1. Introduction to the Immune system: Lectures 1 and 2 Hugh Brady [email_address] Recommended textbook: Janeway’s Immunobiology (7 th Ed) 2008, Garland Science

14. Cells of the immune system

22. Lymphocytes are mostly small and inactive cells

28. An infection and the response to it can be divided into a series of stages

29. Innate immunity Many barriers prevent pathogens from crossing epithelia and colonizing tissues

30. Time frame for different stages of immune response

34. Macrophages are activated by pathogens and both engulf them and initiate inflammatory responses

40. Complement system

48. T and B cell responses are initiated in secondary lymphoid organs - lymph nodes and spleen Haematopoiesis B cells Neutrophils etc T cell development

49. Primary and secondary immune responses

52. Smallpox Vaccination well known in 16 th century China

53. Smallpox is the only major human disease to have been eradicated.

60. Antigens are the molecules recognized by the immune response Epitopes are sites within antigens to which antigen receptors bind

61. An antibody binds an antigen directly whereas a T-cell receptor binds a complex of antigen fragment and self molecule

77. Primary and secondary immune responses

82. How T-cells are made

83. Mechanism of host defence against intracellular infection by viruses

84. Mechanism of host defence against intracellular infection by Bacterium

85. MHC class I molecules present antigen derived from proteins in the cytosol

87. MHC class II molecules present antigen originating in intracellular vesicles