Advanced Data Analysis (ADAC) Centre

1. Wed 2nd Oct 2013 1ADAC Launch Event University of Nottingham
Advanced Data Analysis Centre
ADAC Launch Event
2nd October 2013
http://www.nottingham.ac.uk/adac/
General enquiries: adac@nottingham.ac.uk
Bioinformatics queries: richard.emes@nottingham.ac.uk
Informatics queries: jon.garibaldi@nottingham.ac.uk
@ADAC_UoN
Wed 2nd Oct 2013 ADAC Launch Event University of Nottingham 2
What is ADAC?
The Advanced Data Analysis Centre (ADAC) was funded by the University
Strategic Development Fund to support research by the analysis and
interpretation of complex data.
Why is this important?
• Complex data underpins current research
• Innovative analysis can prompt new discoveries
• Excellent research can often be stalled due to a lack of expertise in
conducting data analysis
• ADAC supports high-class research by providing analysts to help with
• development of a research strategy
• grant writing
• interpretation of complex data

2. Wed 2nd Oct 2013 ADAC Launch Event University of Nottingham 3
Meet the Team:
Dr Richard Emes
Director of Bioinformatics:
Integration of genetic/genomic data,
comparative genomics and molecular
evolution.
Professor Jon Garibaldi
Director of Informatics:
development of artificial intelligence
techniques for biomedical decision
support.
Dr Dov Stekel
Integrative Systems Biology.
Dr Grazziela Figueredo.
Data analyst: multi-scale
modelling and simulation
Dr Tom Giles
Data analyst:
bioinformatics of high
throughput genomic data
Dr Jo Moreton
Data analyst:
bioinformatics of high
throughput genomic data
Dr Daniele Soria
Data analyst: artificial
intelligence and modelling
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Current Areas of expertise:
• Integration of complex datasets
• Microarray, second generation
sequencing
• Comparative genomics
• Identification of biomarkers from
genetic and epigenetic datasets
• Artificial intelligence for decision
support
• Machine Learning
• Data Management

3. Activity Summary
• Projects
– contributed to around 20 projects so far
• Income
– approximately £100k grant income secured to ADAC
• Outputs
– seven manuscripts with ADAC co-authors
• acknowledgement for more minor contribution: none yet
– assisted in preparation of over ten external grant submissions
– contribution to an external grant milestone
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Wed 2nd Oct 2013 ADAC Launch Event University of Nottingham 6
Professor Saul Tendler, PVC Research
Dr Alistair Hulme:
Quantitative analysis of organelle transport in micro-patterned cells
Dr Paddy Tighe:
High-content intracellular signaling pathway analysis for drug repurposing
Dr Nigel Mongan:
Cancer Models: Of mice, men and dogs?
Professor Kevin Morgan:
Deciphering biomarker patterns in Alzheimer's
Professor David Walker:
Gathering emotion data from sailing events
Dr Ian Fisk:
Satiation management through flavour delivery
Professor Graham Seymour:
A new frontier: the epigenetic control of fruit ripening
!

4. Example Interactions
• Data generation
– bioinformatic: wet-lab experimentation
– informatic: data acquisition devices / software
• Primary data analysis
– clustering; classification; complex / specialist analysis pipelines
– performing statistical tests
• semi-independent hypothesis testing
– presentation of results (effective graphs, etc.) for manuscripts
• Advice
– what type of data to collect
– how many samples required
– which analysis methods / tools to use
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• Available to provide (limited) support without cost
– collaborative (pilot) projects with deliverables
• publications
• proposal submissions
– small ‘micro’ tasks
• e.g. preparing data analysis work packages on proposals
• Available to be costed on proposals
– flexible data analysis work packages
• from days to months to years of time, not necessarily contiguous
• Added value to existing projects
– additional publications at project end
– data archiving at project end
• Across all UoN, and externally (academic / industrial)
Monday, 7 October 13
Example Modalities

5. 9
ADAC
impact
Monday, 7 October 13