This course covers bionanotechnology and nanomedicine. Topics include nanoparticle synthesis and applications in diagnostics and therapeutics. Techniques for patterning, microscopy, and biosensor functionalization will be discussed. Instructors will cover fundamental physics and chemistry of bionano materials, principles of microscopy, molecular nanotechnology, nanoparticle properties, and bio-nano imaging. Students will present on special topics and submit an essay on their presentation topic. The course meets twice weekly for 4 hours each session. Examinations include a presentation and essay due at the end of the course.

1. Bionanotechnology
and Nanomedicin
Introduction of this course

2. Course Description
 This course will cover the physics and chemistry relevant to the
design, synthesis, and characterization of bionanotechnology.
Topics include nanoparticle synthesis, functionalization, surface
engineering, and applications in diagnostics and therapeutics.
The properties of semiconductor quantum dots and magnetic
nanoparticles will be reviewed along with techniques for
nanoparticle manipulation, particle tracking and their
applications in drug delivery.
 Patterning tools including soft lithography, optical lithography,
e-beam lithography, and template lithography will be discussed.
Electron and scanning probe microscopy will be reviewed.
 Strategies for functionalization of biosensors are covered with
focus on methods for attaching biomolecules. Bio-nanosensors
functionalized with biologically-active molecules, genes,
antibodies or other proteins, will be used to probe cell function
and to develop methods to enhance our ability to deliver bio-
active molecules to cells and tissues. The discussions covered
will be on areas of human cancers and nanotechnology and
include the latest developments from studies of model
organisms.
 This course allows students the opportunity last week to review
and present on special research topics related to
nanobiotechnology.

3. Instructors
1. Prof. Dr. Guang Yang
 Her current research interest focuses on
Biochemical engineering, Bionic nano-
composite, Polymer physics & chemistry,
involving in study on nano-assembly of
ordered eco-friendly materials and their
structures & properties, proceeding
control and optimization of bio-refining,
design and fabrication of novel nano-drug
transporter, tissue engineering scaffold
materials for biomedical applications,
etc.

4. Instructors
2. Prof Glyn.O.Phillips
Professor Phillips' research interests have
centered upon carbohydrate and
biomaterial systems, particularly on food
hydrocolloids and medically-related
biopolymers of connective tissue. He has
been a collaborator with Dr Endre A.
Balazs since 1963, lately with Biomatrix
Inc, (now incorporated into Genzyme Inc)
which produced HYLAN, an FDA approved
product, which was used for the
replacement for synovial fluid damaged
by osteoarthritis ( “SYNVISC” ).

5. Instructors
3. Prof. Mario Gauthier
 Anionic polymerization: Arborescent
and other graft polymers, telechelic
polymers, block copolymers. Stable
free-radical polymerization reactions.
Emulsion polymerization. Ion-
containing polymers: Ionomers,
polyelectrolytes. Copolymerization and
post-polymerization modification
reactions. Polymer characterization:
Applications of laser light scattering
techniques, size-exclusion
chromatography. Rheological
properties and mechanical testing.
Solution properties.

6. Instructors
 TA. S.Morteza Zendehbad
 Current research interests are
nanotechnology and
nanobiotechnology, biomedical
optoelectronic devices. Multi-walled
Nano Carbon Tubes and Bacterial
Cellulose (MWNCTs & BC); Electrically
Conductive Bacterial Cellulose by
Incorporation of Carbon Nanotubes;
Signal Processing via MATLAB;
Renewable Energy

7. Subjects
 Fundamental Physics & Chemistry of bio and
nanomaterials
 Principle of Electron Microscopy
Surface functionalization – structure
polypeptides- naturals biological
assembly- self-assembly of bio inspired
nanomaterial
History – Terminologies- Principles and
methodology - biology application –
classification : SEM,TEM
Advance investigation of tools –
classification: SPM ,AFM

8. Subjects
 Molecular Nanotechnology
 Nanoparticles
 Nano drug delivery
Collagen, cell, biomolecules ,cytoskeleton, …
Biomolecular design and biotechnology
Classification, physical and chemical biological
synthesis – QDs –carbon nanotubes, polymers
Cancer therapy , Gene technology – florescent
detection
History, classification – drug targeting –
nanoparticles – BC – liposome…

9. Subjects
 Bio-Nano imaging and Diagnostic
 Biosensor and biomolecular Electronics
 Micro and Nano machining
Classification – MRI – DNA and Protein
microarrays- Biomedical Robot for
Surgery- Transdermal Patches
History – Terminologies - concept and
future prospects –Principle –Classification
– controlled release -nanowire - Optical
fiber …
MEMS –NEMS – BIOMEMS- biology
application –Biochips

10. References
 BioNanotechnology, Elisabeth S.
Papazoglou, Aravind Parthasarathy,
2007
 Nanobiotechnology, C. M. Niemeyer
and C. A. Mirkin, 2004
 BIONANOTECHNOLOGY- Lessons from
Nature; David S. Goodsell, 2004
 NANOTECHNOLOGY IN BIOLOGY AND
MEDICINE (Methods, Devices, and
Applications), Tuan Vo-Dinh, 2007

11. Time
Each Week : 2 times and 4 hours  8 hours per week
Regularly : Tuesday and Friday BUT ….

12. Examination
 Presentation
 Subject: According to several topics of this course
 Time: 20-25 min for each student
 Date: 21th
and 24th
May
 Essay
 Subject: Cover your presentation
 Submit: Hard and soft version (paper and MS Word)
 Deadline : 30th May