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Myasthenia Gravis was first described by Thomas Willis in 1672. “Myasthenia Gravis” literally means “muscle weakness”. MG is often called the “snowflake disease” because it differs so much from person to person. Definition Myasthenia gravis (MG) is an autoimmune disease that causes chronic, progressive damage of the neuromuscular junction. The underlying defect is a decrease in the number of available acetylcholine receptor (AChRs) at neuromuscular junctions due to an antibody-mediated autoimmune attack. Clinical Features Eye muscles Drooping of one or both eyelid (Ptosis) Double vision (diplopia) Face and throat muscles Dysarthria Dysphasia Problem in chewing Limited facial expression Snarling expression Respiratory symptoms Weakness of intercostal muscle and diaphragm. Weakness of pharyngeal muscles Palate muscle weakness Nasal voice Nasal regurgitation Swallowing may be difficult and regurgitation of food can occur. Coughing and chocking while drinking Limb muscle weakness in MG is often proximal and may be asymmetric. In ~85% o patients, the weakness becomes generalized, affecting the limb muscles as well. If weakness remains restricted to the extra ocular muscles for 3 years, it is likely that it will not become generalized, and these patients are said to have ocular MG.
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Mysthenia Gravis.ppt
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MYASTHENIA GRAVIS
Dr. Shamanthakamani Narendran M.D. (Pead), Ph.D. (Yoga Science)
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CT Chest Thymoma
Single-fiber EMG
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How antibodies against
acetylcholine receptor block impulse conduction in synapse
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Notas do Editor
Neuromuscular junction (closer view) 1. presynaptic terminal 2. sarcolemma 3. synaptic vesicles 4. Acetylcholine receptors 5. mitchondrion
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