Mechanism Of Pathogenecity

Microbial Mechanisms of Pathogenesis

Pathogenesis ,[object Object],[object Object],[object Object],[object Object]

Pathogenicity - Ability to cause disease Virulence - Degree of pathogenicity ,[object Object],[object Object]

Portals of Entry ,[object Object],[object Object],[object Object]

1. Mucus Membranes ,[object Object],[object Object],[object Object],[object Object],[object Object]

Common Diseases contracted via the Respiratory Tract ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

Mucus Membranes ,[object Object],[object Object],[object Object]

Common diseases contracted via the G.I. Tract ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

Fecal - Oral Diseases ,[object Object],[object Object],[object Object]

Mucus Membranes of the Genitourinary System Acidic urine Vaginal secretion- Acidic due to fermentation of glycogen by lactobacillus Gonorrhea Neisseria gonorrhoeae Syphilis Treponema pallidum Chlamydia Chlamydia trachomatis HIV Herpes Simplex II

Mucus Membranes ,[object Object],[object Object],[object Object],[object Object],[object Object]

2. Skin ,[object Object],[object Object],[object Object],[object Object],[object Object]

3. Parentarel ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

Number of Invading Microbes ,[object Object],[object Object],[object Object],[object Object]

How do Bacterial Pathogens penetrate Host Defenses? 1. Adherence - almost all pathogens have a means to attach to host tissue Binding Sites adhesins ligands

How Bacterial Pathogens Penetrate Host Defenses ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

Adhesins and ligands are usually on Fimbriae ,[object Object],[object Object],[object Object]

2. Capsules ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],K. pneumoniae

A. Leukocidins ,[object Object],[object Object],[object Object],[object Object]

B. Hemolysins - cause the lysis of RBC’s Streptococci

1. Alpha Hemolytic Streptococci - secrete hemolysins that cause the incomplete lysis or RBC’s

2. Beta Hemolytic Streptococci - Secrete hemolysins that cause the complete lysis of RBC’s

C. Coagulase - cause blood to coagulate ,[object Object],[object Object],[object Object],[object Object]

D. Kinases - enzymes that dissolve blood clots ,[object Object],[object Object],[object Object],[object Object]

E. Hyaluronidase ,[object Object],[object Object],[object Object]

F. Collagenase ,[object Object],[object Object],[object Object]

G. Necrotizing Factor - Causes death (necrosis) to tissue cells “ Flesh Eating Bacteria”

Bacterial Toxins ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

Types of Toxins ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

Exotoxins ,[object Object],[object Object],[object Object],[object Object]

Types of Exotoxins ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

Response to Toxins ,[object Object],[object Object],[object Object],[object Object]

Endotoxins ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

Bacteriocin ,[object Object],[object Object],[object Object],[object Object]

[object Object],[object Object],[object Object],[object Object]

[object Object],[object Object],[object Object]

Mechanism Of Pathogenecity

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Mechanism Of Pathogenecity