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Quality of
Life in Midlife
Dr. Asha Jain
This Photo by Unknown Author is licensed under CC BY-NC-ND
Dr. Asha Jain
MD, DNB, MNAMS, MBA
asha@drasha.in
• Director – SMSA Raipur
• Medical Director – CPRS Raipur
• Elected Member – Chhattisgarh Medical
Council 2020-24
• Secretary – IMA Raipur 2019-21
• President – ROGS 2018-20 2020-22
• President – Rotary Club
Raipur North 2019-20
28/02/21 Dr. Asha Jain
What is
QOL -
WHO
WHO defines Quality of Life as an
individual's perception of their
position in life in the context of the
culture and value systems in which
they live and in relation to their goals,
expectations, standards and concerns
It is a broad ranging concept affected
in a complex way by the person's
physical health, psychological state,
personal beliefs, social relationships
and their relationship to salient
features of their environment.
28/02/21 Dr. Asha Jain
What is Health - WHO
Health is a state of complete
physical, mental and social well-
being and not merely the
absence of disease or infirmity.
28/02/21 Dr. Asha Jain
Growth
Midlife
Decline
Senile
Child
Cross Road/Pivot/Bridge
28/02/21 Dr. Asha Jain
Midlife in the United Stated – MIDUS Study
Physical Health Cognitive
Functioning
Well Being
28/02/21 Dr. Asha Jain
Multi-directionality
Variability
Plasticity
In Nature
In Direction
28/02/21 Dr. Asha Jain
Study of
Women’s
health
across the
nations –
SWAN
Study
Physical Component
Summary - PCS
Mental Component
Summary - MCS
N - 2614
28/02/21 Dr. Asha Jain
PCS and MCS
28/02/21 Dr. Asha Jain
Better PCS
HIGHER BASELINE
PHYSICAL ACTIVITY
INCREASE IN ACTIVITY
FROM BASELINE
28/02/21 Dr. Asha Jain
Decreased PCS
• Time/Aging
• Higher baseline BMI
• Increase in BMI over time
• Smoking
• 2 or more medical conditions
• Sleep Problems
• Urinary Incontinence
28/02/21 Dr. Asha Jain
Increase in MCS
• Early and Late Menopause increase the MCS
• Premenopause has no effect
28/02/21 Dr. Asha Jain
Low MCS
Less than very
good health
Sleep problems
Stressful life
events
Higher
perceived stress
Anxiety trait
28/02/21 Dr. Asha Jain
Race and Ethnicity
are related to
MCS not PCS
28/02/21 Dr. Asha Jain
Conclusion
of Study
Increase the quality of life
Potentially modifiable midlife factors
like
Improved
sleep hygiene
Physical
Activity
Body mass
index
28/02/21 Dr. Asha Jain
Ovarian Aging
Ovarian
Aging
Bone
CVS
Cognitive
Musculoskeletal
health
28/02/21 Dr. Asha Jain
Changes independent
of Ovarian Aging
Endocrine
change
OR
Coincidental
Bone
loss
Osteoarthritis
Adverse
Lipid
Profiles
Diabetes
Metabolic
Syndrome
Sleep
Disturbances
28/02/21 Dr. Asha Jain
Better Physical Health
leads to Better mental
health, Cognitive health
28/02/21 Dr. Asha Jain
Evidence
28/02/21 Dr. Asha Jain
Midlife (35-60y) is a
critical window of
opportunity to prevent
Chronic Disease, and
Optimize health and
functioning
Symptoms
that are
Hallmark of
Menopause
• Vasomotor Symptoms or Hot flashes
• Additionally, other conditions peak or
are exacerbated at this time
• Fibroids à Hysterectomy
• Migraine
• Systemic Lupus Erythematosus
• Various precancers, and cancers
• TODO – Care for Gynecological and
Hormone Sensitive conditions
28/02/21 Dr. Asha Jain
Which period of
life is defined as
Midlife?
Usual studies take 60 years and above
Window of opportunity of primary
prevention is missed
28/02/21 Dr. Asha Jain
Redefining
Midlife
• Here it is redefined as 35 to
60 years
• This includes late
reproductive phase to late
menopause
• Includes the menopausal
transition up to a period
when ovarian senescence
has no longer any effect on
aging
28/02/21 Dr. Asha Jain
25% recently
menopausal
women report
disability
Health
Midlife
Transition
Disability
28/02/21 Dr. Asha Jain
The hardest hit is mobility
In one study upto 39% reported
loss of mobility within 2 years
of menopause
28/02/21 Dr. Asha Jain
Additional Factors
• Metabolic Syndrome
• Diabetes
• Adverse Lipid Profiles
• Hearing Loss
• Diminished vision
• Osteoarthritis
• Body composition changes
• 66% had pain due to osteoarthiritis
28/02/21 Dr. Asha Jain
Osteoporosis leading to fractures
This chart shows bone mass in
women as it relates to age.
Reproduced from J Bernstein, ed:
Musculoskeletal Medicine.
Rosemont, IL, American Academy
of Orthopaedic Surgeons, 2003.
28/02/21 Dr. Asha Jain
Of all the boneloss that occurs
in a women in her entire life,
50% occurs in just 7 years.
2 years before and 5 years
after last menstrual period
28/02/21 Dr. Asha Jain
WHI Study
and heart
health
• Within 2 years of menopause, there is
• Increased LDL
• Increased Cholesterol
• Increased Apolipoprotein B
• Therefore increased aortic calcification
• Increased hot flashes have an increased CV
risk
28/02/21 Dr. Asha Jain
Depression
• 20% to 30% of midlife women have incidental or recurrent
episodes of clinical depression
• Causes
• Hormonal
• Sleep Disturbances
28/02/21 Dr. Asha Jain
Social Health
• Infertility
• Failed Contraception
• Empty Nest Syndrome
• Taking care of aging parents
• Career issues in working women
• Social Connect
• Failed Marriages
• Loss of partner
• Retirement Anxiety
28/02/21 Dr. Asha Jain
Conclusion
• Critical changes are occurring in midlife that need
• Change into a healthy lifestyle
• Behavioral Change
• Social Engagement
• Healthcare practices
• Focus needs to be on modifiable critical factors in midlife to
have healthy instead of unhealthy aging
28/02/21 Dr. Asha Jain
Future Research Requirement
• Research in our country
• Impact on midlife of
• Early childbirth
• Late childbirth
• Lifelong under nutrition
• Obesity
• Racial and ethnic differences
• Impact of environment
• Impact of occupation
28/02/21 Dr. Asha Jain
Age Gracefully
Be Beautiful, Be Alert
Be Active, Be Self Reliant
BE HAPPY!
This Photo by Unknown Author is licensed under CC BY-SA
28/02/21 Dr. Asha Jain
Thank you
This Photo by Unknown Author is licensed under CC BY-SA
28/02/21 Dr. Asha Jain
References and Acknowledgements
• J Gerontol A Biol Sci Med Sci,2018, Vol. 73, No. 11, 1574–
1580doi:10.1093/gerona/gly062
• Harlow and DerbyWomen's Midlife Health (2015) 1:5 DOI
10.1186/s40695-015-0006-7
28/02/21 Dr. Asha Jain

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Midlife - Caring for the Golden Period

  • 1. Quality of Life in Midlife Dr. Asha Jain This Photo by Unknown Author is licensed under CC BY-NC-ND
  • 2. Dr. Asha Jain MD, DNB, MNAMS, MBA asha@drasha.in • Director – SMSA Raipur • Medical Director – CPRS Raipur • Elected Member – Chhattisgarh Medical Council 2020-24 • Secretary – IMA Raipur 2019-21 • President – ROGS 2018-20 2020-22 • President – Rotary Club Raipur North 2019-20 28/02/21 Dr. Asha Jain
  • 3. What is QOL - WHO WHO defines Quality of Life as an individual's perception of their position in life in the context of the culture and value systems in which they live and in relation to their goals, expectations, standards and concerns It is a broad ranging concept affected in a complex way by the person's physical health, psychological state, personal beliefs, social relationships and their relationship to salient features of their environment. 28/02/21 Dr. Asha Jain
  • 4. What is Health - WHO Health is a state of complete physical, mental and social well- being and not merely the absence of disease or infirmity. 28/02/21 Dr. Asha Jain
  • 6. Midlife in the United Stated – MIDUS Study Physical Health Cognitive Functioning Well Being 28/02/21 Dr. Asha Jain
  • 8. Study of Women’s health across the nations – SWAN Study Physical Component Summary - PCS Mental Component Summary - MCS N - 2614 28/02/21 Dr. Asha Jain
  • 9. PCS and MCS 28/02/21 Dr. Asha Jain
  • 10. Better PCS HIGHER BASELINE PHYSICAL ACTIVITY INCREASE IN ACTIVITY FROM BASELINE 28/02/21 Dr. Asha Jain
  • 11. Decreased PCS • Time/Aging • Higher baseline BMI • Increase in BMI over time • Smoking • 2 or more medical conditions • Sleep Problems • Urinary Incontinence 28/02/21 Dr. Asha Jain
  • 12. Increase in MCS • Early and Late Menopause increase the MCS • Premenopause has no effect 28/02/21 Dr. Asha Jain
  • 13. Low MCS Less than very good health Sleep problems Stressful life events Higher perceived stress Anxiety trait 28/02/21 Dr. Asha Jain
  • 14. Race and Ethnicity are related to MCS not PCS 28/02/21 Dr. Asha Jain
  • 15. Conclusion of Study Increase the quality of life Potentially modifiable midlife factors like Improved sleep hygiene Physical Activity Body mass index 28/02/21 Dr. Asha Jain
  • 17. Changes independent of Ovarian Aging Endocrine change OR Coincidental Bone loss Osteoarthritis Adverse Lipid Profiles Diabetes Metabolic Syndrome Sleep Disturbances 28/02/21 Dr. Asha Jain
  • 18. Better Physical Health leads to Better mental health, Cognitive health 28/02/21 Dr. Asha Jain
  • 20. Midlife (35-60y) is a critical window of opportunity to prevent Chronic Disease, and Optimize health and functioning
  • 21. Symptoms that are Hallmark of Menopause • Vasomotor Symptoms or Hot flashes • Additionally, other conditions peak or are exacerbated at this time • Fibroids à Hysterectomy • Migraine • Systemic Lupus Erythematosus • Various precancers, and cancers • TODO – Care for Gynecological and Hormone Sensitive conditions 28/02/21 Dr. Asha Jain
  • 22. Which period of life is defined as Midlife? Usual studies take 60 years and above Window of opportunity of primary prevention is missed 28/02/21 Dr. Asha Jain
  • 23. Redefining Midlife • Here it is redefined as 35 to 60 years • This includes late reproductive phase to late menopause • Includes the menopausal transition up to a period when ovarian senescence has no longer any effect on aging 28/02/21 Dr. Asha Jain
  • 25. The hardest hit is mobility In one study upto 39% reported loss of mobility within 2 years of menopause 28/02/21 Dr. Asha Jain
  • 26. Additional Factors • Metabolic Syndrome • Diabetes • Adverse Lipid Profiles • Hearing Loss • Diminished vision • Osteoarthritis • Body composition changes • 66% had pain due to osteoarthiritis 28/02/21 Dr. Asha Jain
  • 27. Osteoporosis leading to fractures This chart shows bone mass in women as it relates to age. Reproduced from J Bernstein, ed: Musculoskeletal Medicine. Rosemont, IL, American Academy of Orthopaedic Surgeons, 2003. 28/02/21 Dr. Asha Jain
  • 28. Of all the boneloss that occurs in a women in her entire life, 50% occurs in just 7 years. 2 years before and 5 years after last menstrual period 28/02/21 Dr. Asha Jain
  • 29. WHI Study and heart health • Within 2 years of menopause, there is • Increased LDL • Increased Cholesterol • Increased Apolipoprotein B • Therefore increased aortic calcification • Increased hot flashes have an increased CV risk 28/02/21 Dr. Asha Jain
  • 30. Depression • 20% to 30% of midlife women have incidental or recurrent episodes of clinical depression • Causes • Hormonal • Sleep Disturbances 28/02/21 Dr. Asha Jain
  • 31. Social Health • Infertility • Failed Contraception • Empty Nest Syndrome • Taking care of aging parents • Career issues in working women • Social Connect • Failed Marriages • Loss of partner • Retirement Anxiety 28/02/21 Dr. Asha Jain
  • 32. Conclusion • Critical changes are occurring in midlife that need • Change into a healthy lifestyle • Behavioral Change • Social Engagement • Healthcare practices • Focus needs to be on modifiable critical factors in midlife to have healthy instead of unhealthy aging 28/02/21 Dr. Asha Jain
  • 33. Future Research Requirement • Research in our country • Impact on midlife of • Early childbirth • Late childbirth • Lifelong under nutrition • Obesity • Racial and ethnic differences • Impact of environment • Impact of occupation 28/02/21 Dr. Asha Jain
  • 34. Age Gracefully Be Beautiful, Be Alert Be Active, Be Self Reliant BE HAPPY! This Photo by Unknown Author is licensed under CC BY-SA 28/02/21 Dr. Asha Jain
  • 35. Thank you This Photo by Unknown Author is licensed under CC BY-SA 28/02/21 Dr. Asha Jain
  • 36. References and Acknowledgements • J Gerontol A Biol Sci Med Sci,2018, Vol. 73, No. 11, 1574– 1580doi:10.1093/gerona/gly062 • Harlow and DerbyWomen's Midlife Health (2015) 1:5 DOI 10.1186/s40695-015-0006-7 28/02/21 Dr. Asha Jain