Enviar pesquisa
Carregar
OncoGenomics Explorer2
•
2 gostaram
•
685 visualizações
H
hlodeniu
Seguir
Tecnologia
Saúde e medicina
Denunciar
Compartilhar
Denunciar
Compartilhar
1 de 23
Baixar agora
Baixar para ler offline
Recomendados
OncoGenomics Explorer
OncoGenomics Explorer
hlodeniu
Trends in Biotech. Maggio, Goncalves
Trends in Biotech. Maggio, Goncalves
Manuel Goncalves
Identification of disease genes
Identification of disease genes
Prasanthperceptron
Friend Oslo 2012-09-09
Friend Oslo 2012-09-09
Sage Base
Gene mapping
Gene mapping
Assam Agricultural University
Genotyping, linkage mapping and binary data
Genotyping, linkage mapping and binary data
FAO
Gene mapping
Gene mapping
Deepak Kumar
Mapping
Mapping
Chongtham Allaylay Devi
Recomendados
OncoGenomics Explorer
OncoGenomics Explorer
hlodeniu
Trends in Biotech. Maggio, Goncalves
Trends in Biotech. Maggio, Goncalves
Manuel Goncalves
Identification of disease genes
Identification of disease genes
Prasanthperceptron
Friend Oslo 2012-09-09
Friend Oslo 2012-09-09
Sage Base
Gene mapping
Gene mapping
Assam Agricultural University
Genotyping, linkage mapping and binary data
Genotyping, linkage mapping and binary data
FAO
Gene mapping
Gene mapping
Deepak Kumar
Mapping
Mapping
Chongtham Allaylay Devi
Kurrey_et_al-2009-STEM_CELLS
Kurrey_et_al-2009-STEM_CELLS
Swati Jalgaonkar
Genetic mapping
Genetic mapping
Bruno Mmassy
Difference between genetic linkage and physical map
Difference between genetic linkage and physical map
Kanimoli Mathivathana
Gene mapping
Gene mapping
uog
Association mapping
Association mapping
Senthil Natesan
PHYSICAL MAPPING STRATEGIES IN GENOMICS
PHYSICAL MAPPING STRATEGIES IN GENOMICS
Usman Arshad
Gene mapping
Gene mapping
Sanju Kaladharan
Association mapping in plants
Association mapping in plants
Waseem Hussain
Gene mapping ppt
Gene mapping ppt
prashant tripathi
GENE MAPPING
GENE MAPPING
Koppala RVS Chaitanya
BITS - Comparative genomics: gene family analysis
BITS - Comparative genomics: gene family analysis
BITS
Association mapping
Association mapping
Senthil Natesan
Mapping population
Mapping population
Nivethitha T
Gene mapping
Gene mapping
Bahauddin Zakariya University lahore
Genetic mapping
Genetic mapping
Imdad Takkar
Gene mapping
Gene mapping
rashzz
genome wide linkage mapping
genome wide linkage mapping
Ravi Kamble
Construction of human gene map through map integration- from genetic map to p...
Construction of human gene map through map integration- from genetic map to p...
Central University Of Kerala
Location and mapping of chromosomes using conventional and cytological means.
Location and mapping of chromosomes using conventional and cytological means.
Noor e Mujjassim
Boc Lecture 3 the multistep nature of cancer, Karobi Moitra
Boc Lecture 3 the multistep nature of cancer, Karobi Moitra
Karobi Moitra CFD, MS, PhD
Genomics Technologies
Genomics Technologies
Sean Davis
NORMAL-CELLS-versus-CANCER-CELLS.pptxssss
NORMAL-CELLS-versus-CANCER-CELLS.pptxssss
RashadHamada
Mais conteúdo relacionado
Mais procurados
Kurrey_et_al-2009-STEM_CELLS
Kurrey_et_al-2009-STEM_CELLS
Swati Jalgaonkar
Genetic mapping
Genetic mapping
Bruno Mmassy
Difference between genetic linkage and physical map
Difference between genetic linkage and physical map
Kanimoli Mathivathana
Gene mapping
Gene mapping
uog
Association mapping
Association mapping
Senthil Natesan
PHYSICAL MAPPING STRATEGIES IN GENOMICS
PHYSICAL MAPPING STRATEGIES IN GENOMICS
Usman Arshad
Gene mapping
Gene mapping
Sanju Kaladharan
Association mapping in plants
Association mapping in plants
Waseem Hussain
Gene mapping ppt
Gene mapping ppt
prashant tripathi
GENE MAPPING
GENE MAPPING
Koppala RVS Chaitanya
BITS - Comparative genomics: gene family analysis
BITS - Comparative genomics: gene family analysis
BITS
Association mapping
Association mapping
Senthil Natesan
Mapping population
Mapping population
Nivethitha T
Gene mapping
Gene mapping
Bahauddin Zakariya University lahore
Genetic mapping
Genetic mapping
Imdad Takkar
Gene mapping
Gene mapping
rashzz
genome wide linkage mapping
genome wide linkage mapping
Ravi Kamble
Construction of human gene map through map integration- from genetic map to p...
Construction of human gene map through map integration- from genetic map to p...
Central University Of Kerala
Location and mapping of chromosomes using conventional and cytological means.
Location and mapping of chromosomes using conventional and cytological means.
Noor e Mujjassim
Boc Lecture 3 the multistep nature of cancer, Karobi Moitra
Boc Lecture 3 the multistep nature of cancer, Karobi Moitra
Karobi Moitra CFD, MS, PhD
Mais procurados
(20)
Kurrey_et_al-2009-STEM_CELLS
Kurrey_et_al-2009-STEM_CELLS
Genetic mapping
Genetic mapping
Difference between genetic linkage and physical map
Difference between genetic linkage and physical map
Gene mapping
Gene mapping
Association mapping
Association mapping
PHYSICAL MAPPING STRATEGIES IN GENOMICS
PHYSICAL MAPPING STRATEGIES IN GENOMICS
Gene mapping
Gene mapping
Association mapping in plants
Association mapping in plants
Gene mapping ppt
Gene mapping ppt
GENE MAPPING
GENE MAPPING
BITS - Comparative genomics: gene family analysis
BITS - Comparative genomics: gene family analysis
Association mapping
Association mapping
Mapping population
Mapping population
Gene mapping
Gene mapping
Genetic mapping
Genetic mapping
Gene mapping
Gene mapping
genome wide linkage mapping
genome wide linkage mapping
Construction of human gene map through map integration- from genetic map to p...
Construction of human gene map through map integration- from genetic map to p...
Location and mapping of chromosomes using conventional and cytological means.
Location and mapping of chromosomes using conventional and cytological means.
Boc Lecture 3 the multistep nature of cancer, Karobi Moitra
Boc Lecture 3 the multistep nature of cancer, Karobi Moitra
Semelhante a OncoGenomics Explorer2
Genomics Technologies
Genomics Technologies
Sean Davis
NORMAL-CELLS-versus-CANCER-CELLS.pptxssss
NORMAL-CELLS-versus-CANCER-CELLS.pptxssss
RashadHamada
Cancer Gene Prioritization
Cancer Gene Prioritization
Biomedical Genomics (GRIB)
OKC Grand Rounds 2009
OKC Grand Rounds 2009
Sean Davis
Microbiology:Oncogenes
Microbiology:Oncogenes
St Mary's College,Thrissur,Kerala
Cancer and CNV
Cancer and CNV
shahid chamran university of Ahvaz
Tumor Type Search
Tumor Type Search
Biomedical Genomics (GRIB)
CDAC 2018 Gonzales-Perez understanding cancer genomes
CDAC 2018 Gonzales-Perez understanding cancer genomes
Marco Antoniotti
Friend EORTC 2012-11-08
Friend EORTC 2012-11-08
Sage Base
poster
poster
shahid chamran university of Ahvaz
Cancer and genetic influences
Cancer and genetic influences
Shalimar Shadeed
Biology of cancer, lecture 2 tumor viruses,oncogenes,tsgs
Biology of cancer, lecture 2 tumor viruses,oncogenes,tsgs
Karobi Moitra CFD, MS, PhD
Cancer evolution
Cancer evolution
somaie mohammadpour
Cancer genetics [autosaved]
Cancer genetics [autosaved]
prachiupadhyay8
Gene therapy Otolaryngology
Gene therapy Otolaryngology
Balasubramanian Thiagarajan
Gene Remedy: A New-Fangled Line of Attack to Pay for Sicknesses
Gene Remedy: A New-Fangled Line of Attack to Pay for Sicknesses
BRNSSPublicationHubI
01_IJPSCR_2020_0001.pdf
01_IJPSCR_2020_0001.pdf
BRNSS Publication Hub
Genetic instability
Genetic instability
Chamara Prabhath
Advanced genome & epigenome editing tools.pptx
Advanced genome & epigenome editing tools.pptx
berciyalgolda1
Oncogenes
Oncogenes
Dhanya K C
Semelhante a OncoGenomics Explorer2
(20)
Genomics Technologies
Genomics Technologies
NORMAL-CELLS-versus-CANCER-CELLS.pptxssss
NORMAL-CELLS-versus-CANCER-CELLS.pptxssss
Cancer Gene Prioritization
Cancer Gene Prioritization
OKC Grand Rounds 2009
OKC Grand Rounds 2009
Microbiology:Oncogenes
Microbiology:Oncogenes
Cancer and CNV
Cancer and CNV
Tumor Type Search
Tumor Type Search
CDAC 2018 Gonzales-Perez understanding cancer genomes
CDAC 2018 Gonzales-Perez understanding cancer genomes
Friend EORTC 2012-11-08
Friend EORTC 2012-11-08
poster
poster
Cancer and genetic influences
Cancer and genetic influences
Biology of cancer, lecture 2 tumor viruses,oncogenes,tsgs
Biology of cancer, lecture 2 tumor viruses,oncogenes,tsgs
Cancer evolution
Cancer evolution
Cancer genetics [autosaved]
Cancer genetics [autosaved]
Gene therapy Otolaryngology
Gene therapy Otolaryngology
Gene Remedy: A New-Fangled Line of Attack to Pay for Sicknesses
Gene Remedy: A New-Fangled Line of Attack to Pay for Sicknesses
01_IJPSCR_2020_0001.pdf
01_IJPSCR_2020_0001.pdf
Genetic instability
Genetic instability
Advanced genome & epigenome editing tools.pptx
Advanced genome & epigenome editing tools.pptx
Oncogenes
Oncogenes
Último
ProductAnonymous-April2024-WinProductDiscovery-MelissaKlemke
ProductAnonymous-April2024-WinProductDiscovery-MelissaKlemke
Product Anonymous
Workshop - Best of Both Worlds_ Combine KG and Vector search for enhanced R...
Workshop - Best of Both Worlds_ Combine KG and Vector search for enhanced R...
Neo4j
Bajaj Allianz Life Insurance Company - Insurer Innovation Award 2024
Bajaj Allianz Life Insurance Company - Insurer Innovation Award 2024
The Digital Insurer
Strategies for Unlocking Knowledge Management in Microsoft 365 in the Copilot...
Strategies for Unlocking Knowledge Management in Microsoft 365 in the Copilot...
Drew Madelung
From Event to Action: Accelerate Your Decision Making with Real-Time Automation
From Event to Action: Accelerate Your Decision Making with Real-Time Automation
Safe Software
🐬 The future of MySQL is Postgres 🐘
🐬 The future of MySQL is Postgres 🐘
RTylerCroy
Strategize a Smooth Tenant-to-tenant Migration and Copilot Takeoff
Strategize a Smooth Tenant-to-tenant Migration and Copilot Takeoff
sammart93
Data Cloud, More than a CDP by Matt Robison
Data Cloud, More than a CDP by Matt Robison
Anna Loughnan Colquhoun
AWS Community Day CPH - Three problems of Terraform
AWS Community Day CPH - Three problems of Terraform
Andrey Devyatkin
Apidays New York 2024 - Scaling API-first by Ian Reasor and Radu Cotescu, Adobe
Apidays New York 2024 - Scaling API-first by Ian Reasor and Radu Cotescu, Adobe
apidays
A Year of the Servo Reboot: Where Are We Now?
A Year of the Servo Reboot: Where Are We Now?
Igalia
HTML Injection Attacks: Impact and Mitigation Strategies
HTML Injection Attacks: Impact and Mitigation Strategies
Boston Institute of Analytics
How to Troubleshoot Apps for the Modern Connected Worker
How to Troubleshoot Apps for the Modern Connected Worker
ThousandEyes
A Domino Admins Adventures (Engage 2024)
A Domino Admins Adventures (Engage 2024)
Gabriella Davis
GenCyber Cyber Security Day Presentation
GenCyber Cyber Security Day Presentation
Michael W. Hawkins
+971581248768>> SAFE AND ORIGINAL ABORTION PILLS FOR SALE IN DUBAI AND ABUDHA...
+971581248768>> SAFE AND ORIGINAL ABORTION PILLS FOR SALE IN DUBAI AND ABUDHA...
?#DUbAI#??##{{(☎️+971_581248768%)**%*]'#abortion pills for sale in dubai@
Advantages of Hiring UIUX Design Service Providers for Your Business
Advantages of Hiring UIUX Design Service Providers for Your Business
Pixlogix Infotech
Developing An App To Navigate The Roads of Brazil
Developing An App To Navigate The Roads of Brazil
V3cube
Finology Group – Insurtech Innovation Award 2024
Finology Group – Insurtech Innovation Award 2024
The Digital Insurer
Boost Fertility New Invention Ups Success Rates.pdf
Boost Fertility New Invention Ups Success Rates.pdf
sudhanshuwaghmare1
Último
(20)
ProductAnonymous-April2024-WinProductDiscovery-MelissaKlemke
ProductAnonymous-April2024-WinProductDiscovery-MelissaKlemke
Workshop - Best of Both Worlds_ Combine KG and Vector search for enhanced R...
Workshop - Best of Both Worlds_ Combine KG and Vector search for enhanced R...
Bajaj Allianz Life Insurance Company - Insurer Innovation Award 2024
Bajaj Allianz Life Insurance Company - Insurer Innovation Award 2024
Strategies for Unlocking Knowledge Management in Microsoft 365 in the Copilot...
Strategies for Unlocking Knowledge Management in Microsoft 365 in the Copilot...
From Event to Action: Accelerate Your Decision Making with Real-Time Automation
From Event to Action: Accelerate Your Decision Making with Real-Time Automation
🐬 The future of MySQL is Postgres 🐘
🐬 The future of MySQL is Postgres 🐘
Strategize a Smooth Tenant-to-tenant Migration and Copilot Takeoff
Strategize a Smooth Tenant-to-tenant Migration and Copilot Takeoff
Data Cloud, More than a CDP by Matt Robison
Data Cloud, More than a CDP by Matt Robison
AWS Community Day CPH - Three problems of Terraform
AWS Community Day CPH - Three problems of Terraform
Apidays New York 2024 - Scaling API-first by Ian Reasor and Radu Cotescu, Adobe
Apidays New York 2024 - Scaling API-first by Ian Reasor and Radu Cotescu, Adobe
A Year of the Servo Reboot: Where Are We Now?
A Year of the Servo Reboot: Where Are We Now?
HTML Injection Attacks: Impact and Mitigation Strategies
HTML Injection Attacks: Impact and Mitigation Strategies
How to Troubleshoot Apps for the Modern Connected Worker
How to Troubleshoot Apps for the Modern Connected Worker
A Domino Admins Adventures (Engage 2024)
A Domino Admins Adventures (Engage 2024)
GenCyber Cyber Security Day Presentation
GenCyber Cyber Security Day Presentation
+971581248768>> SAFE AND ORIGINAL ABORTION PILLS FOR SALE IN DUBAI AND ABUDHA...
+971581248768>> SAFE AND ORIGINAL ABORTION PILLS FOR SALE IN DUBAI AND ABUDHA...
Advantages of Hiring UIUX Design Service Providers for Your Business
Advantages of Hiring UIUX Design Service Providers for Your Business
Developing An App To Navigate The Roads of Brazil
Developing An App To Navigate The Roads of Brazil
Finology Group – Insurtech Innovation Award 2024
Finology Group – Insurtech Innovation Award 2024
Boost Fertility New Invention Ups Success Rates.pdf
Boost Fertility New Invention Ups Success Rates.pdf
OncoGenomics Explorer2
1.
22 March 2012 OncoGenomics
Explorer Taming Big Data Copyright © 2012 MediSapiens Ltd. All rights reserved. • medisapiens.com
2.
Page: 2
| Copyright © 2012 MediSapiens Ltd. All rights reserved. • medisapiens.com
3.
Which are the
most frequently mutated genes in ovarian serous carcinoma? Samples from ovarian serous carcinoma Page: 3 | Copyright © 2012 MediSapiens Ltd. All rights reserved. • medisapiens.com
4.
TP53, BRCA1 and
BRCA2 are the three most frequently mutated genes TP53 is mutated in almost all tumors Page: 4 | Copyright © 2012 MediSapiens Ltd. All rights reserved. • medisapiens.com
5.
Mutation of the
p53 gene is the key event in the development of high-grade tumors. Unlike low-grade serous carcinoma, mutations of KRAS, BRAF, or ERBB2 occur very infrequently in high-grade carcinoma. Page: 5 | Copyright © 2012 MediSapiens Ltd. All rights reserved. • medisapiens.com
6.
Most high-grade tumors
are characterized by TP53 mutations and lack mutations of KRAS, BRAF, or ERBB2. Vang R., et al., 2009: Ovarian low- grade and high-grade serous carcinoma: pathogenesis, clinicopathologic and molecular biologic features, and diagnostic problems. Page: 6 | Copyright © 2012 MediSapiens Ltd. All rights reserved. • medisapiens.com
7.
Serous ovarian cancer
is also characterized by a low prevalence but statistically recurrent mutations in a number of other genes, including NF1, RB1 and FAT3. Page: 7 | Copyright © 2012 MediSapiens Ltd. All rights reserved. • medisapiens.com
8.
Study for example
the proportions of point mutations or AA types in NF1... Page: 8 | Copyright © 2012 MediSapiens Ltd. All rights reserved. • medisapiens.com
9.
...or study the
mutations in NF1 in detail with the Gene viewer - The blue boxes represent the exons - Substitutions are shown as red vertical lines, insertions as light blue triangles, and deletions as pink triangles - The SIFT score predicts whether a mutations will affect protein function Can be zoomed all the way down to sequence level Page: 9 | Copyright © 2012 MediSapiens Ltd. All rights reserved. • medisapiens.com
10.
Is there a
correlation between copy number variations of CCNE1 and overall survival of the patients ? Select the gene/genes of interest, in this case CCNE1 Page: 10 | Copyright © 2012 MediSapiens Ltd. All rights reserved. • medisapiens.com
11.
Overall survival tends
to be lower for patients with CCNE1 amplification The Cancer Genome Atlas Research Network, 2011: Integrated genomic analyses of ovarian carcinoma Page: 11 | Copyright © 2012 MediSapiens Ltd. All rights reserved. • medisapiens.com
12.
RAB25 seems to
be epigenetically silenced in a subset of HG-OvCa tumors The Cancer Genome Atlas Research Network, 2011: Integrated genomic analyses of ovarian carcinoma Page: 12 | Copyright © 2012 MediSapiens Ltd. All rights reserved. • medisapiens.com
13.
Genes with correlated
CNV and expression include KRAS, POP4 and C19orf2 Wrzeszczynski KO. et al, 2011: Identification of tumor suppressors and oncogenes from genomic and epigenetic features in ovarian cancer Page: 13 | Copyright © 2012 MediSapiens Ltd. All rights reserved. • medisapiens.com
14.
Are genes in
a region of frequent copy number gain differentially expressed between amplified and unamplified groups of samples? Define the two groups to be compared, for example samples with copy number gain vs. samples with normal copy number Select the genes to be included, for example all genes in chromosome region 3q26 Page: 14 | Copyright © 2012 MediSapiens Ltd. All rights reserved. • medisapiens.com
15.
A volcano plot
presenting the results of expression analyses between amplified and unamplified samples in the 3q26 region The results are shown as a volcano plot that enables the identification of genes that display high differences in expression that also are statistically significant Page: 15 | Copyright © 2012 MediSapiens Ltd. All rights reserved. • medisapiens.com
16.
MYNN is a
gene that is located in a region of frequent copy number gain on 3q26.2. It is differently expressed between amplified and unamplified groups MYNN shows a strong correlation between copy number and expression Ramakrishna M. et al., 2010: Identification of candidate growth promoting genes in ovarian cancer through integrated copy number and expression analysis Page: 16 | Copyright © 2012 MediSapiens Ltd. All rights reserved. • medisapiens.com
17.
In the volcano
plot, an interesting group of genes can be selected Select for example genes with significant p-values and large difference estimates Page: 17 | Copyright © 2012 MediSapiens Ltd. All rights reserved. • medisapiens.com
18.
A heat map
can be drawn of the genes from the defined gene selection and of the samples from the two selected sample groups Select an interesting cluster of samples in the heat map... ...and examine a summary of clinical covariates Page: 18 | Copyright © 2012 MediSapiens Ltd. All rights reserved. • medisapiens.com
19.
Find out how
genetic values correlate with clinical reference data... Study for example how expression values of genes in chromosome region 8p correlate with overall survival Page: 19 | Copyright © 2012 MediSapiens Ltd. All rights reserved. • medisapiens.com
20.
...or how genetic
values correlate with genetic reference data Study for example Interesting how expression genes can be values of genes in selected for chromosome further analysis region 8p correlate with CNVs of BRCA1 Page: 20 | Copyright © 2012 MediSapiens Ltd. All rights reserved. • medisapiens.com
21.
- Find new
drug targets - Find new biomarkers - Stratify patient groups - Find clinical correlations Page: 21 | Copyright © 2012 MediSapiens Ltd. All rights reserved. • medisapiens.com
22.
Contact us for
demo •contact@medisapiens.com •tommi.pisto@medisapiens.com Page: 22 | Copyright © 2012 MediSapiens Ltd. All rights reserved. • medisapiens.com
23.
MediSapiens Ltd.
Biomedicum Helsinki +358 50 363 1848 Tukholmankatu 8A contact@medisapiens.com FIN-00290 Helsinki medisapiens.com Copyright © 2012 MediSapiens Ltd. All rights reserved. • www.medisapiens.com
Baixar agora