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Urinary Tract Infection Department of Nephrology,the First Affiliated Hospital , Sun Yat-sun University   Qiongqiong Yang [email_address]
[object Object],Definitions Dysuria  frequency  urgency
[object Object],[object Object],[object Object],Categories urethra Female Urinary System bladder ureter kidney uterus
[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],Categories
EPIDEMIOLOGY ,[object Object],[object Object],[object Object],*Data from 30,196 women 1 st  Affiliated Hospital of SunYat sen Uni
EPIDEMIOLOGY ,[object Object],[object Object],[object Object],[object Object]
Etiology ,[object Object],[object Object],[object Object],[object Object],[object Object]
Pathogenesis ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
[object Object],Sources of infection Ascending infection bladder urethre
Sources of infection Ascending infection ,[object Object],[object Object],entrance ,[object Object],rectal introitus Vaginal introitus  Dital urethra
[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],Predisposing factor
[object Object],[object Object],[object Object],Predisposing factor Hydronephrosis Dilation of ureter Obstruction Retrograde pyelograpy
[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],Predisposing factor
[object Object],[object Object],[object Object],[object Object],[object Object],Local and systemic host defence mechanisms
Bacterial virulence factors   E coli: specific O,K, and H serogroups
[object Object],[object Object],[object Object],[object Object],[object Object],Clinical Manifestation
Clinical Manifestation Cystitis acute pyelonephritis Dysuria, frequency, urgency  obvious  obvious Fever, shaking chills none showed Costovertebral  angles tenderness /sensitive to percussion  none showed WBC mostly normal increased pathogenic bacterium  Escherichia coli ( 75%) coagulated negative staphylococcus ( 15% )  Escherichia coli 、 bacillus proteus 、 Klebsiella
Clinical Manifestation ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Complication ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Laboratory test ,[object Object],[object Object],[object Object]
Pyuria ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
 
Bacteriuria ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],significant
[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],Bacteriuria
[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Gram negative bacilli. Escherichia coli Gram positive cocci  in chains.  Enterococcus faecalis Gram positive cocci   Staphylococcus saprophyticus Gram positive budding yeasts and large pseudohyphae. Candida albicans
False bacteriuria should be excluded ,[object Object],[object Object],[object Object]
False negative in Urine culture ,[object Object],[object Object],[object Object],[object Object],[object Object]
Other examination ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Diagnosis ,[object Object],[object Object],[object Object],[object Object],Bacteriuria
Diagnosis ,[object Object],[object Object],[object Object],cystitis ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],Pyelonephritis
Review of  3 days therapy No symptoms , pyuria, bacteriuria Noninfectious Urethral syndrome Without bacteriuira With symptoms Without symptoms Yes No Without bacteriuira With bacteriuira Woman with  urethral stimulate symptom 3 days antibiotics  therapy ( TMP-SMZ 2 # Bid / Ofloxacin 0.2g Bid ) Urinalysis and urine bacteria culture Cystitis  (cured) Symptoms relapse  with pyuria  and bacteriuria pyelonephritis (occult ) pyuira pyelonephritis Urethral syndrome caused by chlamydia trachomatis 7 days later 1W~1M
Differential Diagnosis ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Renal tuberculosis ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Renal tuberculosis ,[object Object],[object Object],[object Object],[object Object],[object Object]
Urethral syndrome ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Treatment ,[object Object],[object Object]
Principle(1) ,[object Object],[object Object],[object Object],[object Object]
Principle(2) ,[object Object],[object Object],[object Object]
Principle(3) ,[object Object],[object Object],[object Object],[object Object]
Principle(4) ,[object Object],[object Object],[object Object],[object Object],[object Object]
Principle(5) ,[object Object],[object Object],[object Object],[object Object]
Treatment for different  types of UTIs ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Acute uncomplicated Cystitis in women ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Acute uncomplicated Cystitis in women ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
CASE I   ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
.  Diagnosis Bacteriuria? ,[object Object],[object Object],[object Object],[object Object],[object Object],cystitis 3 days antibiotics  therapy ( TMP-SMZ 2 # Bid / Ofloxacin 0.2g Bid )
Review of  3 days therapy No symptoms , pyuria, bacteriuria Without symptoms Urinalysis and urine bacteria culture Cystitis  (cured) 7 days later
Acute uncomplicated pyelonephritis ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Acute uncomplicated pyelonephritis 14 days antibiotics course  Acute uncomplicated pyelonephritis Follow up at the 2 nd  wk and 6 th  wks Failure  within 72 hr relapse Relief from symptoms without bacteriuria Cured ,[object Object],[object Object],[object Object],predisposing factors: ,[object Object],[object Object],[object Object]
Recurrent  UTIs ,[object Object],[object Object],[object Object],[object Object]
Recurrent  UTIs ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Recurrent  UTIs ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Recurrent  UTIs ,[object Object],[object Object],[object Object],[object Object]
History of recurrent UTIs,  with UTI symptoms Short-term therapy Review 7 days later effective reinfection sensitive antibiotics Long-term low-dose  antibiotics failure effective failure pyelonephritis ,[object Object],[object Object],relapse recurrent UTIs frequencly Antibiotic-resistent Recurrent  UTIs
Complicated UTIs ,[object Object],[object Object],[object Object]
Complicated UTIs ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],Catheter-Associated UTIs
UTIs in Pregnancy ,[object Object],[object Object],[object Object],[object Object],[object Object]
UTIs in Pregnancy ,[object Object],[object Object],[object Object],Urine culture should be performed to ensure cure, and repeated monthly until delivery. UTIs in Pregnancy Recurrent  infection : continuous low-dose prophylaxis with nitrofurantoin.
Asymptomatic bacteriuria ,[object Object],[object Object],[object Object],[object Object],[object Object],longer-term therapy(4-6 wks) in high-risk pts persistent asympomatic bacteriura Monitoring without further treatment
Prognosis ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Prevention ,[object Object],[object Object],[object Object],[object Object]
Prevention ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Take Home Messages ,[object Object],[object Object],[object Object],[object Object]
Thanks !

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Uti english ppts

  • 1. Urinary Tract Infection Department of Nephrology,the First Affiliated Hospital , Sun Yat-sun University Qiongqiong Yang [email_address]
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  • 15. Bacterial virulence factors   E coli: specific O,K, and H serogroups
  • 16.
  • 17. Clinical Manifestation Cystitis acute pyelonephritis Dysuria, frequency, urgency obvious obvious Fever, shaking chills none showed Costovertebral angles tenderness /sensitive to percussion none showed WBC mostly normal increased pathogenic bacterium Escherichia coli ( 75%) coagulated negative staphylococcus ( 15% ) Escherichia coli 、 bacillus proteus 、 Klebsiella
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  • 26. Gram negative bacilli. Escherichia coli Gram positive cocci in chains. Enterococcus faecalis Gram positive cocci Staphylococcus saprophyticus Gram positive budding yeasts and large pseudohyphae. Candida albicans
  • 27.
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  • 32. Review of 3 days therapy No symptoms , pyuria, bacteriuria Noninfectious Urethral syndrome Without bacteriuira With symptoms Without symptoms Yes No Without bacteriuira With bacteriuira Woman with urethral stimulate symptom 3 days antibiotics therapy ( TMP-SMZ 2 # Bid / Ofloxacin 0.2g Bid ) Urinalysis and urine bacteria culture Cystitis (cured) Symptoms relapse with pyuria and bacteriuria pyelonephritis (occult ) pyuira pyelonephritis Urethral syndrome caused by chlamydia trachomatis 7 days later 1W~1M
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  • 48. Review of 3 days therapy No symptoms , pyuria, bacteriuria Without symptoms Urinalysis and urine bacteria culture Cystitis (cured) 7 days later
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Notas do Editor

  1. classified
  2. Very common. Epidemiological study 30196 普查女性结果
  3. UTIs appear to remain common throughout a woman's life In a report of girls who were followed from their first known infection in childhood into adulthood (and who may have represented a selected group at higher risk for UTI than the general population), the incidence of acute cystitis dropped to low levels, increased to approximately 0.5 episodes per year during their late teens and early twenties (presumably due to sexual activity), and then dropped to approximately 0.1 episodes per year in their early thirties
  4. Introitus:entrance
  5. 唇 anatomy
  6. Inhibit or kill bactria
  7. Systemic toxic symptom
  8. HP high power field WBC 脂酶试纸阳性 ; sterile The most accurate method for assessing pyuria is to examine an unspun voided midstream urine specimen with a simple hemocytometer; 10 or more leukocytes per microL are considered abnormal
  9. 10 to 5 power make sense
  10. The most accurate method for assessing pyuria is to examine an unspun voided midstream urine specimen with a simple hemocytometer; 10 or more leukocytes per microL are considered abnormal wet mount or Gram's stain 浸试条法 : 白细胞酯酶
  11. The most accurate method for assessing pyuria is to examine an unspun voided midstream urine specimen with a simple hemocytometer; 10 or more leukocytes per microL are considered abnormal wet mount or Gram's stain 浸试条法 : 白细胞酯酶
  12. These are some examples.
  13. 发现皮质瘢痕及肾盂肾盏变形或不对称 肾脏缩小
  14. 绿脓杆菌、变形杆菌、粪链球菌;
  15. acute urethral syndrome Azithromycin 〖中文通用名〗阿奇霉素
  16. 1.a quantitative urine culture or a comparable alternative diagnostic test should be performed except acute uncomplicated cystitis. 2.Before empirical treatment is begun When culture results become available, antimicrobial sensitivity testing should be used to further direct therapy.
  17. Obstruction is caused by Urinary stones, it should be corrected surgically if possible.
  18. Despite increasing resistance, community-acquired infections, especially initial infections, are usually due to more antibiotic-sensitive strains.
  19. After completing one course of treatment , we need to judge the results of treatment.
  20. Early recurrences due to the same strain may results from an unresolved upper tract focus of infection but often results from persistent vaginal colonization. Vaginal and rectal folra.
  21. 头孢泊肟酯 Empirical therapy: oral TMP-SMX,TMP, fluoroquinolone ,amoxicillin, macrocrystalline nitrofurantoin, cefpodoxime proxetil
  22. These are some examples.
  23. 绿脓杆菌、变形杆菌、粪链球菌;
  24. Penbritin 广谱青霉素 , 氨基苄青霉素 Chose the one that can reach a
  25. Penbritin 广谱青霉素 , 氨基苄青霉素 Chose the one that can reach a
  26. Bacteriuria appear again after cessation of treatment. Reinfection:
  27. the following conditions should be considered : After completing one course of treatment , we need to judge the results of treatment.
  28. , the following conditions should be considered:
  29. 头孢曲松, 头孢他定。 If the infection is not more severe, or the infecting strain is Abs resistant , prolong therapy
  30. Because Abs usually unsucessful and may result in infection with more resistant stain.
  31. Non-pregnant women Elderly people Complicated UTIs: not recommended to treat because of hard to achieve radical cure.
  32. urinate every 2~3 hours in order to douching bladder and uretha and avoiding pathogenic bacteria breeding in the urinary tract.