1. © 2013 Pearson Education, Inc.
PowerPoint®
Lecture Slides
prepared by
Meg Flemming
Austin Community College
C H A P T E R 4
The Tissue
Level of
Organization

2. © 2013 Pearson Education, Inc.
Chapter 4 Learning Outcomes
• 4-1
• Identify the body's four basic types of tissues and describe their
roles.
• 4-2
• Describe the characteristics and functions of epithelial cells.
• 4-3
• Describe the relationship between form and function for each type
of epithelium.
• 4-4
• Compare the structures and functions of the various types of
connective tissues.

3. © 2013 Pearson Education, Inc.
Chapter 4 Learning Outcomes
• 4-5
• Explain how epithelial and connective tissues combine to form four
types of tissue membranes, and specify the functions of each.
• 4-6
• Describe the three types of muscle tissue and the special structural
features of each.
• 4-7
• Discuss the basic structure and role of neural tissue.
• 4-8
• Explain how injuries affect the tissues of the body.
• 4-9
• Describe how aging affects the tissues of the body.

4. © 2013 Pearson Education, Inc.
Tissues (4-1)
• Collections of cells and cell products that perform
specific, limited functions
• Histology
• The study of tissues
• Four types of tissues
1. Epithelial
2. Connective
3. Muscle
4. Neural

5. © 2013 Pearson Education, Inc.
CELLS
That
secrete
and
regulate
EXTRACELLULAR
MATERIAL
AND FLUIDS
EPITHELIAL TISSUE
• Covers exposed
surfaces
• Lines internal
passageways and
chambers
• Produces glandular
secretions
CONNECTIVE TISSUE
• Fills internal spaces
• Provides structural
support
• Stores energy
MUSCLE TISSUE
• Contracts to produce
active movement
NEURAL TISSUE
• Conducts electrical
Impulses
• Carries information
Combine to form
TISSUES
with special functions
Combine
to form
ORGANS
with multiple functions
Interact
in
ORGAN SYSTEMS
Chapters 5–20
Figure 4-1 An Orientation to the Tissues of the Body.

6. © 2013 Pearson Education, Inc.
Checkpoint (4-1)
1. Define histology.
2. List the four basic types of tissues in the body.

7. © 2013 Pearson Education, Inc.
Epithelial Tissue (4-2)
• Covers body surfaces
• Lines cavities
• Lines tubular structures
• Serves essential functions

8. © 2013 Pearson Education, Inc.
Characteristics of Epithelial Tissue (4-2)
• Cellularity (cell junctions)
• Polarity (apical and basal surfaces)
• Attachment
• Avascularity
• Regeneration

9. © 2013 Pearson Education, Inc.
Functions of Epithelia (4-2)
• Provide physical protection
• Control permeability
• Provide sensation
• Produce specialized secretions (glandular
epithelium)
• Exocrine glands
• Endocrine glands

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Intercellular Connections (4-2)
• Support and communication
• Cell adhesion molecules (CAMs)
• Transmembrane proteins
• Intercellular cement
• Proteoglycans

11. © 2013 Pearson Education, Inc.
Three Common Cell Junctions (4-2)
1. Tight junctions
2. Gap junctions
3. Desmosomes
• Form bonds with other cells or extracellular material

12. © 2013 Pearson Education, Inc.
Figure 4-2a Cell Junctions.
Tight junction
Adhesion belt
Spot
desmosome
Gap
junctions
This is a
Diagrammatic
view of an
epithelial cell,
showing the
major types of
Intercellular
connections.
Hemidesmosome

13. © 2013 Pearson Education, Inc.
Figure 4-2b Cell Junctions.
Interlocking
junctional
proteins
Tight junction
Adhesion belt
Spot
desmosome
Gap
junctions
Hemidesmosome
A tight junction is formed by the fusion of the outer
layers of two plasma membranes. Tight junctions
prevent the diffusion of fluids and solutes between
the cells. A continuous adhesion belt deep to the
tight junction is tied to the microfilaments of the
cytoskeleton.
Adhesion belt
Tight junction

14. © 2013 Pearson Education, Inc.
Figure 4-2c Cell Junctions.
Tight junction
Adhesion belt
Spot
desmosome
Gap
junctions
Hemidesmosome
Embedded proteins
(connexons)
Gap junctions permit
the free diffusion of
ions and small mol-
ecules between two
cells.

15. © 2013 Pearson Education, Inc.
Tight junction
Adhesion belt
Spot
desmosome
Gap
junctions
Hemidesmosome
Intermediate
filaments
Dense area
Proteoglycans
A spot desmosome
ties adjacent cells
together.
Cell adhesion
molecules (CAMs) Hemidesmosomes attach a
cell to extracellular
structures, such as the
protein fibers in the basement
membrane.
Tight junction
Adhesion belt
Spot
desmosome
Gap
junctions
Hemidesmosome
Basement
membrane
Figure 4-2d-e Cell Junctions.

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The Epithelial Surface (4-2)
• Apical surface is exposed
• Basal surface is connected to deeper connective
tissue with basement membrane

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Figure 4-3 The Surfaces of Epithelial Cells.
Cilia
Microvilli
Apical
surface
Golgi
apparatus
Nucleus
Mitochondria
Basement membrane

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Epithelial Renewal and Repair (4-2)
• Epithelia are replaced by mitosis
• Cell division of stem cells (germinative cells)
• Occurs near basement membrane

19. © 2013 Pearson Education, Inc.
Checkpoint (4-2)
3. List five important characteristics of epithelial tissue.
4. Identify four essential functions of epithelial tissue.
5. Identify the three main types of epithelial cell
junctions.
6. What physiological functions are enhanced by the
presence of microvilli or cilia on epithelial cells?

20. © 2013 Pearson Education, Inc.
Classification of Epithelia (4-3)
• Combines a cell shape with the number of layers
of cells
• Example:
• Simple (one layer) cuboidal (square shape)

21. © 2013 Pearson Education, Inc.
Cell Layers and Cell Shapes (4-3)
• Classification is based on layers
• Simple epithelium: single layer of cells
• Stratified epithelium: several layers of cells
• Classification is based on shape
• Squamous epithelia: thin and flat
• Cuboidal epithelia: square shaped
• Columnar epithelia: tall, slender rectangles

22. © 2013 Pearson Education, Inc.
Table 4-1 Classifying Epithelia

23. © 2013 Pearson Education, Inc.
Figure 4-4a Simple Epithelia.
Cytoplasm
Nucleus
Connective tissue
Lining of peritoneal cavity
LM x 238
Simple Squamous Epithelium
LOCATIONS: Epithelia lining
ventral body cavities; lining heart
and blood vessels; portions of
kidney tubules (thin sections of
nephron loops); inner lining of
cornea; alveoli (air sacs) of lungs
FUNCTIONS: Reduces friction;
controls vessel permeability;
performs absorption and secretion

24. © 2013 Pearson Education, Inc.
Figure 4-4b Simple Epithelia.
Connective
tissue
Nucleus
Cuboidal
cells
Kidney tubule LM x 650
Basement
membrane
LOCATIONS: Glands; ducts;
portions of kidney tubules; thyroid
gland
FUNCTIONS: Limited protection,
secretion, absorption
Simple Cuboidal Epithelium

25. © 2013 Pearson Education, Inc.
Figure 4-4c Simple Epithelia.
LM x 350
Microvilli
Cytoplasm
Nucleus
Basement
membrane
Connective
tissue
Intestinal lining
LOCATIONS: Lining of
stomach, intestine, gallbladder,
uterine tubes, and collecting
ducts of kidneys
FUNCTIONS: Protection,
secretion, absorption
Simple Columnar Epithelium

26. © 2013 Pearson Education, Inc.
Figure 4-5a Stratified Epithelia.
Stratified Squamous Epithelium
Squamous
superficial cells
Stem cells
Basement
membrane
Connective
tissue LM x 310Surface of tongue
LOCATIONS: Surface of
skin; lining of mouth, throat,
esophagus, rectum, anus,
and vagina
FUNCTIONS: Provides physical
protection against abrasion,
pathogens, and chemical attack

27. © 2013 Pearson Education, Inc.
Figure 4-5b Stratified Epithelia.
Cytoplasm
Cilia
Nuclei
Basement
membrane
Connective
tissue
LM x 350
Pseudostratified Ciliated Columnar Epithelium
Trachea
LOCATIONS: Lining of
nasal cavity, trachea, and
bronchi; portions of male
reproductive tract
FUNCTIONS: Protection,
secretion, move mucus
with cilia

28. © 2013 Pearson Education, Inc.
Figure 4-5c Stratified Epithelia.
Transitional Epithelium
Epithelium
(relaxed)
Basement membrane
Connective tissue and
smooth muscle layers LM x 400
Epithelium
(stretched)
Basement membrane
Connective tissue and
smooth muscle layersFull bladder
Empty bladder
Urinary bladder
LM x 400
LOCATIONS: Urinary
bladder; renal pelvis;
ureters
FUNCTIONS: Permits
expansion and recoil
after stretching

29. © 2013 Pearson Education, Inc.
Glandular Epithelia (4-3)
• Endocrine glands
• Release hormones:
• Into interstitial fluid and plasma
• No ducts
• Exocrine glands
• Produce secretions:
• Onto epithelial surfaces
• Through ducts

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Glandular Secretion (4-3)
• Merocrine secretion
• Produced in Golgi apparatus
• Released by vesicles (exocytosis)
• Example: sweat glands
• Apocrine secretion
• Produced in Golgi apparatus
• Released by shedding cytoplasm
• Example: mammary glands

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Glandular Secretion (4-3)
• Holocrine secretion
• Released by cells bursting, killing gland cells
• Gland cells replaced by stem cells
• Example: sebaceous glands

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Secretory
vesicle
Golgi
apparatus
Nucleus
Merocrine. In merocrine secretion, the contents of secretory
vesicles are discharged at the apical surface of the gland cell
by exocytosis.
Breaks
down
Golgi apparatus
Salivary gland
Mammary
gland
Secretion Regrowth
Apocrine. Apocrine secretion involves the loss of apical cytoplasm.
Inclusions, secretory vesicles, and other cytoplasmic components
are shed in the process. The gland cell then undergoes growth and
repair before it releases additional secretions.
Cells burst, releasing
cytoplasmic contents
Cells produce secretion,
increasing in size
Cell division replaces
lost cells
Holocrine. Holocrine secretion occurs as superficial gland cells
burst. Continued secretion involves the replacement of these cells
through the mitotic division of underlying stem cells.
Sebaceous
gland
Hair
Hair follicle
TEM x 3039
Stem cell
Figure 4-6 Mechanisms of Glandular Secretion.

33. © 2013 Pearson Education, Inc.
Figure 4-6a Mechanisms of Glandular Secretion.
Secretory
vesicle
Golgi
apparatus
Nucleus
Merocrine. In merocrine secretion, the contents of secretory
vesicles are discharged at the apical surface of the gland cell
by exocytosis.
Salivary gland
Mammary
gland
Sebaceous
gland
Hair
Hair follicle
TEM x 3039

34. © 2013 Pearson Education, Inc.
Figure 4-6b Mechanisms of Glandular Secretion.
Breaks
down
Golgi apparatus
Salivary gland
Mammary
gland
Secretion Regrowth
Apocrine. Apocrine secretion involves the loss of apical cytoplasm.
Inclusions, secretory vesicles, and other cytoplasmic components
are shed in the process. The gland cell then undergoes growth and
repair before it releases additional secretions.
Sebaceous
gland
Hair
Hair follicle

35. © 2013 Pearson Education, Inc.
Salivary gland
Mammary
gland
Cells burst, releasing
cytoplasmic contents
Cells produce secretion,
increasing in size
Cell division replaces
lost cells
Holocrine. Holocrine secretion occurs as superficial gland cells
burst. Continued secretion involves the replacement of these cells
through the mitotic division of underlying stem cells.
Sebaceous
gland
Hair
Hair follicle
Stem cell
Figure 4-6c Mechanisms of Glandular Secretion.

36. © 2013 Pearson Education, Inc.
Types of Secretion (4-3)
• Serous glands
• Watery secretions
• Mucous glands
• Secrete mucins
• Mixed exocrine glands
• Both serous and mucous

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Table 4-2 A Classification of Exocrine Glands

38. © 2013 Pearson Education, Inc.
Checkpoint (4-3)
7. Identify the three cell shapes characteristic of
epithelial cells.
8. Using a light microscope, you examine a tissue and
see a simple squamous epithelium on the outer
surface. Can this be a sample of skin surface?
9. Name the two primary types of glandular epithelia.

39. © 2013 Pearson Education, Inc.
Checkpoint (4-3)
10.The secretory cells of sebaceous glands fill with
secretions and then rupture, releasing their
contents. Which mechanism of secretion occurs
in sebaceous glands?
11.Which type of gland releases its secretions
directly into the extracellular fluid?

40. © 2013 Pearson Education, Inc.
Connective Tissue (4-4)
• Provides a protective structural framework for
other tissue types
• Three basic components
1. Specialized cells
2. Solid extracellular protein fibers
3. Fluid extracellular ground substance

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Characteristics of Connective Tissue (4-4)
• The extracellular components of connective
tissues (fibers and ground substance) make up the
matrix
• Majority of tissue volume
• Determines specialized function

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Functions of Connective Tissue (4-4)
• Support and protection
• Transportation of materials
• Storage of energy reserves
• Defense of the body

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Figure 4-7 Major Types of Connective Tissue.
CONNECTIVE TISSUES
CONNECTIVE TISSUE PROPER FLUID CONNECTIVE TISSUES SUPPORTING CONNECTIVE TISSUES
LOOSE DENSE BLOOD LYMPH CARTILAGE BONE
Solid, crystalline
matrix
Solid, rubbery
matrix
Flows within
lymphatic
system
Flows within
cardiovascular
system
Fibers densely
packed
Fibers create
loose, open
framework

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Three Major Types of Connective Tissue (4-4)
1. Connective tissue proper
2. Fluid connective tissues
3. Supporting connective tissues

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Cells of Connective Tissue Proper (4-4)
• Fibroblasts
• Most abundant cells in connective tissue proper
• Produce connective tissue fibers and ground substance
• Macrophages
• Scattered throughout the matrix
• Phagocytize damaged cells or pathogens that enter the tissue
• Release chemicals that mobilize the immune system

46. © 2013 Pearson Education, Inc.
Cells of Connective Tissue Proper (4-4)
• Fat cells (adipocytes)
• Permanent residents
• Number of fat cells vary
• Mast cells
• Small, mobile cells often found near blood vessels
• Cytoplasm is packed with vesicles
• Filled with chemicals that are released to begin body's
defensive activities after an injury or infection

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Three Basic Types of Connective Tissue Fibers
(4-4)
1. Collagen fibers
• Long, straight, unbranched
• Strong, but flexible
• Most common
2. Elastic fibers
• Branched and wavy
• After stretching, they will return to their original length
• Contain the protein elastin

48. © 2013 Pearson Education, Inc.
Three Basic Types of Connective Tissue Fibers
(4-4)
3. Reticular fibers
• Made of same protein subunits as collagen fibers, but
arranged differently
• Thinner than collagen fibers
• Form branching, interwoven framework in various
organs
• Least common

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Ground Substance (4-4)
• Clear, colorless, and viscous
• Fills spaces between cells and slows pathogen
movement

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Types of Connective Tissue Proper (4-4)
• Loose connective tissue
• "Packing materials" of the body
• More ground substance, fewer fibers
• Example: fat (adipose tissue)
• Dense connective tissue
• Tough, strong, and durable
• More fibers, less ground substance
• Example: tendons

51. © 2013 Pearson Education, Inc.
Figure 4-8 Cells and Fibers of Connective Tissue Proper.
Reticular
fibers
Fixed
macrophage
Antibody
producing cell
Blood in
vessel
Adipocytes
(fat cells)
Ground
substance
Mast cell
Elastic
fibers
Free
macrophage
Collagen
fibers
Fibroblast
Stem cell
White blood
cell

52. © 2013 Pearson Education, Inc.
Figure 4-9a Loose Connective Tissues.
Mast cell
Collagen
fibers
Fat cell
Fibroblasts
Elastic fibers
Macrophage
LM x 400Areolar tissue
Areolar Tissue
LOCATIONS: Beneath dermis of
skin, digestive tract, respiratory
and urinary tracts; between
muscles; around blood vessels,
nerves, and around joints
FUNCTIONS: Cushions
organs; provides support
but permits independent
movement; phagocytic
cells provide defense
against pathogens

53. © 2013 Pearson Education, Inc.
Figure 4-9b Loose Connective Tissues.
Adipocytes
LM x 300
Adipose tissue
LOCATIONS: Deep to the skin,
especially at sides, buttocks,
breasts; padding around eyes
and kidneys
FUNCTIONS: Provides
padding and cushions
shocks; insulates
(reduces heat loss);
stores energy
Adipose Tissue

54. © 2013 Pearson Education, Inc.
Figure 4-9c Loose Connective Tissues.
LOCATIONS: Liver, kidney, spleen,
lymph nodes, and bone marrow
FUNCTIONS: Provides supporting
framework
Reticular Tissue
Reticular
fibers
LM x 375
Reticular tissue
from liver Reticular tissue

55. © 2013 Pearson Education, Inc.
Figure 4-10a Dense Connective Tissues.
LOCATIONS: Between skeletal
muscles and skeleton (tendons
and aponeuroses); between
bones or stabilizing positions
of internal organs (ligaments);
covering skeletal muscles;
deep fasciae
FUNCTIONS: Provides
firm attachment; conducts
pull of muscles; reduces
friction between muscles;
stabilizes relative positions
of bones
Collagen
fibers
Fibroblast
nuclei
Tendon LM x 440
Dense Regular Connective Tissue

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Figure 4-10b Dense Connective Tissues.
Deep dermis
Collagen
fiber
bundles
Dense Irregular Connective Tissue
LM x 111
LOCATIONS: Capsules of
visceral organs; periostea
and perichondria; nerve
and muscle sheaths; deep
dermis of the skin
FUNCTIONS: Provides
strength to resist forces
applied from many
directions; helps
prevent overexpansion
of organs such as
the urinary bladder

57. © 2013 Pearson Education, Inc.
Fluid Connective Tissues (4-4)
• Blood and lymph
• Watery matrix of dissolved proteins
• Carry specific cell types (formed elements)
• Formed elements of blood
• Red blood cells
• White blood cells
• Platelets

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Supporting Connective Tissues (4-4)
• Cartilage
• Gel-type ground substance
• For shock absorption and protection
• Bone
• Calcified (made rigid by calcium salts, minerals)
• For weight support

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Cartilage (4-4)
• Cartilage matrix
• Proteoglycans derived from chondroitin sulfates
• Ground substance proteins
• Chondrocytes (cartilage cells)
• Surrounded by lacunae (chambers)

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Cartilage Structure (4-4)
• Avascular
• Chondrocytes found in pockets called lacunae
• Perichondrium
• Outer, fibrous layer (for strength)
• Inner, cellular layer (for growth and maintenance)

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Three Major Types of Cartilage (4-4)
1. Hyaline cartilage
• Stiff, flexible support
• Reduces friction between bones
• Found in synovial joints, rib tips, sternum, and trachea
2. Elastic cartilage
• Supportive but bends easily
• Found in external ear and epiglottis
3. Fibrocartilage
• Limits movement
• Prevents bone-to-bone contact
• Pads knee joints
• Found between pubic bones and intervertebral discs

62. © 2013 Pearson Education, Inc.
Figure 4-11a Types of Cartilage.
LOCATIONS: Between tips of ribs
and bones of sternum; covering
bone surfaces at synovial joints;
supporting larynx (voice box),
trachea, and bronchi; forming part
of nasal septum
FUNCTIONS: Provides stiff but
somewhat flexible support;
reduces friction
between bony
surfaces
Chondrocytes
in lacunae
Matrix
Hyaline cartilage
LM x 500
Hyaline Cartilage

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Elastic Cartilage
Chondrocyte
In lacuna
Elastic fibers
in matrix
LM x 358
Elastic cartilage
LOCATIONS: Auricle of external ear;
epiglottis; auditory canal; cuneiform
cartilages of larynx
FUNCTIONS: Provides support, but
tolerates distortion without
damage and returns
to original shape
Figure 4-11b Types of Cartilage.

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Figure 4-11c Types of Cartilage.
Fibrocartilage
Chondrocytes
in lacunae
Fibrous
matrix
LM x 400
Fibrocartilage
LOCATIONS: Pads within knee joint;
between pubic bones of pelvis;
intervertebral discs
FUNCTIONS: Resists
compression;
prevents bone-to-bone
contact; limits
movement

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Bone (4-4)
• Or osseous tissue
• Strong (hard calcium compounds)
• Resists shattering (flexible collagen fibers)
• Bone cells or osteocytes
• Arranged around central canals within matrix
• Small channels through matrix (canaliculi) access blood
supply

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Periosteum (4-4)
• Covers bone surfaces
• Fibrous layer
• Cellular layer

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Figure 4-12 Bone.
Osteon
Canaliculi
Lacunae
(contain osteocytes)
Matrix
Central canal
Blood vessels
Fibrous
layer
Cellular
layer
Periosteum
Osteon LM x 375

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Table 4-3 A Comparison of Cartilage and Bone

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Checkpoint (4-4)
12.Identify several functions of connective tissues.
13.List the three types of connective tissues.
14.Which type of connective tissue contains
primarily triglycerides?
15.Lack of vitamin C in the diet interferes with the
ability of fibroblasts to produce collagen. What
effect might this interference have on connective
tissue?
16.Which two types of connective tissue have a fluid
matrix?

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Checkpoint (4-4)
17. Identify the two types of supporting connective
tissue.
18. Why does cartilage heal slower than bone?

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Tissue Membranes (4-5)
• Membranes
• Are physical barriers
• Line or cover portions of the body
• Consist of:
• An epithelium
• Supported by connective tissues

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Four Types of Tissue Membranes (4-5)
1. Mucous membranes
2. Serous membranes
3. Cutaneous membrane
4. Synovial membranes

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Figure 4-13 Tissue Membranes.
Mucous membranes
are coated with the
secretions of mucous
glands. These
membranes line the
digestive, respiratory,
urinary, and
reproductive tracts.
Serous membranes
line the ventral body
cavities (the perito-
neal, pleural, and
pericardial cavities).
The cutaneous
membrane, or skin,
covers the outer
surface of the body.
Synovial membranes
line joint cavities and
produce the fluid
within the joint.
Mucous secretion
Epithelium
Lamina propria
(areolar tissue)
Serous fluid
Epithelium
Areolar tissue
Epithelium
Areolar tissue
Dense irregular
connective tissue
Articular (hyaline)
cartilage
Synovial fluid
Capsule
Capillary
Adipocytes
Areolar
tissue
Epithelium
Synovial
membrane
Bone

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Mucous Membranes (4-5)
• Also known as mucosae
• Line passageways that have external connections
• In digestive, respiratory, urinary, and reproductive tracts
• Epithelial surfaces must be moist
• To reduce friction
• To facilitate absorption and excretion
• Lamina propria
• Made of areolar tissue

75. © 2013 Pearson Education, Inc.
Mucous membranes
are coated with the
secretions of mucous
glands. These
membranes line the
digestive, respiratory,
urinary, and
reproductive tracts.
Mucous secretion
Epithelium
Lamina propria
(areolar tissue)
Figure 4-13a Tissue Membranes.

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Serous Membranes (4-5)
• Line cavities not open to the outside
• Are thin but strong
• Have fluid transudate to reduce friction
• Have a parietal portion covering the cavity
• Have a visceral portion (serosa) covering the
organs

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Three Serous Membranes (4-5)
1. Pleura
• Lines pleural cavities
• Covers lungs
2. Peritoneum
• Lines peritoneal cavity
• Covers abdominal organs
3. Pericardium
• Lines pericardial cavity
• Covers heart

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Serous membranes
line the ventral body
cavities (the perito-
neal, pleural, and
pericardial cavities).
Serous fluid
Epithelium
Areolar tissue
Figure 4-13b Tissue Membranes.

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The Cutaneous Membrane (4-5)
• Is skin
• Covers the surface of the body
• Thick, waterproof, and dry

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The cutaneous
membrane, or skin,
covers the outer
surface of the body.
Epithelium
Areolar tissue
Dense irregular
connective tissue
Figure 4-13c Tissue Membranes.

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Synovial Membranes (4-5)
• Line moving, articulating joint cavities
• Produce synovial fluid (lubricant)
• Protect the ends of bones
• Lack a true epithelium

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Synovial membranes
line joint cavities and
produce the fluid
within the joint.
Articular (hyaline)
cartilage
Synovial fluid
Capsule
Capillary
Adipocytes
Areolar
tissue
Epithelium
Synovial
membrane
Bone
Figure 4-13d Tissue Membranes.

83. © 2013 Pearson Education, Inc.
Checkpoint (4-5)
19. Identify the four types of tissue membranes
found in the body.
20. How does a plasma (cell) membrane differ from
a tissue membrane?
21. What is the function of fluids produced by serous
membranes?
22. The lining of the nasal cavity is normally moist,
contains numerous mucous cells, and rests on a
layer of areolar tissue. Which type of membrane
is this?

84. © 2013 Pearson Education, Inc.
Three Types of Muscle Tissue (4-6)
1. Skeletal muscle tissue
• Large body muscles responsible for movement
2. Cardiac muscle tissue
• Found only in the heart
3. Smooth muscle tissue
• Found in walls of blood vessels
• Found around hollow organs such as the urinary bladder
• Around the respiratory, digestive, and reproductive tracts

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Functions of Muscle Tissue (4-6)
• Specialized for contraction
• Produces all body movement

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Cells are long, cylindrical, striated,
and multinucleate.
LOCATIONS: Combined with
connective tissues and neural
tissue in skeletal muscles
FUNCTIONS: Moves or stabilizes
the position of the skeleton; guards
entrances and exits to the digestive,
respiratory, and urinary tracts;
generates heat; protects internal
organs
Nuclei
Muscle
fiber
Striations
Skeletal Muscle Tissue
Skeletal muscle
LM x 180
Figure 4-14a Muscle Tissue.

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Figure 4-14b Muscle Tissue.
Cells are short, branched, and striated,
usually with a single nucleus; cells are
interconnected by intercalated discs.
LOCATION: Heart
FUNCTIONS: Circulates blood;
maintains blood (hydrostatic) pressure
Cardiac Muscle Tissue
Cardiac muscle
Nucleus
Cardiac
muscle
cells
Intercalated
discs
Striations
LM x 450

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Figure 4-14c Muscle Tissue.
Cells are short, spindle-shaped, and
nonstriated, with a single, central
nucleus.
LOCATIONS: Found in the walls of
blood vessels and in digestive,
respiratory, urinary, and reproductive
organs
FUNCTIONS: Moves food, urine, and
reproductive tract secretions; controls
diameter of respiratory passageways;
regulates diameter of blood vessels
Smooth Muscle Tissue
Nucleus
Smooth
muscle
cell
Smooth muscle
LM x 235

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Checkpoint (4-6)
23. Identify the three types of muscle tissue in the
body.
24. Voluntary control is restricted to which type of
muscle tissue?
25. Which type of muscle tissue has small, tapering
cells with single nuclei and no obvious striations?

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Neural Tissue (4-7)
• Also called nervous or nerve tissue
• Specialized for conducting electrical impulses
• Rapidly senses internal or external environment
• Processes information and controls responses

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Neural Tissue (4-7)
• Concentrated in the central nervous system
• Brain
• Spinal cord

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Two Kinds of Neural Cells (4-7)
1. Neurons
• Nerve cells
• Perform electrical communication
2. Neuroglia
• Supporting cells
• Repair and supply nutrients to neurons

93. © 2013 Pearson Education, Inc.
Cell Parts of a Neuron (4-7)
• Cell body
• Contains the nucleus and nucleolus
• Dendrites
• Short branches extending from the cell body
• Receive incoming signals
• Axon (nerve fiber)
• Long, thin extension of the cell body
• Carries outgoing electrical signals to their destination

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Axon
terminals
Brain
Spinal
cord
Cell
body
Axon
Neuron
Nuclei of
neuroglia
Nucleus
of neuron
Axon
Dendrites
Cell body
LM x 600
Photomicrograph
of neuron cell
body
Figure 4-15 Neural Tissue.

95. © 2013 Pearson Education, Inc.
Checkpoint (4-7)
26. A tissue contains irregularly shaped cells with
many projections, including some several
centimeters long. These are probably which type
of cell?
27. Why are both skeletal muscle cells and axons
also called fibers?

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Tissue Injuries and Repair (4-8)
• Tissues respond to injuries to maintain
homeostasis
• Cells restore homeostasis with two processes
1. Inflammation
2. Regeneration

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Inflammation (4-8)
• Inflammatory response
• The tissue's first response to injury
• Signs and symptoms include:
• Swelling
• Heat
• Redness
• Pain

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Inflammatory Response (4-8)
• Can be triggered by:
• Trauma (physical injury)
• Infection (the presence of harmful pathogens)

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Checkpoint (4-8)
28. Identify the two phases in the response to tissue
injury.
29. What signs and symptoms are associated with
inflammation?
30. What is fibrosis?

100. © 2013 Pearson Education, Inc.
Aging Tissue (4-9)
• With age:
• Rate of tissue repair declines
• Cancer rates increase

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Aging and Tissue Structure (4-9)
• Speed and efficiency of tissue repair decrease
with age due to:
• Slower rate of energy consumption (metabolism)
• Hormonal alterations
• Reduced physical activity

102. © 2013 Pearson Education, Inc.
Aging and Cancer Incidence (4-9)
• Cancer rates increase with age
• 1 in 4 people in the United States develops cancer
• Cancer is the #2 cause of death in the United States
• Environmental chemicals and cigarette smoke cause cancer

103. © 2013 Pearson Education, Inc.
Checkpoint (4-9)
31.Identify some age-related factors that affect
tissue repair and structure.