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INDIAN DENTAL ACADEMY
Leader in continuing dental education
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TISSUE ENGINEERING – ITS
APPLICATION IN ORAL
AND MAXILLOFACIAL
SURGERY
CONTENTS
















Introduction
Definition
Principles of tissue engineering
Scaffolds
Growth factors
Cells
PRP
BMPs
Hard tissue engineering
Soft tissue engineering
Application in various aspects of oral and maxillofacial
surgery
Conclusion
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References
Introduction

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Definition


The interdisciplinary field applying the
principles and methods of engineering and life
sciences to fundamentally understand and
develop biological substitutes to restore,
maintain or improve tissue functions

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Principles of tissue engineering

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Scaffolds



Role of scaffolds
Types of scaffolds

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Charecteristics of scaffolds

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Growth factors





PRP
BMPs
rhPDGF-BB
rhBMP

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Platelet rich plasma

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Bone morphogenetic protein

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Cells




Osteoblasts
Undifferentiated cells/ pluripotent cells
chondroblasts

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

Application in oral and maxillofacial
surgery

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Soft tissue engineering

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Hard tissue engineering


Guided bone regeneration

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Ridge preservation

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Vertical ridge augmentation

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Maxillary sinus augmenatation

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Tissue engineering in distraction
osteogenesis

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Craniofacial reconstruction

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Mandibular continuity defects

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Preprosthetic maxillomanibular
deficiencies

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Traumatic facial bone loss

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Reconstruction in growing
patients





Cleft lip and palate
Mandibular atrophy
Craniofacial trauma
Hemimandibular defect

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Tissue engineering in TMJ

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Conclusuion

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REFERENCES
















1. Kakehi, Takada. Effect of titanium surface roughness on the
cytocompatibilty of osteoblast like cells. J Oral Tissue Engin 2006;2:77-88.
2. Matsuzaka, Yoshinari. Bone formation in titanium porous scaffold with
immobilisation of BMP- 2. J Oral Tissue Engin 2005;2:60-65
3. Ahukawa, Michael Shin. Reconstruction of mandibular defects with
autologous tissue engineered bone. J Oral Maxillofac Surg 2004;62:601606.
4. Francoise Marja. Developmental biology of tissue engineering. Birth
Defects Research 2007;8:320-328
5. Sonie A.C.Modino, Sharpe. Tissue engineering of teeth using adult stem
cells. Archives of oral biology 2005;50:255-258.
6. ZhI li,Zu. Repair of mandible defects with tissue engineering bone in
rabbits. ANZ J. Surg 2005:75;1017-1021.
7. Rainer Schmelzeiseh, Schimming. Making bone: implant tnsertion into
tissue engineered bone for maxillary sinus augmentation- a preliminary
report. J Cranio maxillofac Surg 2003;31:34-39.
8. Samuel E. Lynch, Robert Marx, Myron Nevins. Tissue engineeringapplications in oral and maxillofacial surgery, second edition.
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Thank you
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Tissue engineering – its application in oral and maxillo facial surgery /certified fixed orthodontic courses by Indian dental academy