stage
Early Mid Late
1 18 10
2 15 9
3 10 2
4 9 6
4 9 6
6 8 3
6 8 7
8 7 3
9 6 7
9 6 5
9 6 4
THE TOP INVESTORS OF 2016
We are seeing huge strides in new investors coming into the digital health scene. All of the top 10 investors of 2016 are either
maintaining or increasing their involvement in the digital health Industry.
DEALS & FUNDING GEOGRAPHY INVESTORS
Source: StartUp Health Insights | startuphealth.com/insights Note: Report based on public data on seed, venture, corporate venture and private equity funding only. © 2017 StartUp Health LLC

24. 0
13
26
39
52
65
78
91
104
117
130
2010 2011 2012 2013 2014 2015 2016
2 3 4 5 6+
1
In 2016, we saw the total investor count jump by 42% - a huge signal of a booming industry. Not only are more investors entering
the scene, but they are also participating in more rounds than ever. 2016 brought investment from almost 900 unique firms,
angels or investment arms - almost 300 more than last year.
208
318 343
517
617 609
865
InvestorCount
# of Deals by Investor
NUMBER OF INVESTORS YEAR OVER YEAR
Total Investors
DEALS & FUNDING GEOGRAPHY INVESTORS
Source: StartUp Health Insights | startuphealth.com/insights Note: Report based on public data on seed, venture, corporate venture and private equity funding only. © 2017 StartUp Health LLC

25. THANK YOU
JOIN THE HEALTH TRANSFORMER MOVEMENT 16™ & © 2017 StartUp Health Holdings, Inc. All rights reserved.