Grupo de investigación adscrito al itdUPM

1. http://www.die.upm.es/im/
BIOMEDICAL IMAGE TECHNOLOGIES LAB
Universidad Politécnica de Madrid
CIBER-BBN

2. Background
• Universidad Politécnica de Madrid: the largest
and oldest technical university in Spain
– ~ 50,000 students
• Telecommunication Eng. School (ETSI
Telecomunicación)
– ~ 4,000 students
• Electronic Engineering Dept.

3. Introduction
Vision: Contribute to improve health care delivery through advances in
biomedical imaging technologies.
Mission: The application of technological solutions to actual clinical or
biological problems, especially with the aim of early diagnosis and
treatment.
• Director: Prof. Andres Santos
 2 Associate Professors (María J Ledesma Carbayo, Georgios Kontaxakis)
 8 Researchers (4 PhD)
 4 PhD students
 1 Technician
Ranked 2nd (2006) and 4th (2007) among UPM emerging groups: 1st in
research dissemination (publications)

4. Research Activities

5. Cardiovascular imaging
AIM:
to contribute to an early diagnosis of
cardiovascular pathologies, by providing
functional and quantitative information of the
heart and vessels obtained from images
(mainly echocardiography, MRI and CT).
Hospital G.U. Gregorio Marañón. Madrid.
National Institutes of Health. Bethesda (MD, USA)
Johns Hopkins Univ. (MD, USA)
Siemens – Acuson (CA, USA)

6. Myocardial Motion Estimation
Dense Displacement Field
Bspline non-rigid registration
2 3
Regional
Analysis
• Displacement
• Velocity
• Strain
Analysis of cardiac
dynamics
Ledesma-Carbayo. IEEE T Med Imag, 2005.
Ledesma-Carbayo. Ultrasound Med Biol, 2006

7. Maps of Anterior Infarct. Relation
between Voltage and Signal Intensity
Mapping
7
Endocardial DE-MRI map
Electroanatomical Map
(CARTO ®)Perez-David. J. Am. Coll. Cardiol, 2011
Arenal. Cardiovasc. Res., 2012

8. High Resolution Pre-clinical
Imaging
AIM:
to contribute to the design and
implementation of high resolution
experimental Positron Emission Tomography
(PET) scanners. A new research line has been
started on Optical Tomography.
Hospital G.U. Gregorio Marañón. Madrid.
SEDECAL (SUINSA). Spain
Università di Pisa (Italy)

9. PETonCHIP Concept
Event and coincidence resolution in single FPGA
Guerra. IEEE Trans Nucl Sci, 2008

10. Iterative
reconstruction120º
120º
Simulation of other
architectures
Simulation and tomographic
reconstruction
Ortuño. Phys. Med. Biol., 2010
Sportelli. Med. Phys., 2013
Sportelli. Phys. Med. Biol., 2014

11. Image-guided radiotherapy and
dosimetry
AIM:
to contribute to the radiotherapy planning,
dosimetry and surgery planning by means of
image registration, image segmentation and
MC simulations.
GMV Soluciones Globales Internet. Spain
Hospital G.U. Gregorio Marañón. Madrid.

13. Multimodality Imaging
Image guided
liver surgery
(Hosp. G. Marañón)
Visualization of
anatomy and
metabolic activity
Analysis of MRI dynamic studies
(Universitat Autònoma Barcelona)
Multimodal brain
image analysis
(Hosp. Clínic Barcelona)
Marti-Fuster. Neuroinformatics, 2013
Ortuño. BMC Bioinformatics, 2013
Fernandez-de-Manuel. Med. Image Anal., 2014

14. www.MalariaSpot.org
14
Crowdsourcing and gamification

15. Microscopy Image
Analysis for Systems
BiologyAIM:
to develop image analysis methods to process data acquired with the
most recent state-of-the-art microscopy technologies for biomedical
understanding.
Multidimensional in-vivo observations of organism models such as
zebrafish embryo need images analysis to solve new challenges in systems
biology at the different genetic, proteomic, cellular, organic and individual
levels.
Institut de Neurobiologie Alfred Fessard - CNRS, France
Complex Systems Institute of Paris (ISC-PIF), France
Spanish National Center of Biotechnology (CSIC-CNB), Spain

16. In-toto reconstruction of early zebrafish embryogenesis
OUTCOME: DIGITAL EMBRYO
Olivier, Luengo-Oroz, Duloquin. Science, 2010
Rubio-Guivernau. Bioinformatics, 2012
Luengo-Oroz. IEEE Trans. Image Process,

17. Gene atlas of zebrafish embryo
development
Data 1
GENE X
NUCLEI
GENE A
Data 2
GENE X
NUCLEI
GENE B
Data N
GENE X
NUCLEI
GENE N
PARTIAL EMBRYOS COMPLETE EMBRYO
TEMPLATE
NUCLEI
GENE X
QUANTIFICATION
QUANTITATIVE 3D ATLAS OF
GENE EXPRESSION
– The extraction of both the cellular localizations
and the level of expression of different genes
at different developmental stages will help the
understanding of genetic regulatory networks
in their spatiotemporal context
– Acquired images of pairs of gene expressions
with double Fluorescent In-Situ Hybridization
protocols (FISH)
REGISTRATION

18. Embryo and cell dynamics
Institut de Neurobiologie Alfred Fessard - CNRS, France
Complex Systems Institute of Paris (ISC-PIF), France
Spanish National Center of Biotechnology (CSIC-CNB), Spain
Universidad Carlos III, Spain
University of California San Diego, US
3D TFM

19. e1
90%
Epiboly
Bud
Shield
Growing
Epiboly
75%
EpibolyQ P
PDensity
TopologyVelocity 6h
7h
8h
9hQ Topology
Planar
Compression
Velocity
Velocity
10hPRotation Topologye1
Total Inc Strain
e1
e1
de1
de1
de1
Velocity

20. www.itd.upm.es
itd@upm.es
@itdupm
itdupm