The lecture has been given on Dec. 12th, 2010 by Dr. Mohammad Yousif.

1. Epidermal Tumors

3. Keratoacanthoma

4. Epidermal nevi

5. Cutaneous cysts

6. Warty dyskeratoma

7. Clear cell acanthoma

9. Erythroplasia of Queyrat (Bowen’s dis. of glans penis)10% 6-17% 5-11% SCC 30%

10. Seborrheic keratosis One or more sharply defined, light brown to black, slightly raised lesions (as if stuck on surface) with soft velvety or finely verrucous surface. It occurs on trunk, face or extremities. Treatment 1. Removal with a small sharp curette. 2. Freezing. 3. TCA. 4. Cauterization.

15. Multiple self-healing epitheliomas (Ferguson-Smith).

18. Curettage and cauterization of small lesions.

19. 5-fluorouracil intralesionally.

20. Radiotherapy.

23. “Nevus verrucous” is keratinocytes

24. “Nevus sebaceous” from sebaceous glands

25. “Nevus comedomicus” from hair follicles

29. Traumatic implantation of epidermis into the dermis.

33. Secondarymilia: arise

34. In association with many dermatoses, e.g. BP, DEB, PCT, LSA.

38. Sun-exposed areas as face, dorsa of hands & bald portions of the scalp in men.

44. Electrodessication & curettage.

45. Cryosurgery with liquid nitrogen.

46. Topical chemotherapy: 5-fluorouracil, 0.1-5% (5-FU) – Efudex cream®.

47. Chemical peel with TCA 35%.

48. Retinoids: oral or topical.Radiotherapy is contraindicated.

50. Verrucousleukoplakia.

51. Speckled leukoplakia: white nodules on an erythematous background. Increased risk of malignant change.

52. Smokers keratosis.

53. Oral hairy leukoplakia.All cases of leukoplakia should be examinedhistologically.

55. Mechanical irritation through dental stumps.

56. HPV: HPV-11 & HPV-16.

57. Candidal infection.

61. Unexposed skin (caused by the ingestion of arsenic).

62. On lesions of EV (caused by HPV-5).

63. On lesions of porokeratosis.

64. No etiological factors.5

68. Exposure to carcinogenic cpds, e.g. coal, arsenic, tobacco.

69. Ionizing radiations from X-rays.

72. Shallow ulcer with raised everted edge, indurated base.

74. Grade 2, more than 50%.

75. Grade 3, more than 25%.

76. Grade 4, less than 25% are differentiated (more malignant).The degree of atypicality of the tumor cells & the depth of penetration are important factors in grading.

78. Curettage & electrodessication.

79. Cryosurgery.

80. CO2 laser ablation.

81. Intralesional & topical 5-fluorouracil.

82. Radiotherapy.

84. Age: 55 years.

85. It occurs unilaterally on the areola & nipple as a sharply defined, slightly infiltrated area of erythema showing scaling, oozing & crusting. Ulceration or retraction of the nipple may be found.

89. Autosomal dominant.

90. Numerous, rounded, skin-colored, firm nodules located mainly in the nasolabial folds, forehead & upper lip.

93. In puberty, verrucous or nodular.

94. Later in life, some lesions may develop various types of appendage tumors, e.g. syringocystadenoma papilliferum, BCC.3 Stages

95. Three phases of N. sebaceus Tumor phase Adults usually Exact % unknown Probably <5% Infant phase Flat, smooth Decreased hair Pubertal phase Grows when oil glands expand – papular Orange peel surface

99. More in females.

100. In lower lids, cheeks, axillae, abdomen and vulva.

101. Small, skin-colored or slightly yellow, soft papules.

106. Chronic intake of inorganic arsenic.

107. Predisposing skin conditions: dermatofibromas, nevus sebaceous of Jahadsson, burn scars.

108. Predisposing syndromes: nevoid basal cell carcinoma syndrome, Basex syndrome, Rombo’s syndrome & xeroderma pigmentosum.

109. Immunsuppression & X-ray irradiations.However, BCC may arise without apparent cause.

111. Pigmented.

112. Superficial.

113. Morphea-like.

116. Radiotherapy.

117. Curettage & electrosurgery.

118. Cryosurgery.

119. Mohs micrographic surgery (MMS).

120. Cytotoxic agents: e.g. 5-fluorouracil topically.

121. Intralesional injection of -2b interferon (IntronA®).