Cebr 1st Incubation Sig 2

TLS Foundation Toscana Life Sciences Foundation was established in Siena two years ago by different public and private subjects, with the aim of supporting research activities in the field of life Sciences and, in particular, fostering the development of projects from basic research to industrial application in the field of Life Sciences The TLS final mission is to trigger the technological and industrial development and improve job and wealth creation in the Tuscan Region

TLS mission Toscana Life Sciences Regional Universities Public Administration Local Financial Institutions Strengthening the value of research Territory Industrial development

Germano Carganico General Manager Andrea Paolini Administration Ilaria Niccolai Administrative Assistant Francesco Refi Infrastructures/ IT Francesco Maria Senatore Business Development Letizia Sensini Comunication Cristina Tinti Scientific Affairs Laura Salvini Technology Facilities TLS Foundation boards and staff Founders Board Executive Board Scientific Advisory Board

[object Object],[object Object],[object Object],[object Object],TLS – Activities

TLS project chronology December 2007 Other two companies move in December 2004 September 2005 December 2005 February 2006 July 2006 November 2006 March 2007 TLS foundation’s establishment TLS operations begin 1° Call for Incubation Restructuring of Bio-incubator starts First project selection The Bio-incubator is inaugurated First two companies start operations

Total surface area: 83.000 sq. mt. Total buildings surface: 38.400 sq. mt. Labs (research/devel./Q.A.): 8.200 sq. mt. Production plants: 6.800 sq. mt. Warehouses: 2.800 sq. mt. Offices: 8.400 sq. mt. Services: 4.700 sq. mt. TLS bio-incubator and Sienabiotech ,[object Object],[object Object],[object Object],[object Object],Location: Siena - “Torre Fiorentina” Novartis site

TLS bio-incubator – facilities ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

TLS bio-incubator - funding ,[object Object],[object Object],[object Object]

Positioning the TLS bio-incubator ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],What we offer - Nurturing the young projects

Consulting services - Nurturing the young project ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],Support for financing - Nurturing the young project

Financing Incubated Companies ,[object Object],[object Object],[object Object],[object Object]

BioFound ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

Second round financing Z- Cube

[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],Major reasons for establishing the bio-incubator

19 Tuscany Cluster The cluster is home to: 19 Biotech companies,10 of which born since 2000 14 Global Biotech & Pharma research centers active in clinical trials 55 Biotech/Pharma locations of Manufacturing, Research and Administration 3 Universities areas (more than 7.600 graduates in technical e scientific fields in 2004) 78 Hospitals involved in clinical trial (with an average of 23 trials per organization) 1.029 Clinical trials (excluding phase I) conducted in the period 2000-2004 Total = 19 Number of Biotech Companies by Sector 2004 Tuscany: a strategic research location From “Invest in Tuscany – Biotechnology Report 2006” Territory : • Inhabitants: 3,6 millions • Population density: (163 inhabitants/ sq.km) • Surface 2.992 Km

Bio-incubator - mission and goals ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

[object Object],[object Object],[object Object],[object Object],[object Object],Access to the TLS bio-incubator

The deal -flow International Call for Application Scouting Tight relationship with the TTO of the Tuscan universities project selection (quality as guiding criterion) Finding start up financing Business plan submission TLS Executive Board approval Incubation

Selected companies Photodynamic antimicrobial therapy Diagnostics for autoimmune diseases Pain treatment and new antipsychotics New targets for oncology and autoimmunity Degenerative diseases (VEGF-D biology) Cocaine addiction treatment Branched peptides for tumor targeting Cancer vaccines ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],Project Company

Features of the first 8 selected projects ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

TLS science park companies Externautics AxaPharm

Unmet needs ,[object Object],[object Object],[object Object],[object Object]

TLS bioincubator peculiarity ,[object Object],[object Object],[object Object],[object Object],[object Object]

Cebr 1st Incubation Sig 2

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Cebr 1st Incubation Sig 2