Allopurinol in angina

OLD GOUT DRUG – NEW TRICKS ON ANGINA ,[object Object],[object Object],[object Object],[object Object],[object Object]

Why Allopurinol ,[object Object],[object Object],[object Object]

Why Allopurinol ,[object Object],[object Object]

Study Design ,[object Object],[object Object],[object Object],[object Object]

Inclusion Criteria ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

Exclusion criteria ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

Figure 1 Source: The 6(10)60391-1)

Figure 4 Source: The Lancet 2010; 375:2161-2167 (DOI:10.1016/S0140-6736(10)60391-1) Terms and Conditions RESULTS: Time To Chest Pain BASE LINE PLACEBO ALLOPURINOL P VALUE TIME TO CHEST PAIN 234 (189-382) 272 (200-421) 304 (272-421) 0.001

Figure 3 total exercise time from baseline BASE LINE ALLOPURINOL PLACEBO P VALUE TOTAL EXERCISE TIME 301 (251-441) 393 (290-519) 307(222-420) 0.003

Time To ST Depression From Baseline BASELINE PLACEBO ALLOPURINOL P VALUE TIME TO ST DEPRESSION 232 (182-380) 249(200-375) 298 (211-408) 0.002

BNP & CRP ,[object Object],[object Object]

CONCLUSIONS ,[object Object],[object Object]

Interpretation ,[object Object]

What is the mechanism of the anti-ischaemic effect of allopurinol? ,[object Object],[object Object],[object Object],[object Object],[object Object]

ADVANTAGES OVER OTHER ANTI ANGINAL DRUS ,[object Object],[object Object],[object Object],[object Object]

Anti ischemic effects similar to other anti anginal drugs ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

Allopurinol could be another second agent option for angina symptoms ,[object Object],[object Object]

1.Mechanistic Insights Into the Therapeutic Use of High-Dose Allopurinol in Angina Pectoris Narasimharajapura S. Rajendra, MD*,Sheila Ireland, RGN, RM, Jacob George, MD,Jill J.F. Belch, MD, Chim C. Lang, MD andAllan D. Struthers, MD ,[object Object]

2.The Effect of Allopurinol on B-Type Natriuretic Peptide Levels in Patients with Chronic Stable Angina Awsan Noman; Maheshwar Pauriah; Allan D Struthers Ninewells Hosp, Dundee, United Kingdom ,[object Object]

3.Allopurinol regresses left ventricular hypertrophy in chronic kidney disease JULY 7, 2010 | Daniel M Keller ,[object Object]

OPT CHF TRIAL: Allopurinol - exercise capacity in CHF NOT EFFECTIVE ?? ,[object Object],[object Object],[object Object],[object Object],[object Object]

Thank U ,[object Object],[object Object],[object Object]

Allopurinol in angina

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