3. Objectives
By the end of this lecture the students will be able to:-
I) Definition
II) Pathogenesis
III) Diseases
IV) Lab. Diagnosis
V) Treatment
VI) Prevention
Herpes simplex virus-1
Herpes simplex virus-2
Objectives
Introduction
85. Q1
Monocyte
2-3 days
HSV-2 cause the following diseases
Monocyte
2-3 days
Genital herpes
Herpes labialis
Herpetic whitlow
Neonatal herpes
86. Q2
Monocyte
2-3 days
HSV-2 remain latent
Monocyte
2-3 days
Monocyte
2-3 days
Sacral ganglia
Trigeminal ganglia
Lymphoid cells
B cells
87. Q3
Monocyte
2-3 days
Infection with HSV-2 occurs by the
following modes
Sexual contact
Transplacental
Through birth canal
Reactivation of latent virus
88. Q4
Monocyte
2-3 days
During latency, Herpes simplex virus-2 causes
Genital herpes
Herpetic whitlow
Keratoconjunctivitis
No clinical manifestations
104. Centripetal rash (in smallpox
centrifugal واليدين الرجلين األطراف في
distribution)
• Superficial Do not reach basal cell
layer (Healing without
disfigurement)
• Umbilicated lesion
• Polymorphic (papule, pustules,
vesicle at the same time in a same
110. II) Pathogenesis of Varicella-Zoster virus
All stages may be
seen at one time
111. II) Pathogenesis of Varicella-Zoster virus
Droplets
Or contact
Respiratory
mucosa
regional
nodes
2nd
viremia
Into liver &
spleen
1ry viremia
Into
Mononuclear
cells
I.P 10-21 days
112. II) Pathogenesis of Varicella-Zoster virus
Into
mononuclear
cells
Transport to skin &
mucous membrane
dorsal root
ganglia
Skin rash
Replication in
epidermal cells
I.P 10-21 days
113. II) Pathogenesis of Varicella-Zoster virus
Pre-eruptive
stage
Fever (firstly)
Eruptive
stage
After 1-2
days
Malaise &
headache
Macule, papule, vesicle
& Pustule (Crusts)
Trunk Face Limbs
154. Q1
Monocyte
2-3 days
The spot diagnosis of varicella
(Chickenpox)
Centripetal rash
All types of rash are present
Umbilicated lesion
Heal with scar