2. What Is stridor?
• high-pitched, monophonic sound made when breathing that is best heard
over the anterior neck.
• In all cases, stridor should be differentiated from stertor, which is a lower-
pitched, snoring-type sound generated at the level of the nasopharynx,
oropharynx, and, occasionally, supraglottis.
• Stridor is caused by the oscillation of a narrowed airway, and its presence
suggests significant obstruction of the large airways
3.
4. What is croup?
• The term croup has been used to describe a variety of upper respiratory
conditions in children, including laryngitis, laryngotracheitis,
laryngotracheobronchitis, bacterial tracheitis, or spasmodic croup.
5. Laryngotracheitis (croup)
• It’s an inflammation of the larynx and trachea, it’s characterized by
inspiratory stridor, barking cough, and hoarseness.
• Croup most commonly occurs in children 6 to 36 months of age.
• It is more common in boys, with a male:female ratio of approximately 1.4:1
• Family history of croup is a risk factor for croup and recurrent croup
6. Causes
• Parainfluenza virus type 1 is the most common cause of acute
laryngotracheitis, especially the fall and winter epidemics
• Parainfluenza type 2 sometimes causes croup outbreaks, but usually with
milder disease than type 1.
• Parainfluenza type 3 causes sporadic cases of croup that often are more
severe than those due to types 1 and 2.
• infection caused by parainfluenza virus type 4 is less likely to be associated
with stridor and croup in children.
7. Causes
• Measles
• Influenza virus
• Rhinoviruses, enteroviruses (especially Coxsackie types A9, B4, and B5, and
echovirus types 4, 11, and 21), and herpes simplex virus are occasional causes of
sporadic cases of croup that are usually mild.
• Metapneumoviruses cause primarily lower respiratory tract disease similar to RSV
• Human coronavirus NL63 (HCoV-NL63), first identified in 2004, has been
implicated in croup and other respiratory illnesses
• RSV and adenoviruses are relatively frequent causes of croup.
8. Causes
• Croup also may be caused by bacteria.
• Mycoplasma pneumoniae has been associated with mild cases of croup.
• secondary bacterial infection may occur in children with laryngotracheitis,
laryngotracheobronchitis, or laryngotracheobronchopneumonitis.
• The most common secondary bacterial pathogens include Staphylococcus
aureus, Streptococcus pyogenes, and Streptococcus pneumoniae
9. Clinical features
• The onset of symptoms is usually gradual, beginning with nasal discharge,
congestion, and coryza.
• Symptoms generally progress over 12 to 48 hours to include fever,
hoarseness, barking cough, and stridor.
• Respiratory distress increases as upper airway obstruction becomes more
severe.
• Cough usually resolves within three days; other symptoms may persist for
seven days with a gradual return to normal.
10. Clinical features
• In mild cases, the child is hoarse and has nasal congestion. There is minimal,
if any, pharyngitis.
• As airway obstruction progresses, stridor develops, and there may be mild
tachypnea with a prolonged inspiratory phase.
• The presence of stridor is a key element in the assessment of severity.
• Biphasic stridor at rest is a sign of significant upper airway obstruction.
11. Clinical features
• When airway obstruction becomes severe, suprasternal, subcostal, and
intercostal retractions may be seen. Breath sounds can be diminished.
• Hypoxia and cyanosis can develop, as can respiratory fatigue from sustained
increased respiratory effort. High respiratory rates also tend to correlate with
the presence of hypoxia.
12. History
• Fever – The absence of fever from onset of symptoms to the time of presentation is suggestive of spasmodic croup or
a noninfectious etiology (eg, subglottic cyst, subglottic hemangioma).
• Barking cough – The classic physical finding in a patient with subglottic narrowing is a barky seal-like cough.
• Hoarseness – Hoarseness may be present in croup, particularly in older children, whereas hoarseness is not a typical
finding in epiglottitis or foreign body aspiration.
• Difficulty swallowing – Difficulty swallowing may occur in acute epiglottitis. Rarely, a large, ingested foreign body may
lodge in the upper esophagus, where it distorts and narrows the upper trachea, thus mimicking the croup syndrome
(including barking cough and inspiratory stridor).
• Drooling – Drooling may occur in children with peritonsillar or retropharyngeal abscesses, retropharyngeal cellulitis,
and epiglottitis. In an observational study, drooling was present in approximately 80 percent of children with epiglottitis,
but only 10 percent of those with croup
• Throat pain – Complaints of dysphagia and sore throat are more common in children with epiglottitis than croup
(approximately 60 to 70 percent versus <10 percent)
13. Physical examination
• Overall appearance
• Quality of the voice
• A muffled "hot potato" voice is suggestive of epiglottitis, retropharyngeal abscess, or peritonsillar abscess.
• Degree of respiratory distress
• Lung examination – Are there abnormal respiratory sounds during inspiration or expiration?
Inspiratory stridor indicates upper airway obstruction, whereas expiratory wheezing is a sign of lower
airway obstruction. If there is stridor, is it present at rest or only with agitation?. The presence of
crackles (rales) also suggests lower respiratory tract involvement (eg, laryngotracheobronchitis,
laryngotracheobronchopneumonitis, or bacterial tracheitis).
• Assessment of hydration status.
14. Components of the examination that are useful in
distinguishing croup from other causes of acute
upper airway obstruction
• Preferred posture
• Examination of the oropharynx for the following signs:
• Cherry red, swollen epiglottis, suggestive of epiglottitis.
• Pharyngitis, typically minimal in laryngotracheitis, may be more pronounced in epiglottitis or laryngitis.
• Excessive salivation, suggestive of acute epiglottitis, peritonsillar abscess, parapharyngeal abscess or retropharyngeal abscess.
• Tonsillar asymmetry or deviation of the uvula suggestive of peritonsillar abscess.
• Midline or unilateral swelling of the posterior pharyngeal wall suggestive of retropharyngeal abscess.
• Examination of the cervical lymph nodes, which can be enlarged in patients with retropharyngeal or peritonsillar abscesses.
• Other physical findings may be present, depending on the particular inciting virus. As an example, rash, conjunctivitis,
exudative pharyngitis, and adenopathy are suggestive of adenovirus infection.
• Otitis media (acute or with effusion) may be present as a primary viral or secondary bacterial process.
15. **Concerns have been raised about safety of examining the pharynx in children
with upper airway obstruction and possible epiglottitis since such efforts have
been reported to precipitate cardiorespiratory arrest. However, in two series,
each including more than 200 patients with epiglottitis or viral croup, direct
examination of the oropharynx was not associated with sudden clinical
deterioration
16. Westley croup severity score
Clinical feature Assigned score
Level of consciousness
Normal, including sleep = 0
Disoriented = 5
Cyanosis
None = 0
With agitation = 4
At rest = 5
Stridor
None = 0
With agitation = 1
At rest = 2
Air entry
Normal = 0
Decreased = 1
Markedly decreased = 2
Retractions
None = 0
Mild = 1
Moderate = 2
Severe = 3
17. Score Severity Description Management
≤2 Mild
Occasional barky cough, no stridor at rest,
mild or no retractions
Home treatment: Symptomatic care
including antipyretics, mist, and oral fluids
Outpatient treatment: Single dose of oral
dexamethasone 0.6 mg/kg (maximum 10
mg)*
3 to 7 Moderate
Frequent barky cough, stridor at rest, and
mild to moderate retractions, but no or little
distress or agitation
Single dose of oral dexamethasone 0.6
mg/kg (maximum 10 mg)*
Nebulized epinephrine
¶
Hospitalization is generally not needed, but
may be warranted for persistent or worsening
symptoms after treatment with
glucocorticoid and nebulized epinephrine
8 to 11 Severe
Frequent barky cough, stridor at rest, marked
retractions, significant distress and agitation
Single dose of oral/IM/IV dexamethasone
0.6 mg/kg (maximum 10 mg)*
Repeated doses of nebulized
epinephrine
¶
may be needed
Inpatient admission is generally required
unless marked improvement occurs after
treatment with glucocorticoid and nebulized
epinephrine
≥12 Impending respiratory failure
Depressed level of consciousness, stridor at
rest, severe retractions, poor air entry,
cyanosis or pallor
Single dose of IM/IV dexamethasone 0.6
mg/kg (maximum 10 mg)*
Repeated doses of nebulized
epinephrine
¶
may be needed
Intensive care unit admission is generally
required
Consultation with anesthesiologist or ENT
surgeon may be warranted to arrange for
intubation in a controlled setting
18. Imaging
• In children with croup, a posterior-anterior chest radiograph demonstrates
subglottic narrowing, commonly called the "steeple sign". The lateral view may
demonstrate overdistention of the hypopharynx during inspiration and subglottic
haziness .The epiglottis should have a normal appearance.
• In contrast, the lateral radiograph in virtually all children with epiglottitis
demonstrates swelling of the epiglottis, sometimes called the "thumb sign"
• The lateral radiograph in children with bacterial tracheitis may demonstrate only
nonspecific edema or intraluminal membranes and irregularities of the tracheal wall
19.
20. Laboratory study
• Laboratory studies, which are rarely indicated in children with croup, are of limited
diagnostic utility, but may help guide management in more severe cases.
• Blood tests
• WBC count can be low, normal, or elevated; WBC counts >10,000 cells/microL are common.
Neutrophil or lymphocyte predominance may be present on the differential. The presence of a large
number of band-form neutrophils is suggestive of primary or secondary bacterial infection. Croup is
not associated with any specific alterations in serum chemistries.
• Microbiology
• Confirmation of etiologic diagnosis is not necessary for most children with croup, since croup is a self-
limited illness that usually requires only symptomatic therapy. When an etiologic diagnosis is necessary,
viral culture and/or rapid diagnostic tests that detect viral antigens are performed on secretions from
the nasopharynx or throat.
21.
22.
23. Differential diagnosis
• Acute epiglottitis
• rare in the era of vaccination against Haemophilus
influenzae type b, is distinguished from croup by the
absence of barking cough and the presence of anxiety
that is out of proportion to the degree of respiratory
distress. Onset of symptoms is rapid, and because of the
associated bacteremia, the child is highly febrile, pale,
toxic, and ill-appearing. Because of the swollen epiglottis,
the child will have difficulty swallowing and is often
drooling. The children usually prefer to sit up and seldom
have observed cough.
24. Differential diagnosis – acute epiglottitis
• Maintenance of the airway is the first priority for patients with epiglottitis.
• For patients who are not maintaining their airway as indicated by drooling, "sniffing", or "tripod" posture , and severe
respiratory distress, the physician should first proceed with bag-valve-mask (BVM) ventilation with 100 percent oxygen.
• children younger than six years of age with epiglottitis undergo endotracheal intubation as described for oxygenating
patients who cannot maintain their airway
• empiric combination therapy with a third-generation cephalosporin (eg, ceftriaxone or cefotaxime) AND an
antistaphylococcal agent (eg, vancomycin or as determined by the local prevalence and sensitivities of MRSA isolates)
• Bronchodilators and parenteral glucocorticoids have both been used as adjunctive treatments for patients with epiglottitis,
but these agents are not routinely necessary
• All patients with epiglottitis should be monitored in an intensive care unit.
• Intubation for two to three days is usually necessary before extubation can be safely accomplished
25. Differential diagnosis
• Bacterial tracheitis
• Bacterial tracheitis may present as a primary or secondary infection.
• In primary infection, there is acute onset of symptoms of upper airway obstruction with fever and toxic appearance.
• In secondary infection, there is marked worsening during the clinical course of viral laryngotracheitis, with high fever, toxic
appearance, and increasing respiratory distress secondary to tracheal obstruction from purulent secretions.
• In both of these presentations, signs of lower airway disease, such as crackles and wheezes, may be present. However, the upper
airway obstruction is the more clinically significant manifestation
• generally occurs during the first six years of life but may occur at any age.
• Although uncommon, it is among the most frequent pediatric airway emergencies requiring admission to an ICU.
• The cornerstones of treatment for bacterial tracheitis are maintenance of the airway, fluid resuscitation (if needed), and
administration of appropriate antimicrobial agents. Some children require emergent or urgent evaluation of the airway via
endoscopy. This procedure generally is best performed in the operating room, intensive care unit, or equivalent setting
26. Suggested intravenous antimicrobial
treatment regimens for bacterial tracheitis
in children
For patients without hypersensitivity to penicillin or cephalosporin
Vancomycin*
¶
OR
40 to 60 mg/kg per day in three to four divided doses
Maximum daily dose 4 g
Clindamycin
40 mg/kg per day in three divided doses
Maximum daily dose 2.7 g
PLUS
Ceftriaxone
Δ
OR
50 to 100 mg/kg per day once daily or in two divided doses
Maximum daily dose 2 g
Cefotaxime
¶Δ
OR
150 to 200 mg/kg per day in four divided doses
Maximum daily dose 10 g
Ampicillin-sulbactam
¶ 150 to 200 mg/kg (of ampicillin component) per day in four divided doses
Maximum daily dose 8 g
27.
28. Differential diagnosis
• Retropharyngeal abscess
• Most retropharyngeal abscesses occur in children between two and four years of age.
• Early in the disease process, the findings may be indistinguishable from those of uncomplicated
pharyngitis. As the disease progresses, symptoms include fever, dysphagia and drooling, unwillingness
to move neck, muffled or "hot potato" voice, and inspiratory stridor.
• Peritonsillar abscess
• Peritonsillar abscess generally arises as a complication of tonsillitis or pharyngitis. Its incidence peaks in
children older than 10 years of age, when streptococcal pharyngitis becomes more common.
• The typical clinical presentation is a severe sore throat (usually unilateral), fever, muffled or "hot
potato" voice, sometimes with inspiratory stridor, drooling, trismus, or neck swelling
29. • Foreign body aspiration
• If an inhaled foreign body lodges in the larynx, it will produce hoarseness and stridor.
If a large foreign body is swallowed, it may lodge in the upper esophagus, resulting in
distortion of the adjacent soft extrathoracic trachea, producing a barking cough and
inspiratory stridor. Ingestion of a non-obstructive but subsequently erosive foreign
bodies such as a button battery may produce stridor more remote from the time of
ingestion that persist or recur.
30. Outpatient management
• children with mild croup who are seen in the outpatient setting be treated
with a single dose of oral dexamethasone (0.15 to 0.6 mg/kg, maximum dose
10 mg)
• Treatment with nebulized epinephrine is not typically necessary for
management of mild croup.
• Children with mild croup who are tolerating fluids and have not received
nebulized epinephrine can be sent home after specific follow-up
31. Home treatment
• The caregivers of children with mild croup who are managed at home should be instructed
in provision of supportive care including mist, antipyretics, and encouragement of fluid
intake.
• In acute situations and for short periods of time, caregivers may try sitting with the child in
a bathroom filled with steam generated by running hot water from the shower to improve
symptoms. This may help reassure parents that "something" is being done to reverse the
symptoms, and anecdotal evidence supports some benefit with this measure.
• Exposure to cold night air also may lessen symptoms of mild croup, although this has never
been systematically studied. If parents or caregivers wish to use humidifiers at home, only
those that produce mist at room temperature should be used to avoid the risk of burns from
steam or the heating element.
32. Management of moderate-severe croup
• administration of dexamethasone (0.6 mg/kg, maximum of 10 mg) in all
children with moderate to severe croup.
• Dexamethasone should be administered by the least invasive route possible
• The oral preparation of dexamethasone (1 mg/mL) has an unpleasant taste.
The IV preparation is more concentrated (4 mg per mL) and can be given
orally mixed with syrup.
• A single dose of nebulized budesonide (2 mg [2 mL solution] via nebulizer)
is an alternative option, particularly for children who are vomiting
33. Management of moderate-severe croup
• In addition to dexamethasone, it’s recommended to use nebulized epinephrine in all
patients with moderate to severe croup:
• Racemic epinephrine is administered as 0.05 mL/kg per dose (maximum of 0.5 mL) of a
2.25 percent solution diluted to 3 mL total volume with normal saline. It is given via
nebulizer over 15 minutes.
• L-epinephrine is administered as 0.5 mL/kg per dose (maximum of 5 mL) of a 1:1000
dilution. It is given via nebulizer over 15 minutes.
• Patients should be observed for three to four hours after initial treatment. The need
for additional intervention and/or admission to the hospital is determined chiefly by
the response to therapy with corticosteroids and nebulized epinephrine.
34. Inpatient management
Respiratory care — Respiratory support for children hospitalized with croup may include the
following:
• Nebulized epinephrine − Repeated doses of nebulized epinephrine may be warranted for children
with moderate to severe distress. It is not always required; one study of 365 hospitalizations for
croup found that only 49 percent required additional nebulized epinephrine during the inpatient stay
. Nebulized epinephrine can be repeated every 15 to 20 minutes. However, children who require
frequent doses of epinephrine (eg, more frequently than every one to two hours) should
be admitted/transferred to an intensive care unit for close cardiopulmonary monitoring.
• Supplemental oxygen − Oxygen should be administered to children who are hypoxemic (oxygen
saturation of <92 percent in room air). Supplemental oxygen should be humidified to decrease
drying effects on the airways, since drying may impede the physiologic removal of airway secretions
via mucociliary and cough mechanisms.
35. Inpatient management
• Heliox − Heliox is a mixture of helium (70 to 80 percent) and oxygen (20 to 30 percent). Heliox may decrease the work of
breathing in children with croup by reducing turbulent airflow. A meta-analysis of three trials concluded that while there is
evidence to suggest a short-term benefit of heliox, a larger trial is needed before recommendations regarding the use of heliox in
children with croup can be made . While the evidence from these trials does not suggest a large benefit from Heliox to support its
routine use in the management of croup, in patients with severe symptoms who are at risk for respiratory failure, it may be used
in an attempt to avoid the need for intubation. An important limitation of heliox use is the low fractional concentration of
inspired oxygen (FiO2) in the gas mixture, which may not be adequate for children with hypoxia.
• Intubation − The need for intubation should be anticipated in children with progressive respiratory failure so that the procedure
can be performed in a controlled setting if possible. Intubation can be challenging due to the narrowed subglottic airway and
should be performed with the assistance of a skilled provider (ie, an anesthesiologist or otolaryngologist). Neuromuscular
blocking agents should be avoided unless the ability to provide bag-mask ventilation has been demonstrated. An endotracheal
tube that is 0.5 to 1 mm smaller than would typically be used should be placed
• Endotracheal intubation is rarely required for management of croup. In a large study at one institution, less than 1 percent of
children admitted to the hospital for croup required intubation
36. Inpatient management
• Mist − Humidified air is frequently used in the treatment of croup, although a
meta-analysis of three trials evaluating the use of humidified air in croup found only
marginal improvement in croup scores. Mist therapy may provide a sense of
comfort and reassurance to both the child and family; however, if the child is
instead agitated by the mist, it should be discontinued.
• Infection control — Children who are admitted to the hospital with croup should
be managed with contact precautions (ie, gown and gloves for contact), particularly
if parainfluenza or respiratory syncytial virus is the suspected etiology. If influenza
is suspected, droplet isolation measures (ie, respiratory mask within three feet) also
should be followed.
37. Discharge criteria
• No stridor at rest
• Normal pulse oximetry in room air
• Good air exchange
• Normal color
• Normal level of consciousness
• Demonstrated ability to tolerate fluids by mouth
** Symptoms of croup resolve in most children within three days, but may persist for up to one
week. Approximately 8 to 15 percent of children with croup require hospital admission, and among
those, less than 1 percent require intubation. Mortality is rare, occurring in <0.5 percent of
intubated children
38.
39. Complications
• Complications of croup are uncommon.
• Children with moderate to severe croup are at risk for hypoxemia (oxygen saturation <92 percent
in room air) and respiratory failure.
• Other complications include pulmonary edema, pneumothorax, and pneumomediastinum. These
complications can be anticipated and managed by aggressive monitoring and intervention in the
medical setting. Out-of-hospital cardiac arrest and death also have been reported.
• Secondary bacterial infections may arise from croup. Bacterial tracheitis, bronchopneumonia, and
pneumonia occur in a small number of patients. In most instances, the child has been relatively
stable or beginning to improve after several days of illness, but then suddenly worsens, with
higher or recurrent fever, increased (and potentially productive) cough, and/or respiratory
distress.
40. Laryngotracheobronchitis (LTB)
• LTB occurs when inflammation extends into the bronchi, resulting in lower airway
signs (eg, wheezing, crackles, air trapping, increased tachypnea) and sometimes more
severe illness than laryngotracheitis alone.
• This term commonly is used interchangeably with laryngotracheitis, and the entities
are often indistinct clinically.
• Further extension of inflammation into the lower airways results in
laryngotracheobronchopneumonitis, which sometimes can be complicated by
bacterial superinfection.
• Bacterial superinfection can be manifest as pneumonia, bronchopneumonia, or
bacterial tracheitis.
41. • Spasmodic croup
• Spasmodic croup is characterized by the sudden onset of inspiratory stridor at night, short duration
(several hours), and sudden cessation
• This is often in the setting of a mild upper respiratory infection, but without fever or inflammation.
• Although the initial presentation can be dramatic, the clinical course is usually benign. Symptoms are
almost always relieved by comforting the anxious child and administering humidified air. Rarely,
children may benefit from treatment with corticosteroids and/or nebulized epinephrine
• Laryngitis
• Laryngitis refers to inflammation limited to the larynx and manifests itself as hoarseness. It usually
occurs in older children and adults and, similar to croup, is frequently caused by a viral infection
Inspiratory stridor suggests a laryngeal obstruction
Expiratory stridor implies tracheobronchial obstruction
Biphasic stridor suggests a subglottic or glottic anomaly
Acute or subacute onset
Supraglottic area – This area includes the nasopharynx, epiglottis, larynx, aryepiglottic folds, and false vocal cords. The walls supporting this region are made of soft tissue and muscles, and lack cartilaginous support. Therefore, airway collapse and obstruction can occur easily and progress rapidly in this area.
●Glottic and subglottic area – This portion of the airway extends from the vocal cords to the extrathoracic segment of the trachea, just before it enters the thoracic cavity. The glottic area has some cartilaginous support (ie, cricoid cartilage and incomplete tracheal rings), which makes it less vulnerable to collapse than the supraglottic area. The subglottis, surrounded by the cricoid cartilage, is the narrowest part of the trachea. The diameter of the subglottis is 5 to 7 mm at birth and steadily increases to an average diameter on 20 mm in adults. In the narrow airway of an infant, a small decrease in diameter dramatically increases the airway resistance (because resistance is inversely proportional to the radius to the fourth power [r4]). As an example, a narrowing by 1 mm in the subglottic area in an infant will decrease the cross-sectional area by approximately 50 percent [2] and increase airway resistance 16-fold [3].
Intrathoracic obstruction — The intrathoracic region includes the portion of the trachea that lies within the thoracic cavity, as well as the mainstem bronchi. Compression of the proximal trachea can result in expiratory stridor, whereas compression of the more distal intrathoracic airways tends to cause typical polyphonic wheezing rather than stridor. Congenital disorders are a prominent cause of obstruction at this level (eg, vascular rings and webs) [4]. Foreign bodies and compression by enlarged lymph nodes or tumors can also occur at this level
It is seen in younger infants (as young as three months) and in preschool children, but it is uncommon in children >6 years old
. However, children hospitalized with influenzal croup tend to have longer hospitalization and greater risk of readmission for relapse of laryngeal symptoms than those with parainfluenzal croup.
The laryngotracheal component of disease is usually less significant than that of the lower airways
Deviation from this expected course should prompt consideration of diagnoses other than laryngotracheitis.
If stridor is more significant while the patient is awake, and even more pronounced during exercise or agitation, then the possibility of vocal cord dysfunction or other laryngeal, tracheal, or bronchial obstruction should be suspected.
Alteration in mental status (lethargy, anxiety) with increased work of breathing can point to an impending airway obstruction.
Drooling and a muffled voice usually suggest that the obstruction is supraglottic, including retropharyngeal abscess and epiglottitis. Drooling and dysphagia can occur with epiglottis, a foreign body in the trachea, or a mass compressing the anterior esophageal wall.
– A barking cough is almost always present in laryngotracheitis (croup), and typically absent in children with acute epiglottitis, foreign body aspiration, and anaphylaxis.
A change in the voice tone (hoarseness or pitch) suggests a laryngeal lesion such as vocal cord injury due to inflammation (eg, croup) or paralysis [26]. A muffled voice suggests supraglottic obstruction, such as in retropharyngeal or peritonsillar abscess or epiglottitis.
– Respiratory distress and stridor related to feeding can be caused by aspiration either secondary to swallowing dysfunction, certain types of tracheoesophageal fistula, or gastroesophageal reflux.
– Presence of rash, hypotension, and wheezing with acute onset of stridor indicates an allergic reaction with angioedema.
– If a patient develops airway obstructive episodes during sleep, it is most likely that the origin of the stridor arises from the pharynx, in which case, the tonsils and adenoids should be evaluated. Spasmodic croup also tends to present episodically during sleep
– If stridor is more significant while the patient is awake, and even more pronounced during exercise or agitation, then the possibility of vocal cord dysfunction or other laryngeal, tracheal, or bronchial obstruction should be suspected.
– Is the child comfortable and interactive, anxious and quiet, or obtunded? Is there stridor at rest? Stridor at rest is a sign of significant upper airway obstruction. Children with significant upper airway obstruction may prefer to sit up and lean forward in a "sniffing" position (neck is mildly flexed, and head is mildly extended). This position tends to improve the patency of the upper airway.
Signs of respiratory distress include tachypnea, hypoxemia, and increased work of breathing (intercostal, subcostal, or suprasternal retractions; nasal flaring; grunting; use of accessory muscles)
The initial examination often can be accomplished by observing the child in a comfortable position with the caretaker. Every effort should be made to measure the child's weight and vital signs.
Nebulized epinephrine has an onset of effect within 10 minutes. Nebulized racemic epinephrine is administered as 0.05 mL/kg per dose (maximum of 0.5 mL) of a 2.25% solution diluted to 3 mL total volume with normal saline. Racemic epinephrine is commercially available in the United States and some other countries as a nebulizer preparation (ie, single-use preservative free bullets [ampules]). Nebulized L-epinephrine is administered as 0.5 mL/kg per dose (maximum of 5 mL) of a 1 mg/mL (1:1000) preservative-free solution. L-epinephrine is the same type of epinephrine used in other medical indications (eg, IM injection for anaphylaxis) and is widely available as a parenteral preparation.
Radiographic confirmation of acute laryngotracheitis is not required in the vast majority of children with croup. Radiographic evaluation of the chest and/or upper trachea is indicated if the diagnosis is in question, the course is atypical, an inhaled or swallowed foreign body is suspected (although the majority are not radio-opaque), croup is recurrent, and/or there is a failure to respond as expected to therapeutic interventions.
ateral neck radiograph demonstrating widening of the retropharyngeal space and reversal of the normal cervical spine curvature. The retropharyngeal space normally measures one-half the width of the adjacent vertebral body and is considered widened if it is greater than a full vertebral body at C2 or 3 when the spine is properly extended in an infant or child younger than 5 years of age. The epiglottis and subglottic area in this radiograph are normal.
The anteroposterior (AP) view demonstrates tapering of the upper trachea, known as the "steeple sign" of croup. Note that the finding can be simulated by differing phases of respiration even in normal children.
Lateral neck radiograph showing subglottic narrowing (arrow) and distended hypopharynx (arrowheads) consistent with acute laryngotracheitis.
First larynx, second subglottic trachea, third trache and bronchus
Note the adherent mucopurulent membranes within the trachea.
he differential diagnosis of croup includes other causes of stridor and/or respiratory distress. The primary considerations are those with acute onset, particularly those that may rapidly progress to complete upper airway obstruction, and those that require specific therapy. Underlying anatomic anomalies of the upper airway also must be considered, since they may contribute to more severe disease
Haemophilus influenzae type b
●Streptococcus pneumoniae, including strains that may be penicillin-resistant
●Group A Streptococcus
●Staphylococcus aureus, including community-acquired methicillin-resistant S. aureus (MRSA) strains
Most patients have prodromal symptoms and signs suggestive of viral respiratory tract infection for one to three days before more severe signs of illness develop, including stridor and respiratory distress, often with cough and a preference to lie flat.
he larynx of healthy individuals is often colonized with bacterial species common to the upper respiratory tract, some of which are potential pathogens (eg, Staphylococcus aureus, Streptococcus pneumoniae, gram-negative enteric bacteria, Pseudomonas aeruginosa). Such colonization can extend, at least transiently, into the trachea [7]. Bacterial colonization of the trachea may be present within 24 hours after birth, even in infants born at <31 weeks' gestation
Bacterial tracheitis almost always occurs in the setting of prior airway mucosal damage, as occurs with antecedent viral infection [9,10] (see 'Predisposing viruses' below). Aspiration of bacteria-laden secretions into the trachea during bacterial infection of the upper respiratory tract (eg, acute bacterial sinusitis, streptococcal pharyngitis) or after tonsillectomy also may lead to bacterial tracheitis [9,11].
: oral if oral intake is tolerated, intravenous (IV) if IV access has been established, or intramuscular (IM) if oral intake is not tolerated and IV access has not been established.
there was no difference in effectiveness between racemic epinephrine and L-epinephrine
Supportive care — Supportive care for children hospitalized with moderate to severe croup includes:
Fluids − Administration of intravenous fluids may be necessary in some children. Fever and tachypnea may increase fluid requirements, and respiratory difficulty may prevent the child from achieving adequate oral intake.
Fever control − High fever can contribute to tachypnea and respiratory distress in children with croup, and treatment with antipyretics can improve work of breathing and insensible fluid losses.
Comfort − Care must be taken to avoid provoking agitation or anxiety in children with moderate to severe croup as this can worsen the degree of respiratory distress and airway obstruction. Children with severe croup should be approached cautiously and unnecessary invasive interventions should be avoided. The parent or caregiver should be instructed to hold and comfort the child and to assist in care. The use of sedatives or anxiolytics to reduce agitation is discouraged as this may cause respiratory depression.
Racemic epinephrine is administered as 0.05 mL/kg per dose (maximum of 0.5 mL) of a 2.25 percent solution diluted to 3 mL total volume with normal saline. It is given via nebulizer over 15 minutes.
●No stridor at rest
●Normal pulse oximetry
●Good air exchange
●Normal color
●Normal level of consciousness
●Demonstrated ability to tolerate fluids by mouth
●Caregivers understand the indications for return to care and would be able to return if necessary
●L-epinephrine is administered as 0.5 mL/kg per dose (maximum of 5 mL) of a 1:1000 dilution. It is given via nebulizer over 15 minutes.
* Signs of impending respiratory failure include: fatigue and listlessness, profound retractions, decreased or absent breath sounds, depressed level of consciousness, tachycardia out of proportion to fever (note that tachycardia may also be caused by epinephrine), and/or poor color (cyanosis or pallor).¶ The intravenous preparation of dexamethasone (4 mg per mL) can be given orally; mix with flavored syrup.Δ A single dose of nebulized budesonide (2 mg [2 mL solution] via nebulizer) may provide an alternative to IM or IV dexamethasone for children with vomiting and no IV access.◊ Nebulized epinephrine has an onset of effect within 10 minutes. Nebulized racemic epinephrine is administered as 0.05 mL/kg per dose (maximum of 0.5 mL) of a 2.25% solution diluted to 3 mL total volume with normal saline. Racemic epinephrine is commercially available in the United States and some other countries as a nebulizer preparation (ie, single-use preservative free bullets [ampules]). Nebulized L-epinephrine is administered as 0.5 mL/kg per dose (maximum of 5 mL) of a 1 mg/mL (1:1000) preservative-free solution. L-epinephrine is the same type of epinephrine used in other medical indications (eg, IM injection for anaphylaxis) and is widely available as a parenteral preparation. Use of either product by nebulization is acceptable and may be determined by availability and institutional protocol. Refer to UpToDate content on the management of croup for details.§ Discharge criteria include all of the following: no stridor at rest, normal pulse oximetry, good air exchange, normal color, tolerating fluids by mouth, and caregivers understand instructions and are able to return for care if needed.¥ Poor response to nebulized epinephrine in conjunction with high fever and toxic appearance should prompt consideration of bacterial tracheitis. Refer to UpToDate topic on evaluation and diagnosis of croup for a guide to the differential diagnosis
Approximately 5 percent of children treated for croup in the outpatient setting have repeat visits for recurrent symptoms within seven days following discharge [19]. Children who have recurrent episodes of classic viral croup may require radiographic evaluation or bronchoscopy to evaluate for underlying airway abnormalities. Recurrent episodes of croup-like symptoms occurring outside the typical age range for "viral croup" (ie, six months to three years) and recurrent episodes that do not appear to be simple "spasmodic croup" should raise suspicion for large airway lesions, gastroesophageal reflux or eosinophilic esophagitis, or atopic conditions
A striking feature of spasmodic croup is its recurrent nature, hence the alternate descriptive term, "frequently recurrent croup." Because of some clinical overlap with atopic diseases, it is sometimes referred to as "allergic croup.“
As the course progresses, the episodic nature of spasmodic croup and relative wellness of the child between attacks differentiate it from classic croup, in which the symptoms are continuous.