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Surgical Complications And Bevacizumab

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Bevacizumab inhibits VEGF, compromising wound healing. Animal studies show it reduces vascular density in capillary beds by 70%. Surgical complications of bevacizumab include proteinuria, bleeding, and delayed wound healing. The risk is highest in the first 6 months and with conditions like peptic ulcers. For elective surgery, withhold bevacizumab for 2-3 half lives (40-60 days) but surgery may be safe after 28 days. Major surgery requires withholding bevacizumab and avoiding anastomoses.

Saúde e medicina
1 de 18
SURGICAL COMPLICATIONS AND BEVACIZUMAB PETER HEWETT MBBS FRACS
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Gordon M. Oncology 2005;69(suppl 3):25–33
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Scappaticci FA. Surgical wound healing complications in metastatic colorectal cancer patients treated with bevacizumab. J Surg Oncol 2005;91:173– 180
Elective Surgery ,[object Object],[object Object]
Minor surgery ,[object Object],[object Object],[object Object]
Major Surgery ,[object Object],[object Object],[object Object],[object Object],[object Object]
Surgical morbidity substudy ,[object Object],[object Object],[object Object],[object Object]
Perforation ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Grading of Perforation ,[object Object],[object Object],[object Object],[object Object],[object Object]
Wound Healing ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
 

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