4. What is Migraine ?
• Derived from the Greek word “ hemikranios“ = half head
• A migraine is a common type of headache that may occur with
symptoms such as nausea, vomiting, or sensitivity to light. In many
people, a throbbing pain is felt only on one side of the head.
• Migraine attacks are characterized by unilateral and pulsating
severe headache, lasting 4-72 hours.
5. What causes migraines?
Some people who suffer from migraines can clearly identify triggers or
factors that cause the headaches, but many cannot. Potential migraine
triggers include :
• Allergies and allergic reactions
• Bright lights, loud noises, and certain odors or perfumes
• Physical or emotional stress
• Changes in sleep patterns or irregular sleep
• Smoking or exposure to smoke
• Skipping meals or fasting
Triggers do not always cause migraines, and avoiding triggers does not always
prevent migraines.
8. Primary theory of Migraine:
The primary theory is related to increased
excitability of the cerebral cortex and
abnormal control of pain neurons in the
trigeminal nucleus of the brainstem.
10. Pathophysiology
• There is dilatation of scalp arteries and large
amplitude pulsations during attacks of migraine
• Radioactive xenon cerebral blood flow studies
show significantly reduced regional flow through
the cortex during the aura stage of migraine with
aura.
13. Concluding Remarks
•Neurobiology and patho-physiology of migraine is near
to endless.
•Hence I am stopping at this, there are many other
models also, but it may be too much.
14.
15. references
• Goadsby PJ et al. N Engl J Med. 2002.
• wikipedia
• Daniela Pietrobon* and Jörg Striessnig
Peitrobon_Striessning_nrn2003_migraine,
nature reviews , neuro scince.