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www.insightscare.com
Dr. John Moller
CEO
NOVOTECH
2019 Vol.6/ Issue-2
ACatalyst for Growth and
a Better Tomorrow
1
TH
0
E
COMPANIES
BOOMING
IN
HEALTHCA
RE
SECTOR
THETOMORROW OF
HEALTHCARE
he landscape of healthcare has noticeably changed compared to what it was a few years ago.
The global expenditure of healthcare has been on a spree, rising at the rate of 5.7 percent
Tannually, between the years 2017 to 2022. This growth is driven by various factors including
the rise in the population of people in older age groups, increased chronic disease rates, new demands
of the care receivers and newer approach of care givers, and many more. Based on the scenario of the
global healthcare industry in 2019, we can predict a few possibilities that will drive the market in the
years to come.
The two big trends that have emerged in the past few years are the shifting of this industry towards
personalized, outcome-based care and the developments in diagnostic and preventive care. These
trends will continue to gain popularity and many new startups as well as well-settled business players
are seen to focus on them. The advancements in healthcare have come with huge investments and
there is a rising need to bring in better solutions at affordable prices. Many new researches and
funding for drug development and treatments, along with technological advancements, are seen and
are expected to increase further. The future holds a promise for various disruptive innovations to make
this a reality. We will also owe it to mergers and collaborations among various healthcare and non-
healthcare organizations to attain financial sustainability.
Technological innovation is another key factor driving the steering of tomorrow for healthcare niche.
With emergence and wide-spread acceptance of developments in wearable devices, remote healthcare,
telemedicine, patient management apps, digital healthcare, and more, myriads of companies are seen
to invest in these areas. The consumer demands have changed with their increased role in the system
and therefore, the focus should be shifted to patient engagement and building of more personal
relationships. Additionally, technologies like AI, VR, 3D printing, medical imaging, etc. have entered
the healthcare sector and are assisting the providers in offering more accurate and enhanced care to
the patients.
With increase in the number of changes the industry is witnessing, there is increase in the need of
regulatory policies and compliances as well. Other than that, patient data has become the new
currency in healthcare. Along with this comes the need of cyber-security for protecting the highly
sensitive and critical healthcare data. Additionally, the trend of health food habits and self-care has
grown tremendously. The industry will be focusing on these aspects as well.
The stakeholders of healthcare, including providers, investors, and consumers, have newer demands
and the ecosystem is, therefore, shifting towards better and sustainable solutions. The industry is
expected to grow further, market as well as development wise. Preventive care, financial
sustainability, digitalization, and so many other popular factors may take us towards an enhanced,
affordable, and accessible tomorrow!
Aishwarya Nawandhar
Editor
Editor’s Column
NOVOTECH
A Catalyst for Growth and a Better Tomorrow
InterviewwithInsightsCare
Sanomics
Improving Healthcare
with Innovation and
Compassion
16
Cover Story
10
22
Industry Insight
What Digital Startups
Need To Succeed In The
Healthcare Space
CX
O
24
David
HealthSolutions
Movement as
Medicine
34
SpineMark
Corporation
Transforming Care
Delivery Through
Exceptional CareServices
CONTENTS
32
Accutest
ResearchLaboratories
The Preferred CRO
Partner for Healthcare
Companies
Articles
36
NovelDiscoveries
Top Health Tech
Innovations in2019
that are Breaking
the Barriers
28
In-houseOpinion
Social MediaMarketing
A Necessary Trend to
Pick for Healthcare
Professionals
evelopment is a continuous process in any sector. It brings in more comfort, more precision, and more
enhanced way of living. Almost all the industries have and will continue to witnessextensive
Ddevelopments in their respective niches and healthcare sector is not aloof of this process. The health
and medical industry has grown through the years with technological and device developments,pharmaceutical
advancements, process enhancement, and more. It owes this to various organizations and people that have
dedicated their resources and expertise to improve several areas of healthcare.
Acknowledging the remarkable contribution of the leading companies in the care sector, we bring to you the
special issue of “The 10 Companies Booming in Healthcare Sector”. This edition portrays the inspiring
stories of the listed pre-eminent organizations that are shaping the future of healthcare through innovation and
dedication.
Featured on the cover is the internationally recognized leading regional full-service contract research
organization (CRO), Novotech. The company has been delivering CRO services in the Asia-Pacific regionfor
more than 23 years.
Apart from the engaging cover story, the issue encompasses the prominent leaders of the industry including
David Health Solutions, a world leader in rehabilitation solutions for musculoskeletal problems; SpineMark
Corporation, a premier global spine service company for the development of Spine Destination Centers and
Spine Research Organizations (SRO); Accutest Research Laboratories, a top-notch independent and
internationally accredited India-based Contract Research Organization (CRO); an interview by Sanomics, a
fast-growing company contributing relentlessly to the future of healthcare with novel gene therapy solutions;
Youshow AI tech Development; Pacific Healthcare; Paradigm Pharma; Teleme Technology; and Meditech
Solution.
This edition also includes few interesting articles by our in-house editors and industry expert.
So, walk through the pages and enjoy a good read!
Market Leaders
Driving Development
in Care Industry
Follow us on : www.facebook.com/InsightsCare/ https://twitter.com/Insightscare
Weare also available on :
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Reprint rights remain solely with Insights Success MediaandTechnologyPvt. Ltd. Insights Care is powered byInsights Success MediaandTechnologyPvt. Ltd.
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June, 2019
Corporate Of ces:
Co-designer Paul Belin
Art &Picture Editor Karan Gaikwad
Pooja M. Bansal
Anish Miller
Ashwini S. Deshpande
Aishwarya Nawandhar
Shambhavi Mhetre
David King
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Editor-in-Chief
Senior Editor
Managing Editor
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Contributing Editor
Visualiser
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Sales Executives
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Circulation Manager
Peter Collins
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Pooja, Amy, John
Jacob Smile
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David, Robert
Alina Sege
Prashant Chevale
Manoj, Gemson
Eric Smith Tanaji
Dr. John Moller
CEO
NOVOTECH
Aleading regional CRO in the Asia-Paci c region
andthe
Cover
Story
”
ACatalyst for Growth
and a Better
Tomorrow
Biotech sector, offering full service clinical trial services
”
The cost of research for new drugs has almost
tripled over the last 25 years and new models are
emerging to face these increasing expenses.
Multinational pharmaceutical companies are derivingan
even larger share of their revenues from biotech
acquisitions or external discovery, and an increasing
focus is put on clinical development operational
improvements and optimization.
Novotech is internationally recognized as the leading
regional full-service contract research organization
(CRO) in Asia-Pacific and is dedicated to supporting
biotech companies in their drug development by tapping
into the benefits of the region. With a focus on clinical
monitoring, it has been instrumental in the success of
hundreds of Phase I - IV clinical trials in the AsiaPacific
region.
Headquartered in Sydney, Novotech has been delivering
CRO services in the region for more than 23 years. It has
offices in twelve countries, including two customer-
facing offices in the US, and more than 550 staff to
accommodate increased demand from international
biotech companies for specialist clinical services.
Strong Focus on Asia-Pacific with a GlobalReach
Novotech delivers clinical development services across
all clinical trial phases and therapeutic areas. These
include feasibility assessments, ethics committee and
regulatory submissions, data management, statistical
analysis, medical monitoring, safety services, central lab
services, report write-up to ICH requirements, and
project and vendor management. The company’s strong
Asia Pacific presence allows them to run clinical trialsin
all key regional markets. It also has worldwide reach
through the company’s network of strategic partners.
Full Service for Biotechnology Companies
Novotech is known as the leading regional CRO in the
Asia-Pacific region and the biotech sector. The company
and its employees have won numerous awards and
recognitions in the CRO industry over the last several
years and has been dedicated to delivering consistently
high-quality service for its clients. In addition, the
company ensures that the customer satisfaction is closely
and objectively monitored across a range of KPIs
throughout the lifespan of each project.
Speaking of what sets them apart in today’s highly
competitive global world, Dr. John Moller, the CEO of
Novotech, said, “Novotech is focused on delivering
world-class clinical services in the Asia-Pacific region
for the biotech sector. We offer the very latest in Oracle
and Medidata technology, and all our projects are
measured on quality of service and customersatisfaction
throughout every stage of our engagement.”
The customers of the company value its leadership as a
regional CRO specialist, who can understand local
cultures, customs, regulations, and have developeddeep
relationships with the key investigators in the region.
Novotech follows a unique strategy for all its clients’
projects. When discussing a new potential project with a
client, the company brings in its senior clinical staff,
country managers, and potentially investigators into the
discussions as early as possible. Through this, it ensures
that the sponsor can gain the confidence that their project
will receive the attention they may not otherwise have
with global CRO players.
In addition to this, Novotech has a significant focus on
appointing and retaining the best people and is strongly
passionate about developing its employees. In fact, inthe
year of 2018, 30% of the company’s employees were
promoted.
Focused on Client Satisfaction
Novotech has implemented a systematic mechanism of
monitoring customer and investigator satisfaction across
a range of items. It has invested in new technology and
established clear processes to systematically reach out to
its customers after key milestones for each project. The
company finds this initiative very important as it nurtures
relationships with its clients to address potential issues
well in advance and ensures continuous improvement in
the services it provides. Validating the success of this
approach is Novotech’s excellent levels of client
satisfaction - mostly 8 and 9 out of 10 - and especially
project communications which consistently scores above
9 out of 10.
Following are some feedback comments fromfrom
Novotech clients.
“We’re delighted with the way our project was managed.
The structure of having the study team together with the
governance team was effective. The team was very
responsive, and issues were resolved within expected
timeframes.” - Senior Clinical Project Manager of a
Swiss Biotech company
Key Highlights of 2018
Novotech’s acquisition of Australia specialist CNS last
year was one of the major milestones in its journey. This
acquisition has further strengthened Novotech’spresence
in the region and has allowed the company to offer all
clients a ‘BioDesk,’ capability that provides early stage
product development advice including toxicology, CMC
and FDA/EMA regulatory consulting.
Moreover, Asia-Pacific was the fastest growing region
for biotech-sponsored trials again last year, with an
increase of about 35% compared with 2017. In the year
2018, Novotech maintained its focus on bringing in and
retaining the best people, nurturing relationships with
clients, investigators and partners, and brand
development initiatives. The organization also made an
important investment in relation to technology
improvements with the next generation of Oracle’sTrial
Management system.
Novotech has further reinforced its position of leading
CRO for the biotech sector in the Asia-Pacific region in
2018 with a very strong performance in key markets
such as ANZ, Hong Kong, Thailand, Taiwan, andSouth
Korea where Novotech estimates its market share has
increased to over 30% in key territories.
Foundational Values
Values are the roots of any company. The core values lay
the foundation of an organization and helps define its
vision and shape its culture. Novotech abides by the
following values:
Wemaintain and
monitor the
quality of service
and client
satisfaction at
every step of ourengageme
nt
”
”
 Performance Passion – According to Novotech, an
attitude of making it happen drives a dedicatedfocus
on engagement, quality, accountability, and
performance results
 Open Engagement – Novotech’s style ofworking
recognizes the value of everyone involved
 Uncompromised Integrity – It follows the belief that
one should never to hesitate to say or do theright
thing
 Unlocking Talent - Novotech seeks andnurtures
people with exceptional talent
Novotech’s Take on Latest Developments
Novotech believes that clinical data quality is considered
the key priority for 2019. According to a recent survey
conducted by J.P. Morgan amongst life sciences’
investors this is especially true given the increasing
complexity of trials and trial designs.
Novotech has driven an increasing investment in upfront
clinical development strategy, including the use of
carefully designed protocols. These include multi-arm,
multi-stage designs with adaptive randomization.
According to Novotech, an efficient approach toclinical
trial design will have the greatest impact in containing
the escalating cost of drug development. It also believes
that the effectiveness of clinical trials also relies on the
selection of the right investigators and excellence in
CRO study management. The company, therefore,
invests heavily in building formal partnerships with
major hospitals and medical specialist sites through
formal site partnership agreements, as well as site
management services which facilitate rapid start-up
activities and patient recruitment to meet the sponsor’s
goals.
Bringing in More for a BetterTomorrow
With biotech companies investing in more complex and
global programs, Novotech sees that biotech sponsors
are increasingly considering locations outside of the US
for their trials, such as Eastern Europe andAsia-Pacific.
The company’s clinical staff numbers have grown by
more than 20% in Asia over the last quarter of 2018and
50% over the last twelve months. This growth in the
number of staff members is fuelled by demand for a
regional CRO with international accreditation and
reputation, combined with local knowledge,
partnerships, and expertise in the region. Furthermore,
the company’s initiative of integration of capabilities,
such as BioDesk, will bring tremendous support to
biotech companies looking for global regulatory
services.
he healthcare industry is looking for better answers to diagnose and treat various life-threatening diseases we hear of
today. One of these diseases that the industry is trying to combat since long is cancer. Although there have been
Tvarious advancements related to cancer treatment, no specific solution is reached yet. By far, the best possible
solution comes from gene therapy. Apart from cancer treatment, gene therapy has showed a lot of potential to improve the
treatment of number of deadly diseases.
Sanomics is a fast-growing company, which is contributing relentlessly to the future of healthcare with novel gene therapy
solutions. It is remarkably revolutionizing cancer treatments for the patients with safe and efficient liquid-based and tissue-
based genomic tests. To know more about the story of this ingenious company, we at Insightscare bring to you an exclusive
interview with its CEO, Mr. Sy Ming Yiu, Stanley.
1. Tell us in brief about Sanomics Limited.
Established in Hong Kong Science and Technology Parks Corporation in 2015, Sanomics Limited is a Hong Kong based
biotechnology start-up that specializes in liquid biopsy and tissue-based genomic diagnostics for cancer patients, so as to
help doctors decide personalized cancer solutions for patients. Since 2015, Sanomics’ service covers 20 countries and
regions and it has completed more than 7,000 patient cases over the world. Sanomics (Thailand) Limited was founded in
October 2018 in Bangkok, which is the first Hong Kong biotechnology start-up launched in Thailand.
Focusing on lung and women cancer, Sanomics’ comprehensive cancer genomic screening services covers both somatic
mutation and germline mutations, adopting Droplet Digital Polymerase Chain Reaction (ddPCR), Next Generation
Sequencing (NGS) technology to complete Comprehensive Genomic Profiling (CGP), and Real-time Polymerase Chain
Reaction (Real-time PCR).
SANOMICSImproving Healthcarewith InnovationandCompassion
Interview with Insights Care
Mr. Sy Ming Yiu
CEO
|June 2019|16
2. What were the motivating factors that led towards the inception of the company?
“Patient first” is absolutely the most motivating factor. An accurate genomic test result is critical for helping doctors to
design a personalized treatment for cancer patients. We strive to provide the genomic tests which are of higher quality,
cheaper price, and quicker turnaround time to help cancer patients to save time and medical expenses.
3. Which is your flagship product? Also, tell us how Sanomics stands tall and differentiates itself from others in this
competitive world.
Requiring only 20ml of blood and 2 working days of turnaround time, p-EGFR®
liquid biopsy test detects the EGFR gene
mutation which causes lung cancer. Comparing with traditional tissue biopsy which is an invasive operation, costly, and
time consuming, p-EGFR®
is non-invasive, affordable, and quick. Since the launch of p-EGFR®
in August 2015 in Hong
Kong, it has become the market leader in Hong Kong within just 8 months.
What makes Sanomics stand out is our dedication to execution. We always emphasis the innovation of Sanomics is in
execution. Ranging from test request, specimen collection to release report, we try our best to keep the process as simple
as possible, so that physicians’ precious time can be spent on treating patients instead of dealing with clumsy procedures.
For example, we simplify the process of requesting Sanomics’ tests to 3 steps only and keep our form and test report in 1
page to save time of physicians. Also, we launched Sanomics Portal mobile app for doctors to keep posted.
4. What are all the products and services that Sanomics Limited provides?
The pEGFR®
test screens for the presence of Exon 19 deletions, Exon 21 L858R,
Exon 20 T790M, C797S mutations in blood specimens using droplet digital PCR
technology. This test is useful for assessing and monitoring whether TKI therapies
would be effective mostly for lung cancer patients.
The pBRAF V600ETM test screens for the presence of BRAF V600E mutation in
blood specimens using droplet digital PCR technology. The test targets lung, thyroid,
colorectal, and melanoma and it is useful for assessing whether the indicated
therapies would be useful. It is suggested that if the test results are positive,
dabrafenib, and trametinib can be used as targeted therapy.
Guardant360® identifies somatic mutations of 73 genes, proven to be clinically
relevant, and reports on microsatellite instability (MSI) status through the detection
of circulating tumor DNA (ctDNA) in blood specimens using NGS technologies.The
test is suitable for patients with advanced solid tumors. The report would present
targeted treatment options including approved therapies and therapies undergoing
late-stage clinical trials, as well as immunotherapy options. The test would be
performed in the US.
|June 2019|
BRCA Zoom® identifies germline mutation of BRCA1 and BRCA2. The testis suitable
for patients who have been diagnosed with breast, ovarian, prostate, and pancreatic
cancer; people with family history of the above mentioned cancer and other cancer
high-risk groups.
Each person carries BRCA1 and BRCA2 genes. These two genes are mainly
responsible for repairing damaged DNA and maintaining stable cellgrowth.
If a person carries a mutation of the BRCA gene, the risks of developingbreast, ovarian,
prostate cancer or pancreatic cancer in a lifetime also increases. Also, the family
members of that person would also have a possibility of carrying the mutated BRCA
genes.
17
OncoSnap® is a pioneering tumor tissue profiling test which screens for clinically
relevant somatic mutations of 130 genes in solid tumor tissues by using NGS
technologies, and offers FDA-approved therapies undergoing clinical trials.
Able to detect single nucleotide variations (SNVs), insertions and deletions (indels),
selected fusions and copy number alterations
OncoSnap BRCATM is a pioneering NGS-based tumor tissue profiling test which
screens for somatic mutations of BRCA1 and BRCA2 genes in solid tumor tissues.
This test is useful for assessing patients who are diagnosed with breast cancer,
ovarian cancer and prostate cancer on whether they could be benefited from selected
PARP inhibitor treatments.
5. With respect to your distinctive products and services, how have you helped bring positive developments in
the healthcare industry?
Sanomics contributed to provide genomic tests to help doctors decide personalized cancer solutions for patients. Wekeep
providing solutions to tackle with the pain points in current cancer management process. For example, Sanomics is the
first local private company in Hong Kong to adopt liquid biopsy, a non-invasive cancer screening technology that spares
patients from the painful tissue biopsy, a traditional procedure of collecting tissue samples from tumors. Another example
is that tissue samples often run outs before answering all the clinical questions that guide treatment selection, therefore,
by launching OncoSnap NonetTM
, this test can screen for 9 genes in tumor tissue samples to make best use of tissue.
6. Are there any social activities that your company organizes to uplift healthcare space?
To raise the public awareness of adopting genomic test in cancer management, Sanomics organizes workshops and
seminars for healthcare professionals and general public. We also co-operate with our strategic partners, such as
OncoSnap NonetTM screens for 9 genes in tumor tissue samples, intending to aid
physicians to identify multi-genetic biomarkers for potential treatment options for
primary diagnosed non-small-cell lung cancer patients.
PD-L1 IHC 22C3 pharmDx is a qualitative immunohistochemical assay using
Monoclonal Mouse Anti-PD-L1, Clone 22C3 to detect PD-L1 protein in FFPE tissue
specimens using EnVision FLEX visualization system on Autostainer Link 48. It
detects PD-L1 expression with a dynamic range of tumor-positive (TPS) 0-100% and
combined positive score (CPS) 0-10+.
Cancers include lung cancer, gastric cancer, urothelial cancer, cervical cancer, etc.
EmbryoSafeTM screens all 24 chromosomes of IVF and ICSI embryos to detect
pathogenic chromosome copy number changes, including aneuploidy, mosaicism,
unbalanced translocations, and microduplications/microdeletions (> 10 Mb).
|June 2019|18
AstraZeneca and Bio-Rad to organize large scale symposium, to discuss about the latest development of genomic
diagnostics and provide a platform for intellectual exchange in the healthcare industry.
7. Tell us some interesting things about your leader (CEO, CFO, COO or any other personality which you want to
highlight in this issue).
“Keep moving, keep thinking and keep solving”, this is the common value that we share in Sanomics.
8. Mention the notable awards and accreditations Sanomics has received so far.
So far, Sanomics has won 19 awards. Some highlighted awards include:
2018 The Top 50 Innovative Biotechnology Enterprises in Guangdoug-Hong Kong-Macau Greater Bay Area by
ZDVC Research Institute, KPMG & Guangdoug Medical Valley
Innovative Business Gold Award 2018 by The Hong Kong and Shanghai Banking Corporation Limited and Hong
Kong Economic Times
Caring Company Award by The Hong Kong Council of Social Service
9. Can you share with us your upcoming projects?
Big data will be our next step. Big Data is everywhere in our daily life, actually DNA big data can also be digitalized to
assist scientists and doctors to analyze and make advances in cancer treatment. Currently, there is no existing DNA
database of Asian cancer patients. To address the need for building Asian cancer patients’ big data, we initiate to establish
a DNA Big Data Centre in Hetao district at Lok Ma Chau. By doing so, we aim to attract more genetic related start-ups to
set up their offices in Great Bay Area, so as to create an ecosystem of biotechnology companies in Great BayArea.
The initial design of this DNA big database is by subscription base. The meta data of the database will be open for public
access. However, to get full access, users must register and pay certain amount of subscription fee, as well as unveiling
their data model to sustain the platform. The three main roles of the owner of this DNA Big Data Centre are - first, to
provide basic legal support and protection to the DNA data supplying and demanding sides; second, to set up a rating
scheme and payment scheme for DNA data transaction; and thirdly, to be the DNA big data manager. The idea of this
Asian DNA big data base is like a combination of Asian DNA eBay and DNA cloud.
We believe that more valuable studies and commercialized applications of DNA data will be generated once thisAsian
Big Data sharing platform has been launched. We foresee that ultimately this will enhance the overall life quality and
improve the cancer solution for Asian.
Fig.: Important Milestones in the Journey of Sanomics
|June 2019| 19
Tania Martin-Mercado
Chief Technology Of cer
ABOUT THEAUTHOR
Tania Martin-Mercado, PhD, is theChief Technology Of cerof YGEIA, a
digital healthcarecompanyfocusedonhomehealthcareandchronic disease
management.Sheholds various degreesin IT, healthcare,as well as biotechnology and
is seasonedwithalot of experienceatvarious prestigious posts throughouttheyears. Being a curious
soul andalwaysbeenfascinatedwithtechnology, Taniahas beenapartof various healthcare innovations.
|June 2019|22
e hear a lot of buzz in the industry and in the
marketplace about the latest in digital
Whealthcare. From artificial intelligence, machine
learning, remote patient monitoring and wearable
technology to home monitoring and data, data, data –
digital healthcare has morphed into one of the most
transformative healthcare trends.
While this is one of the most exciting times to be in the
digital healthcare market, startups focused on this space
need to make sure their product and service have three-fold
impact: Improved patient outcomes, reduced cost of
delivery, and quality of care. Cost, quality and patient
experience often go unnoticed or ignored in favor of
technical functionality. The latest and greatest digital
healthcare technology will fail if the patients don’t
understand how to use it, providers can’t implement it into
their workflow, and payors won’t reimburse for its use.
By starting with a patient-centered focus, digital startups
will find they may need to slow down and get a better
understanding of the healthcare industry, which operates
differently than the tech world. There are more stakeholders
in healthcare that need consideration: doctors, patients,
insurers, regulators; each of these stakeholders holds a
unique perspective on the technology being adopted.
Healthcare is complex because patients are complex. As
digital startups focus on one area, such as a particular
disease, they may stumble onto the multiple factors that
contribute to that disease, what insurers do and don’t cover
related to that disease and its symptoms, and more variables
that directly or indirectly affect their product or service.
The development of a product or service requires research
into clinical practice, medical study, patient and doctor
interviews, and several focus groups. Digital healthcare
startups need to have patience – something that is
unattractive to some investors, causing digital healthcare
startups to rush into product development too quickly.
Instead, involving key stakeholders early in the
development process and fully understanding the concerns
and perspective will allow these startups to impact the
healthcare space where it matters most – patient care.
The Medical Futurist published a fantastic article earlier
this year that highlights why healthcare startups fail.
Forgetting about the patient, not including the provider,
difficulty creating clinical value and overclaiming what the
technology can do area just a few of areas discussed in this
article.
Another area often overlooked by digital healthcare startups
is the need to integrate. Healthcare data is massive, and
there is no “central repository” to draw from. By
understanding and embracing the need for shared services,
integration with other startups or providers in the healthcare
industry can foster innovation and better meet patient need
or demand. Instead startups may focus on siloed solutions
that make it difficult for providers to implement into their
practice, thus not offering value to the patient. By
understanding how patient data is viewed from a provider
and payor perspective, digital healthcare startups will find
out how their product or service will be most useful.
This is such an exciting time to be in the healthcare space.
The satisfaction of making a positive impact in
communities by improving patient care is why many
startups dive into the healthcare space. By taking a few of
these points into consideration, digital healthcare startups
will find their endeavors bearing fruit.
WHAT
DIGITAL STARTUPS NEED
TO SUCCEEDIN THE
HEALTHCARESPACE
Industry Insight
|June 2019| 23
eadquarter in Helsinki, Finland; David Health SolutionsLtd.
is a rehabilitation solutions provider for musculoskeletal
Hproblems. Established in the year 1981 by Arno Parviainen,
the CEO, the company has its operations on a global platform.The
company is transforming spine and orthopedic care with a data-driven,
device-based exercise therapy solution that is directly in consensuswith
the latest guidelines. It promotes exercise and cognitive support as the
first line treatment for most chronic musculoskeletal problems.
Exercise combined with the body’s ability to regenerate is a powerful
tool. Unfortunately, it is underutilized in healthcare. However, times are
changing. What DHS found out over 30 years ago is becoming the
norm now. Indeed, its solution used to be the last remedy in the
toolbox; now, it is the first. Decades ago, Arno was convinced that the
best way to treat musculoskeletal pain was targeted and controlled
exercise therapy using specially designed devices. Having startedsmall,
David Health Solutions has now set up more than 350 centers around
the world using its intelligent solutions for spine and orthopedic care.
The Journey of Innovation & Intelligence
Several years were spent on intense research and development in
building biomechanically optimal training devices for each joint.David
Health Solutions quickly found out that with this approach it was
possible to start movement and training, even for the patients suffering
from severe pain. The key was to design devices that were gentle for
the joints, but demanding for the muscles. The company visualizes
becoming the torchbearer in one of the biggest changes in healthcare,
covering the most costly and debilitating healthcare problem.
“In anything we do, the well-being of the patient is always the most
‘‘
‘‘
|June 2019|24
important factor. No technology alone can solve these
problems unless there are unified minds at all levels to
bring the benefits to the patient,” asserts Arno. The
company is strictly a ‘school medicine’ company,
meaning that it makes no unsubstantiated claims and
bases its philosophy on data and science. Therefore, to
keep up with technology, it is now developing an AI
system that can learn from the hundreds of thousandsof
patient cases to provide better and more individualized
care for each patient.
David Health Solutions works on the core value of
‘patient wellbeing’, this is also the reason it is
transforming itself from a device company to a service
company. “This is the only way we can ensure the best
quality and operational efficiency. We have centers
under the “Nordic Health” brand, either owned by us or
under our management in Finland, Netherlands, Saudi
Arabia, and now coming to USA. Our first Nordic Health
Spine and Ortho Center will open in Tulsa, Oklahoma,in
partnership with neurosurgeons. The next ones will open
in California and New Jersey,” says Arno. There is a
great need for integrated services providing the whole
continuum of care, believes DHS.
Distinctive Services and Solutions
The David Exercise Therapy Solution utilizes specially
designed devices with joint-specific isolation andloading
curves, guaranteeing safe and pain-free training
experience. Its cloud based, state-of-the-art ITsystem
guides and motivates the patient and simultaneously
collects all relevant data automatically for easy
reporting.
Every device is also a testing device for strength and
mobility. Based on these test results, the software will
automatically provide individualized training weights
and movement ranges. All parameters of the exerciseare
digitally controlled this way. Nordic Health clinic, which
is equipped with the full system, is frequently visited by
the staff of the clinic for exercise and preventative care.
“It is great to see everyone, from our COO to our
Marketing Associates, so enthusiastic to utilize the
technology for both rehabilitation and preventive care,”
he says.
The company’s medical rehabilitation system is unique
because it is the only fully equipped solution in the
market. The DAVID product portfolio includes
intelligent devices that specifically target the spine, hip
& knee, and shoulder joints. This is great news for
rehabilitation clinics because the practice can offer
|June 2019| 25
patients care for a variety of musculoskeletalproblems
with a turn-key solution that has been validated in a
number of studies and in use in hundreds of centers.
Distinguishing Itself from Others
Typical services in this area are run by therapists on a
one-to-one basis, using poor and outdated tools. This isa
very consuming work for the therapists and the work is
typically quite random. There are no standardized and
structured programs and due to high costs, most
programs are cut short before the patient is well.
DAVID’s innovative solution uses advanced training
technology and cloud-based software for guidance,
control, and data-gathering. This has dramatically
changed the role of the therapists from manualworkers
to that of a coach, expert, and motivator. After a few
sessions with the therapists, a patient learns to use the
system independently and is empowered to take careof
his/her own health. This frees the therapists to
concentrate on the more difficult cases, while the
technology guides the other patients through the
program. “Up to six patients can be treated by one
therapist,” says Arno.
This has also opened a completely new market for
medical centers, the on-going prevention care with a
membership model. Most of the patients that went
through the program are willing to continue once aweek
in the maintenance program. This requires very little
personnel resources and provides steady income stream
for the clinic.
Awards and Appreciations
The company and Parviainen have been awarded tens of
different patents in connection to technical solutions and
methods. The company’s production has an ISO 13485
certificate which is GMP in Europe, coveringproduction
of medical devices. All the devices are also separately
medically certified. The praise it receives form its
|June 2019|26
Parviainen has a degree in economics,
but his knowledge in how to build
biomechanically correct devices is very
rare in the industry. He started his
interest aGer travelling in the US at the
age of seventeen and got acquainted
with devices in the market there. He
built his own set of devices at the age
of eighteen and from there on his
passion has been to develop
technologies that can help patients
suffering in back and joint pain.
“Life is a Marathon”
Arno Parviainen knows the power of
exercise firsthand. AGer multiple
injuries in water skiing, cycling, and
tennis, he could have been disabled
with any of those incidences. But he
was fortunate to know the possibilities
device-based training can offer. The
most serious injury caused a cauda-
equina with total nerve block and
paralyzed his calves. It took him five
years of persistent training and running
before he was able to run same
distances and at same speeds as before
the accident. His experience is well
documented in his blog: “Life is a
marathon”.
Mr. Arno
Parviainen
CEO &Founder
|June 2019| 27
customers speaks leaps and bounds of the company’s excellent
service.
“We at St. Lucas in Bruges, Belgium, adopted the use of device-based
back treatment already in 1998. Due to the evidence of its efficacy, a
national insurance code was issued for this method. In December of
2015, we moved to a new phase in our operation when we changed to
a fully integrated DAVID Solution with automatic adjustments,
patient guidance, and tracking of all critical variables. Our
experience is that patients are more motivated, results seem to be
better, and integration to the hospital’s electronic patient record
system saves a lot of administrational work.”−Dr. Marc Soenen, AZ
Sint-Lucas Hospital
“Having been a neurosurgeon for over thirty years, I have always
maintained the desire to explore conservative, non-operative options
for my patients. In 2015, we became acquainted with the DAVID
Spine Concept. We have been so impressed with the DAVID Solution
that we are on our third set of DAVID Spine equipment and have now
integrated DAVID’s hip and shoulder therapy as well. It is rewarding
to see that active rehabilitation can dramatically change people’s
lives for the better and help them avoid surgery.” −Luke Knox M.D.
F.A.C.S, Northwest Arkansas Neurosurgery Clinic
Bright Future of DAVID
The fact that device-based exercise therapy is going to gain ground in
the medical world is already clear. National level insurance
reimbursements and contracts with health ministries in different
countries are a proof of that, believes Arno. “When people become
more familiar with these ideas and have a chance to personally try in
practice how the system works, attitudes will change,” he says. The
company strives to improve its operations and offerings to continueto
provide the world’s most comprehensive solution formusculoskeletal
rehabilitation.
The next major jump forward will be when David Health Solutions
will put its AI engine in clinical use. This system will provide the
most accurate and individualized care of any system available. It will
consider all background factors of the patient, like diagnosis, pain
level, education, psychological profile, test results, and so on. It will
well understand that musculoskeletal problems are complex, and not
only physical, and therefore it is critical to incorporate all successand
failure factors in the program.
To know more, visit www.davidhealth.com
Social Media
MarketingANecessaryTrend toPickfor Healthcare Professionals
Today, we don’t know if we are conquering the digital world or the digital world is
conquering us. Living in an era like this, we need to ensure we are abreast with all the
trends and developments that directly affect us. One trend that has moved all the
industries and all parts of the world is the extensive use of social media. The millennial
generation has embraced various social platforms with open arms and it is now a major part of
their lives. On the top of this generation is the next, generation Z. Generation Z, also known as
the iGeneration, is immersed in technology. They spend most of their time on social media.
It has, therefore, become very important for all types of businesses in all the sectors to leverage
the technique of social media marketing to attract the millennials and genzers. This will not only
increase the sales but help you build a chain of loyal customers.
In-house Opinion
|June 2019|28
|June 2019| 29
Healthcare industry is also affected by this trend, but it lags
behind in exploiting it to the fullest. Let’s understand what
benefits it brings to you.
The idea of searching and following a doctor on some
social platform would seem absurd if you thought about it a
few years back. But, time has changed and so has the trend.
When it comes to health, although people won’t shop
around, they will still look for the best. Advertising
everything that a provider has to offer on a platform
reaching anyone and everyone is a great idea to mark
him/her in the minds of people.
Additionally, users, all around the globe, surf their social
media feeds number of times a day. If one makes sure to
update their account regularly, users are likely to come
across their post number of times. This leaves an impact on
the users. Where else can one make their presence felt so
frequently?
It also allows a company to connect with their patients in
real-time. And this can be done from anywhere and
everywhere!
With social media, you can ensure customer-centricity.
Putting up health tips and staying in touch with the patients
through social platforms are some ways to do this.
Moreover, healthcare providers can put up about the
practices, services, and products that they provide and the
stories of how they have helped others for better. This will
help them build a sense of trust in the clients as well as the
audience visiting their account.
Other than this, social media marketing comes with a lot
more advantages. To stand out and make it fun, here are a
few ways that will help.
Educational Posts
A healthcare brand can educate their clients or patients
through their social media feed. This can include posting
health tips, a video of successful surgery carried by a
hospital, awareness and precautions for particular disease,
short description of a new device or technology, and many
more. Being connected with the brand, the patients will
look out for such tips and probably implement them as well.
Not only will it help the brand in building better
relationship with its clients, but also help improve the
patients’ lifestyle.
Start a Campaign, Use Hash tags
It is a very good idea for a healthcare company to start its
own campaign on social media. The campaign can be about
anything from awareness about a disease to encouraging
audience to share their success stories to starting a social
initiative and calling out audience to join in. Using hash
tags to promote such campaigns brings a lot of benefits. Say
for example, a company starts a campaign for the patients
of aids, calling out people to share the success stories of
themselves or their loved ones in conquering aids. Hash tag
like #companynameforaids can be used by everyone joining
in the campaign. This helps improve the company’s
branding alongside a good cause.
Interactive Communication
Clients/patients do not usually indulge in the interactive
communication with the healthcare providers. On a social
platform, this can be initiated. This will help the patients
feel more close to the company and hence, build a long,
trustful relationship.
Leverage Infographics
Infographics can help one provide highly informative
content in very short time. Without taking up a lot of the
audience’s time, a company can portray its strengths with
the help of infographics. A step further is infographic
videos. They say a lot of things in matter of seconds.Also,
the combination of an audio, video, content, and colors is
easier to remember and leaves a high impact on the
viewers.
These are just some of the ways to leverage social media
for marketing by healthcare brands. The scope for ideas is
wide, as when it comes to creativity, the sky is the limit. It
is the need of the hour to walk with the trends of the world
and use them for your benefit. Social media marketing
brings in a vast opportunity for healthcare companies to
brand and advertise their strengths and connect to the
clients better.
|June 2019|30
- Aishwarya Nawandhar, Editor
AccutestResearch
Laboratories
demand in the market for BABE
studies conduction as a mandatory
regulatory requirement for the generic
pharma manufacturers.
Dr. Sawant has been instrumental in
manifold growth of Accutest bysetting
up a friendly and inclusive work
culture, which does not compromise on
quality while serving the clients with
utmost integrity and efficiency.
Journeying to the Top
The idea of Accutest Research
Laboratories was on the mind of Dr.
Sawant since he completed his Ph. D in
Pharmaceutical Sciences. After serving
Indian pharma industry for about 15
years in the areas of drug research
related to pharma testing using various
modern chromatographic techniques,
Dr Sawant set on a path to turn his
long cherished dream into reality. In
1998, Accutest entered the industry as
a small startup. Initially taking up
small projects, the company gradually
consolidated its position in the CRO
industry.
When Accutest had started making its
mark, there were not many USFDA
accredited laboratories available to
outsource clinical research
requirements for pharma organisations.
Pharma market was opening up and
Indian Pharma Industry was gearing up
to launch their products in developed
countries like US and Europe. Thus, in
2004, the company got the approval
from USFDA. After this initial step,
there was no looking back whether it
was to add new facilities, increase
capacities or subsequent audits and
approvals from prominent regulatory
bodies across the world.
Under steady leadership of Dr Sawant,
Accutest kept on innovating itself by
adding range of diverse services.
Accutest and its leadership have
consistently been recognized for its
success and constant good work with
prestigious awards and accolades
throughout its journey of 21 years so
far.
The Preferred CRO Partner for
Healthcare Companies
The Sculptor of Accutest
Dr. Satish Sawant, the Founder and
CEO of Accutest, is a very down to
earth technocrat and a cricket
enthusiast. He has completed his
doctorate in analytical chemistry. He
has spearheaded and shaped the
incredible journey of Accutest asone
of leading CROs in the industry
through his sheer grit, farsighted
business strategies, and zeal to
consistently add value to research
industry. His business acumen has
rightly led him to exploit the huge
he healthcare industry in India
has caught pace and is moving
Tahead with continuous
developments. CROs are playing a
major role in this and have witnessed a
positive growth in the past few years.
Through outsourced R&D services to
the pharma, clinical device, and
biotechnology companies, CROs bring
in the promise of further developments
in the healthcare space. From clinical
research to product development, these
companies provide the processes and
services on contract basis. One of the
leading companies contributing to the
future of Indian healthcare industry
through its comprehensive services is
Accutest Research Laboratories (I)
Pvt. Ltd.
Headquartered in Navi Mumbai,
Accutest is a top-notch independent
and internationally accredited India-
based Contract Research Organization
(CRO). Incepted in 1998, it offers best-
in-class services along the whole drug
development process to
pharmaceutical, generics, and
biotechnology companies. The
company operates out of three facilities
viz. Navi Mumbai, Ahmedabad, and
Baroda. Accutest has emerged to bethe
undisputed leader in BABE segment
for over two decades now.
Dr. Satish Sawant
Founder & CEO
|June 2019|32
Eclectic Services
Accutest provides services across
various verticals like
Bioavailability/Bioequivalence
(BA/BE) studies for Generic Industry,
Clinical Development Services (CDS)
for New Chemical Entities, and Bio-
analytical Services to Biologics/Bio-
similar drug molecules. Speaking
about all that they offer to the clients,
Dr. Sawant says, “At Accutest, we
assist Pharma industries in their drug
development life cycle by evaluating its
safety, efficacy, ADME character, and
quality aspect before the product is
certified as appropriate for marketing.
As a CRO, we become a part of the
pharmaceutical organizations in their
research program to evaluate
medicines for their quality and test on
human population for the safety,
effectiveness, and blood levels of the
drug after they are consumed.”
Accutest has undoubtedly emerged to
be the preferred CRO for first-to-file
studies. The company also focuses on
Phase II-IV clinical trials services for
drug development companies in India
and abroad. It conducts clinical trials
as per Standard Operating Procedures
(SOPs) developed in-house, in
accordance with ICH GCPguidelines
and Indian GCP to accomplish and
efficiently cater to requirements of its
clients.
Accutest Biologics, its subsidiary, is a
one-stop solution for analytical and
bio-analytical services from early stage
characterization to the late stage
clinical evaluation of biologics.
Bioanalytical services include
Pharmacokinetics, Pharmacodynamics,
and Immunogenicity assessment of
biologics, bio-therapeutics, biosimilars,
vaccines, and non-biological complex
drugs using high-end assay formats
like ELISA, MSD, and GYROS. It also
provides in vitro activity/potency and
bioassays services for evaluating the
biological activities besides toxic
kinetics and related services.
What sets It Apart?
Being in clinical research field for 21
years now, Accutest is setting aniche
in the industry with its unmatched
expertise and services. The success
stories of Accutest andaccreditations
from global regulators, like US FDA,
WHO, EMA, ANVISA, DCGI, MCC
and other prominent authorities, stand
as a testament to its unwavering
commitment to international quality
standards and operating procedures.
Recently, the company received the
prestigious OECD GLP certification by
NGCMA. Accutest is the first and only
independent biologics testing facility in
India to be honored with this
international accreditation. The
company constantly strives to reinvent
itself, along with providing advanced
services to its clients.
Incredible Team
Accutest takes great pride in its
dynamic team, which understands
customer requirements and gives
optimal solutions. Dr. Sawant asserts,
“We have a rich pool of well qualified
and dedicated professionals, these are
our assets. Their rich experience and
involvement during clients’ drug
development program gives clients the
confidence to outsource their clinical
development needs. Timely delivery,
our regulatory history, global reach,
staff and our ability to work hand-in-
hand with the clients are some of our
value propositions which set us apart
from other competitors in the market.”
Perfect R&D Partner
Accutest is the partner of choice for
generic drug manufacturers looking to
execute BA/BE studies with a high
degree of quality and speed, at
competitive prices. It has one of the
largest data banks of 41,000+
volunteers along with strong regulatory
track records. The company’s state-of-
the-art infrastructure comprises of
more than 400 beds, 38 LCMS-MS,
and 700+ validated methods, enabling
it to serve the clients with ease and
quality. Acutest is rendering numerous
benefits to its clients by catering to
their complete, complex, and cross
functional service requirements, under
one roof with ease and expertise.
We offer an
umbrella
contract-based
R&D servicesto
our industry
partners witha
focus on quality
and quick
turnaround
time
‘‘
‘‘
|June 2019| 33
SpineMark
Corporation
Thought Leadership
Marcy T. Rogers, M.Ed., is the
President and Chief Executive
Officer of SpineMark. Rogers has built
her executive career in the healthcare
industry through the development of
niche surgical centers of excellence
fueled by innovation and clinical
research. A proven leader, she hasbuilt
trust and rapport with physicians,
hospitals, ambulatory surgery centers,
and medical device manufacturers in
spine, orthopedics, biologics, and
interventional pain. She has dedicated
over 30 years of her life to delivering
results.
Through alliances, partnerships, and
collaborations in the field of spinal
care, Rogers is getting things done. Her
destination center model integrates and
aligns stakeholders in the delivery of
spine services, and she has successfully
demonstrated solid financial results as
well as strong returns on investment
for the hospitals, ambulatory surgery
centers, and physician groups she has
managed and counseled. She has
consulted and worked with over 300
hospitals and surgery centers on their
musculoskeletal and neurological
service lines, formation of new centers,
or expanding facilities on its campuses
in the US and abroad.
Through her recognitions and
endeavors, Rogers has established
herself as a key opinion leader in the
field of spine among her clients,
professional colleagues, and peers.
The Vision of SpineMark
The company strives to create a new
standard of care for patients suffering
from back pain. “Currently there is no
standard of care and the field of spine
is fragmented at best with many
different providers labeling themselves
as spine experts as naturopaths,
chiropractors, spine surgeons,
interventional pain specialists,
neurologists, et al.,” says Rogers.
SpineMark is working towards
building a network of dozens of sites
Transforming Care Delivery Through
Exceptional CareServices
operating committee of four or more
members of the team who provide
clinical oversight.
A nurse navigator and an intake
coordinator are recruited to provide
coordination of care and follow up. A
medical “gatekeeper” is recruited to
manage new and established patients
through their care needs and the system
itself. Outcomes data and process
measures as well as transparency are
the key components of SpineMark’s
system for patient care.
pine injuries can be life altering
and fatal in some cases. A great
Sdeal of perseverance and
dedicated physical exercise is required
to recover from spinal injuries or
surgeries. One such organization that is
built around the needs of spine patients
is SpineMark Corporation.
Headquarter in San Diego, California,
the company was established in 2011.
Its patient-centric, transparent, and
outcome-accountable services are what
set it apart from its counterparts.
The model of SpineMark’s spine
centers of excellence are built around
the needs of patients. The centers
advocate for their patients and cater to
the patients’ needs. The service
protocols for patients include an
integrated delivery system with a team
of multispecialty providers, including
personnel for diagnostic, operative,
non-operative care, and holistic or
conservative care modalities.
Every SpineMark center starts with the
physician and surgeon champions, who
recognize the need for collaboration, a
facility partner, and algorithms from
the least to most invasive type of care.
This is based on failure along a
cascading chain of modalities, team
conference staffing of patients, clinical
research activities, and a clinical
Marcy T. Rogers
President & Chief Executive Officer
|June 2019|34
across the US and outside the US,
including in Kuwait, China, and
Europe. The company works towards
standardizing the treatment of patients
suffering from back pain via a
treatment protocol, quality service,
positive outcomes, efficacy, and quality
data.
The organization’s values are always
focused on the least invasive “do no
harm” approach to treating patients.
This starts with 4-6 weeks of
conservative care, which includes
interventional pain procedures to
minimally invasive spine surgery.
These are the first choices if supported
by the patient’s condition. “We want
the patient to have the right procedure
at the right time by the right doctor(s).
That is our mantra,” asserts Rogers.
Distinctive Services and Solutions
SpineMark is the premier global spine
service company for the development
of Spine Destination Centers and Spine
Research Organizations in partnership
with medical professionals, hospitals,
and industry medical manufacturers.
Its centers provide excellent medical,
operative, non-operative, and ancillar
services, all delivered under one
integrated delivery system. This
reduces patient chaos, cost, and
duplication of procedures.
The establishment of clinical research
units at each site, as well as
mainstreaming minimally invasive
spine surgery procedures at numerous
sites of the organization, is the most
distinct feature of its service. The
company’s model is built on disease-
based medical management and is
measured for quality.
Communication is the key to success,
believes Rogers. Thanks to the use of a
nurse navigator and intake coordinator,
patients never fall through the cracks.
Speaking about the nurse navigator
support system, Rogers says, “We
support patients through our services,
model, management of their distinct
needs throughout the course of
treatment by using nurse navigators to
guide them through various phases of
care.” SpineMark also often links new
patients with existing patients who
have been treated by its team and have
similar pretreatment or surgical issues.
Hence, its post-operative patients are
the greatest advocates for proving
SpineMark’s model.
SpineMark holds itself accountable
through outcomes and quality data
collection, transparency, and a focused
approach on the identification of the
somatic origin of the pain. Diagnosis is
key; surgery is always the last resort.
Bright Future for SpineMark
“We are looking to expand our sites
throughout the US and abroad, with
centers locally, regionally, and
nationally,” says Rogers. There are 1.8
billion people disabled by back pain.
The company wants to be a resource to
as many of these patients as possible.
Advancement in Spine Treatment
“The new development in spine
treatment has been ‘through clinical
research’,” asserts Rogers. Minimally
invasive spine surgery techniques are
finally taking the field by storm and are
becoming mainstream. “A few years
ago, this was not the case,” she
continues. Technological advances in
robotics, instrumentation, fixation, and
implants combined with cell and gene
therapy biologics is changing the
treatment of spinal conditions.
Today, one can perform complex spine
procedures - both lumbar and cervical
fusion - arthroscopically, reducing
rehabilitation and recovery, and
allowing patients to return to normal
function in little time. Spine treatment
is becoming more holistic and
non-invasive with the advancement in
technology. SpineMark, with its
clinical research units, is making sure
it keeps up with the innovation.
Our diagnostic,
conservative
care, holistic,
operative,
non-operative
care, and clinical
research units
are set up to
participate,
so that we
are always
advancing care
through research
‘‘
‘‘
|June 2019| 35
|June 2019|36
TopHealthTech
Innovations IN2019that are
Breakingt
h
e
Barriers
very day, new technologies are emerging. Humans are using all their brains to invent something new,
somethingunique, andsomethingthathelps mankind.With all therecentadvancements,technology
“Every once in a while, a new technology, an old problem, and a big idea turn into an innovation.”
- Dean Kamen
Ein the healthcare and medical sector has geared up as well. The embedding of arti cial intelligence
andIoT is nowdoneextensivelyin thehealthcaresector.Various newtechniquesarebeinginvented that helpsocietyto
growin aself-suf cient manner.From electric carstogenerating electricity through nuclear energy, humansare
advancingin all aspects.
Health has always beenonthetoppriority for aperson so it is essential thathe/sheis treatedwithin time andwith
perfection.Duetoinnovativeminds, therehavebeenvarious upgradesin the eld. There are treatmentsfor many
diseases anddisorders whichwerenotthoughtof afewyears ago.Various instruments andfacilities havebecome
affordabletothehealthcareservice providers like hospitals and clinics.
Researchersaretrying hardtoprovide everything for bettertreatmentof thepublic. Various medicines have beenusedto
treatdiseases successfully andmanydiseases havealready beeneradicatedfrom theearth. Newtypesofequipmenthave
helpedthedoctorsin various complicatedsurgeries. In thefollowing year, therehavebeenmanynewinnovations for the
bettermentofthelives ofpeople.Here areafewnotable technological innovations:
Novel Discoveries
|June 2019| 37
3-D PRINTING
Surgeries areverycomplicatedandinvolve alengthy process. Precision is very
importantandpracticingit beforehandis highly crucial.Doctors use 3-D models
for practicingthesurgeries. The 3-D printing machine modelsaremadein
accordancewith thepatient’sanatomy. In recent times, fewimportantdevelopments
in 3-D printing havecomein external prosthetics,cranial or orthopedic implants,
andcustomairway stents. It has also been helpful in surgical planning as well in
complex open heart surgeries. There areresearchesbeingcarried outtoprint
human tissue
that will make organtransplants possible.
ARTIFICIAL INTELLIGENCE
The biggest problem in making a drug for a rare disease is the huge data of the
patients and their compliance. Many researchers and pharmaceutical companies are
taking the help of AI to organize the data from the medical records and nd
commonalities with the diseases. AI has been a huge plus point for doctors and
general practitioners as it helps to collect and nd the data of the patients whenever
required. This technology is transforming all areas of the healthcare industry, from
work process control and diagnostics to process automatization, productivity-
enhancing,andenhancementsin diagnosticsaccuracy.
RNA-BASED
THERAPEUTICS
Recently, RNA-based therapeutics are beingused whereRNA is modi ed or replaced
before it forms into a protein. It allows the clinicians to detectany genetic abnormality
beforehand and treat the problem by replacing it accordingly with functioning or non-
functioning proteins. Advancement in RNA therapeutics may even lead to solving the
problems of rare diseases like Huntington’s disease, neurologic disorders, and
several formsofcancer.
NEW IMMUNOTHERAPY
TECHNIQUES
Basically, immunotherapyis atreatmentfor cancer.In this typeof treatment, white
blood cells are increased in the patient’s body so as to
ght against various diseases. Avarietyofexperimentsarebeingcarried outin
combinationwith joint therapyandengineeredT-cells thatcanprove tobeeffective
against awiderangeof tumor cells.
|June 2019|38
TELEHEALTH
With everything beingdigitized, therewasaneedtomonitor aperson’s health through
digital services. Now,this has becomepossible. Doctors canmonitor their patient's
healthevenfrom adistance.The doctorcanmakea primary conclusionfrom analyzing
thereport thatis generateddigitally. This way, the expensesof thepatientsarereducedto
agreatextent.
ROBOTIC SURGERY
Roboticshas beenadministeredin various medicaltreatments.Nanobots are being
administeredin bloodstreamsofthepatientsthatcandiagnoseand preventdiseases.
Movementdisabilities canbemonitoredbyexoskeletons with theassistanceof physical
therapy. Oneof themajor innovations of 2019 is roboticsurgery. Now,robots canbe
useful in performingvarious proceduresduring surgery. Arobotcanperform tasks and
provide medical assistancelike giving aninjection andgatheringinformation. There are
supporting robots thatmanagetocourier medicalinstruments andother related
supplies.
HEALTH WEARABLE
As it is said in afamousquote,‘Precautionis betterthancure’,it is important to
maintain ahealthylife. Peoplehavestartedtounderstandthatbeing healthyis really
helpful in avoidinganyfuture diseases or disorders. There arevarious companiesthat
haveinvented uniquehealthwearablethathelpa person trackhis/her ownhealth. Onecan
monitor theheartrate, glucose level, physical activity, andalso sleeptimings with these.
This way,theperson cananalyze whereheis lackingandwork onit, accordingly.
|June 2019| 39
GENOMICS
Aperson’s identity is from his/her genes.Even, whatdisease canaffecta person is decided
bythegeneticmakeof thebody.Biotechcompanies havecomeup with technologythatcanbe
helpful in decodingindividualgenomic makeup andaidin enhancingthediagnosis and
treatmentfor various geneticand non- geneticdiseases. These companiesarefurther
trying todevelopa personalized treatmentwith thehelpof this technology.In 2017,
CRISPR, ageneediting tool was used to successfully edit human embryos in which
hypertrophic cardiomyopathy,acomplexheartdisease, within 42 embryoswas eradicated.
Technologyhas beenproving tobeworking handin handwith thehealthcareindustry for thebettermentofthe quality of careprovided.
Everyday,theworld witness’s newdevelopmentsandwith this mankindis movingtowards moreaccurateandaffordabletreatment
options.
- Shambhavi Mhetre, Editor
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The 10 companies booming in healthcare sector small

  • 1. www.insightscare.com Dr. John Moller CEO NOVOTECH 2019 Vol.6/ Issue-2 ACatalyst for Growth and a Better Tomorrow 1 TH 0 E COMPANIES BOOMING IN HEALTHCA RE SECTOR
  • 2.
  • 3.
  • 4. THETOMORROW OF HEALTHCARE he landscape of healthcare has noticeably changed compared to what it was a few years ago. The global expenditure of healthcare has been on a spree, rising at the rate of 5.7 percent Tannually, between the years 2017 to 2022. This growth is driven by various factors including the rise in the population of people in older age groups, increased chronic disease rates, new demands of the care receivers and newer approach of care givers, and many more. Based on the scenario of the global healthcare industry in 2019, we can predict a few possibilities that will drive the market in the years to come. The two big trends that have emerged in the past few years are the shifting of this industry towards personalized, outcome-based care and the developments in diagnostic and preventive care. These trends will continue to gain popularity and many new startups as well as well-settled business players are seen to focus on them. The advancements in healthcare have come with huge investments and there is a rising need to bring in better solutions at affordable prices. Many new researches and funding for drug development and treatments, along with technological advancements, are seen and are expected to increase further. The future holds a promise for various disruptive innovations to make this a reality. We will also owe it to mergers and collaborations among various healthcare and non- healthcare organizations to attain financial sustainability. Technological innovation is another key factor driving the steering of tomorrow for healthcare niche. With emergence and wide-spread acceptance of developments in wearable devices, remote healthcare, telemedicine, patient management apps, digital healthcare, and more, myriads of companies are seen to invest in these areas. The consumer demands have changed with their increased role in the system and therefore, the focus should be shifted to patient engagement and building of more personal relationships. Additionally, technologies like AI, VR, 3D printing, medical imaging, etc. have entered the healthcare sector and are assisting the providers in offering more accurate and enhanced care to the patients. With increase in the number of changes the industry is witnessing, there is increase in the need of regulatory policies and compliances as well. Other than that, patient data has become the new currency in healthcare. Along with this comes the need of cyber-security for protecting the highly sensitive and critical healthcare data. Additionally, the trend of health food habits and self-care has grown tremendously. The industry will be focusing on these aspects as well. The stakeholders of healthcare, including providers, investors, and consumers, have newer demands and the ecosystem is, therefore, shifting towards better and sustainable solutions. The industry is expected to grow further, market as well as development wise. Preventive care, financial sustainability, digitalization, and so many other popular factors may take us towards an enhanced, affordable, and accessible tomorrow! Aishwarya Nawandhar Editor
  • 6. NOVOTECH A Catalyst for Growth and a Better Tomorrow InterviewwithInsightsCare Sanomics Improving Healthcare with Innovation and Compassion 16 Cover Story 10 22 Industry Insight What Digital Startups Need To Succeed In The Healthcare Space CX O
  • 7. 24 David HealthSolutions Movement as Medicine 34 SpineMark Corporation Transforming Care Delivery Through Exceptional CareServices CONTENTS 32 Accutest ResearchLaboratories The Preferred CRO Partner for Healthcare Companies Articles 36 NovelDiscoveries Top Health Tech Innovations in2019 that are Breaking the Barriers 28 In-houseOpinion Social MediaMarketing A Necessary Trend to Pick for Healthcare Professionals
  • 8. evelopment is a continuous process in any sector. It brings in more comfort, more precision, and more enhanced way of living. Almost all the industries have and will continue to witnessextensive Ddevelopments in their respective niches and healthcare sector is not aloof of this process. The health and medical industry has grown through the years with technological and device developments,pharmaceutical advancements, process enhancement, and more. It owes this to various organizations and people that have dedicated their resources and expertise to improve several areas of healthcare. Acknowledging the remarkable contribution of the leading companies in the care sector, we bring to you the special issue of “The 10 Companies Booming in Healthcare Sector”. This edition portrays the inspiring stories of the listed pre-eminent organizations that are shaping the future of healthcare through innovation and dedication. Featured on the cover is the internationally recognized leading regional full-service contract research organization (CRO), Novotech. The company has been delivering CRO services in the Asia-Pacific regionfor more than 23 years. Apart from the engaging cover story, the issue encompasses the prominent leaders of the industry including David Health Solutions, a world leader in rehabilitation solutions for musculoskeletal problems; SpineMark Corporation, a premier global spine service company for the development of Spine Destination Centers and Spine Research Organizations (SRO); Accutest Research Laboratories, a top-notch independent and internationally accredited India-based Contract Research Organization (CRO); an interview by Sanomics, a fast-growing company contributing relentlessly to the future of healthcare with novel gene therapy solutions; Youshow AI tech Development; Pacific Healthcare; Paradigm Pharma; Teleme Technology; and Meditech Solution. This edition also includes few interesting articles by our in-house editors and industry expert. So, walk through the pages and enjoy a good read! Market Leaders Driving Development in Care Industry
  • 9. Follow us on : www.facebook.com/InsightsCare/ https://twitter.com/Insightscare Weare also available on : Copyright © 2019 Insights Success MediaandTechnologyPvt. Ltd., All rights reserved. The content andimages used in this magazineshould not bereproduced or transmitted in any form or byanymeans, electronic, mechanical, photocopying, recording or otherwise, without prior permission from Insights success. Reprint rights remain solely with Insights Success MediaandTechnologyPvt. Ltd. Insights Care is powered byInsights Success MediaandTechnologyPvt. Ltd. Insights SuccessMedia Tech LLC 555 Metro PlaceNorth, Suite 100, Dublin, OH 43017, United States Phone- (614)-602-1754 Email: info@insightscare.com For Subscription: www.insightscare.com Insights SuccessMedia andTechnology Pvt. Ltd. Of ce No. 22 &510, RainbowPlaza, Shivar Chowk, Pimple Saudagar,Pune, Maharashtra 411017 Phone- India: +91 7410079881/ 82/ 83/ 84/ 85 Email: info@insightscare.com For Subscription: www.insightscare.com sales@insightscare.com June, 2019 Corporate Of ces: Co-designer Paul Belin Art &Picture Editor Karan Gaikwad Pooja M. Bansal Anish Miller Ashwini S. Deshpande Aishwarya Nawandhar Shambhavi Mhetre David King Amol Kamble Poonam Mahajan Editor-in-Chief Senior Editor Managing Editor Executive Editor Contributing Editor Visualiser Art & Design Head Art & Design Assistant Business Development Manager Marketing Manager Business Development Executive Sales Executives Technical Head Assistant Technical Head Technical Consultants Digital Marketing Manager Assistant Digital Marketing Manager SME-SMO Executives ResearchAnalyst Circulation Manager Peter Collins Marry D’Souza Mark Williams Pooja, Amy, John Jacob Smile Pratiksha Patil David, Robert Alina Sege Prashant Chevale Manoj, Gemson Eric Smith Tanaji
  • 10.
  • 11.
  • 13. NOVOTECH Aleading regional CRO in the Asia-Paci c region andthe Cover Story ” ACatalyst for Growth and a Better Tomorrow Biotech sector, offering full service clinical trial services ”
  • 14. The cost of research for new drugs has almost tripled over the last 25 years and new models are emerging to face these increasing expenses. Multinational pharmaceutical companies are derivingan even larger share of their revenues from biotech acquisitions or external discovery, and an increasing focus is put on clinical development operational improvements and optimization. Novotech is internationally recognized as the leading regional full-service contract research organization (CRO) in Asia-Pacific and is dedicated to supporting biotech companies in their drug development by tapping into the benefits of the region. With a focus on clinical monitoring, it has been instrumental in the success of hundreds of Phase I - IV clinical trials in the AsiaPacific region. Headquartered in Sydney, Novotech has been delivering CRO services in the region for more than 23 years. It has offices in twelve countries, including two customer- facing offices in the US, and more than 550 staff to accommodate increased demand from international biotech companies for specialist clinical services. Strong Focus on Asia-Pacific with a GlobalReach Novotech delivers clinical development services across all clinical trial phases and therapeutic areas. These include feasibility assessments, ethics committee and regulatory submissions, data management, statistical analysis, medical monitoring, safety services, central lab services, report write-up to ICH requirements, and project and vendor management. The company’s strong Asia Pacific presence allows them to run clinical trialsin all key regional markets. It also has worldwide reach through the company’s network of strategic partners. Full Service for Biotechnology Companies Novotech is known as the leading regional CRO in the Asia-Pacific region and the biotech sector. The company and its employees have won numerous awards and recognitions in the CRO industry over the last several years and has been dedicated to delivering consistently high-quality service for its clients. In addition, the company ensures that the customer satisfaction is closely and objectively monitored across a range of KPIs throughout the lifespan of each project. Speaking of what sets them apart in today’s highly competitive global world, Dr. John Moller, the CEO of Novotech, said, “Novotech is focused on delivering world-class clinical services in the Asia-Pacific region for the biotech sector. We offer the very latest in Oracle and Medidata technology, and all our projects are measured on quality of service and customersatisfaction throughout every stage of our engagement.” The customers of the company value its leadership as a regional CRO specialist, who can understand local cultures, customs, regulations, and have developeddeep relationships with the key investigators in the region. Novotech follows a unique strategy for all its clients’ projects. When discussing a new potential project with a client, the company brings in its senior clinical staff, country managers, and potentially investigators into the discussions as early as possible. Through this, it ensures that the sponsor can gain the confidence that their project will receive the attention they may not otherwise have with global CRO players. In addition to this, Novotech has a significant focus on appointing and retaining the best people and is strongly passionate about developing its employees. In fact, inthe year of 2018, 30% of the company’s employees were promoted. Focused on Client Satisfaction Novotech has implemented a systematic mechanism of monitoring customer and investigator satisfaction across a range of items. It has invested in new technology and established clear processes to systematically reach out to its customers after key milestones for each project. The company finds this initiative very important as it nurtures relationships with its clients to address potential issues well in advance and ensures continuous improvement in the services it provides. Validating the success of this approach is Novotech’s excellent levels of client satisfaction - mostly 8 and 9 out of 10 - and especially project communications which consistently scores above 9 out of 10. Following are some feedback comments fromfrom Novotech clients. “We’re delighted with the way our project was managed. The structure of having the study team together with the governance team was effective. The team was very
  • 15. responsive, and issues were resolved within expected timeframes.” - Senior Clinical Project Manager of a Swiss Biotech company Key Highlights of 2018 Novotech’s acquisition of Australia specialist CNS last year was one of the major milestones in its journey. This acquisition has further strengthened Novotech’spresence in the region and has allowed the company to offer all clients a ‘BioDesk,’ capability that provides early stage product development advice including toxicology, CMC and FDA/EMA regulatory consulting. Moreover, Asia-Pacific was the fastest growing region for biotech-sponsored trials again last year, with an increase of about 35% compared with 2017. In the year 2018, Novotech maintained its focus on bringing in and retaining the best people, nurturing relationships with clients, investigators and partners, and brand development initiatives. The organization also made an important investment in relation to technology improvements with the next generation of Oracle’sTrial Management system. Novotech has further reinforced its position of leading CRO for the biotech sector in the Asia-Pacific region in 2018 with a very strong performance in key markets such as ANZ, Hong Kong, Thailand, Taiwan, andSouth Korea where Novotech estimates its market share has increased to over 30% in key territories. Foundational Values Values are the roots of any company. The core values lay the foundation of an organization and helps define its vision and shape its culture. Novotech abides by the following values: Wemaintain and monitor the quality of service and client satisfaction at every step of ourengageme nt ” ”
  • 16.  Performance Passion – According to Novotech, an attitude of making it happen drives a dedicatedfocus on engagement, quality, accountability, and performance results  Open Engagement – Novotech’s style ofworking recognizes the value of everyone involved  Uncompromised Integrity – It follows the belief that one should never to hesitate to say or do theright thing  Unlocking Talent - Novotech seeks andnurtures people with exceptional talent Novotech’s Take on Latest Developments Novotech believes that clinical data quality is considered the key priority for 2019. According to a recent survey conducted by J.P. Morgan amongst life sciences’ investors this is especially true given the increasing complexity of trials and trial designs. Novotech has driven an increasing investment in upfront clinical development strategy, including the use of carefully designed protocols. These include multi-arm, multi-stage designs with adaptive randomization. According to Novotech, an efficient approach toclinical trial design will have the greatest impact in containing the escalating cost of drug development. It also believes that the effectiveness of clinical trials also relies on the selection of the right investigators and excellence in CRO study management. The company, therefore, invests heavily in building formal partnerships with major hospitals and medical specialist sites through formal site partnership agreements, as well as site management services which facilitate rapid start-up activities and patient recruitment to meet the sponsor’s goals. Bringing in More for a BetterTomorrow With biotech companies investing in more complex and global programs, Novotech sees that biotech sponsors are increasingly considering locations outside of the US for their trials, such as Eastern Europe andAsia-Pacific. The company’s clinical staff numbers have grown by more than 20% in Asia over the last quarter of 2018and 50% over the last twelve months. This growth in the number of staff members is fuelled by demand for a regional CRO with international accreditation and reputation, combined with local knowledge, partnerships, and expertise in the region. Furthermore, the company’s initiative of integration of capabilities, such as BioDesk, will bring tremendous support to biotech companies looking for global regulatory services.
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  • 18. he healthcare industry is looking for better answers to diagnose and treat various life-threatening diseases we hear of today. One of these diseases that the industry is trying to combat since long is cancer. Although there have been Tvarious advancements related to cancer treatment, no specific solution is reached yet. By far, the best possible solution comes from gene therapy. Apart from cancer treatment, gene therapy has showed a lot of potential to improve the treatment of number of deadly diseases. Sanomics is a fast-growing company, which is contributing relentlessly to the future of healthcare with novel gene therapy solutions. It is remarkably revolutionizing cancer treatments for the patients with safe and efficient liquid-based and tissue- based genomic tests. To know more about the story of this ingenious company, we at Insightscare bring to you an exclusive interview with its CEO, Mr. Sy Ming Yiu, Stanley. 1. Tell us in brief about Sanomics Limited. Established in Hong Kong Science and Technology Parks Corporation in 2015, Sanomics Limited is a Hong Kong based biotechnology start-up that specializes in liquid biopsy and tissue-based genomic diagnostics for cancer patients, so as to help doctors decide personalized cancer solutions for patients. Since 2015, Sanomics’ service covers 20 countries and regions and it has completed more than 7,000 patient cases over the world. Sanomics (Thailand) Limited was founded in October 2018 in Bangkok, which is the first Hong Kong biotechnology start-up launched in Thailand. Focusing on lung and women cancer, Sanomics’ comprehensive cancer genomic screening services covers both somatic mutation and germline mutations, adopting Droplet Digital Polymerase Chain Reaction (ddPCR), Next Generation Sequencing (NGS) technology to complete Comprehensive Genomic Profiling (CGP), and Real-time Polymerase Chain Reaction (Real-time PCR). SANOMICSImproving Healthcarewith InnovationandCompassion Interview with Insights Care Mr. Sy Ming Yiu CEO |June 2019|16
  • 19. 2. What were the motivating factors that led towards the inception of the company? “Patient first” is absolutely the most motivating factor. An accurate genomic test result is critical for helping doctors to design a personalized treatment for cancer patients. We strive to provide the genomic tests which are of higher quality, cheaper price, and quicker turnaround time to help cancer patients to save time and medical expenses. 3. Which is your flagship product? Also, tell us how Sanomics stands tall and differentiates itself from others in this competitive world. Requiring only 20ml of blood and 2 working days of turnaround time, p-EGFR® liquid biopsy test detects the EGFR gene mutation which causes lung cancer. Comparing with traditional tissue biopsy which is an invasive operation, costly, and time consuming, p-EGFR® is non-invasive, affordable, and quick. Since the launch of p-EGFR® in August 2015 in Hong Kong, it has become the market leader in Hong Kong within just 8 months. What makes Sanomics stand out is our dedication to execution. We always emphasis the innovation of Sanomics is in execution. Ranging from test request, specimen collection to release report, we try our best to keep the process as simple as possible, so that physicians’ precious time can be spent on treating patients instead of dealing with clumsy procedures. For example, we simplify the process of requesting Sanomics’ tests to 3 steps only and keep our form and test report in 1 page to save time of physicians. Also, we launched Sanomics Portal mobile app for doctors to keep posted. 4. What are all the products and services that Sanomics Limited provides? The pEGFR® test screens for the presence of Exon 19 deletions, Exon 21 L858R, Exon 20 T790M, C797S mutations in blood specimens using droplet digital PCR technology. This test is useful for assessing and monitoring whether TKI therapies would be effective mostly for lung cancer patients. The pBRAF V600ETM test screens for the presence of BRAF V600E mutation in blood specimens using droplet digital PCR technology. The test targets lung, thyroid, colorectal, and melanoma and it is useful for assessing whether the indicated therapies would be useful. It is suggested that if the test results are positive, dabrafenib, and trametinib can be used as targeted therapy. Guardant360® identifies somatic mutations of 73 genes, proven to be clinically relevant, and reports on microsatellite instability (MSI) status through the detection of circulating tumor DNA (ctDNA) in blood specimens using NGS technologies.The test is suitable for patients with advanced solid tumors. The report would present targeted treatment options including approved therapies and therapies undergoing late-stage clinical trials, as well as immunotherapy options. The test would be performed in the US. |June 2019| BRCA Zoom® identifies germline mutation of BRCA1 and BRCA2. The testis suitable for patients who have been diagnosed with breast, ovarian, prostate, and pancreatic cancer; people with family history of the above mentioned cancer and other cancer high-risk groups. Each person carries BRCA1 and BRCA2 genes. These two genes are mainly responsible for repairing damaged DNA and maintaining stable cellgrowth. If a person carries a mutation of the BRCA gene, the risks of developingbreast, ovarian, prostate cancer or pancreatic cancer in a lifetime also increases. Also, the family members of that person would also have a possibility of carrying the mutated BRCA genes. 17
  • 20. OncoSnap® is a pioneering tumor tissue profiling test which screens for clinically relevant somatic mutations of 130 genes in solid tumor tissues by using NGS technologies, and offers FDA-approved therapies undergoing clinical trials. Able to detect single nucleotide variations (SNVs), insertions and deletions (indels), selected fusions and copy number alterations OncoSnap BRCATM is a pioneering NGS-based tumor tissue profiling test which screens for somatic mutations of BRCA1 and BRCA2 genes in solid tumor tissues. This test is useful for assessing patients who are diagnosed with breast cancer, ovarian cancer and prostate cancer on whether they could be benefited from selected PARP inhibitor treatments. 5. With respect to your distinctive products and services, how have you helped bring positive developments in the healthcare industry? Sanomics contributed to provide genomic tests to help doctors decide personalized cancer solutions for patients. Wekeep providing solutions to tackle with the pain points in current cancer management process. For example, Sanomics is the first local private company in Hong Kong to adopt liquid biopsy, a non-invasive cancer screening technology that spares patients from the painful tissue biopsy, a traditional procedure of collecting tissue samples from tumors. Another example is that tissue samples often run outs before answering all the clinical questions that guide treatment selection, therefore, by launching OncoSnap NonetTM , this test can screen for 9 genes in tumor tissue samples to make best use of tissue. 6. Are there any social activities that your company organizes to uplift healthcare space? To raise the public awareness of adopting genomic test in cancer management, Sanomics organizes workshops and seminars for healthcare professionals and general public. We also co-operate with our strategic partners, such as OncoSnap NonetTM screens for 9 genes in tumor tissue samples, intending to aid physicians to identify multi-genetic biomarkers for potential treatment options for primary diagnosed non-small-cell lung cancer patients. PD-L1 IHC 22C3 pharmDx is a qualitative immunohistochemical assay using Monoclonal Mouse Anti-PD-L1, Clone 22C3 to detect PD-L1 protein in FFPE tissue specimens using EnVision FLEX visualization system on Autostainer Link 48. It detects PD-L1 expression with a dynamic range of tumor-positive (TPS) 0-100% and combined positive score (CPS) 0-10+. Cancers include lung cancer, gastric cancer, urothelial cancer, cervical cancer, etc. EmbryoSafeTM screens all 24 chromosomes of IVF and ICSI embryos to detect pathogenic chromosome copy number changes, including aneuploidy, mosaicism, unbalanced translocations, and microduplications/microdeletions (> 10 Mb). |June 2019|18
  • 21. AstraZeneca and Bio-Rad to organize large scale symposium, to discuss about the latest development of genomic diagnostics and provide a platform for intellectual exchange in the healthcare industry. 7. Tell us some interesting things about your leader (CEO, CFO, COO or any other personality which you want to highlight in this issue). “Keep moving, keep thinking and keep solving”, this is the common value that we share in Sanomics. 8. Mention the notable awards and accreditations Sanomics has received so far. So far, Sanomics has won 19 awards. Some highlighted awards include: 2018 The Top 50 Innovative Biotechnology Enterprises in Guangdoug-Hong Kong-Macau Greater Bay Area by ZDVC Research Institute, KPMG & Guangdoug Medical Valley Innovative Business Gold Award 2018 by The Hong Kong and Shanghai Banking Corporation Limited and Hong Kong Economic Times Caring Company Award by The Hong Kong Council of Social Service 9. Can you share with us your upcoming projects? Big data will be our next step. Big Data is everywhere in our daily life, actually DNA big data can also be digitalized to assist scientists and doctors to analyze and make advances in cancer treatment. Currently, there is no existing DNA database of Asian cancer patients. To address the need for building Asian cancer patients’ big data, we initiate to establish a DNA Big Data Centre in Hetao district at Lok Ma Chau. By doing so, we aim to attract more genetic related start-ups to set up their offices in Great Bay Area, so as to create an ecosystem of biotechnology companies in Great BayArea. The initial design of this DNA big database is by subscription base. The meta data of the database will be open for public access. However, to get full access, users must register and pay certain amount of subscription fee, as well as unveiling their data model to sustain the platform. The three main roles of the owner of this DNA Big Data Centre are - first, to provide basic legal support and protection to the DNA data supplying and demanding sides; second, to set up a rating scheme and payment scheme for DNA data transaction; and thirdly, to be the DNA big data manager. The idea of this Asian DNA big data base is like a combination of Asian DNA eBay and DNA cloud. We believe that more valuable studies and commercialized applications of DNA data will be generated once thisAsian Big Data sharing platform has been launched. We foresee that ultimately this will enhance the overall life quality and improve the cancer solution for Asian. Fig.: Important Milestones in the Journey of Sanomics |June 2019| 19
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  • 24. Tania Martin-Mercado Chief Technology Of cer ABOUT THEAUTHOR Tania Martin-Mercado, PhD, is theChief Technology Of cerof YGEIA, a digital healthcarecompanyfocusedonhomehealthcareandchronic disease management.Sheholds various degreesin IT, healthcare,as well as biotechnology and is seasonedwithalot of experienceatvarious prestigious posts throughouttheyears. Being a curious soul andalwaysbeenfascinatedwithtechnology, Taniahas beenapartof various healthcare innovations. |June 2019|22
  • 25. e hear a lot of buzz in the industry and in the marketplace about the latest in digital Whealthcare. From artificial intelligence, machine learning, remote patient monitoring and wearable technology to home monitoring and data, data, data – digital healthcare has morphed into one of the most transformative healthcare trends. While this is one of the most exciting times to be in the digital healthcare market, startups focused on this space need to make sure their product and service have three-fold impact: Improved patient outcomes, reduced cost of delivery, and quality of care. Cost, quality and patient experience often go unnoticed or ignored in favor of technical functionality. The latest and greatest digital healthcare technology will fail if the patients don’t understand how to use it, providers can’t implement it into their workflow, and payors won’t reimburse for its use. By starting with a patient-centered focus, digital startups will find they may need to slow down and get a better understanding of the healthcare industry, which operates differently than the tech world. There are more stakeholders in healthcare that need consideration: doctors, patients, insurers, regulators; each of these stakeholders holds a unique perspective on the technology being adopted. Healthcare is complex because patients are complex. As digital startups focus on one area, such as a particular disease, they may stumble onto the multiple factors that contribute to that disease, what insurers do and don’t cover related to that disease and its symptoms, and more variables that directly or indirectly affect their product or service. The development of a product or service requires research into clinical practice, medical study, patient and doctor interviews, and several focus groups. Digital healthcare startups need to have patience – something that is unattractive to some investors, causing digital healthcare startups to rush into product development too quickly. Instead, involving key stakeholders early in the development process and fully understanding the concerns and perspective will allow these startups to impact the healthcare space where it matters most – patient care. The Medical Futurist published a fantastic article earlier this year that highlights why healthcare startups fail. Forgetting about the patient, not including the provider, difficulty creating clinical value and overclaiming what the technology can do area just a few of areas discussed in this article. Another area often overlooked by digital healthcare startups is the need to integrate. Healthcare data is massive, and there is no “central repository” to draw from. By understanding and embracing the need for shared services, integration with other startups or providers in the healthcare industry can foster innovation and better meet patient need or demand. Instead startups may focus on siloed solutions that make it difficult for providers to implement into their practice, thus not offering value to the patient. By understanding how patient data is viewed from a provider and payor perspective, digital healthcare startups will find out how their product or service will be most useful. This is such an exciting time to be in the healthcare space. The satisfaction of making a positive impact in communities by improving patient care is why many startups dive into the healthcare space. By taking a few of these points into consideration, digital healthcare startups will find their endeavors bearing fruit. WHAT DIGITAL STARTUPS NEED TO SUCCEEDIN THE HEALTHCARESPACE Industry Insight |June 2019| 23
  • 26. eadquarter in Helsinki, Finland; David Health SolutionsLtd. is a rehabilitation solutions provider for musculoskeletal Hproblems. Established in the year 1981 by Arno Parviainen, the CEO, the company has its operations on a global platform.The company is transforming spine and orthopedic care with a data-driven, device-based exercise therapy solution that is directly in consensuswith the latest guidelines. It promotes exercise and cognitive support as the first line treatment for most chronic musculoskeletal problems. Exercise combined with the body’s ability to regenerate is a powerful tool. Unfortunately, it is underutilized in healthcare. However, times are changing. What DHS found out over 30 years ago is becoming the norm now. Indeed, its solution used to be the last remedy in the toolbox; now, it is the first. Decades ago, Arno was convinced that the best way to treat musculoskeletal pain was targeted and controlled exercise therapy using specially designed devices. Having startedsmall, David Health Solutions has now set up more than 350 centers around the world using its intelligent solutions for spine and orthopedic care. The Journey of Innovation & Intelligence Several years were spent on intense research and development in building biomechanically optimal training devices for each joint.David Health Solutions quickly found out that with this approach it was possible to start movement and training, even for the patients suffering from severe pain. The key was to design devices that were gentle for the joints, but demanding for the muscles. The company visualizes becoming the torchbearer in one of the biggest changes in healthcare, covering the most costly and debilitating healthcare problem. “In anything we do, the well-being of the patient is always the most ‘‘ ‘‘ |June 2019|24
  • 27. important factor. No technology alone can solve these problems unless there are unified minds at all levels to bring the benefits to the patient,” asserts Arno. The company is strictly a ‘school medicine’ company, meaning that it makes no unsubstantiated claims and bases its philosophy on data and science. Therefore, to keep up with technology, it is now developing an AI system that can learn from the hundreds of thousandsof patient cases to provide better and more individualized care for each patient. David Health Solutions works on the core value of ‘patient wellbeing’, this is also the reason it is transforming itself from a device company to a service company. “This is the only way we can ensure the best quality and operational efficiency. We have centers under the “Nordic Health” brand, either owned by us or under our management in Finland, Netherlands, Saudi Arabia, and now coming to USA. Our first Nordic Health Spine and Ortho Center will open in Tulsa, Oklahoma,in partnership with neurosurgeons. The next ones will open in California and New Jersey,” says Arno. There is a great need for integrated services providing the whole continuum of care, believes DHS. Distinctive Services and Solutions The David Exercise Therapy Solution utilizes specially designed devices with joint-specific isolation andloading curves, guaranteeing safe and pain-free training experience. Its cloud based, state-of-the-art ITsystem guides and motivates the patient and simultaneously collects all relevant data automatically for easy reporting. Every device is also a testing device for strength and mobility. Based on these test results, the software will automatically provide individualized training weights and movement ranges. All parameters of the exerciseare digitally controlled this way. Nordic Health clinic, which is equipped with the full system, is frequently visited by the staff of the clinic for exercise and preventative care. “It is great to see everyone, from our COO to our Marketing Associates, so enthusiastic to utilize the technology for both rehabilitation and preventive care,” he says. The company’s medical rehabilitation system is unique because it is the only fully equipped solution in the market. The DAVID product portfolio includes intelligent devices that specifically target the spine, hip & knee, and shoulder joints. This is great news for rehabilitation clinics because the practice can offer |June 2019| 25
  • 28. patients care for a variety of musculoskeletalproblems with a turn-key solution that has been validated in a number of studies and in use in hundreds of centers. Distinguishing Itself from Others Typical services in this area are run by therapists on a one-to-one basis, using poor and outdated tools. This isa very consuming work for the therapists and the work is typically quite random. There are no standardized and structured programs and due to high costs, most programs are cut short before the patient is well. DAVID’s innovative solution uses advanced training technology and cloud-based software for guidance, control, and data-gathering. This has dramatically changed the role of the therapists from manualworkers to that of a coach, expert, and motivator. After a few sessions with the therapists, a patient learns to use the system independently and is empowered to take careof his/her own health. This frees the therapists to concentrate on the more difficult cases, while the technology guides the other patients through the program. “Up to six patients can be treated by one therapist,” says Arno. This has also opened a completely new market for medical centers, the on-going prevention care with a membership model. Most of the patients that went through the program are willing to continue once aweek in the maintenance program. This requires very little personnel resources and provides steady income stream for the clinic. Awards and Appreciations The company and Parviainen have been awarded tens of different patents in connection to technical solutions and methods. The company’s production has an ISO 13485 certificate which is GMP in Europe, coveringproduction of medical devices. All the devices are also separately medically certified. The praise it receives form its |June 2019|26
  • 29. Parviainen has a degree in economics, but his knowledge in how to build biomechanically correct devices is very rare in the industry. He started his interest aGer travelling in the US at the age of seventeen and got acquainted with devices in the market there. He built his own set of devices at the age of eighteen and from there on his passion has been to develop technologies that can help patients suffering in back and joint pain. “Life is a Marathon” Arno Parviainen knows the power of exercise firsthand. AGer multiple injuries in water skiing, cycling, and tennis, he could have been disabled with any of those incidences. But he was fortunate to know the possibilities device-based training can offer. The most serious injury caused a cauda- equina with total nerve block and paralyzed his calves. It took him five years of persistent training and running before he was able to run same distances and at same speeds as before the accident. His experience is well documented in his blog: “Life is a marathon”. Mr. Arno Parviainen CEO &Founder |June 2019| 27 customers speaks leaps and bounds of the company’s excellent service. “We at St. Lucas in Bruges, Belgium, adopted the use of device-based back treatment already in 1998. Due to the evidence of its efficacy, a national insurance code was issued for this method. In December of 2015, we moved to a new phase in our operation when we changed to a fully integrated DAVID Solution with automatic adjustments, patient guidance, and tracking of all critical variables. Our experience is that patients are more motivated, results seem to be better, and integration to the hospital’s electronic patient record system saves a lot of administrational work.”−Dr. Marc Soenen, AZ Sint-Lucas Hospital “Having been a neurosurgeon for over thirty years, I have always maintained the desire to explore conservative, non-operative options for my patients. In 2015, we became acquainted with the DAVID Spine Concept. We have been so impressed with the DAVID Solution that we are on our third set of DAVID Spine equipment and have now integrated DAVID’s hip and shoulder therapy as well. It is rewarding to see that active rehabilitation can dramatically change people’s lives for the better and help them avoid surgery.” −Luke Knox M.D. F.A.C.S, Northwest Arkansas Neurosurgery Clinic Bright Future of DAVID The fact that device-based exercise therapy is going to gain ground in the medical world is already clear. National level insurance reimbursements and contracts with health ministries in different countries are a proof of that, believes Arno. “When people become more familiar with these ideas and have a chance to personally try in practice how the system works, attitudes will change,” he says. The company strives to improve its operations and offerings to continueto provide the world’s most comprehensive solution formusculoskeletal rehabilitation. The next major jump forward will be when David Health Solutions will put its AI engine in clinical use. This system will provide the most accurate and individualized care of any system available. It will consider all background factors of the patient, like diagnosis, pain level, education, psychological profile, test results, and so on. It will well understand that musculoskeletal problems are complex, and not only physical, and therefore it is critical to incorporate all successand failure factors in the program. To know more, visit www.davidhealth.com
  • 30. Social Media MarketingANecessaryTrend toPickfor Healthcare Professionals Today, we don’t know if we are conquering the digital world or the digital world is conquering us. Living in an era like this, we need to ensure we are abreast with all the trends and developments that directly affect us. One trend that has moved all the industries and all parts of the world is the extensive use of social media. The millennial generation has embraced various social platforms with open arms and it is now a major part of their lives. On the top of this generation is the next, generation Z. Generation Z, also known as the iGeneration, is immersed in technology. They spend most of their time on social media. It has, therefore, become very important for all types of businesses in all the sectors to leverage the technique of social media marketing to attract the millennials and genzers. This will not only increase the sales but help you build a chain of loyal customers. In-house Opinion |June 2019|28
  • 32. Healthcare industry is also affected by this trend, but it lags behind in exploiting it to the fullest. Let’s understand what benefits it brings to you. The idea of searching and following a doctor on some social platform would seem absurd if you thought about it a few years back. But, time has changed and so has the trend. When it comes to health, although people won’t shop around, they will still look for the best. Advertising everything that a provider has to offer on a platform reaching anyone and everyone is a great idea to mark him/her in the minds of people. Additionally, users, all around the globe, surf their social media feeds number of times a day. If one makes sure to update their account regularly, users are likely to come across their post number of times. This leaves an impact on the users. Where else can one make their presence felt so frequently? It also allows a company to connect with their patients in real-time. And this can be done from anywhere and everywhere! With social media, you can ensure customer-centricity. Putting up health tips and staying in touch with the patients through social platforms are some ways to do this. Moreover, healthcare providers can put up about the practices, services, and products that they provide and the stories of how they have helped others for better. This will help them build a sense of trust in the clients as well as the audience visiting their account. Other than this, social media marketing comes with a lot more advantages. To stand out and make it fun, here are a few ways that will help. Educational Posts A healthcare brand can educate their clients or patients through their social media feed. This can include posting health tips, a video of successful surgery carried by a hospital, awareness and precautions for particular disease, short description of a new device or technology, and many more. Being connected with the brand, the patients will look out for such tips and probably implement them as well. Not only will it help the brand in building better relationship with its clients, but also help improve the patients’ lifestyle. Start a Campaign, Use Hash tags It is a very good idea for a healthcare company to start its own campaign on social media. The campaign can be about anything from awareness about a disease to encouraging audience to share their success stories to starting a social initiative and calling out audience to join in. Using hash tags to promote such campaigns brings a lot of benefits. Say for example, a company starts a campaign for the patients of aids, calling out people to share the success stories of themselves or their loved ones in conquering aids. Hash tag like #companynameforaids can be used by everyone joining in the campaign. This helps improve the company’s branding alongside a good cause. Interactive Communication Clients/patients do not usually indulge in the interactive communication with the healthcare providers. On a social platform, this can be initiated. This will help the patients feel more close to the company and hence, build a long, trustful relationship. Leverage Infographics Infographics can help one provide highly informative content in very short time. Without taking up a lot of the audience’s time, a company can portray its strengths with the help of infographics. A step further is infographic videos. They say a lot of things in matter of seconds.Also, the combination of an audio, video, content, and colors is easier to remember and leaves a high impact on the viewers. These are just some of the ways to leverage social media for marketing by healthcare brands. The scope for ideas is wide, as when it comes to creativity, the sky is the limit. It is the need of the hour to walk with the trends of the world and use them for your benefit. Social media marketing brings in a vast opportunity for healthcare companies to brand and advertise their strengths and connect to the clients better. |June 2019|30 - Aishwarya Nawandhar, Editor
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  • 34. AccutestResearch Laboratories demand in the market for BABE studies conduction as a mandatory regulatory requirement for the generic pharma manufacturers. Dr. Sawant has been instrumental in manifold growth of Accutest bysetting up a friendly and inclusive work culture, which does not compromise on quality while serving the clients with utmost integrity and efficiency. Journeying to the Top The idea of Accutest Research Laboratories was on the mind of Dr. Sawant since he completed his Ph. D in Pharmaceutical Sciences. After serving Indian pharma industry for about 15 years in the areas of drug research related to pharma testing using various modern chromatographic techniques, Dr Sawant set on a path to turn his long cherished dream into reality. In 1998, Accutest entered the industry as a small startup. Initially taking up small projects, the company gradually consolidated its position in the CRO industry. When Accutest had started making its mark, there were not many USFDA accredited laboratories available to outsource clinical research requirements for pharma organisations. Pharma market was opening up and Indian Pharma Industry was gearing up to launch their products in developed countries like US and Europe. Thus, in 2004, the company got the approval from USFDA. After this initial step, there was no looking back whether it was to add new facilities, increase capacities or subsequent audits and approvals from prominent regulatory bodies across the world. Under steady leadership of Dr Sawant, Accutest kept on innovating itself by adding range of diverse services. Accutest and its leadership have consistently been recognized for its success and constant good work with prestigious awards and accolades throughout its journey of 21 years so far. The Preferred CRO Partner for Healthcare Companies The Sculptor of Accutest Dr. Satish Sawant, the Founder and CEO of Accutest, is a very down to earth technocrat and a cricket enthusiast. He has completed his doctorate in analytical chemistry. He has spearheaded and shaped the incredible journey of Accutest asone of leading CROs in the industry through his sheer grit, farsighted business strategies, and zeal to consistently add value to research industry. His business acumen has rightly led him to exploit the huge he healthcare industry in India has caught pace and is moving Tahead with continuous developments. CROs are playing a major role in this and have witnessed a positive growth in the past few years. Through outsourced R&D services to the pharma, clinical device, and biotechnology companies, CROs bring in the promise of further developments in the healthcare space. From clinical research to product development, these companies provide the processes and services on contract basis. One of the leading companies contributing to the future of Indian healthcare industry through its comprehensive services is Accutest Research Laboratories (I) Pvt. Ltd. Headquartered in Navi Mumbai, Accutest is a top-notch independent and internationally accredited India- based Contract Research Organization (CRO). Incepted in 1998, it offers best- in-class services along the whole drug development process to pharmaceutical, generics, and biotechnology companies. The company operates out of three facilities viz. Navi Mumbai, Ahmedabad, and Baroda. Accutest has emerged to bethe undisputed leader in BABE segment for over two decades now. Dr. Satish Sawant Founder & CEO |June 2019|32
  • 35. Eclectic Services Accutest provides services across various verticals like Bioavailability/Bioequivalence (BA/BE) studies for Generic Industry, Clinical Development Services (CDS) for New Chemical Entities, and Bio- analytical Services to Biologics/Bio- similar drug molecules. Speaking about all that they offer to the clients, Dr. Sawant says, “At Accutest, we assist Pharma industries in their drug development life cycle by evaluating its safety, efficacy, ADME character, and quality aspect before the product is certified as appropriate for marketing. As a CRO, we become a part of the pharmaceutical organizations in their research program to evaluate medicines for their quality and test on human population for the safety, effectiveness, and blood levels of the drug after they are consumed.” Accutest has undoubtedly emerged to be the preferred CRO for first-to-file studies. The company also focuses on Phase II-IV clinical trials services for drug development companies in India and abroad. It conducts clinical trials as per Standard Operating Procedures (SOPs) developed in-house, in accordance with ICH GCPguidelines and Indian GCP to accomplish and efficiently cater to requirements of its clients. Accutest Biologics, its subsidiary, is a one-stop solution for analytical and bio-analytical services from early stage characterization to the late stage clinical evaluation of biologics. Bioanalytical services include Pharmacokinetics, Pharmacodynamics, and Immunogenicity assessment of biologics, bio-therapeutics, biosimilars, vaccines, and non-biological complex drugs using high-end assay formats like ELISA, MSD, and GYROS. It also provides in vitro activity/potency and bioassays services for evaluating the biological activities besides toxic kinetics and related services. What sets It Apart? Being in clinical research field for 21 years now, Accutest is setting aniche in the industry with its unmatched expertise and services. The success stories of Accutest andaccreditations from global regulators, like US FDA, WHO, EMA, ANVISA, DCGI, MCC and other prominent authorities, stand as a testament to its unwavering commitment to international quality standards and operating procedures. Recently, the company received the prestigious OECD GLP certification by NGCMA. Accutest is the first and only independent biologics testing facility in India to be honored with this international accreditation. The company constantly strives to reinvent itself, along with providing advanced services to its clients. Incredible Team Accutest takes great pride in its dynamic team, which understands customer requirements and gives optimal solutions. Dr. Sawant asserts, “We have a rich pool of well qualified and dedicated professionals, these are our assets. Their rich experience and involvement during clients’ drug development program gives clients the confidence to outsource their clinical development needs. Timely delivery, our regulatory history, global reach, staff and our ability to work hand-in- hand with the clients are some of our value propositions which set us apart from other competitors in the market.” Perfect R&D Partner Accutest is the partner of choice for generic drug manufacturers looking to execute BA/BE studies with a high degree of quality and speed, at competitive prices. It has one of the largest data banks of 41,000+ volunteers along with strong regulatory track records. The company’s state-of- the-art infrastructure comprises of more than 400 beds, 38 LCMS-MS, and 700+ validated methods, enabling it to serve the clients with ease and quality. Acutest is rendering numerous benefits to its clients by catering to their complete, complex, and cross functional service requirements, under one roof with ease and expertise. We offer an umbrella contract-based R&D servicesto our industry partners witha focus on quality and quick turnaround time ‘‘ ‘‘ |June 2019| 33
  • 36. SpineMark Corporation Thought Leadership Marcy T. Rogers, M.Ed., is the President and Chief Executive Officer of SpineMark. Rogers has built her executive career in the healthcare industry through the development of niche surgical centers of excellence fueled by innovation and clinical research. A proven leader, she hasbuilt trust and rapport with physicians, hospitals, ambulatory surgery centers, and medical device manufacturers in spine, orthopedics, biologics, and interventional pain. She has dedicated over 30 years of her life to delivering results. Through alliances, partnerships, and collaborations in the field of spinal care, Rogers is getting things done. Her destination center model integrates and aligns stakeholders in the delivery of spine services, and she has successfully demonstrated solid financial results as well as strong returns on investment for the hospitals, ambulatory surgery centers, and physician groups she has managed and counseled. She has consulted and worked with over 300 hospitals and surgery centers on their musculoskeletal and neurological service lines, formation of new centers, or expanding facilities on its campuses in the US and abroad. Through her recognitions and endeavors, Rogers has established herself as a key opinion leader in the field of spine among her clients, professional colleagues, and peers. The Vision of SpineMark The company strives to create a new standard of care for patients suffering from back pain. “Currently there is no standard of care and the field of spine is fragmented at best with many different providers labeling themselves as spine experts as naturopaths, chiropractors, spine surgeons, interventional pain specialists, neurologists, et al.,” says Rogers. SpineMark is working towards building a network of dozens of sites Transforming Care Delivery Through Exceptional CareServices operating committee of four or more members of the team who provide clinical oversight. A nurse navigator and an intake coordinator are recruited to provide coordination of care and follow up. A medical “gatekeeper” is recruited to manage new and established patients through their care needs and the system itself. Outcomes data and process measures as well as transparency are the key components of SpineMark’s system for patient care. pine injuries can be life altering and fatal in some cases. A great Sdeal of perseverance and dedicated physical exercise is required to recover from spinal injuries or surgeries. One such organization that is built around the needs of spine patients is SpineMark Corporation. Headquarter in San Diego, California, the company was established in 2011. Its patient-centric, transparent, and outcome-accountable services are what set it apart from its counterparts. The model of SpineMark’s spine centers of excellence are built around the needs of patients. The centers advocate for their patients and cater to the patients’ needs. The service protocols for patients include an integrated delivery system with a team of multispecialty providers, including personnel for diagnostic, operative, non-operative care, and holistic or conservative care modalities. Every SpineMark center starts with the physician and surgeon champions, who recognize the need for collaboration, a facility partner, and algorithms from the least to most invasive type of care. This is based on failure along a cascading chain of modalities, team conference staffing of patients, clinical research activities, and a clinical Marcy T. Rogers President & Chief Executive Officer |June 2019|34
  • 37. across the US and outside the US, including in Kuwait, China, and Europe. The company works towards standardizing the treatment of patients suffering from back pain via a treatment protocol, quality service, positive outcomes, efficacy, and quality data. The organization’s values are always focused on the least invasive “do no harm” approach to treating patients. This starts with 4-6 weeks of conservative care, which includes interventional pain procedures to minimally invasive spine surgery. These are the first choices if supported by the patient’s condition. “We want the patient to have the right procedure at the right time by the right doctor(s). That is our mantra,” asserts Rogers. Distinctive Services and Solutions SpineMark is the premier global spine service company for the development of Spine Destination Centers and Spine Research Organizations in partnership with medical professionals, hospitals, and industry medical manufacturers. Its centers provide excellent medical, operative, non-operative, and ancillar services, all delivered under one integrated delivery system. This reduces patient chaos, cost, and duplication of procedures. The establishment of clinical research units at each site, as well as mainstreaming minimally invasive spine surgery procedures at numerous sites of the organization, is the most distinct feature of its service. The company’s model is built on disease- based medical management and is measured for quality. Communication is the key to success, believes Rogers. Thanks to the use of a nurse navigator and intake coordinator, patients never fall through the cracks. Speaking about the nurse navigator support system, Rogers says, “We support patients through our services, model, management of their distinct needs throughout the course of treatment by using nurse navigators to guide them through various phases of care.” SpineMark also often links new patients with existing patients who have been treated by its team and have similar pretreatment or surgical issues. Hence, its post-operative patients are the greatest advocates for proving SpineMark’s model. SpineMark holds itself accountable through outcomes and quality data collection, transparency, and a focused approach on the identification of the somatic origin of the pain. Diagnosis is key; surgery is always the last resort. Bright Future for SpineMark “We are looking to expand our sites throughout the US and abroad, with centers locally, regionally, and nationally,” says Rogers. There are 1.8 billion people disabled by back pain. The company wants to be a resource to as many of these patients as possible. Advancement in Spine Treatment “The new development in spine treatment has been ‘through clinical research’,” asserts Rogers. Minimally invasive spine surgery techniques are finally taking the field by storm and are becoming mainstream. “A few years ago, this was not the case,” she continues. Technological advances in robotics, instrumentation, fixation, and implants combined with cell and gene therapy biologics is changing the treatment of spinal conditions. Today, one can perform complex spine procedures - both lumbar and cervical fusion - arthroscopically, reducing rehabilitation and recovery, and allowing patients to return to normal function in little time. Spine treatment is becoming more holistic and non-invasive with the advancement in technology. SpineMark, with its clinical research units, is making sure it keeps up with the innovation. Our diagnostic, conservative care, holistic, operative, non-operative care, and clinical research units are set up to participate, so that we are always advancing care through research ‘‘ ‘‘ |June 2019| 35
  • 39. TopHealthTech Innovations IN2019that are Breakingt h e Barriers very day, new technologies are emerging. Humans are using all their brains to invent something new, somethingunique, andsomethingthathelps mankind.With all therecentadvancements,technology “Every once in a while, a new technology, an old problem, and a big idea turn into an innovation.” - Dean Kamen Ein the healthcare and medical sector has geared up as well. The embedding of arti cial intelligence andIoT is nowdoneextensivelyin thehealthcaresector.Various newtechniquesarebeinginvented that helpsocietyto growin aself-suf cient manner.From electric carstogenerating electricity through nuclear energy, humansare advancingin all aspects. Health has always beenonthetoppriority for aperson so it is essential thathe/sheis treatedwithin time andwith perfection.Duetoinnovativeminds, therehavebeenvarious upgradesin the eld. There are treatmentsfor many diseases anddisorders whichwerenotthoughtof afewyears ago.Various instruments andfacilities havebecome affordabletothehealthcareservice providers like hospitals and clinics. Researchersaretrying hardtoprovide everything for bettertreatmentof thepublic. Various medicines have beenusedto treatdiseases successfully andmanydiseases havealready beeneradicatedfrom theearth. Newtypesofequipmenthave helpedthedoctorsin various complicatedsurgeries. In thefollowing year, therehavebeenmanynewinnovations for the bettermentofthelives ofpeople.Here areafewnotable technological innovations: Novel Discoveries |June 2019| 37
  • 40. 3-D PRINTING Surgeries areverycomplicatedandinvolve alengthy process. Precision is very importantandpracticingit beforehandis highly crucial.Doctors use 3-D models for practicingthesurgeries. The 3-D printing machine modelsaremadein accordancewith thepatient’sanatomy. In recent times, fewimportantdevelopments in 3-D printing havecomein external prosthetics,cranial or orthopedic implants, andcustomairway stents. It has also been helpful in surgical planning as well in complex open heart surgeries. There areresearchesbeingcarried outtoprint human tissue that will make organtransplants possible. ARTIFICIAL INTELLIGENCE The biggest problem in making a drug for a rare disease is the huge data of the patients and their compliance. Many researchers and pharmaceutical companies are taking the help of AI to organize the data from the medical records and nd commonalities with the diseases. AI has been a huge plus point for doctors and general practitioners as it helps to collect and nd the data of the patients whenever required. This technology is transforming all areas of the healthcare industry, from work process control and diagnostics to process automatization, productivity- enhancing,andenhancementsin diagnosticsaccuracy. RNA-BASED THERAPEUTICS Recently, RNA-based therapeutics are beingused whereRNA is modi ed or replaced before it forms into a protein. It allows the clinicians to detectany genetic abnormality beforehand and treat the problem by replacing it accordingly with functioning or non- functioning proteins. Advancement in RNA therapeutics may even lead to solving the problems of rare diseases like Huntington’s disease, neurologic disorders, and several formsofcancer. NEW IMMUNOTHERAPY TECHNIQUES Basically, immunotherapyis atreatmentfor cancer.In this typeof treatment, white blood cells are increased in the patient’s body so as to ght against various diseases. Avarietyofexperimentsarebeingcarried outin combinationwith joint therapyandengineeredT-cells thatcanprove tobeeffective against awiderangeof tumor cells. |June 2019|38
  • 41. TELEHEALTH With everything beingdigitized, therewasaneedtomonitor aperson’s health through digital services. Now,this has becomepossible. Doctors canmonitor their patient's healthevenfrom adistance.The doctorcanmakea primary conclusionfrom analyzing thereport thatis generateddigitally. This way, the expensesof thepatientsarereducedto agreatextent. ROBOTIC SURGERY Roboticshas beenadministeredin various medicaltreatments.Nanobots are being administeredin bloodstreamsofthepatientsthatcandiagnoseand preventdiseases. Movementdisabilities canbemonitoredbyexoskeletons with theassistanceof physical therapy. Oneof themajor innovations of 2019 is roboticsurgery. Now,robots canbe useful in performingvarious proceduresduring surgery. Arobotcanperform tasks and provide medical assistancelike giving aninjection andgatheringinformation. There are supporting robots thatmanagetocourier medicalinstruments andother related supplies. HEALTH WEARABLE As it is said in afamousquote,‘Precautionis betterthancure’,it is important to maintain ahealthylife. Peoplehavestartedtounderstandthatbeing healthyis really helpful in avoidinganyfuture diseases or disorders. There arevarious companiesthat haveinvented uniquehealthwearablethathelpa person trackhis/her ownhealth. Onecan monitor theheartrate, glucose level, physical activity, andalso sleeptimings with these. This way,theperson cananalyze whereheis lackingandwork onit, accordingly. |June 2019| 39 GENOMICS Aperson’s identity is from his/her genes.Even, whatdisease canaffecta person is decided bythegeneticmakeof thebody.Biotechcompanies havecomeup with technologythatcanbe helpful in decodingindividualgenomic makeup andaidin enhancingthediagnosis and treatmentfor various geneticand non- geneticdiseases. These companiesarefurther trying todevelopa personalized treatmentwith thehelpof this technology.In 2017, CRISPR, ageneediting tool was used to successfully edit human embryos in which hypertrophic cardiomyopathy,acomplexheartdisease, within 42 embryoswas eradicated. Technologyhas beenproving tobeworking handin handwith thehealthcareindustry for thebettermentofthe quality of careprovided. Everyday,theworld witness’s newdevelopmentsandwith this mankindis movingtowards moreaccurateandaffordabletreatment options. - Shambhavi Mhetre, Editor