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Chronic pancreatitis.pptx
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6. Chronic Pancreatitis
• Chronic pancreatitis is defined as incurable,
continuing chronic inflammatory process of the
pancreas, characterized by irreversible morphological
changes.
• This chronic inflammation can lead to chronic
abdominal pain and/or impairment of endocrine and
exocrine function of the pancreas.
8. Spectrum of Pancreatitis
1. Acute pancreatitis
2. Recurrent acute pancreatitis
3. Chronic pancreatitis
4. Acute on chronic pancreatitis
9. Acute Pancreatitis
• By definition, chronic pancreatitis is a completely
different process from acute pancreatitis. In acute
pancreatitis, the patient presents with acute and
severe abdominal pain, nausea, and vomiting.
• The pancreas is acutely inflamed (neutrophils and
edema), and the serum levels of pancreatic enzymes
(amylase and lipase) are elevated.
17. Aetiology:
I-Metabolic
2-Hyperlipidemia may cause chronic pancreatitis;
however, it usually presents with repeated attacks
of acute pancreatitis.
3-Hypercalcemia due to hyperparathyroidism now is
a rare cause of chronic pancreatitis, probably
because automation of serum chemistries reveals
hypercalcemia before it results in pancreatitis.
18. Nutritional or tropical, chronic
pancreatitis
• It is an important cause of disease in poorer parts
of the world.
• ?Tapioca – cyanide poisoning.
19. II-Genetic:
1-Hereditaty pancreatitis Autosomal dominant
disorder accounting for about 1% of cases.
2-Cystic fibrosis is one of the most common genetic
abnormalities, is an autosomal recessive disorder
accounting for a small percent of patients with
chronic pancreatitis.
Mutations SPNK1,
21. IV-Obstruction
of the flow of pancreatic juice can cause chronic
pancreatitis:
• Congenital abnormalities such as pancreas
divisum.
• Acquired obstructive forms result from blunt
abdominal trauma, stones or tumours.
22. V-Autoimmune pancreatitis:
• Is uncommon and accounts probably for less than
1% of cases of chronic pancreatitis.
• Increased circulating levels of gamma globulin
(igg4),
• The presence of autoantibodies,
• Association with other autoimmune diseases.
34. Clinical picture:
• Abdominal pain:
• The most common symptom.
• The patient experiences intermittent attacks of
severe pain, often in the mid or left upper
abdomen and occasionally radiating to the back
and lasting for several hours.
35. • A small percentage of patients (20%) have
painless chronic pancreatitis and present with
signs or symptoms of pancreatic exocrine or
endocrine insufficiency.
36. • Other symptoms associated with chronic
pancreatitis include diarrhea and weight loss.
This may be due either to fear of eating (eg,
postprandial exacerbation of pain) or due to
pancreatic exocrine insufficiency and
steatorrhea).
37. • Occasionally, a tender fullness or mass may be
palpated in the epigastrium, suggesting the
presence of a pseudocyst or an inflammatory mass
in the abdomen.
• Patients with advanced disease (ie, patients with
steatorrhea) exhibit decreased subcutaneous fat,
temporal wasting, sunken supraclavicular fossa,
and other physical signs of malnutrition.
38. • Pseudoaneurysm of splenic artery.
• Diabetes mellitus is a late manifestation in
about one third of patients. The tendency to
develop ketoacidosis is low.
47. Lab Investigations:
1-Blood tests-
• Serum amylase and lipase levels may be
slightly elevated in chronic pancreatitis; high
levels are found only during acute attacks of
pancreatitis.
• Diabetes mellitus
• Fecal fat fecal elastase
51. Plain CT
• Pseudocysts, calcifications and pancreatic duct
dilatation can be observed in chronic
pancreatitis.
52. MRCP:
• Noninvasive
• It can assess both pancreatic parenchyma and
ducts at the same time.
• It can detect pancreatic duct dilatation, ductal
narrowing and filling defects.
54. ERCP:
• Provides the most accurate visualization of the
pancreatic ductal system and has been
regarded as the criterion standard for
diagnosing chronic pancreatitis.
• Findings include characteristic “chain of
lakes” beading of the main pancreatic duct,
and intraductal filling defects.
58. Treatment:
1-Behavior modification:
Cessation of alcohol consumption and tobacco
smoking are important. In early-stage alcohol-
induced chronic pancreatitis, lasting pain relief can
occur after abstinence from alcohol, but, in
advanced stages, abstinence does not always lead
to symptomatic improvement.
59. Medical treatment:
• Analgesics: to relieve abdominal pain.
• Avoid opioids high chances of addiction.
• NSAIDs
• Tramodol
• Gabapentin
60. Medical treatment:
Antidepressants: (Amitriptyline hydrochloride)
• In addition to alleviating coexistent depression,
tricyclic antidepressants may ameliorate pain and
potentiate the effects of opiates.
61. Medical treatment:
Pancreas enzyme supplements:
• Used as a dietary supplement to aid digestion in
patients with pancreatic enzyme deficiency. Several
preparations are available.
• When exogenous pancreatic enzymes are taken with a
meal, CCK-releasing factors are degraded and CCK
release in response to a meal is reduced. This
decreases pancreatic stimulation and pain.
62. Acute attack Medical treatment:
• Nil Orally
• IV fluids
• Analgesics
• No Antibiotics
• NO PPIs
• No Octride
• No repeated CT
63. 3-Endoscopic treatment:
I-Papillary stenosis: In appropriately selected patients,
a pancreatic duct sphincterotomy will facilitate
drainage, reduce ductal pressures, and may help
alleviate pain
II-Pancreatic duct strictures: performing a pancreatic
sphincterotomy, dilating the stricture, and placing a
stent. While technical success is achieved in more
than 90% of patients, nearly 20% will have a
complication.
64. 3-Endoscopic treatment:
III-Pancreatic duct stones:
• Requires a pancreatic duct sphincterotomy and
stricture dilation to enable their extraction.
• In addition to various endoscopic techniques,
extracorporeal shockwave lithotripsy often is
necessary to break up impacted or large stones
into smaller pieces suitable for removal.
65. 4-Surgical treatment:
I-Pancreatic duct drainage: In patients with a dilated
pancreatic duct, pancreaticojejunostomy is indicated.
The operative mortality rate is about 3%, and pain
relief is obtained in approximately 75% of patients.
66. 4-Surgical treatment:
II-Pancreatic resection: If the disease is limited to
the head of the pancreas, a Whipple operation
(pancreaticoduodenectomy) can produce good
results.
• In patients with intractable pain and diffuse
disease with nondilated ducts, a subtotal or total
pancreatectomy can be offered.
68. 4-Surgical treatment:
III-Total pancreatectomy and islet
autotransplantation:
In selected patients, the long-term morbidity
caused by diabetes following total pancreatectomy
can be avoided.
• This involves harvesting the islets from the
resected pancreas and injecting them into the
portal system, which then lodges them in the liver.
69. Complications of Chronic
Pancreatitis
Intrapancreatic complications
• Pseudocysts
• Duodenal or gastric obstruction
• Thrombosis of splenic vein
• Abscess
• Perforation
• Erosion into visceral artery
• Inflammatory mass in head of pancreas
• Bile duct stenosis
• Portal vein thrombosis ………
77. Take home messages
• Chronic pancreatitis is destruction of
pancreas.
• Triad of chronic pancreatitis
– recurrent abdominal pain
– steatorrhea
– diabetes mellitus.
• treat by pancreatic enzymes analgesics
insulin
• No role of of octreotide , PPIs,, antibiotics
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This endoscopic retrograde cholangiopancreatography (ERCP) shows advanced chronic pancreatitis. The pancreatogram has blunting of the lateral branches, dilation of the main pancreatic duct, and filling defects consistent with pancreatolithiasis.