This document discusses six key challenges for the next decade: future people, future place, future power, future belief, future behavior, and future business. It then outlines insights from 120 discussions on the world in 2025 conducted as part of the Future Agenda foresight program. Finally, it identifies six major innovation opportunities: reducing food waste, improving basic sanitation, revolutionizing education, creating a data marketplace, developing ethical machines, and fostering deeper collaboration.