Talk at the University of British Columbia Library School April 2, 2008.

1. Open Notebook Science: Implications for the Future of Libraries Jean-Claude Bradley E-Learning Coordinator College of Arts and Sciences Associate Professor of Chemistry Drexel University April 2, 2008 University of British Columbia Library School

2. Open and Closed Science Traditional Lab Notebook (unpublished) Traditional Journal Article Open Access Journal Article Open Notebook Science (full transparency) CLOSED OPEN Traditional Paper Textbook F2F lectures Lectures Notes public Assigned problems public Archived Lectures Public and free online textbooks RESEARCH TEACHING

3. Open Primary Research in Drug Design using Web2.0 tools (blogs, wikis, Second Life, mailing lists) Docking Synthesis Testing Rajarshi Guha Indiana U JC Bradley Drexel U Phil Rosenthal UCSF (malaria) Dan Zaharevitz NCI (tumors) Tsu-Soo Tan Nanyang Inst.

4. BLOG WIKI Mailing List GoogleDocs UsefulChem infrastructure

5. Where’s the Beef?

6. Link to Lab Notebook Page in Wiki

7. Link to Molecules

8. Link to Experimental Plan

9. Link to Docking Procedure (Rajarshi Guha)

10. Link to Docking Results (Rajarshi Guha)

11. Procedure Section

12. Link to Raw Data with JSpecView

13. Conclusion is Fully Supported

14. Indexing the Experiments in Google

15. Searching with Google Custom Search

16. How are people finding our experiments? NMR in TFA Phenylacetaldehyde c4h6o2 nmr methylene chloride/methanol h'nmr of benzophenone sulfuric acid pka tertbutylamine tosyl isocyanide amino furan dichloromethane polar? Reaction between Benzaldehyde and NaBH4 phosphoric acid pka veratraldehyde wiki kinetics boc deprotection Rf value in polar solvent why glycerol is immiscible with ether side reaction of imines 5.8 ppm nmr nmr cdcl3 chloroform side reaction diasterotopic wiki adding anhydrous MgSO4 to the dichlormethane ether extraction hnmr doublet of doublet Boc-protected NMR chromatotron recipe triplet cdcl3 "13c nmr" Specific Compounds Experimental Conditions

17. How are people finding UsefulChem? free downloading chemistry video organic chemistry project + high school how to make poster in second life organic chem. quiz 3d periodic tables animation protein docking docking animation why are acid-base reactions exothermic? lysosomal targets protease and malaria cheminformatics project proposal automated reactions malaria review project synthesis CHEMISTRY WEB 2.0 projects on QSAR & drug design chemistry experiment results database Educational Big Picture

18. Using ChemSpider to archive compound characterization

19. Comparing Experiments with GoogleDocs

20. The Most Important Section!

21. Results in Machine-Friendly Format

22. Comparing Results in a Table

23. Table of Contents

24. Recent Changes in Wiki

25. Tracking Versions of Wiki Pages

26. Comparing Versions of Wiki Pages

27. Telling the story of the failures

28. Mailing List Facilitates inter-group collaboration

29. What about the blog? Discussing Funding

30. Supporting Funding Initiatives

31. Highlight Popular Media Coverage

32. Highlight Peer-Reviewed Coverage

33. Announce Collaborator: Gus Rosania

34. Announce Collaborator: Matthias Zeller

35. Announce Collaborator: Phil Rosenthal

36. Discuss Presentations in Real Life

37. Discuss Presentations in Second Life

38. Showcase Science in New Media

39. Showcase Teaching in New Media

40. Alerts to Broader Impact Opportunities

41. Science Philosophy

42. Gus Rosania’s Notebook

43. Collaboration with Brent Friesen’s Teaching Lab

44. Cameron Neylon’s Notebook

45. Where is Science headed? WE ARE HERE