B-vitamins intervention trial in stable CAD.

1. The Western Norway B-Vitamin Intervention Trial (WENBIT) Ebbing M, Bleie Ø, Ueland PM, et al. Mortality and cardiovascular events in patients treated with homocysteine-lowering B vitamins after coronary angiography. A randomized controlled trial. JAMA . 2008;300:795-804.

15. WENBIT: Percentage of patients with cardiovascular events Ebbing M et al. JAMA 2008; 300:795-804. End point Folic acid+B 12 +B 6 Folic acid+B 12 B 6 Placebo Primary end point 12.2 16.3 13.7 12.5 All-cause death 4.5 4.9 3.6 3.9 Acute MI 7.7 9.9 7.1 7.4 Unstable angina 2.9 3.8 3.1 3.5 Nonfatal thromboembolic stroke 1.4 2.2 2.6 2.4 Cancer 6.0 5.1 4.9 4.0

16. There were no differences in treatment response for the separate endpoints of death, total acute myocardial infarction, or unstable angina. The incidence of total stroke was lower in the groups receiving folic acid; however, this observation was not statistically significant. The incidence of acute hospitalization for angina pectoris was lower in the folic acid groups, reaching borderline statistical significance ( P = .05).