1. UBS West Coast
Life Science Bus Tour
The world leader in serving science
San Jose, CA
March 25, 2009

2. Agenda
Company Overview
Kenneth Apicerno, Vice President, Investor Relations
Technology Overview
Ian Jardine Ph.D., Vice President, Global Research & Development
Factory Tour
Mark Chatfield, High Performance Liquid Chromatography (HPLC) Cell Manager
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3. Company Snapshot
$10.5 billion in revenue
34,000 employees in 40 countries
350,000 customers
150 countries served
#269 on Fortune 500
Clear industry leadership
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4. An Attractive Profile…
Global Reach
Market Strength
Balanced Mix
Asia,
ROW
Services Healthcare 13%
16% 22%
Europe
Life Science
26%
Consumables 46%
Instruments
North America
49% Environmental,
& Equipment
61%
Industrial
30%
& Safety
32%
5%
Software
…to meet diverse needs of global customers
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5. Two Distinct Business Segments
Analytical Laboratory Products
Technologies Segment and Services Segment
Innovative technologies Providing customers
geared toward the easy access to routine
scientist and engineer laboratory products and
services
Focused on providing
41% 59%
integrated workflows Focused on complete
product offerings and
Growth platforms:
outsourced services
• Analytical Instruments
Growth platforms:
• Specialty Diagnostics
• Laboratory Products
• Biosciences
• Customer Channels
• Biopharma Services
Unmatched combination of technology breadth
and purchasing convenience
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6. Analytical Technologies at Glance
Specialty Diagnostics
Analytical Instruments Biosciences
Revenue: $1.3B
Revenue: $2.5B Revenue: $0.7B
Microbiology
Scientific Instruments Immunoassay Life Science Research
Environmental Instruments Molecular Diagnostics Bioprocess Production
Process Instruments Anatomical Pathology Laboratory Chemicals
Key Capabilities Key Capabilities Key Capabilities
Instruments and software: Integrated workflow solutions for High-end reagents for life science
highly specialized diagnostic research:
• Mass spectrometry
tests: • RNAi technologies
• Chromatography
• Drugs of abuse testing • Proteomics workflows
• Molecular spectroscopy
• MRSA infection High content screening kits, cellular
• Elemental analysis
• Cancer detection protein pathways, cell culture
• LIMS and lab software
products
• Organ transplantation
Moving technologies outside
Leader in disposable bioprocess
• Genetic testing
the laboratory
products for biotech manufacturing
Revenue numbers before inter-company eliminations
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7. Laboratory Products and Services at Glance
Customer Channels Biopharma Services
Laboratory Products
Revenue: $0.7B
Revenue: $1.9B Revenue: $4.3B
Laboratory Equipment Research Catalog
Clinical Trials Logistics
Laboratory Consumables Healthcare Catalog
Analytical Services
Laboratory Workstations Safety Catalog
Key Capabilities Key Capabilities Key Capabilities
Equipment: Unparalleled customer access Logistics services for clinical trials:
• Sample preparation Research: World leading resource • Package, label, ship, store
for lab equipment and
• Separation Biological specimen archiving and
consumables management
• Controlled environment
Healthcare: Premier diagnostic test Controlled drug storage and
Liquid handling solutions
catalog for hospitals, reference distribution
Plastic and glass consumables
labs and physicians’ offices
Laboratory furniture and design
Safety: Occupational health and
safety products
Revenue numbers before inter-company eliminations
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8. Agenda
Company Overview
Kenneth Apicerno, Vice President, Investor Relations
Technology Overview
Ian Jardine Ph.D., Vice President, Global Research & Development
Factory Tour
Mark Chatfield, High Performance Liquid Chromatography (HPLC) Cell Manager
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9. Healthcare Funding in the News
Recovery & Reinvestment Act of 2009
(Stimulus Bill)
• $10.4B one-time boost to NIH budget
• $3B one-time boost to National Science
Foundation
Obama’s Current Budget Proposal
• $6B one-time increase in NIH funding
for cancer research
• $1B increase to 2009 NIH budget
(now $30.3B)
• $1B to FDA to support food safety
efforts
Increased opportunities in healthcare
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10. Stem Cell Research
Stem Cell Research is aimed at regenerating
damaged tissues such as bone loss, nerve damage
and replacement of dysfunctional cells
Opportunity to treat diseases such as Alzheimer’s,
Parkinson’s, Type 1 Diabetes and blood cancers
Current administration expected to open up federal
funding in the U.S. (included within stimulus package)
Over $14b of U.S. investment expected over next ten
years from state and private funding and expected to
grow at 9% through 2015
Stem cell research promises to fill gaps where current methods fall short
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11. Stem Cell Research - Integrated Workflow Solutions
Cell Lines
Offering qualified culture ware, media
and controlled environment that stem
cells need in order to grow and multiply
in a predictable way
Technology to allow researchers to
completely monitor, control and analyze
stem cell growth
Detection technology to ensure the Media
Culture Ware
quality of the final cell type, whether for
therapeutics or for drug development
Cell Imaging
Key elements combined to assure stability and reproducibility
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12. Protein Research
Proteins: basic components of all living cells and regulate how our bodies function
Scientists working diligently to identify proteins
• i.e.: ~10,000 proteins in our blood, and only about 3,000 can be detected today
Understanding of proteins is critical for developing effective drug treatments
Identifying the difference in proteins and protein levels in one patient versus another
• Leading to personalized medicine and companion diagnostics
Biomarker identification to enable the development of better diagnostic tests
Protein biomarkers are key indicators of disease
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13. Protein Research – Mass Spectrometry
Mass spectrometry is the instrument of choice to identify protein biomarkers
Speed, resolution and accuracy are all improving rapidly
Offering scientists complete workflow solutions … instruments, reagents, consumables
and software
Accelerating Time
to Identify 1 Protein
2004 2006 2008 Next
Before 1990
1 Every 3/10ths 1 Every 3/100ths
1 Every 1 Every 1 Every
30 seconds of a second of a second
3 seconds
Year
Thermo Fisher Scientific is leading the way in advancing protein science
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14. RNAi Technology
RNA interference (RNAi) silences
a gene and prevents that gene
from producing its protein product
• Nobel Prize winning technology
developed in 1998
Research opportunity:
Scientists are able to
independently manipulate genes
and evaluate the consequences to
cells by silencing certain genes
Therapeutic opportunity:
Scientists are able to silence a
gene and identify those gene
products that are suitable as drug
targets – they can now target
“cancer” causing genes
RNAi research advancing drug discovery
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15. RNAi Technology – Reagents and Services
Industry leading products
Pre-designed libraries of silencing reagents (siRNA,
shRNA, and miRNA)
Screening and profiling services for researchers
mRNA and protein detection reagents
Custom reagents for RNAi research
Automated RNAi screening
Integrated instrumentation and robotics for cell
growth and analysis
Performs high throughput screens using RNAi based
reagents
Standardizes process to maximize efficiency
RNAi discovery services
Provides RNAi-based high-throughput screening and
analysis
Conducting whole genome wide screens that help
identify drug target
Most comprehensive portfolio of RNAi-based reagents and services
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16. Pittcon 2009: New Products for Key Applications
Sample Analysis
Sample Preparation
Data Interpretation
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17. Pittcon 2009: New Products for Sample Preparation
Hamilton
Distinction II
Green Lab
Meters
Furniture
Hamilton Infinity
Fume Hood
Electrodes
siRNA, shRNA, miRNA
Bioreagents
Protein Catalogs
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18. New Thermo Scientific Products for Sample Analysis
Industrial &
Drug Discovery Petroleum &
Environmental &
Basic
Product Testing
& Development Chemical
Food Screening
Research
TSQ Vantage™
LCMS
Transcend TLX™ Access Max™
Accela Exactive™ LCMS
NanoDrop™
2000/2000c
UV/Vis
Titan 4000™
Niton XRF GOLDD™
R
NSX Analyzer
Arena™
Chemistry Analyzer
A range of innovations, from research to routine testing
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19. The Value of High Mass Accuracy and
Ultrahigh Resolution
The Case for Exactive
100%
A mixture of >100 pesticides,
Detected compounds ppm
10
250
mycotoxins and veterinary 45%
drugs at different concentration
99%
levels in horse feed matrix
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analyzed at two resolution 32%
settings utilizing full scan
accurate mass measurements 93%
250
10
(+/- 2ppm)
11%
0 20 40 60 80 100
Orbitrap 100k
% Detected
ToF 10K
10K resolution can’t detect known chemicals
The power of 100K resolution
Vastly superior analytical results with Orbitrap performance
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20. Orbitrap Technology for Routine Screening Applications
Thermo Scientific Exactive
TM
Exactive will displace ToFs and QToFs!
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21. Pittcon 2009: New Data Interpretation Solutions
Pathfinder TraceFinder
Connects
Enterprise
Insights
OMNIC Specta on Raman
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22. The World Leader in Serving Science
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23. Agenda
Company Overview
Kenneth Apicerno, Vice President, Investor Relations
Technology Overview
Ian Jardine Ph.D., Vice President, Global Research & Development
Factory Tour
Mark Chatfield, High Performance Liquid Chromatography (HPLC) Cell Manager
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24. San Jose LC/MS Products
LTQ-ETD
Triple Quads
3D and Linear Ion-traps
LTQ Orbitrap
Surveyor HPLC
LTQ FTMS
Accela UHPLC
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25. The World Leader in Serving Science
We are the leading provider of analytical instruments,
equipment, reagents and consumables, software and services
for research, analysis, discovery and diagnostics.
Thank you!
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