SlideShare uma empresa Scribd logo
1 de 14
1
4th National Conference on “Recent Advances in Engineering Technology and
                      Environmental issues (RAETE)”
                     J.C.D.M.College of Engineering,Sirsa




   A WRONG TURN BY QUANTUM DOTS
   RESULTED TOXICITY

                  AMIT SINGH          B.Pharmacy(final year)
                  Bharat Bhushan    Assistant Professor(JCDM College of Pharmacy)
                  Jagdish Chander   Associate Professor(JCDM College of Engg.)
          2




                            Thursday, Feb23, 2012
Introduction
   Quantum Dots (QDs), a heterogeneous class of
    engineered nanoparticles that are both semiconductors
    and fluorophores, are rapidly emerging as an important
    class of nanoparticles with numerous potential
    applications ranging from medicine to energy.
   Basic structure of QD are nanocrystals composed of a
    semiconductor core encased within a shell comprised of
    a second semiconductor material.
   A typical QD has a diameter in the range of 2–10
    nm, which is comparable with the size of a large protein.



                                                                3
Applications of Quantum Dots
The ability to tune the size of quantum dots is advantageous for many applications. For instance, larger
quantum dots have a greater spectrum-shift towards red compared to smaller dots, and exhibit less
pronounced quantum properties. Conversely, the smaller particles allow one to take advantage of more subtle
quantum effects.


                                                                      Computing

                                                                      Biology

                                                                      Photovoltaic
                                                                      devices
                                                                      Light emitting
                                                                      devices
                                                                      Photodetector
                                                                      devices




                                                                                                              5

              COMPUTING
    Quantum dot technology is one of the most promising candidates for use
    in solid-state quantum computation. By applying small voltages to the
    leads, the flow of electrons through the quantum dot can be controlled
    and thereby precise measurements of the spin and other properties
    therein can be made. With several entangled quantum dots, or
    qubits, plus a way of performing operations, quantum calculations and
    the computers that would perform them might be possible.




                                                                         6
Biology
   Semiconductor quantum dots have also been employed for in vitro
    imaging of pre-labelled cells. The ability to image single-cell
    migration in real time is expected to be important to several research
    areas such as embryogenesis, cancer metastasis,stem-cell
    therapeutics, and lymphocyte immunology.




                                                                         7
   Photovoltaic effect:
    • p-n Junction.
    • Sunlight excites electrons
      and creates electron-hole
      pairs.
    • Electrons concentrate on
      one side of the cell and
      holes on the other side.
    • Connecting the 2 sides
      creates electricity.




                                   8
                                       8
Light emitting devices
                                         9

 Quantum dots are valued for displays, because they emit light in very specific
  Gaussian distributions. This can result in a display that more accurately
  renders the colours that the human eye can perceive. Quantum dots also
  require very little power since they are not colour filtered. Additionally, since
  the discovery of "white-light emitting" QD, general solid-state lighting
  applications appear closer than ever. A colour liquid crystal display (LCD), for
  example, is usually powered by a single fluorescent lamp (or
  occasionally, conventional white LEDs) that is colour filtered to produce
  red, green, and blue pixels. Displays that intrinsically produce monochromatic
  light can be more efficient, since more of the light produced reaches the eye.
PHOTODETECTOR DEVICES
   Quantum dot photodetectors (QDPs) can be fabricated either via
    solution-processing, or from conventional single-crystalline
    semiconductors. Conventional single-crystalline semiconductor QDPs
    are precluded from integration with flexible organic electronics due to the
    incompatibility of their growth conditions with the process windows
    required by organic semiconductors. On the other hand, solution-
    processed QDPs can be readily integrated with an almost infinite variety
    of substrates, and also post processed atop other integrated circuits.
    Such colloidalQDPs have potential applications in surveillance, machine
    vision, industrial inspection, spectroscopy.




                                                                                  10
   Besides the above said positive features of Quantum dots, their internal structure
    have several disadvantages which lead them to wrong path both inside the
    human and in external environment.



                  Cytotoxic Effect


                                                • Phytotoxicity
                  Environmental
                                                • Marine
                     Toxicity                     Toxicity


                                                                                         11
A Road to Wrong Path
                       12
Conclusion




             13
 L. Jacak, P. Hawrylak, A. Wojs. Quantum dots. Springer-Verlag, Berlin, 1998.
 “Quantum Dots Explained.” Evident Technologies. 2008.
    <http://www.evidenttech.com/quantum-dots-explained.html>.
   Hanaki K, Momo A, Oku T, Komoto A, Maenosono S, Yamaguchi Y, Yamamoto K.
    Semiconductor quantum dot/albumin complex is a long-life and highly
    photostable endosome marker. Biochem. Biophys. Res. Commun. 2003;302:496-501
   Guo G, Liu W, Liang J, He Z, Xu H, Yang X. Probing the cytotoxicity of CdSe
    quantum dots with surface modification. Mater. Lett. 2007;61:1641-1644.
   Hardman R. A toxicologic review of quantum dots: Toxicity depends on
    physicochemical and environmental factors. Environ. Health Perspect. 2006;114:165-
    172
   Choi HS, Liu W, Misra P, Tanaka E, Zimmer JP, Itty Ipe B, Bawendi MG, Frangioni
    JV. Nat Biotechnol. 2007 Oct;25(10):1165-70. Epub 2007 Sep 23 (2007). "Renal
    clearance of quantum dots“. Nature biotechnology 25 (10): 1165–70.
   Pelley JL, Daar AS, Saner MA. Toxicol Sci. 2009 Dec;112(2):276-96 (2009). "State of academic
    knowledge on toxicity and biological fate of quantum dots". Toxicological sciences : an official
    journal of the Society of Toxicology 112 (2): 276–96.


                                                                                                       14

Mais conteúdo relacionado

Mais procurados

Mais procurados (20)

Quantum dots
Quantum dotsQuantum dots
Quantum dots
 
Quantum dots
Quantum dotsQuantum dots
Quantum dots
 
Biomedical applications of quantum dots
Biomedical applications of quantum dotsBiomedical applications of quantum dots
Biomedical applications of quantum dots
 
Quantum dots ppt
Quantum dots pptQuantum dots ppt
Quantum dots ppt
 
Carbon Quantum Dots
Carbon Quantum DotsCarbon Quantum Dots
Carbon Quantum Dots
 
Application of Carbon dots ppt
Application of Carbon dots pptApplication of Carbon dots ppt
Application of Carbon dots ppt
 
Quantum dots 1
Quantum dots 1Quantum dots 1
Quantum dots 1
 
Quantum Dots
Quantum DotsQuantum Dots
Quantum Dots
 
Quantum Dots
Quantum DotsQuantum Dots
Quantum Dots
 
Quantum Dots and its applications
Quantum Dots and its applicationsQuantum Dots and its applications
Quantum Dots and its applications
 
carbon quantum dots
carbon quantum dotscarbon quantum dots
carbon quantum dots
 
Quantum dots and its Applications
Quantum dots and its ApplicationsQuantum dots and its Applications
Quantum dots and its Applications
 
QUANTUM DOTS
QUANTUM DOTSQUANTUM DOTS
QUANTUM DOTS
 
Ashok quantum dots
Ashok quantum dotsAshok quantum dots
Ashok quantum dots
 
Doping the quantum dots
Doping the quantum dotsDoping the quantum dots
Doping the quantum dots
 
Carbon Nanotubes
Carbon NanotubesCarbon Nanotubes
Carbon Nanotubes
 
Introduction to nanoscience and nanotechnology
Introduction to nanoscience and nanotechnologyIntroduction to nanoscience and nanotechnology
Introduction to nanoscience and nanotechnology
 
Carbon dots
Carbon dotsCarbon dots
Carbon dots
 
MoS2
MoS2MoS2
MoS2
 
Quantum dots
Quantum dots Quantum dots
Quantum dots
 

Destaque

Intermediate band quantum dot solar cell
Intermediate band quantum dot solar cellIntermediate band quantum dot solar cell
Intermediate band quantum dot solar cell
HITESH Kumawat
 
Quantum dot lasers
Quantum dot lasersQuantum dot lasers
Quantum dot lasers
Bise Mond
 
Triple junction based high efficiency tandem solar cells
Triple junction based high efficiency tandem solar cellsTriple junction based high efficiency tandem solar cells
Triple junction based high efficiency tandem solar cells
Pritam Rath
 
Solar energy ppt
Solar energy pptSolar energy ppt
Solar energy ppt
shubhajit_b
 

Destaque (19)

Nanotechnology: Quantum Dots
Nanotechnology: Quantum DotsNanotechnology: Quantum Dots
Nanotechnology: Quantum Dots
 
Quantum dots
Quantum dotsQuantum dots
Quantum dots
 
Intermediate band quantum dot solar cell
Intermediate band quantum dot solar cellIntermediate band quantum dot solar cell
Intermediate band quantum dot solar cell
 
Quantum dot lasers
Quantum dot lasersQuantum dot lasers
Quantum dot lasers
 
Optical Imaging Probe development
Optical Imaging Probe developmentOptical Imaging Probe development
Optical Imaging Probe development
 
Chapter 1 pt 2
Chapter 1 pt 2Chapter 1 pt 2
Chapter 1 pt 2
 
Triple junction based high efficiency tandem solar cells
Triple junction based high efficiency tandem solar cellsTriple junction based high efficiency tandem solar cells
Triple junction based high efficiency tandem solar cells
 
Quantum dOTS updated
Quantum dOTS  updated Quantum dOTS  updated
Quantum dOTS updated
 
Quantum Dots_MEEE_AIUB
Quantum Dots_MEEE_AIUBQuantum Dots_MEEE_AIUB
Quantum Dots_MEEE_AIUB
 
Oled seminar report
Oled seminar reportOled seminar report
Oled seminar report
 
Nanotechnology and potential in Cancer therapy and treatment
Nanotechnology and potential in Cancer therapy and treatmentNanotechnology and potential in Cancer therapy and treatment
Nanotechnology and potential in Cancer therapy and treatment
 
OLED 2014 PPT
OLED 2014 PPTOLED 2014 PPT
OLED 2014 PPT
 
Carbon nanotube
Carbon nanotubeCarbon nanotube
Carbon nanotube
 
OLED technology Seminar Ppt
OLED technology Seminar PptOLED technology Seminar Ppt
OLED technology Seminar Ppt
 
oled ppt
oled pptoled ppt
oled ppt
 
Solar energy ppt
Solar energy pptSolar energy ppt
Solar energy ppt
 
Lecture 5 oms
Lecture 5 omsLecture 5 oms
Lecture 5 oms
 
16.40 o4 s janssens
16.40 o4 s janssens16.40 o4 s janssens
16.40 o4 s janssens
 
Betel leaves
Betel leavesBetel leaves
Betel leaves
 

Semelhante a Quantum dots ppt

nano imaging its potential and future.pptx
nano imaging its potential and future.pptxnano imaging its potential and future.pptx
nano imaging its potential and future.pptx
KanekiSSS
 
Sigma xi presentation (2)
Sigma xi presentation (2)Sigma xi presentation (2)
Sigma xi presentation (2)
CharlesJohn11
 
Week 9 - lecture 8.pptx
Week 9 - lecture 8.pptxWeek 9 - lecture 8.pptx
Week 9 - lecture 8.pptx
chemeng87
 

Semelhante a Quantum dots ppt (20)

Priya application of quantum dots in biological sciences
Priya application of quantum dots in biological sciencesPriya application of quantum dots in biological sciences
Priya application of quantum dots in biological sciences
 
Peak Level Advancement of Sensors and its Applications.
Peak Level Advancement of Sensors and its Applications.Peak Level Advancement of Sensors and its Applications.
Peak Level Advancement of Sensors and its Applications.
 
nuclear medicine 10 marks questions and answers.docx
nuclear medicine 10 marks questions and answers.docxnuclear medicine 10 marks questions and answers.docx
nuclear medicine 10 marks questions and answers.docx
 
Pavel2010 review
Pavel2010 reviewPavel2010 review
Pavel2010 review
 
Quantam dot by ammad naseem
Quantam dot by ammad naseemQuantam dot by ammad naseem
Quantam dot by ammad naseem
 
nano imaging its potential and future.pptx
nano imaging its potential and future.pptxnano imaging its potential and future.pptx
nano imaging its potential and future.pptx
 
Nano electronics- role of nanosensors, pdf file
Nano electronics- role of nanosensors, pdf fileNano electronics- role of nanosensors, pdf file
Nano electronics- role of nanosensors, pdf file
 
7 imaging
7 imaging7 imaging
7 imaging
 
Characterization techniques of nanoparticles
Characterization techniques of nanoparticlesCharacterization techniques of nanoparticles
Characterization techniques of nanoparticles
 
Sigma xi presentation (2)
Sigma xi presentation (2)Sigma xi presentation (2)
Sigma xi presentation (2)
 
Ohm pres
Ohm presOhm pres
Ohm pres
 
Ohm pres
Ohm presOhm pres
Ohm pres
 
Ohm pres
Ohm presOhm pres
Ohm pres
 
Commonly Used Nanomaterials in Molecular Imaging
Commonly Used Nanomaterials in Molecular ImagingCommonly Used Nanomaterials in Molecular Imaging
Commonly Used Nanomaterials in Molecular Imaging
 
Quantum-Pi_Cairo-09
Quantum-Pi_Cairo-09Quantum-Pi_Cairo-09
Quantum-Pi_Cairo-09
 
Living in a World of Nanobioinfotechnology
Living in a World of NanobioinfotechnologyLiving in a World of Nanobioinfotechnology
Living in a World of Nanobioinfotechnology
 
IRJET- Nanorobots: Application in Data Mining
IRJET- Nanorobots: Application in Data MiningIRJET- Nanorobots: Application in Data Mining
IRJET- Nanorobots: Application in Data Mining
 
Week 9 - lecture 8.pptx
Week 9 - lecture 8.pptxWeek 9 - lecture 8.pptx
Week 9 - lecture 8.pptx
 
Ankit quantum-dots-semina1r
Ankit quantum-dots-semina1rAnkit quantum-dots-semina1r
Ankit quantum-dots-semina1r
 
Nanobiotechnology
NanobiotechnologyNanobiotechnology
Nanobiotechnology
 

Último

Salient Features of India constitution especially power and functions
Salient Features of India constitution especially power and functionsSalient Features of India constitution especially power and functions
Salient Features of India constitution especially power and functions
KarakKing
 

Último (20)

Graduate Outcomes Presentation Slides - English
Graduate Outcomes Presentation Slides - EnglishGraduate Outcomes Presentation Slides - English
Graduate Outcomes Presentation Slides - English
 
Salient Features of India constitution especially power and functions
Salient Features of India constitution especially power and functionsSalient Features of India constitution especially power and functions
Salient Features of India constitution especially power and functions
 
HMCS Max Bernays Pre-Deployment Brief (May 2024).pptx
HMCS Max Bernays Pre-Deployment Brief (May 2024).pptxHMCS Max Bernays Pre-Deployment Brief (May 2024).pptx
HMCS Max Bernays Pre-Deployment Brief (May 2024).pptx
 
How to Create and Manage Wizard in Odoo 17
How to Create and Manage Wizard in Odoo 17How to Create and Manage Wizard in Odoo 17
How to Create and Manage Wizard in Odoo 17
 
TỔNG ÔN TẬP THI VÀO LỚP 10 MÔN TIẾNG ANH NĂM HỌC 2023 - 2024 CÓ ĐÁP ÁN (NGỮ Â...
TỔNG ÔN TẬP THI VÀO LỚP 10 MÔN TIẾNG ANH NĂM HỌC 2023 - 2024 CÓ ĐÁP ÁN (NGỮ Â...TỔNG ÔN TẬP THI VÀO LỚP 10 MÔN TIẾNG ANH NĂM HỌC 2023 - 2024 CÓ ĐÁP ÁN (NGỮ Â...
TỔNG ÔN TẬP THI VÀO LỚP 10 MÔN TIẾNG ANH NĂM HỌC 2023 - 2024 CÓ ĐÁP ÁN (NGỮ Â...
 
On_Translating_a_Tamil_Poem_by_A_K_Ramanujan.pptx
On_Translating_a_Tamil_Poem_by_A_K_Ramanujan.pptxOn_Translating_a_Tamil_Poem_by_A_K_Ramanujan.pptx
On_Translating_a_Tamil_Poem_by_A_K_Ramanujan.pptx
 
Basic Intentional Injuries Health Education
Basic Intentional Injuries Health EducationBasic Intentional Injuries Health Education
Basic Intentional Injuries Health Education
 
Beyond_Borders_Understanding_Anime_and_Manga_Fandom_A_Comprehensive_Audience_...
Beyond_Borders_Understanding_Anime_and_Manga_Fandom_A_Comprehensive_Audience_...Beyond_Borders_Understanding_Anime_and_Manga_Fandom_A_Comprehensive_Audience_...
Beyond_Borders_Understanding_Anime_and_Manga_Fandom_A_Comprehensive_Audience_...
 
Google Gemini An AI Revolution in Education.pptx
Google Gemini An AI Revolution in Education.pptxGoogle Gemini An AI Revolution in Education.pptx
Google Gemini An AI Revolution in Education.pptx
 
Single or Multiple melodic lines structure
Single or Multiple melodic lines structureSingle or Multiple melodic lines structure
Single or Multiple melodic lines structure
 
COMMUNICATING NEGATIVE NEWS - APPROACHES .pptx
COMMUNICATING NEGATIVE NEWS - APPROACHES .pptxCOMMUNICATING NEGATIVE NEWS - APPROACHES .pptx
COMMUNICATING NEGATIVE NEWS - APPROACHES .pptx
 
Jamworks pilot and AI at Jisc (20/03/2024)
Jamworks pilot and AI at Jisc (20/03/2024)Jamworks pilot and AI at Jisc (20/03/2024)
Jamworks pilot and AI at Jisc (20/03/2024)
 
On National Teacher Day, meet the 2024-25 Kenan Fellows
On National Teacher Day, meet the 2024-25 Kenan FellowsOn National Teacher Day, meet the 2024-25 Kenan Fellows
On National Teacher Day, meet the 2024-25 Kenan Fellows
 
General Principles of Intellectual Property: Concepts of Intellectual Proper...
General Principles of Intellectual Property: Concepts of Intellectual  Proper...General Principles of Intellectual Property: Concepts of Intellectual  Proper...
General Principles of Intellectual Property: Concepts of Intellectual Proper...
 
Basic Civil Engineering first year Notes- Chapter 4 Building.pptx
Basic Civil Engineering first year Notes- Chapter 4 Building.pptxBasic Civil Engineering first year Notes- Chapter 4 Building.pptx
Basic Civil Engineering first year Notes- Chapter 4 Building.pptx
 
HMCS Vancouver Pre-Deployment Brief - May 2024 (Web Version).pptx
HMCS Vancouver Pre-Deployment Brief - May 2024 (Web Version).pptxHMCS Vancouver Pre-Deployment Brief - May 2024 (Web Version).pptx
HMCS Vancouver Pre-Deployment Brief - May 2024 (Web Version).pptx
 
Tatlong Kwento ni Lola basyang-1.pdf arts
Tatlong Kwento ni Lola basyang-1.pdf artsTatlong Kwento ni Lola basyang-1.pdf arts
Tatlong Kwento ni Lola basyang-1.pdf arts
 
ICT role in 21st century education and it's challenges.
ICT role in 21st century education and it's challenges.ICT role in 21st century education and it's challenges.
ICT role in 21st century education and it's challenges.
 
How to Add New Custom Addons Path in Odoo 17
How to Add New Custom Addons Path in Odoo 17How to Add New Custom Addons Path in Odoo 17
How to Add New Custom Addons Path in Odoo 17
 
UGC NET Paper 1 Mathematical Reasoning & Aptitude.pdf
UGC NET Paper 1 Mathematical Reasoning & Aptitude.pdfUGC NET Paper 1 Mathematical Reasoning & Aptitude.pdf
UGC NET Paper 1 Mathematical Reasoning & Aptitude.pdf
 

Quantum dots ppt

  • 1. 1
  • 2. 4th National Conference on “Recent Advances in Engineering Technology and Environmental issues (RAETE)” J.C.D.M.College of Engineering,Sirsa A WRONG TURN BY QUANTUM DOTS RESULTED TOXICITY AMIT SINGH B.Pharmacy(final year) Bharat Bhushan Assistant Professor(JCDM College of Pharmacy) Jagdish Chander Associate Professor(JCDM College of Engg.) 2 Thursday, Feb23, 2012
  • 3. Introduction  Quantum Dots (QDs), a heterogeneous class of engineered nanoparticles that are both semiconductors and fluorophores, are rapidly emerging as an important class of nanoparticles with numerous potential applications ranging from medicine to energy.  Basic structure of QD are nanocrystals composed of a semiconductor core encased within a shell comprised of a second semiconductor material.  A typical QD has a diameter in the range of 2–10 nm, which is comparable with the size of a large protein. 3
  • 4.
  • 5. Applications of Quantum Dots The ability to tune the size of quantum dots is advantageous for many applications. For instance, larger quantum dots have a greater spectrum-shift towards red compared to smaller dots, and exhibit less pronounced quantum properties. Conversely, the smaller particles allow one to take advantage of more subtle quantum effects. Computing Biology Photovoltaic devices Light emitting devices Photodetector devices 5
  • 6. COMPUTING Quantum dot technology is one of the most promising candidates for use in solid-state quantum computation. By applying small voltages to the leads, the flow of electrons through the quantum dot can be controlled and thereby precise measurements of the spin and other properties therein can be made. With several entangled quantum dots, or qubits, plus a way of performing operations, quantum calculations and the computers that would perform them might be possible. 6
  • 7. Biology  Semiconductor quantum dots have also been employed for in vitro imaging of pre-labelled cells. The ability to image single-cell migration in real time is expected to be important to several research areas such as embryogenesis, cancer metastasis,stem-cell therapeutics, and lymphocyte immunology. 7
  • 8. Photovoltaic effect: • p-n Junction. • Sunlight excites electrons and creates electron-hole pairs. • Electrons concentrate on one side of the cell and holes on the other side. • Connecting the 2 sides creates electricity. 8 8
  • 9. Light emitting devices 9  Quantum dots are valued for displays, because they emit light in very specific Gaussian distributions. This can result in a display that more accurately renders the colours that the human eye can perceive. Quantum dots also require very little power since they are not colour filtered. Additionally, since the discovery of "white-light emitting" QD, general solid-state lighting applications appear closer than ever. A colour liquid crystal display (LCD), for example, is usually powered by a single fluorescent lamp (or occasionally, conventional white LEDs) that is colour filtered to produce red, green, and blue pixels. Displays that intrinsically produce monochromatic light can be more efficient, since more of the light produced reaches the eye.
  • 10. PHOTODETECTOR DEVICES  Quantum dot photodetectors (QDPs) can be fabricated either via solution-processing, or from conventional single-crystalline semiconductors. Conventional single-crystalline semiconductor QDPs are precluded from integration with flexible organic electronics due to the incompatibility of their growth conditions with the process windows required by organic semiconductors. On the other hand, solution- processed QDPs can be readily integrated with an almost infinite variety of substrates, and also post processed atop other integrated circuits. Such colloidalQDPs have potential applications in surveillance, machine vision, industrial inspection, spectroscopy. 10
  • 11. Besides the above said positive features of Quantum dots, their internal structure have several disadvantages which lead them to wrong path both inside the human and in external environment. Cytotoxic Effect • Phytotoxicity Environmental • Marine Toxicity Toxicity 11
  • 12. A Road to Wrong Path 12
  • 14.  L. Jacak, P. Hawrylak, A. Wojs. Quantum dots. Springer-Verlag, Berlin, 1998.  “Quantum Dots Explained.” Evident Technologies. 2008. <http://www.evidenttech.com/quantum-dots-explained.html>.  Hanaki K, Momo A, Oku T, Komoto A, Maenosono S, Yamaguchi Y, Yamamoto K. Semiconductor quantum dot/albumin complex is a long-life and highly photostable endosome marker. Biochem. Biophys. Res. Commun. 2003;302:496-501  Guo G, Liu W, Liang J, He Z, Xu H, Yang X. Probing the cytotoxicity of CdSe quantum dots with surface modification. Mater. Lett. 2007;61:1641-1644.  Hardman R. A toxicologic review of quantum dots: Toxicity depends on physicochemical and environmental factors. Environ. Health Perspect. 2006;114:165- 172  Choi HS, Liu W, Misra P, Tanaka E, Zimmer JP, Itty Ipe B, Bawendi MG, Frangioni JV. Nat Biotechnol. 2007 Oct;25(10):1165-70. Epub 2007 Sep 23 (2007). "Renal clearance of quantum dots“. Nature biotechnology 25 (10): 1165–70.  Pelley JL, Daar AS, Saner MA. Toxicol Sci. 2009 Dec;112(2):276-96 (2009). "State of academic knowledge on toxicity and biological fate of quantum dots". Toxicological sciences : an official journal of the Society of Toxicology 112 (2): 276–96. 14