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The Digestive System
    by mr. steven puerto, jr




                               Kang Maheso   1
Digestion
• Processing of food
• Types
   – Mechanical (physical)
      •   Chew
      •   Tear
      •   Grind
      •   Mash
      •   Mix
   – Chemical
      • Catabolic reactions
      • Enzymatic hydrolysis
           – Carbohydrate
           – Protein
           – Lipid             Kang Maheso
                                             2
Digestion
• Phases
  –   Ingestion
  –   Movement
  –   Digestion
  –   Absorption
  –   Further digestion



                          Kang Maheso
                                        3
Digestive System Organization

• Gastrointestinal (Gl) tract (Alimentary canal)
   – Tube within a tube
   – Direct link/path between organs
   – Structures
      •   Mouth
      •   Oral Cavity
      •   Pharynx
      •   Esophagus
      •   Stomach
      •   Duedenum
      •   Jejenum
      •   kIleum
      •   Cecum
      •   Ascending colon
                             Kang Maheso
      •   Transverse colon
                                                   4
Digestive System Organization
       •   Descending colon
       •   Sigmoid colon
       •   Rectum
       •   Anus
• Accessory structures
   – Not in tube path
   – Organs
       •   Teeth
       •   Tongue
       •   Salivary glands
       •   Liver
       •   Gall bladder
       •   Pancreas

                              Kang Maheso
                                            5
Anatomy of the Mouth and
        Throat




          Kang Maheso
                           6
Human Deciduous and
  Permanent Teeth




       Kang Maheso
                      7
Dorsal Surface of the Tongue




           Kang Maheso
                               8
The Major Salivary Glands




          Kang Maheso
                            9
Deglutition (swallowing)
• Sequence
   – Voluntary stage
       • Push food to back of
         mouth
   – Pharyngeal stage
       • Raise
           – Soft palate
           – Larynx + hyoid
           – Tongue to soft palate
   – Esophageal stage
       • Contract pharyngeal
         muscles
       • Open esophagus
       • Start peristalsis
                                 Kang Maheso
                                               10
Deglutition (swallowing)
• Control
   – Nerves
      • Glossopharyngeal
      • Vagus
      • Accessory
   – Brain stem
      • Deglutition center
            – Medulla oblongata
            – Pons
   – Disorders
      • Dysphagia
      • Aphagia


                                  Kang Maheso
                                                11
Esophagus
• Usually collapsed (closed)
• 3 constrictions
   – Aortic arch
   – Left primary bronchus
   – Diaphragm
• Surrounded by
   – SNS plexus
   – Blood vessels
• Functions
   – Secrete mucous
   – Transport food     Kang Maheso
                                      12
Peristalsis and Segmentation




           Kang Maheso
                               13
Esophagus
• Sphincters
  – Upper
  – Lower
• Abnormalities
  –   Achalasia
  –   Atresia
  –   Hernia
  –   Barret’s esophagus
  –   Esophageal varices
                           Kang Maheso
                                         14
Stomach
• Usually “J” shaped
• Left side, anterior to the spleen
• Mucous membrane
   – G cells – make gastrin
   – Goblet cells – make mucous
   – Gastric pit – Oxyntic gland – Parietal cells – Make
     HCl
   – Chief cells – Zymogenic cells
      • Pepsin
      • Gastric lipase

                          Kang Maheso
                                                           15
Anatomy of the Stomach




         Kang Maheso
                         16
Stomach
• 3 muscle layers
     – Oblique
     – Circular
     – Longitudinal
• Regions
     –   Cardiac sphincter
     –   Fundus
     –   Antrum (pylorus)
     –   Pyloric sphincter
• Vascular
• Inner surface thrown into
  folds – Rugae
•   Contains enzymes that workKang Maheso
    best at pH 1-2                          17
Stomach
• Functions                                – Absorbs
   – Mix food                                 •   Alcohol
   – Reservoir                                •   Water
   – Start digestion of
                                              •   Lipophilic acid
       • Protein
       • Nucleic acids
                                              •   B 12
       • Fats
   – Activates some enzymes
   – Destroy some bacteria
   – Makes intrinsic factor – B
     12 absorption
   – Destroys some bacteria

                             Kang Maheso
                                                                    18
Small Intestine
• Extends from pyloric
  sphincter  ileocecal
  valve
• Regions
   – Duodenum
   – Jejenum
   – Ileum
• Movements
   – Segmentation
   – Peristalsis


                          Kang Maheso
                                        19
Small Intestine
• Histology
  –   Intestinal glands – Intestinal enzymes
  –   Duodenal glands – Alkaline mucous
  –   Paneth cells – Lysozyme
  –   Microvilli
  –   Lacteals
  –   Plica circularis
  –   Smooth muscle
  –   Lymphatic tissue – GALT
  –   Vascular
                          Kang Maheso
                                               20
Small Intestine
• Absorbs                                    – Lipids
   –   80% ingested water                       •   Monoglycerides
   –   Electrolytes                             •   Fatty acids
   –   Vitamins                                 •   Micelles
   –   Minerals
                                                •   Chylomicrons
   –   Carbonates
        • Active/facilitated
          transport
        • Monosaccharides
   – Proteins
        • Di-/tripeptides
        • Amino acids


                               Kang Maheso
                                                                     21
Structure of the Villi in the
      Small Intestine




            Kang Maheso
                                22
Small Intestine
• Secretes digestive
  enzymes
   – Peptidases
        • Amino-
        • Di-
        • Tri-
   –   Sucrases
   –   Maltase
   –   Lactase
   –   Saccharidases
        • Di-
        • Tri-
   – Lipase
   – Nucleases          Kang Maheso
                                      23
Small Intestine
• Control
• Requires pancreatic
  enzymes & bile to
  complete digestion




                        Kang Maheso
                                      24
Large Intestine
• Extends from ileocecal valve to anus
• Regions
   – Cecum – Appendix
   – Colon
      • Ascending
      • Transverse
      • Descending
   – Rectum
   – Anal canal

                        Kang Maheso
                                         25
Anatomy of the Large Intestine




            Kang Maheso
                                 26
Large Intestine
• Histology
  – No villi
  – No permanent circular folds
  – Smooth muscle
     • Taeniae coli
     • Haustra
  – Epiploic appendages
  – Otherwise like rest of Gl tract
                      Kang Maheso
                                      27
Large Intestine
• Functions
  – Mechanical digestion             – Absorbs
     • Haustral churning                 •More water
     • Peristalsis                       •Vitamins
                                            –B
     • Reflexes
                                            –K
         – Gastroileal
         – Gastrocolic               – Concentrate/eliminate
                                     wastes
  – Chemical digestion –
    Bacterial digestion
     • Ferment carbohydrates
     • Protein/amino acid
       breakdown
                           Kang Maheso
                                                               28
Feces Formation and Defecation
• Chyme dehydrated to                   • Control
  form feces
                                               – Parasympathetic
• Feces composition
   –   Water                                   – Voluntary
   –   Inorganic salts
   –   Epithelial cells
   –   Bacteria
   –   Byproducts of digestion
• Defecation
   – Peristalsis pushes feces
     into rectum
   – Rectal walls stretch
                                 Kang Maheso
                                                                   29
Liver
• Location
   – R. Hypochondrium
   – Epigastric region
• 4 Lobes
   –   Left
   –   Quadrate
   –   Caudate
   –   Right
• Each lobe has lobules – Contains hepatocytes –
  Surround sinusoids – Feed into central vein
                         Kang Maheso
                                                   30
Liver
• Functions
   – Makes bile
      • Detergent – emulsifies
        fats
      • Release promoted by:
          – Vagus n.
          – CCK
          – Secretin
      • Contains
          –   Water
          –   Bile salts
          –   Bile pigments
          –   Electrolytes
          –   Cholesterol
          –   Lecithin
                                 Kang Maheso
                                               31
Liver
– Detoxifies/removes
     • Drugs
     • Alcohol
– Stores
     •   Gycolgen
     •   Vitamins (A, D, E, K)
     •   Fe and other minerals
     •   Cholesterol
–   Activates vitamin D
–   Fetal RBC production
–   Phagocytosis
–   Metabolizes absorbed food
    molecules
     • Carbohydrates
     • Proteins                  Kang Maheso
     • Lipids                                  32
Liver
• Dual blood supply
  – Hepatic portal vein
     • Direct input from small
       intestine
  – Hepatic artery/vein
     • Direct links to heart




                               Kang Maheso
                                             33
The Duodenum and Related
        Organs




          Kang Maheso
                           34
The Organs and Positions in the
      Abdominal Cavity




                           Kang Maheso
                                   35
Structures of the Alimentary
           Canal




           Kang Maheso
                               36
Matur Nuwun
• Sing gelem sinau mesti pinter lan ngerti.
  Sing ngerti bakal begja lan luhur
  wekasane.
• Banda donya sing ora bisa dicolong lan
  ilang yaiku ngelmu lan pangerten.




                    Kang Maheso
                                              37

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Digestivesystem

  • 1. The Digestive System by mr. steven puerto, jr Kang Maheso 1
  • 2. Digestion • Processing of food • Types – Mechanical (physical) • Chew • Tear • Grind • Mash • Mix – Chemical • Catabolic reactions • Enzymatic hydrolysis – Carbohydrate – Protein – Lipid Kang Maheso 2
  • 3. Digestion • Phases – Ingestion – Movement – Digestion – Absorption – Further digestion Kang Maheso 3
  • 4. Digestive System Organization • Gastrointestinal (Gl) tract (Alimentary canal) – Tube within a tube – Direct link/path between organs – Structures • Mouth • Oral Cavity • Pharynx • Esophagus • Stomach • Duedenum • Jejenum • kIleum • Cecum • Ascending colon Kang Maheso • Transverse colon 4
  • 5. Digestive System Organization • Descending colon • Sigmoid colon • Rectum • Anus • Accessory structures – Not in tube path – Organs • Teeth • Tongue • Salivary glands • Liver • Gall bladder • Pancreas Kang Maheso 5
  • 6. Anatomy of the Mouth and Throat Kang Maheso 6
  • 7. Human Deciduous and Permanent Teeth Kang Maheso 7
  • 8. Dorsal Surface of the Tongue Kang Maheso 8
  • 9. The Major Salivary Glands Kang Maheso 9
  • 10. Deglutition (swallowing) • Sequence – Voluntary stage • Push food to back of mouth – Pharyngeal stage • Raise – Soft palate – Larynx + hyoid – Tongue to soft palate – Esophageal stage • Contract pharyngeal muscles • Open esophagus • Start peristalsis Kang Maheso 10
  • 11. Deglutition (swallowing) • Control – Nerves • Glossopharyngeal • Vagus • Accessory – Brain stem • Deglutition center – Medulla oblongata – Pons – Disorders • Dysphagia • Aphagia Kang Maheso 11
  • 12. Esophagus • Usually collapsed (closed) • 3 constrictions – Aortic arch – Left primary bronchus – Diaphragm • Surrounded by – SNS plexus – Blood vessels • Functions – Secrete mucous – Transport food Kang Maheso 12
  • 14. Esophagus • Sphincters – Upper – Lower • Abnormalities – Achalasia – Atresia – Hernia – Barret’s esophagus – Esophageal varices Kang Maheso 14
  • 15. Stomach • Usually “J” shaped • Left side, anterior to the spleen • Mucous membrane – G cells – make gastrin – Goblet cells – make mucous – Gastric pit – Oxyntic gland – Parietal cells – Make HCl – Chief cells – Zymogenic cells • Pepsin • Gastric lipase Kang Maheso 15
  • 16. Anatomy of the Stomach Kang Maheso 16
  • 17. Stomach • 3 muscle layers – Oblique – Circular – Longitudinal • Regions – Cardiac sphincter – Fundus – Antrum (pylorus) – Pyloric sphincter • Vascular • Inner surface thrown into folds – Rugae • Contains enzymes that workKang Maheso best at pH 1-2 17
  • 18. Stomach • Functions – Absorbs – Mix food • Alcohol – Reservoir • Water – Start digestion of • Lipophilic acid • Protein • Nucleic acids • B 12 • Fats – Activates some enzymes – Destroy some bacteria – Makes intrinsic factor – B 12 absorption – Destroys some bacteria Kang Maheso 18
  • 19. Small Intestine • Extends from pyloric sphincter  ileocecal valve • Regions – Duodenum – Jejenum – Ileum • Movements – Segmentation – Peristalsis Kang Maheso 19
  • 20. Small Intestine • Histology – Intestinal glands – Intestinal enzymes – Duodenal glands – Alkaline mucous – Paneth cells – Lysozyme – Microvilli – Lacteals – Plica circularis – Smooth muscle – Lymphatic tissue – GALT – Vascular Kang Maheso 20
  • 21. Small Intestine • Absorbs – Lipids – 80% ingested water • Monoglycerides – Electrolytes • Fatty acids – Vitamins • Micelles – Minerals • Chylomicrons – Carbonates • Active/facilitated transport • Monosaccharides – Proteins • Di-/tripeptides • Amino acids Kang Maheso 21
  • 22. Structure of the Villi in the Small Intestine Kang Maheso 22
  • 23. Small Intestine • Secretes digestive enzymes – Peptidases • Amino- • Di- • Tri- – Sucrases – Maltase – Lactase – Saccharidases • Di- • Tri- – Lipase – Nucleases Kang Maheso 23
  • 24. Small Intestine • Control • Requires pancreatic enzymes & bile to complete digestion Kang Maheso 24
  • 25. Large Intestine • Extends from ileocecal valve to anus • Regions – Cecum – Appendix – Colon • Ascending • Transverse • Descending – Rectum – Anal canal Kang Maheso 25
  • 26. Anatomy of the Large Intestine Kang Maheso 26
  • 27. Large Intestine • Histology – No villi – No permanent circular folds – Smooth muscle • Taeniae coli • Haustra – Epiploic appendages – Otherwise like rest of Gl tract Kang Maheso 27
  • 28. Large Intestine • Functions – Mechanical digestion – Absorbs • Haustral churning •More water • Peristalsis •Vitamins –B • Reflexes –K – Gastroileal – Gastrocolic – Concentrate/eliminate wastes – Chemical digestion – Bacterial digestion • Ferment carbohydrates • Protein/amino acid breakdown Kang Maheso 28
  • 29. Feces Formation and Defecation • Chyme dehydrated to • Control form feces – Parasympathetic • Feces composition – Water – Voluntary – Inorganic salts – Epithelial cells – Bacteria – Byproducts of digestion • Defecation – Peristalsis pushes feces into rectum – Rectal walls stretch Kang Maheso 29
  • 30. Liver • Location – R. Hypochondrium – Epigastric region • 4 Lobes – Left – Quadrate – Caudate – Right • Each lobe has lobules – Contains hepatocytes – Surround sinusoids – Feed into central vein Kang Maheso 30
  • 31. Liver • Functions – Makes bile • Detergent – emulsifies fats • Release promoted by: – Vagus n. – CCK – Secretin • Contains – Water – Bile salts – Bile pigments – Electrolytes – Cholesterol – Lecithin Kang Maheso 31
  • 32. Liver – Detoxifies/removes • Drugs • Alcohol – Stores • Gycolgen • Vitamins (A, D, E, K) • Fe and other minerals • Cholesterol – Activates vitamin D – Fetal RBC production – Phagocytosis – Metabolizes absorbed food molecules • Carbohydrates • Proteins Kang Maheso • Lipids 32
  • 33. Liver • Dual blood supply – Hepatic portal vein • Direct input from small intestine – Hepatic artery/vein • Direct links to heart Kang Maheso 33
  • 34. The Duodenum and Related Organs Kang Maheso 34
  • 35. The Organs and Positions in the Abdominal Cavity Kang Maheso 35
  • 36. Structures of the Alimentary Canal Kang Maheso 36
  • 37. Matur Nuwun • Sing gelem sinau mesti pinter lan ngerti. Sing ngerti bakal begja lan luhur wekasane. • Banda donya sing ora bisa dicolong lan ilang yaiku ngelmu lan pangerten. Kang Maheso 37