This document summarizes a presentation on providing therapeutic lifestyle changes (TLC) for patients. It discusses how TLCs are recommended by national health organizations for treating various conditions. It then outlines a 5 step system used at a chiropractic clinic to implement TLCs, including assessing patients, advising on lifestyle changes, setting goals, providing assistance and arranging follow up. Case studies show TLCs effectively improved patients' health risks, biomarkers and lifestyle factors within 12 weeks.

1. Achieve Vibrant Health & Well-Being With Therapeutic Lifestyle Changes Presented by: Dr. Sarah Corcoran, DC, FLT cp Rebecca Sauer, FLT Certified Practioner & featuring Chris from Metagenics Back To Health Chiropractic 450 Chauncy St., Mansfield

3. From: ACS / ADA / AHA Scientific Statement Preventing Cancer, Cardiovascular Disease, and Diabetes A common Agenda for the American Cancer Society, the American Diabetes Association, and the American Heart Association” Circulation 2004;109:3244-3255 “ In spite of hundreds of medical studies, media reports and advice from health officials, Americans still have not got the message that they can prevent most cases of chronic disease.” – John Seffrin, American Cancer Society CEO

4. From: “ Effectiveness of Therapeutic Lifestyle Changes in Patients With Hypertension, Hyperlipidemia, and/or Hyperglycemia” American Journal of Cardiology 2004;94:1558-1561 “ National clinical guidelines recommend therapeutic lifestyle changes as a standard of care in the management of conventional risk factors (for coronary heart disease).”

5. From: “ Effectiveness of Therapeutic Lifestyle Changes in Patients With Hypertension, Hyperlipidemia, and/or Hyperglycemia” American Journal of Cardiology 2004;94:1558-1561 “… the findings clearly show that many patients who have conventional risk factors for coronary heart disease can achieve goal levels without medications within 12 weeks of initiating therapeutic lifestyle changes…”

6. From: “ Effectiveness of Therapeutic Lifestyle Changes in Patients With Hypertension, Hyperlipidemia, and/or Hyperglycemia” American Journal of Cardiology 2004;94:1558-1561 “ Moreover, therapeutic lifestyle changes can generally be implemented less expensively than most medications and, unlike single drug therapy, favorably impacts multiple cardiovascular disease risk factors.”

10. From: ACS / ADA / AHA Scientific Statement Preventing Cancer, Cardiovascular Disease, and Diabetes A common Agenda for the American Cancer Society, the American Diabetes Association, and the American Heart Association Circulation 2004;109:3244-3255 “ At present, preventive health receives only sporadic attention, in the context of office visits for acute and chronic medical problems. Health care providers and medical organizations must transform this model into systems that provide preventive care and early detection as an integral part of standard medical practice .”

13. From: “ Prevalence of the Metabolic Syndrome Defined by the International Diabetes Federation Among Adults in the U.S.” Diabetes Care 2005;28:2745-2749 “… almost 40% of U.S. adults were classified as having the metabolic syndrome...”

15. From: “ Metabolic Syndrome in Normal-Weight Americans New definition of the metabolically obese, normal weight individual Diabetes Care 2004;27:2222-2228 “ Individuals in the upper normal-weight and slightly overweight BMI range have a relatively high prevalence and are at increased risk of having the metabolic syndrome. Therefore, screening in individuals with normal or slightly elevated BMI is important in the prevention of diabetes and cardiovascular disease.”

16. From: “ Metabolic Syndrome: Time for Action” Am Fam Physician 2004;69:2875-82, 2887-8 “ Soon metabolic syndrome will overtake cigarette smoking as the number one risk factor for heart disease among the U.S. population. The NCEP ATPIII has identified metabolic syndrome as an indication for vigorous lifestyle intervention .”

17. From: “ Metabolic Syndrome: Time for Action” Am Fam Physician 2004;69:2875-82, 2887-8 “ All patients diagnosed with metabolic syndrome should be encouraged to change their diet and exercise habits as primary therapy.”

18. Case History: Metabolic Syndrome and efficacy of TLC’s Complaints : -Occasional fatigue, lethargy, apathy -Dizziness -Restlessness -Rapid heartbeat -Shortness of breath -Heartburn -Overweight - 195 lbs Lifestyle Factors : -Significant stress levels -Eating poor quality food & fast food -Skip meals, only two meals per day -Crave Stimulants such as caffeine, soft drinks (4-5 cups of coffee, 1 soda per day) -Smoking 1 pack per day -Occasional alcohol -Exercises 1-2 times per week E.C. - 50 year old male, 5’10’, 197.5 lbs, 0 meds, unremarkable family and medical history

19. E.C. - Lab data and body composition: Case History: Metabolic Syndrome and efficacy of TLC’s 130/80 Blood Pressure 4.4 PSA, Total 9.7 HS CRP 7.6 Chol / HDL Ratio N/Aval LDL Cholesterol 35 HDL Cholesterol 523 Triglycerides 267 Cholesterol 143 Glucose 74.1% Lean Body Mass 25.9% Fat Mass 28.0 BMI

20. -Metabolic Syndrome (Elevated glucose, triglycerides, blood pressure, low HDL) -High risk to diabetes -High risk to CVD (hyperlipidemia, high HS CRP) -BPH -Sub-optimal over-all health and well-being E.C. - Conclusions: Case History: Metabolic Syndrome and efficacy of TLC’s

22. Initial : -Occasional fatigue, lethargy, apathy -Dizziness -Restlessness -Rapid heartbeat -Shortness of breath -Heartburn -Overweight - 195 lbs Final (12 weeks) : -resolved, has high energy -resolved -resolved -resolved -resolved -resolved -currently 177 lbs E.C. - 50 year old male Final Results Case History: Metabolic Syndrome and efficacy of TLC’s

23. Initial : -Significant stress levels -Eating poor quality, fast food -Skip meals - two meals per day -Crave Stimulants such as caffeine, soft drinks (4-5 cups of coffee, 1 soda per day) -Smoking 1 pack per day -Drinks occasionally -Exercises 1-2 times per week E.C. - 50 year old male Final Results Final (12 weeks) : -Stress well controlled -Eating high quality, healthy food -6 small, low GI meals per day -Eliminated coffee & soda (healthy menu plan eliminated cravings for coffee & soda) -Smoking 1-2 cigarettes per day -Occasional alcohol (wine) -Exercises daily Case History: Metabolic Syndrome and efficacy of TLC’s

24. E.C. - 50 year old male Lab Data: Initial Final* Body Comp: Initial Final* *after 12 weeks Case History: Metabolic Syndrome and efficacy of TLC’s 130/80 Blood Pressure 4.4 PSA, Total 9.7 HS CRP 7.6 Chol / HDL Ratio N/Aval LDL Cholesterol 35 HDL Cholesterol 523 Triglycerides 267 Cholesterol 143 Glucose 74.1% Lean Body Mass 25.9% Fat Mass 28.0 BMI 120/78 2.2 1.2 2.9 70 51 141 149 93 82.3% 17.7% 25.2

35. From: “ Effect of a low glycemic index diet with soy protein and phytosterols on CVD risk factors in post- menopausal women ” Nutrition, Feb 2006;22:104-113 This study compared a low glycemic index diet combined with a medical food to the AHA Step I diet in obese, postmenopausal women.

36. From: “ Effect of a low glycemic index diet with soy protein and phytosterols on CVD risk factors in post- menopausal women ” Nutrition, Feb 2006;22:104-113 +3% +2.1% 63.2% 61.1% % lean body mass -8% 15 lbs 171 lbs 186 lbs Weight -5%/-8% -6/-7 mmHG 124/77 mmHG 130/84 mmHG Blood Pressure -25% 2.1 mcIU/ml 6.2 mcIU/ml 8.3 mcIU/ml Fasting insulin -34 % -1.7 mg/l 3.3 mg/l 5.0 mg/l hs-CRP -48% 2.2 2.4 4.6 TG/HDL-C -21% 1.2 4.6 5.8 tChol/HDL-C +6% +3 mg/dl 51 mg/dl 48 mg/dl HDL-C -15% -27 mg/dl 158 mg/dl 185 mg/dl LDL-C -16% -43 mg/dl 231 mg/dl 274 mg/dl Total Cholesterol -45% -95 mg/dl 117 mg/dl 212 mg/dl Triglycerides % Change Change After Before

38. Comparing Arms From: “ Effect of a low glycemic index diet with soy protein and phytosterols on CVD risk factors in post- menopausal women ” Nutrition, Feb 2006;22:104-113 -7.8 lbs -14.8 lbs Weight -.5mg/dL +2.8 mg/dL HDL-C +3.2 mg/dL -28 mg/dL LDL-C -2.6 mg/dL -43 mg/dL T-Chol -49 mg/dL -95 mg/dL Triglycerides AHA Step 1 Diet LGI diet with medical food

42. Bioimpedance Analysis (BIA) firstline therapy

61. Serving Sizes firstline therapy