1) The document provides information on various direct-to-consumer genomics companies and their offerings, including 23andMe, deCODEme, Navigenics, and others. 2) It discusses the declining prices of whole genome sequencing from $99,500 down to $48,000. 3) The document also briefly describes next-generation DNA sequencing technologies like Pacific Biosciences that can read DNA in real time.

1. Direct-to-Consumer Genomics Offerings: ongoing price declines Single condition Multiple conditions Whole genome Knome Cost $ 1 Research Edition (substantially the same offering) available through 9/31/09 2 Full genome: $99,500; exome: $24,500; research edition may be available for $48,000; $10,000 respectively Offering Breadth Public studies (specific disease or trait) (common diseases) $199-$348 $985 Matchmaking ScientificMatch $1,995 GenePartner $10-$99 $1,000 $399, $99 1 Paternity Genelux $200-$475 Identigene $149-$399 Zygosity Proactive Genetics $160-$240 Nutrigenomics APO E Gene Diet $389 Inherent Health $99 Illumina $48,000 23andme 111 conditions deCODEme 42 conditions Navigenics 128 conditions Coriell 15 conditions Scripps (Navigenics) 28 conditions School PGP Conditions undisclosed Harvard Medical Genomics 90 conditions Pathway $2,500 $999 $350,000 $99,500, $24,500 2 Genetic disorders, Predisposition DNA Direct $200-$3,500 Matrix Genomics $199-$799 Drug sensitivity,

3. Direct-to-consumer genomics: 23andme Source: http://www.23andme.com; open source genomes http://www.snpedia.com/index.php/Genomes 580,000 SNPs scanned and mapped to 78 conditions

4. 23andme colorectal cancer marker Source: http://www.23andme.com

5. Next-gen sequencing: Pacific Biosciences Sources: http://www.pacificbiosciences.com/video_lg.html, http://www.sciencemag.org/cgi/content/abstract/323/5910/133, Science 2 January 2009: Vol. 323. no. 5910, pp. 133 – 138, DOI: 10.1126/science.1162986 Phospholinked nucleotides DNA polymerase wrapped around DNA chain Phospholinked nucleotide binds, fluoresces and detaches as nucleotide base is read 1 2 3a 3b