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Kidney
Location:

www.indiandentalacademy.com
INDIAN DENTAL ACADEMY
Leader in continuing dental education
www.indiandentalacademy.com

www.indiandentalacademy.com
“What is man but an ingenious
machine designed to turn with
‘infinite artfulness’, the red
wine of shiraz into urine” …!
Isak Denison

www.indiandentalacademy.com
Kidney damage is the major
cause of Morbidity and
Mortality in patients with
Diabetes, Hypertension,
Atherosclerosis etc.
(no 1 cause of death in the present time)

www.indiandentalacademy.com
Introduction:
 150gm

each
 1700 liters of blood filtered  180 L of
Gfiltrate  1.5 l of urine / day.
 150gm, retro-peritoneal organ
 Renal Artery & Vein
 One half of kidney is sufficient – reserve
 Filtration, Excretion, Secretion, Hormone
synthesis.
www.indiandentalacademy.com
Kidney Anatomy:

www.indiandentalacademy.com
Nephron
Structure:

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Kidney Histology:

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Kidney Histology:

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Diseases of Kidney:
Glomerulonephritis Glomerular

diseases Destruction of glomeruli by immune
or infections.
Acute tubular necrosis Tubular
diseases Necrosis of tubules by toxins or
infections.
Pyelonephritis Interstitial disease Infections
Nephrosclerosis Vascular diseases ––
thickening of blood vessels Hypertension
leading to microwww.indiandentalacademy.com
infarctions.
Clinical Syndromes:
Nephritic syndrome.
– Oliguria, Haematuria, Proteinuria, Oedema.

Nephrotic syndrome.
– Gross proteinuria, hyperlipidemia,

Acute renal failure
– Oliguria, loss of Kidney function - within

weeks

Chronic renal failure.
– Over months and years - Uremia
www.indiandentalacademy.com
Immune Glomerulonephritis:
C.Immune Complex

ANTI-GBM

www.indiandentalacademy.com

HEYMANN
Glomerulonephritis:



1.
2.
3.
4.

Immune mechanisms – Most common
Toxins - poisoning
Metabolic – acidosis, hemolysis, etc.
Activation of complement system
destruction of glomerular structure
Inflammation
Affect renal function – excess filtration or
decreased filtration. (with RBC & WBC)
www.indiandentalacademy.com
•Normal

•Proliferative
•Post strepto
www.indiandentalacademy.com
Mesangiocapillary GN: (MPGN)

www.indiandentalacademy.com
Chronic Glomerulonephritis:

www.indiandentalacademy.com
Urolithiasis:

www.indiandentalacademy.com
Urolithiasis:

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Urolithiasis Hydronephrosis:

www.indiandentalacademy.com
Urine Microscopy :
 Cells Casts Crystals.
Crystals
 Casts

are formed within nephron.
 Casts Suggest Kidney pathology.
 Casts can be made up of Protein, lipid,
cells or mixed.
 Crystals suggest high concentration or
altered solubility.

www.indiandentalacademy.com
Formation of Casts:

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Granular Cast:

www.indiandentalacademy.com
RBC Casts:

www.indiandentalacademy.com
Epithelial Casts in Urine:

www.indiandentalacademy.com
Granular Casts in Urine:

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WBC Cast Urine:

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RBC in Urine :

www.indiandentalacademy.com
WBC in Urine :

www.indiandentalacademy.com
Urine Oxalate Crystals:

www.indiandentalacademy.com
Mixed Cast Urine:

www.indiandentalacademy.com
www.indiandentalacademy.com
Leader in continuing dental education

www.indiandentalacademy.com

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