OKOK

1. The developing human
陳建榮
http://web.nchu.edu.tw/pweb/users/chenjr/

2. 教科書及參考資料：
1. The Developing Human (7TH, 2003, by
Keith L. Moore & T. V. N. Persaud)
2. Langman’s medical embryology (9th, 2004, by
T.W. Sadler)
3. http://embryology.med.unsw.edu.au/
4. 講義
評量方式：
期中考 (45%)
期末考 (45%)
平時成積 (10%)

3. Embryology
 Human development is a continuous
process that begins when a zygote is
formed
 Development does not stop at birth

4. Developmental
Periods
 Gametogenesis
Gametogenesis
 Spermatogenesis
 Oogenesis
 Prenatal period (Fertilization)
 Embryo: Zygote
 Cleavage
 Implantation
 Gastrulation
 Organogenesis
 Fetus
 Postnatal period
 Neonate (<1 month)
 Infancy (< 1 yr)
 Childhood
 Puberty (13 yr – 16 yr)
 Adulthood

5. 胎齡 :
embryo fetus
LNMP (last normal menstrual period)
Trimester

6. 測量胚胎大小 :
最大長
頂臀長
頂踵長

7. Carnegie stages are a system used by embryologists to
describe the apparent maturity of embryos
1st trimester

9. 1st week

10. Formation of
Bilaminar Embryonic Disc
Stage 5: 7th –12th day full implantation
2nd week

11. Stages 6-9: Day 13-21
Somites
3rd week

12. Stages 10-17
4th to 6th week

13. 7
8
 Embryo (end of the 8th week)
- all major structures are present
 Fetus (after 8th week)

15. Data For Carnegie Stages Comparison Graph
(Species/Days)
Species Stage 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23
Human Days 20 22 24 28 30 33 36 40 42 44 48 52 54 55 58
Baboon Days 23 25 27 28 29 30 31 33 35 37 39 41 43 45 47
Rhesus
Days 21 22 25 28 29 30 32 34 36 37 38 40 42 44 46
Monkey
Marmoset Days 57 60 64 67 74
9. 15.
Mouse Days 9 10 10.5 11 11.5 12 12.5 13 13.5 14 14.5 15 16
5 5
10.
Rat Days 11 11.5 12 12.5 13 13.5 14 14.5 15 15.5 16 16.5 17 17.5
5
Chinese 10 16.
Days 10 11 11.5 12 12.5 13 13.5 14 14.5 15 15.5 16 17
Hamster .5 5
14.
Guinea Pig Days 15 15.5 17 18 19 20 21 22 23 24 25 26 27 29
5
8.
Rabbit Days 8 9.5 10.5 11 12 12.5 13.5 14 14.5 15.5 16 16.5 17 18
5
Sheep Days 15 16 17.5 18.5 19.5 20.5 22 23 24.5 25.5 27.5 29.5 30 33
30.
Pig Days 14 15 16 17 18 19 20.5 21.5 23 24 25.5 27.5 29 32.5
5
1.
Chicken Days 1 2 2.25 2.5 3 3.25 3.75 4.75 5.5 6.25 7.25 7.75 8.5 10
5

16. Genetics and Molecular biology are
applied in human development
 Ian Wilmut [1997]
Somatic cell nuclear transfer – Dolly lamb
 Embryonic stem cell

17. Somatic cell nuclear transfer

18. Embryonic stem cell
Morula Blastocyt
Stem cell

19. Anatomical position