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Iso Allo Idio 2001

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Immunoglobulin: Isotypes, Allotypes and Idiotypes
Immunoglobulin Isotypes ,[object Object]
Human IgM antiserum Reacts with IgM, IgG, IgA, IgD, IgE React with IgG, IgA, IgD and IgE Absorbed antiserum Reacts only with IgM Recognizes determinants specific for  heavy chains (isotypes) Immunoglobulin Isotypes ?? ?? ??
Immunoglobulin Isotypes ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],IgM (kappa) IgG1 (kappa)
Immunoglobulin Allotypes ,[object Object],[object Object],[object Object],[object Object],[object Object],IgG1 (kappa) Person 2 IgG1 (kappa) Person 1
Human Immunoglobulin Allotypes ,[object Object],[object Object],[object Object]
Human Immunoglobulin Allotypes ,[object Object],[object Object],[object Object],Km(1)/Km(3) X Km(1)/Km(1) Km(1)/Km(1) and Km(1)/Km(3) ,[object Object]
[object Object],[object Object],Human Immunoglobulin Allotypes G1m(17) G1m(1) 214 355-358
Immunoglobulin Allotypes ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Immunoglobulin Idiotypes ,[object Object]
DNP-BSA Strain A Mouse Anti-DNP Ab Purified anti-DNP Ab Strain A Mouse Ab against combining site of anti-DNP Ab ?? Immunoglobulin Idiotypes Antigenic determinants created by the HVR = Idiotypes
Immunoglobulin Idiotypes ,[object Object],[object Object],IgG1 (kappa) Person 1 anti-B IgG1 (kappa) Person 1 anti-A
Immunoglobulin Idiotypes ,[object Object],[object Object],[object Object],[object Object],[object Object]
Ag Id anti-Id + - anti-anti-Id + - Regulation by Id/anti-Id
Immunoglobulin Idiotypes ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Anti-Idiotype Vaccines Ag Id anti-Id + - Ag Id anti-Id +
Immunoglobulin Idiotypes ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

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Iso Allo Idio 2001

  • 2.
  • 3. Human IgM antiserum Reacts with IgM, IgG, IgA, IgD, IgE React with IgG, IgA, IgD and IgE Absorbed antiserum Reacts only with IgM Recognizes determinants specific for  heavy chains (isotypes) Immunoglobulin Isotypes ?? ?? ??
  • 4.
  • 5.
  • 6.
  • 7.
  • 8.
  • 9.
  • 10.
  • 11. DNP-BSA Strain A Mouse Anti-DNP Ab Purified anti-DNP Ab Strain A Mouse Ab against combining site of anti-DNP Ab ?? Immunoglobulin Idiotypes Antigenic determinants created by the HVR = Idiotypes
  • 12.
  • 13.
  • 14. Ag Id anti-Id + - anti-anti-Id + - Regulation by Id/anti-Id
  • 15.
  • 16. Anti-Idiotype Vaccines Ag Id anti-Id + - Ag Id anti-Id +
  • 17.