3. Introduction
• The normal function of the urinary bladder
is to
– store and expel urine in a coordinated,
controlled fashion.
• This coordinated activity is regulated by
central and peripheral nervous systems.
4. Introduction
• Three mixed sensory and motor nerves
innervate the lower urinary tract.
• hypogastric
• pelvic and
• pudendal nerves
5. Introduction
• The hypogastric nerve carries
sympathetic autonomic innervation,
• The pelvic nerve carries the
parasympathetic autonomic innervation,
• Pudendal nerve carries the somatic
innervation to the lower urinary tract.
7. Introduction (voiding)
Intense bladder afferent Firing through
pelvic nerve to PMC
PSO to Detrusor and urethral smooth
muscles
Inhibits pudendal outflow to EUS
Detrusor contraction and EUS
relaxation
Micturition
9. Uninhibited bladder
• lesions above the pontine micturition center
produce an uninhibited bladder
• Due to reduced cortical inhibition of PMC
there is
– Reduced awareness of bladder
fullness and a
– Low capacity bladder
10. DSD
• lesions between the pontine
micturition center and sacral
spinal cord producing an upper
motor neuron bladder
• Upper motor neuron neurogenic
bladder dysfunction is
characterized by detrusor-
sphincter dyssynergia (DSD),
11. DSD
• In DSD simultaneous detrusor
and urinary sphincter contractions
occur
• The spinal cord damage renders
the bladder and sphincters
spastic, especially if lesions are
above the T10 level
12. DSD
• The bladder capacity is usually
reduced due to the high detrusor
tonus (neurogenic detrusor
overactivity, or detrusor
hyperreflexia)
• If detrusor pressure exceeds EUS
pressure in the proximal urethra,
then incontinence may occur.
13. Mixed type A neurogenic Bladder
• In the mixed type A neurogenic
bladder detrusor nucleus
damage renders the detrusor
flaccid (detrusor areflexia),
• The pudendal nucleus is intact
& spastic producing a
hypertonic EUS.
14. Mixed type A neurogenic Bladder
• The bladder is large and has low
pressure
• spastic external sphincter produces
urinary retention.
• The detrusor pressure is low so upper
urinary tract damage from
vesicoureteral reflux does not occur,
and incontinence is uncommon.
15. Mixed type B neurogenic Bladder
• Flaccid EUS due to the
pudendal nucleus lesion
• Spastic bladder due to the
disinhibited detrusor nucleus.
• bladder capacity is low but
vesicular pressures are
usually not elevated
• This leads to problems with
incontinence, however.
16. LMN neurogenic Bladder
• the sacral MCs or related
peripheral nerves are damaged
• sympathetic outflow to the lower
urinary tract is intact
• detrusor tone is low (detrusor
areflexia) and internal urinary
sphincter innervation is intact.
17. Detrusor hyperactivity with impaired
bladder contractility DHIC
• first described in nursing home residents
• there is frequent but weak involuntary detrusor
contractions causing incontinence & incomplete
bladder emptying
• There is slow bladder contraction velocity, and
elevated urinary residual volume
19. • The evaluation begins with
• both day and nighttime voiding patterns.
• Voiding symptoms can be irritative or
obstructive.
History and Physical Examination
20. • Irritative
• Dysuria
• Urgency
• Frequency
• Obstructive
• Retention
• Hesitancy
• Staccato voiding
• Straining
• Feeling of incomplete voiding
History and Physical Examination
21. • Whether the child has had a urinary tract
infection (UTI)
– UTI with fever (pyelonephritis)
– UTI without fever (cystitis)
• Constipation is noted
• lower extremity weakness or change in
sensation are recorded.
History and Physical Examination
22. • Physical examination should include
evaluation of the
– abdomen,
– back,
– genitalia, and
– lower extremities.
History and Physical Examination
23. • Abdominal examination should include
palpation for fecaloma and distended
bladder
History and Physical Examination
24.
25. • Examination of the back is essential and
should include
• Cutaneous findings of a hair patch or
• A dimple over the lumbosacral spine
• Asymmetric gluteal crease
• Patients who possess any of these cutaneous
findings should undergo a MRI of the
lumbosacral spine.
History and Physical Examination
26. • Examination of the male genitalia should
include palpation along the entire urethra.
• Induration may be a sign of urethral
inflammation and stricture.
• Position of the testicles should be noted
(cryptorchidism is common in
myelodysplasia.)
History and Physical Examination
27. • The anus should be examined for Tone
and Position.
• Finally, any deficits in lower extremity
reflexes or motor strength should be
noted
History and Physical Examination
28. • A urinalysis should be obtained
• The presence of red cells, white cells,
glucose, and protein should be noted.
• A low specific gravity may reflect poor
concentrating ability secondary to renal
dysfunction.
History and Physical Examination
30. BLADDER ULTRASOUND
• The bladder ultrasound can provide many
clues like
• Thickened bladder wall (UTI & BOO)
• Calculation of PVRU for assessing whether
the patient can efficiently empty the
bladder.
Bladder Ultrasound
31. VOIDING
CYSTOURETHROGRAPHY
• MCU provides information about
– Bladder neck, and urethral anatomy
– Trabeculations
– Diverticuli
– Vesicoureteral reflux is a common finding in both
anatomic and functional causes of bladder
dysfunction
VCUG
32. • The urodynamic evaluation provides indepth functional
information regarding the bladder.
• It establishes
• bladder capacity,
• bladder filling pressures,
• patient’s perception of bladder filling, and the ability to
empty efficiently and in proper coordination with EUS
UDS
33. • Neurologic modulation combined with the
viscoelastic properties of the healthy
detrusor muscle allow the bladder to maintain
fairly constant pressure throughout the filling
phase.
• As a result, intravesical pressures in the
healthy bladder remain at or below 5 to 10 cm
H2O pressure
UDS
34. • compliance can be adversely affected
(mechanical obstruction or by U & LMN
lesions) resulting in increased intravesical
storage pressures.
• Storage pressures higher than 40 cm
H2O, lead to renal injury.
UDS
39. Neuropathic bladder secondary
to myelodysplasia
• Myelodysplasia, defined as abnormal development
of the spinal canal and spinal cord
• It is the most common etiology of NB in children.
• Workup is done in the neonatal period, usually
after the surgical closure of the defect.
• workup will include RBUS, urodynamic study &
MCU
40. • This baseline information can identify
children at risk for urinary tract
deterioration (poor compliant or overactive detrusor or
outflow obstruction as a part of DSD.)
• In such cases proactive approach is
necessary.
Myelodysplasia
41. • The neurological lesion produced by
MMC can be variable.
• The vertebral level provides little or no
clue to the exact neurologic level or lesion
produced.
Myelodysplasia
42. • MMC influences lower urinary tract function in
a variety of ways and cannot be predicted
by spinal anomalies or the neurogenic function
of the lower extremities.
• The neurologic lesion in MMC is a dynamic
disease process in which changes take place
throughout childhood.
Myelodysplasia
43. • Three categories of lower urinary tract
dynamics may be detected:
– synergic (26%)
– dyssynergic with and without poor detrusor
compliance (37%) and
– complete denervation (36%).
Myelodysplasia
44. • Dyssynergy:
• When the external sphincter fails to decrease
or actually increases in its activities during a
detrusor contraction
• It is associated with a poorly compliant
bladder with high pressures. This results in a
bladder that empties only at high pressures.
Myelodysplasia
45. • Synergy is characterized by complete
silencing of the sphincter during a
detrusor contraction
• Voiding pressures are usually within
normal range.
Myelodysplasia
46. • Complete denervation: is noted when no
bioelectric potentials are detectable in the
region of the EUS at any time during
micturition cycle.
Myelomeningocele
47. • Within the first 3 years of life urinary tract
deterioration is seen in
• 71% of newborn with DSD
• 17% of synergic children and
• 23% of completely denervated patients.
Myelomeningocele
48. • Outlet obstruction is a major contributor to the
development of urinary tract deterioration.
• Leak point pressure and detrusor filling
pressure both are significant markers to predict
upper tract deterioration.
• Detrusor filling pressures should be
maintained lower than 30 cm H2O.
Myelomeningocele
49. • clean intermittent catheterisation (CIC) is
indicated when
– detrusor filling pressures exceed 30 cm H2O and
– voiding pressure exceeds 100 cm H2O, is
necessary.
• Sequential urodynamic studies, on a yearly
base during the first 5 years of life, provide a
safe monitoring of these children.
Myelomeningocele
50. Occult Spinal Dysraphisms
• Affects the formation of the spinal
column but does not result in an open
vertebral canal.
• In children younger than 3 months the
vertebral bones have not ossified, thus a
window exists for ultrasound to screen
spinal cord lesions.
Occult spinal dysraphism
51. • 90% of children with various occult
dysraphic status have cutaneous lesions.
– small dimple
– skin tag
– tuft of hair
– dermal vascular malformation,
– subcutaneous lipoma
– asymmetrically curving gluteal cleft.
Occult spinal dysraphism
52. • On careful inspection of the lower extremities,
we can detect a
– high arched foot,
– alteration of configuration of toes, or
– pressure zones on the feet with atrophic lesions
on the skin.
• Lower urinary tract function is abnormal in 40–
90% of affected elder children.
Occult spinal dysraphism
53. • In most of the children lower extremity
examination is normal
• Patients become symptomatic during
pubertal Growth spurt
• During pubertal growth spurt differential
growth of spinal cord and vertebral bodies
produces compression of nerve roots
Occult spinal dysraphism
54. • Lipomeningocele, intradural lipoma, and
other anomalies of filum terminale may be
present.
• Urodynamic evaluation reveals abnormalities in
one third
• These congenital anomalies produce different
neurologic findings.
Occult spinal dysraphism
55. • Lipomas cause UMN lesion alone or in
combination with LMN lesion.
• The reason to consult a specialist may be
– difficulty in toilet training,
– urinary incontinence after an initial period of
successful dryness
– recurrent UTI, and
– fecal soiling.
Occult spinal dysraphism
56. • In such lesions
• RBUS, MRI studies are needed and a full
urodynamic evaluation with EMG should be
done.
• The therapeutic measures should be discussed
with a neurosurgeon.
• MCU is warranted when the urodynamics
parameters suggest risk to the upper urinary tract
Occult spinal dysraphism
57. Sacral Agenesis
• Defined as the partial or complete absence of lowermost
vetebral bodies
• There may be
– absence of just two or three vetebral bodies or
– Absence of scaral and several lumbar bones
• These children appear normal with no lower extremity
abnormality
• Usually failed toilet training brings the child to consult
his paediatrician.
Sacral agenesis
58. • Patient has flat bottom, and even absent vertebrae in
palpating the coccyx.
• The pathognomic sign is absence of the upper end of
the gluteal cleft, with flattened buttocks.
• The diagnosis can be confirmed by
– a simple lateral plain x-ray of the sacral area.
– spinal ultrasound in infants
• A spinal MR reveals a sharp cut off to the cord at
about T-12, with nerve roots streaming from it.
Sacral agenesis
59. • Urodynamic Study may show either
– overactive detrusor with sphincter dyssynergy (UMN)
– acontractile detrusor with complete denervation in the
urethral sphincter (LMN)
• UM lesions are characterized by an overactive
detrusor, exaggerated sacral reflex and DSD
• The VCUG shows thick trabeculated bladder with
closed bladder neck.
Sacral agenesis
60.
61. • Lower motor lesions show an
acontractile detrusor with open bladder
neck
• VCUG shows small thin walled bladder.
• Management will depend mainly on the
urodynamic findings and the
morphological aspect on the VCUG.
Sacral agenesis
62. Anorectal Malformations (ARM)
• Spinal cord anomalies (tethered cord, filum terminale anomalies, and a lipoma)
may be found in up to 50% of cases of ARM, specially in
high type ARM.
• Neurogenic bladder dysfunction is a frequent finding
• Bladder dysfunction can be either due to the congenital
spinal anomalies or secondary to the surgical trauma.
63. • Most common finding on urodynamic studies
is an upper motor lesion with DSD
• Currently urodynamic studies are reserved to
children
– who have symptoms or
– Who have abnormalities on the simplified
urodynamic studies (flowmetry, EMG, postvoid
residual).
Anorectal Malformations (ARM)
64. Cerebral Palsy
• Cerebral palsy is a non progressive injury of
the brain occurring in the perinatal period.
• Most children with cerebral palsy develop total
urinary control.
• Incontinence is a feature in some
• Overactive detrusor with DSD is the most
common finding.
Cerebral palsy
65. • Most common injuries are of the cervical and high
thoracic regions.
• The high spinal lesions will produce an UMN lesion
with overactive detrusor and DSD
• Urodynamic studies are done after stabilisation
of the spinal trauma, usually 2 months after the
injury and to be repeated 6–9 months after.
Traumatic Injuries of the Spine
66. • sacral spinal injuries cause acontractile
detrusor with inactive external sphincter.
• There is low risk for the urinary tract
deterioration but need specific measures for
incontinence.
Traumatic Injuries of the Spine
68. Management of a child with a neurogenic
bladder
• the main objective
– to preserve a normal upper urinary tract.
• The second main objective is
– to improve the social life and the quality of life of
these children, giving them urinary and fecal
continence
69. • These goals need a reservoir (the bladder)
with adequate capacity and low storage
pressure, able to empty itself with a normal
micturation pressure.
Management of NB
70. • The management will have to be tailored
according to
• urodynamic results and
• motor and intellectual capacities of the
patient.
Management of NB
71. • to achieve a complete emptying of the
bladder
• to maintain or restore an adequate
bladder capacity and compliance, and
• to reinforce the sphincter outlet
resistance when needed.
Goals of treatment
72. Clean Intermittent Catheterization (CIC)
• CIC was introduced by Lapides in 1971
• Remains the most important tool in the
management NB.
• As fewer than 10% of children with congenital NB
will develop satisfactory bladder control,
• Parents are reminded at periodic follow-ups to
expect this intervention by the age of toilet
training
73. Clean Intermittent Catheterization (CIC)
• Some authors prefer early institution of CIC
because
– by the age of 3 years, CIC will be required in
all for achieving continence,
– starting CIC in toddlers is difficult.
• CIC may be realized with classical Nelaton
catheter kept in an antiseptic solution.
74. • It allows a complete emptying of the bladder
– lowers the risk of UTI
– protects the upper urinary tract against high
bladder pressure
– Is a valuable tool to keep child dry
Clean Intermittent Catheterization (CIC)
75. • CIC is a clean but not sterile procedure.
• Starting CIC will frequently result in chronic
colonization of the bladder by bacteria.
• These bacteria are generally of low clinical
significance
• Antibiotic use should be reserved only for a
symptomatic episode of UTI & pseudomonas and
proteus.
Clean Intermittent Catheterization (CIC)
76. • CIC should be started as soon as possible to avoid UTI
and deterioration of the bladder.
• CIC may be realized through the urethra or through a
continent cystostomy (the Mitrofanoff principle).
Clean Intermittent Catheterization (CIC)
77. • In cases where despite CIC urinary tract
deterioration occurs, the overnight catheter
drainage of the bladder may be tried.
• Overnight drainage may increase bladder
compliance and capacity
Clean Intermittent Catheterization (CIC)
78. Pharmacologic Treatment of NB
• Aim of the pharmacotherapy is
– Decrease detrusor over activity
– Increase bladder capacity
– Increase bladder outlet resistance ( in incontinence)
– Dercrease bladder outlet resistance (in DSD)
79. • Oxybutinin remains the gold standard of treatment
of bladder overactivity.
• It is as an anticholinergic agent acts on M3
muscarinic receptors.
• It decreases intravesical pressures and uninhibited
contractions and
• indirectly increases bladder capacity.
Oxybutynin
80. • It also has an
– anti-spasmodic,
– local anaesthetic and
– Calcium channel blocking
• It converts overactive detrusor into an inactive
reservoir
Oxybutynin
81. • It is administered orally in the dose of 0.2-0.4
mg/kg/day in 2-3 divided doses.
• side effects of altered thermoregulation and
constipation.
• These side effects may be reduced by direct
instillation of the oxybutinin in the bladder.
Oxybutynin
82. • Other bladder relaxant drugs include
• propiverine (0.8mg/kg/day),
• trospium, and tolterodine.
• The current experience with these compounds is still
limited
Other bladder Relaxants
83. • Madersbacher et al* concluded that long-term
efficacy and tolerability of propiverine in
children is promising with clinically
relevant improvements in key urodynamic
outcomes.
*Madersbacher H, Mürtz G, Alloussi S, Domurath B,Henne T, Körner I et al. Propiverine vs oxybutynin for treating
neurogenic detrusor overactivity in children and adolescents: results of a multicentre observational cohort study.
BJU Int 2009;103:776-81.
Propiverine
84. • Another study evaluated long-term efficacy and
safety of tolterodine in 30 children with neurogenic
detrusor overactivity.
• They concluded that tolterodine was effective and
well tolerated in children with neurogenic detrusor
overactivity
• *Reddy PP, Borgstein NG, Nijman RJ, Ellsworth PI. Longterm efficacy and safety of tolterodine in children with
neurogenic detrusor overactivity. J Pediatr Urol 2008;4:428-33.
Tolterodine
85. α - Blocker
• For children with DSD, one may try alpha-blocker therapy
such as tamsulosin, prazosin or doxazosin.
• These have achieved success, are low risk to try,
• They can be followed for effectiveness by
– symptomatic improvement, as well as with a noninvasive
uroflow study with postvoid residue
86. Antibiotics
• The problem of daily antibiotics is the risk of developing
antibiotic-resistant organisms
• Low dose, low efficacy antibiotics such as
cotrimoxazole and nitrofurantoin should be used in an
alternative fashion for prophylaxis and
• High-efficacy full dose drugs are used for an active
infection.
87. Botulinum toxin A
• BOTOX results in decreased muscle activity by
blocking the release of acetylcholine from the neuron
• This effectively weakens the muscle for a period of three
to four months
• It increases bladder capacity, decreased pressures,
decreased incidence of reflux and improves
continence.
88. • Botulinum toxin A is injected in the detrusor muscle
under cystoscopic guidance
• 5 IU/kg body weight with a maximum dose of 300 IU.
• The sites of injection are spread through the
bladder except the trigone not to induce reflux.
• The effect lasts between 6 to 9 months.
• This minimally invasive procedure, may be
repeated.
Botulinum toxin A
89. • It is useful to consider strategies of scheduled
evacuation.
• This includes healthy
• Toilet trainaing
• dietary fiber intake and a
• daily stool softener, coupled with a
• method of daily evacuation to achieve effective
bowel management.
Bowel management
Mineral Oil 2-4 ml/kg/day
Milk of Magnesia 1-3 ml/kg/day
Polyethylene glycol 0.5-1.5 g/kg/day
Sorbitol or lactulose 1-2 ml/kg/day
90. • A number of surgical options are available
should a combination of pharmacotherapy and
CIC prove inadequate in halting the progression
of urinary tract damage.
• It is imperative that one must have a mechanism
of satisfactory bladder emptying.
Bladder Augmentation
91. The goal of bladder augmentation is
• to protect the upper urinary tract when
the less invasive procedures are ineffective,
and
• to induce dryness in children where the
incontinence is related to low compliance
and capacity.
.
Bladder Augmentation
92. Bladder Augmentation
• Bladder augmentation should only be
realized in a patient when CIC is impossible
by the urethra, sensitive or technically
impossible
• Bladder augmentation is usually kept low on
the list of surgical options due to long-term
morbidity of these procedures
Bladder Augmentation
93. Bladder Augmentation
The augmentation induces many complications
• Infections
• stone formation
• metabolic complications
• perforation and
• cancer.
Bladder Augmentation
94. Bladder Augmentation
• Enterocystoplasty and clam cystoplasty are
good alternatives to autoaugmentation
when the surgeon is faced with a small,
scarred bladder.
• It is often associated with the construction
of a catheterizable channel (Mitrofanoff
principle)
Bladder Augmentation
95. Bladder Augmentation
• The choice of surgery leans towards continent
urinary diversion and bladder augmentation in the
event of
– intractable incontinence,
– diminishing renal functions and
– hypertension following long-term renal damage.
Bladder Augmentation
96. Bladder Augmentation
• Neuromodulation therapy aims to treat the
abnormal innervation of the bladder
• It tries to "re-train" the nerve-muscle interaction to
attain more normal bladder function.
Neuromodulation
97. Bladder Augmentation
• The available treatments include
– transurethral electrical bladder stimulation
– implantation of a sacral neuromodulation
pacemaker device; and
– operative procedures that reconfigure sacral
nerve root anatomy
Neuromodulation
98. Bladder Augmentation
• Sacral neuromodulation by a reversible implantable
device (Medtronic,USA), is thought to improve bladder
function either
– by consistent stimulation of the efferent fibers of the
sacral nerve roots or
– by providing rhythmic contractions of the pelvic floor
Neuromodulation
99. Bladder Augmentation
• Another method of counteracting a small, hyperactive bladder
is the intradural transection of the S2-S4 nerve roots
• Guys et al studied the results of sacral nerve stimulation
(SNS) therapy in children with neurogenic bladder
dysfunction.
• They did not find significantly better results in the SNS group
Neuromodulation
100. Bladder Augmentation
• In case of Incompetent Bladder Outlet, bladder
neck procedures are the way to achieve
continence.
• Agents like Durasphere (zirconium oxide beads) & Deflux
(hyaluronic acid polymer) have been employed for this
purpose
• The main disadvantage with this approach is the
difficulty in CIC which follows.
Bladder Neck Bulking Agents
101. Bladder Augmentation
• Neel et al have introduced the concept of TEM in children
with noncompliant NB to address continence and treatment of
VUR.
• Ten children with NB were treated with cystoscopic injection
of botulinum-A toxin in the detrusor and subureteric injection
of Deflux.
• There was significant increase in BC and decrease in max.
detrusor pressure. VUR was successfully treated in 15 of 16
ureters
Total endoscopic management (TEM)
102. Outlet Resistance
• In other patients the outlet resistance may be obtained by
the
1. open cervicoplasty
2. sling suspension of the bladder neck
3. artificial urinary sphincter
4. bladder neck closure with mitrofanoff.
103. • Bladder neck sling is considered by many as the procedure of
choice in females and
• it has also been advocated in male patients by some.
• The sling is made of autologous material in most cases (rectus
fascia).
• Castellan et al. report good continence with a mean follow-up
of 4 years in 58 patients.
104. • Artificial Urinary Sphincter (AUS) is considered
by many as the procedure of choice in boys when
a reinforcement of outlet resistance is needed to
gain adequate continence.
• Continence rates between 80% and 90% are
reported among children.
• AUS may be associated with erosion, sepsis or
dysfunction.
105.
106. • Children with AUS undergo many procedures
due to device technical problems.
• In one French multi-institutional study 63/107
children had to be re-operated on and 42 of
them more than once.
• Most do not recommend implantation of an AUS
device before puberty
107. ,
• Bladder neck closure was initially proposed by
Mitrofanoff in the management of children with a
neuropathic bladder.
• it exposes the bladder and upper urinary tract to a
high risk of deterioration in case of bad
compliance to CIC.
108. Procedures Increasing the Outlet Resistance
• Any of these procedures imply the risk of bladder
and upper urinary tract deterioration with renal
insufficiency.
• A close follow-up is mandatory to detect any
change in the urodynamic profile and any dilation
of the upper urinary tract.
109. • The management of a child with a
neurogenic bladder needs a
multidisciplinary team
• Treatment and has to be tailored to each
child with respect to his familial
environment, and his orthopedic and or
mental limitations.
Conclusion
110. • CIC is the most important part of the treatment
and should be started as early as possible
after birth and repair of the spinal defect.
• It will not always be sufficient to gain
continence but it is mandatory to protect the
upper urinary tract which is the main goal of
the treatment.
Conclusion