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1. DISEASES INVOLVING
BLOOD PLATELETS-II
INDIAN DENTAL ACADEMY
Leader in continuing Dental Education
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2. LEARNING OBJECTIVES
• At the end of the lecture student should be able to
• Describe etiology, clinical features &
histopathological features of thrombocytasthenia
• Describe etiology, clinical features &
histopathological features of thrombocytopenic
purpura
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3. • THROMBOCYTASTHENIA
•It is characterized by qualitative defect in the blood
platelet.
•FAMILIAL THROMBASTHENIA (Glanzman
thrombasthenia)-hereditary,chronic hemorrhagic disease
transmitted as an autosomal recessive trait.
•C/F -Excessive bleeding following minor trauma.
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4. • Purpuric hemorrhages of skin are common.
• Epistaxis and GIT bleeding.
• O/F-
• Spontaneous gingival bleeding.
• Palatal petechiae.
• L/F-Bleeding time prolonged
• Clot retraction is impaired .
• Number of platelet normal.
• Amount of certain membrane glycoprotein on the
surface of the platelet is reduced.www.indiandentalacademy.com

5. THROMBOCYTOPATHIC
PURPURA
•A group of rare disorders of unknown etiology in
which the patients manifest a bleeding tendency due to
qualitative defects in blood platelets.
•Severe bleeding tendency and bruise easily even after
minor trauma.
•Menstrual bleeding so severe as to require blood
transfusion.
O/M : Gingival bleeding
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6. •Excessive and prolonged bleeding from dental
extractions may be a serious management problem.
L/F
•Platelate count – Normal
•Bleeding time prolonged or normal
•Storage pool disease – Deficiency in nonmetabolic
storage pool of the platelet adenine nucleotides.
•Portsmouth syndrome: Abnormal or absent collagen
induced platelet aggregation.
•Bernard soulier syndrome – abnormal platelet
response to fibrinogen
Treatment :Conventional haemostatic agent and blood
transfusion.
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7. THROMBOCYTHEMIA
(THROMBOCYTOSIS)
•It is characterized by increase in number of platelets.
•Types – Primary  unknown
Secondary  after injury, inflammation,
surgical procedures or parturition.
•In association with anemia, myeloid leukemia,
tuberculosis,polycythemia.
•Secondary thrombocytosis may be due to over
production of cytokines – IL-1, IL,-6, IL-11www.indiandentalacademy.com

8. C/F
• Bleeding tendency inspite of elevated platelet
count.
• Epistaxis and bleeding into GIT
O/M
• Spontaneous gingival bleeding
• Excessive and prolonged bleeding after dental
extraction.
L/F- Platelete count increase 14 lacs per cubic
milimeter.
• Clotting time, prothombin time, clot retraction
and tourniquet test  normal
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9. SUMMARY
• Etiology, clinical features & histopathological
features of thrombocytasthenia.
• Etiology, clinical features & histopathological
features of thrombocytopenic purpura
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10. BIBLIOGRAPHY
• Shafer’s-6th edition- Oral Pathology
• Sembulingam- Physiology
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11. THANK YOU!
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