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Odontogenic
cysts
Fouzina Fareed
BDS Final Year
Introduction
“A cyst is an epithelium lined sac
containing fluid or semifluid material”
 The epithelial cells first proliferate and later undergo
degeneration and liquefaction.
Grow by expansion, causing displacement of adjacent
teeth.
On Basis of Origin
• Originate from residues of the tooth-forming organ
Derived from 3 ORIGINS
 Dental lamina:
Odontogenic keratocyst
Lateral periodontal cyst
Gingival cysts
Reduced enamel epithelium :
Dentigerous cyst
Eruption cyst
Paradental cyst
Rests of Malassez :
Radicular cysts
On the basis of etiology
Developmental
Odontogenic keratocyst 5% to 10%
Dentigerous cyst 10% to 15%
Eruption cyst
lateral periodontal cyst <1%
Gingival cyst <1%
Inflammatory
Radicular cyst 65% to 75%
a)Apical
b)Lateral
c)Residual
Paradental cyst 3% to 5%
Radicular Cysts
Subdivided into :
Apical
Lateral
Residual
APICAL CYST
Develops from a preexisting periapical granuloma,
Related to the apex of a non vital tooth
Clinical features
• Most common cystic lesions of jaw.
• High incidence in Anterior maxillary teeth.
• Usually symptomless.
• When enlarged cause expansion of the alveolar
arch and may discharge through a sinus
• The rate of expansion 5mm/year in diameter
Histopathology
• Lined by non-keratinized stratified squamous
epithelium
• Chronically inflamed fibrous tissue capsule
• Newly formed cysts have irregular epithelial lining with
variable thickness. Becomes regular and even in thickness
• The connective tissue capsule becomes
more fibrous, less vascular, and with less
inflammatory cells
• Metaplasia of epithelial lining may
give rise to mucous cells, rarely
ciliated respiratory epithelium
• In some cases the lining contains
hyaline eosinophilic bodies,
Rushton bodies
Radiographic features
• Well defined, Round radiolucency at the root apex
surrounded by radiopaque margin
• Root resorption is common
• 40 % of apical radiolucencies are cystic
Contents
Hypertonic fluid containing
• breakdown products of epithelial
• inflammatory products
• connective tissue elements
• serum proteins (5-11 g/dl), Immunoglobulin higher
then serum.
• cholesterol crystals
CYST EXPANSION
• majority of the radicular cyst do not grow to large
dimension
• Cyst enlarges and causes bone resorption centrally
increments of sub periosteal bone are laid down to
maintain integrity of cortex , producing bony hard
expansion
• The rate of expansion is greater then the rate of periosteal
deposition leading to progressive thinning of cortex
• Clinical sign of OIL-CAN BOTTOMING & EGG
SHELL CRACKLING
Differential Diagnosis
• Periapical granuloma
• Periapical abcess
• Cemetoblastoma
Management
• Small cyst : Root canal Treatment
• Large Cyst : Enucleation or marsupialiazation
Residual cyst
• It is a radicular cyst that is retained after the
extraction of the related tooth
• May continue growth causing significant
bone resorption
Lateral Radicular cyst
• An Uncommon type of Radicular cyst
• Arise as a result of pulpal inflammation
into lateral preriodontium.
Dentigerous cyst
“Cyst that originates by the separation of follicle
from around the crown of unerupted tooth”
Also called as Follicular Cyst
Clinical features
• Twice as common in mandible
• Usually asymptomatic
• Twice as common in males
• Large cyst tends to expand the outer plate
Radiographic
examination
• Well-defined, unilocular, radiolucent, related
to the crown
• Associated with impacted or delayed
eruption (most commonly lower 8, upper 3)
Histopathology
• Lining is a thin, regular, 2-5 cells thick, non-
keratinized, stratified squamous or cuboidal
• Fibrous CT capsule free from inflammatory cell
infiltration
• Occasional cholesterol clefts
Radiographically
Odontogenic keratocyst
• Relatively uncommon
• 2nd to 3rd decades, or fifth decade
• More common in males
• Asymptomatic
• Gain much attention because of its unusual growth
pattern (anterioposterior direction) and tendency recur.
• Multiple cysts are associated with nevoid basal cell
carcinoma syndrome (Gorlin syndrome)
Radiographic features
• 3rd molar and ramus of mandible are common sites
• Well-defined radiolucency
• Can displace and resorb teeth
• Uni or multi locular
Histopathology
• wall is thin , friable.
• 5-10 cells thick stratified squamous epithelium
• Characteristic folded wall
• Basal cell layer is well defined, contains columnar or
cuboidal cells
• satellite cyst (daughter cysts) usually found, formed by
independent small groups of epithelial cells resembling
dental lamina reside in fibrous capsule
• Thin fibrous capsule free from inflammatory
cells
• High recurrence due to rupture
• Cyst contains keratinous debris, white cheesy
material, protein level 4 g/dl
Gorlin Syndrome
• autosomal dominant, uncommon
• Manifestations:
• Skin: multiple naevoid basal cell carcinomas
• Oral: multiple odontogenic keratocysts
• Skeletal: rib, vertebral anomalies. Polyductyly, cleft
lip/palate
• CNS: calcified falx cerebri brain tumors
Gingival cyst
Neonates
• Common in neonates
• Also knows as Bohn’s nodules or Epstein pearls
• Disappear by 3 months of age
• Arise from remnants of dental lamina, form
keratinizing cysts
Gingival cyst
Adults
• Uncommon
• Interpremolar region is most coomon site
• Arise from rest of dental lamina
Developmental lateral
periodontal cyst
• Uncommon
• Canine and premolar region of the mandible
• Derived from either reduced enamel epithelium or rests
of dental lamina
• Occasionally multilocular (Grape like structure) called as
botryoid odontogenic cyst
Radiographically
• well-defined radiolucency
• Large cysts can displace teeth
and cause expansion
Histopathology
• Non keratinized squamous epithelium.
• One or two cell thick
• Foci of Clear cytoplasmic
(glycogen rich) cells are found
Management
• Conservative enucleation is the treatment of
choice
Paradental cyst
• Arises alongside an unerupted third molar involved
with pericoronitis
• Occur mostly in mandible
and mostly distobucally located
Radiographically
• well-defined radiolucency related
to the neck of the tooth and
coronal third of the root
QUICK REVIEW
Bibliography
•Oral pathology Soames Edition 4th
•Oral and maxillofacial pathology
Nevile 3rd Edition.
Odontogenic cyst

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Odontogenic cyst

  • 2.
  • 3. Introduction “A cyst is an epithelium lined sac containing fluid or semifluid material”  The epithelial cells first proliferate and later undergo degeneration and liquefaction. Grow by expansion, causing displacement of adjacent teeth.
  • 4.
  • 5. On Basis of Origin • Originate from residues of the tooth-forming organ Derived from 3 ORIGINS  Dental lamina: Odontogenic keratocyst Lateral periodontal cyst Gingival cysts
  • 6. Reduced enamel epithelium : Dentigerous cyst Eruption cyst Paradental cyst Rests of Malassez : Radicular cysts
  • 7. On the basis of etiology Developmental Odontogenic keratocyst 5% to 10% Dentigerous cyst 10% to 15% Eruption cyst lateral periodontal cyst <1% Gingival cyst <1%
  • 8. Inflammatory Radicular cyst 65% to 75% a)Apical b)Lateral c)Residual Paradental cyst 3% to 5%
  • 9.
  • 10. Radicular Cysts Subdivided into : Apical Lateral Residual
  • 11. APICAL CYST Develops from a preexisting periapical granuloma, Related to the apex of a non vital tooth
  • 12. Clinical features • Most common cystic lesions of jaw. • High incidence in Anterior maxillary teeth. • Usually symptomless. • When enlarged cause expansion of the alveolar arch and may discharge through a sinus • The rate of expansion 5mm/year in diameter
  • 13. Histopathology • Lined by non-keratinized stratified squamous epithelium • Chronically inflamed fibrous tissue capsule • Newly formed cysts have irregular epithelial lining with variable thickness. Becomes regular and even in thickness
  • 14. • The connective tissue capsule becomes more fibrous, less vascular, and with less inflammatory cells • Metaplasia of epithelial lining may give rise to mucous cells, rarely ciliated respiratory epithelium • In some cases the lining contains hyaline eosinophilic bodies, Rushton bodies
  • 15. Radiographic features • Well defined, Round radiolucency at the root apex surrounded by radiopaque margin • Root resorption is common • 40 % of apical radiolucencies are cystic
  • 16.
  • 17. Contents Hypertonic fluid containing • breakdown products of epithelial • inflammatory products • connective tissue elements • serum proteins (5-11 g/dl), Immunoglobulin higher then serum. • cholesterol crystals
  • 18. CYST EXPANSION • majority of the radicular cyst do not grow to large dimension • Cyst enlarges and causes bone resorption centrally increments of sub periosteal bone are laid down to maintain integrity of cortex , producing bony hard expansion • The rate of expansion is greater then the rate of periosteal deposition leading to progressive thinning of cortex • Clinical sign of OIL-CAN BOTTOMING & EGG SHELL CRACKLING
  • 19.
  • 20.
  • 21. Differential Diagnosis • Periapical granuloma • Periapical abcess • Cemetoblastoma
  • 22. Management • Small cyst : Root canal Treatment • Large Cyst : Enucleation or marsupialiazation
  • 23. Residual cyst • It is a radicular cyst that is retained after the extraction of the related tooth • May continue growth causing significant bone resorption
  • 24.
  • 25. Lateral Radicular cyst • An Uncommon type of Radicular cyst • Arise as a result of pulpal inflammation into lateral preriodontium.
  • 26. Dentigerous cyst “Cyst that originates by the separation of follicle from around the crown of unerupted tooth” Also called as Follicular Cyst
  • 27. Clinical features • Twice as common in mandible • Usually asymptomatic • Twice as common in males • Large cyst tends to expand the outer plate
  • 28. Radiographic examination • Well-defined, unilocular, radiolucent, related to the crown • Associated with impacted or delayed eruption (most commonly lower 8, upper 3)
  • 29.
  • 30. Histopathology • Lining is a thin, regular, 2-5 cells thick, non- keratinized, stratified squamous or cuboidal • Fibrous CT capsule free from inflammatory cell infiltration • Occasional cholesterol clefts
  • 32. Odontogenic keratocyst • Relatively uncommon • 2nd to 3rd decades, or fifth decade • More common in males • Asymptomatic • Gain much attention because of its unusual growth pattern (anterioposterior direction) and tendency recur. • Multiple cysts are associated with nevoid basal cell carcinoma syndrome (Gorlin syndrome)
  • 33. Radiographic features • 3rd molar and ramus of mandible are common sites • Well-defined radiolucency • Can displace and resorb teeth • Uni or multi locular
  • 34.
  • 35. Histopathology • wall is thin , friable. • 5-10 cells thick stratified squamous epithelium • Characteristic folded wall • Basal cell layer is well defined, contains columnar or cuboidal cells • satellite cyst (daughter cysts) usually found, formed by independent small groups of epithelial cells resembling dental lamina reside in fibrous capsule
  • 36. • Thin fibrous capsule free from inflammatory cells • High recurrence due to rupture • Cyst contains keratinous debris, white cheesy material, protein level 4 g/dl
  • 37. Gorlin Syndrome • autosomal dominant, uncommon • Manifestations: • Skin: multiple naevoid basal cell carcinomas • Oral: multiple odontogenic keratocysts • Skeletal: rib, vertebral anomalies. Polyductyly, cleft lip/palate • CNS: calcified falx cerebri brain tumors
  • 38.
  • 39.
  • 40. Gingival cyst Neonates • Common in neonates • Also knows as Bohn’s nodules or Epstein pearls • Disappear by 3 months of age • Arise from remnants of dental lamina, form keratinizing cysts
  • 41. Gingival cyst Adults • Uncommon • Interpremolar region is most coomon site • Arise from rest of dental lamina
  • 42.
  • 43. Developmental lateral periodontal cyst • Uncommon • Canine and premolar region of the mandible • Derived from either reduced enamel epithelium or rests of dental lamina • Occasionally multilocular (Grape like structure) called as botryoid odontogenic cyst
  • 44. Radiographically • well-defined radiolucency • Large cysts can displace teeth and cause expansion
  • 45. Histopathology • Non keratinized squamous epithelium. • One or two cell thick • Foci of Clear cytoplasmic (glycogen rich) cells are found
  • 46. Management • Conservative enucleation is the treatment of choice
  • 47. Paradental cyst • Arises alongside an unerupted third molar involved with pericoronitis • Occur mostly in mandible and mostly distobucally located
  • 48. Radiographically • well-defined radiolucency related to the neck of the tooth and coronal third of the root
  • 50. Bibliography •Oral pathology Soames Edition 4th •Oral and maxillofacial pathology Nevile 3rd Edition.