16. Pathology:
. Marked thickening of bone cortices and trabeculae
with marked narrowing of marrow spaces
. Narrowing of neural foramina with compression of
exiting nerves
17. Defect in CBFA1 gene
Absent of clavicles
Craniofacial malformasion
Wormian bone of skull
Cleft palate
Failure of eruption of permanent
teeth
Supernumerary teeth
Mandibular prognathism
Lack of secondary cementum
41. Aneurysmal bone cyst
Rare in jaws
Jaw lesions are usually in the mandibular ramus and angle
Affect patients usually between 10 and 20 years
Are of unknown etiology
Form very expansile soap-bubble radiolucencies which may be
mistaken clinically and radiografically for ameloblastoma
Histologically consist of a mass of blood-filled spaces with
scattered giant cells (blood – soaked spongy )
Are treated by curettage but sometimes recure
64. Benign, second decade; males (3:1)
Painful (high prostaglandin levels in
lesion)
Central nidus of vascular spaces
surrounded by interlacing reactive
trabecular bone.
Therapy - Resection of nidus - bone graft.
68. Clinically similar to osteoid osteoma (large)
Common location -- vertebral column
Histology similar – but rare nidus
Can be locally aggressive
Therapy - curettage/resection with bone
graft
73. Osteomas are benign tumors composed of mature compact
or cancellous bone
Osteomas are essentially restricted to the craniofacial skeleton
The common palatal and mandibular tori and buccal exostoses
periosteal osteoma, or endosteal osteoma
detected in young adults and are generally asymptomatic,
solitary lesions
74. Histopathologic Features:
Compact osteomas are composed of normal-
appearing dense bone showing minimal marrow
tissue
Cancellous osteomas are composed of
trabeculae of bone and fibrofatty marrow.
Osteoblastic activity may be fairly prominent
83. resorption of the roots of teeth involved by the tumor(spiking"
resorption)
84. Histopathologic Features
direct production of osteoid by malignant mesenchymal
Cells
♦ Osteoblastic
♦ Chondroblastic
♦ Fibroblastic
Chondroblastic osteosarcomas constitute a substantial
proportion of all osteosarcomas of the jaws
90. CHONDROSARCOMA
Chondrosarcoma is a malignant tumor characterized by the formation of
cartilage, but not bone, by the tumor Cells
Clinical and Radiographic Findings:
chondrosarcoma is primarily a neoplasm of adulthood(6-7decay)
Chondrosarcomas arise most frequently in the maxilla
A painless mass or swelling is the most common presenting
Sign
Radiographically, the tumor usually shows features suggestive of a
malignancy, consisting of a radiolucent process with poorly defined
borders
Root resorption or symmetric widening of the periodontal ligament
space of the teeth involved by the tumor also may be noted
92. Histopathologic Features
Chondrosarcomas are composed of cartilage showing
varying degrees of maturation and cellularity
Typical lacunar formation within the chondroid
matrix is visible, although this feature may be scarce in
poorly differentiated tumors
The tumor often shows a lobular growth pattern, with tumor
lobules
separated by thin
fibrous connective
tissue septa