Fertility drugs are often the first thing and alternative treatment for women who aren't ovulating. They work in the same way as the body's own hormones, triggering the ovaries to release eggs.
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New fertility drugs and ivf treatments
1. New Fertility drugs and IVF treatments
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Fertility drugs are often the first thing and alternative treatment for women who aren't ovulating. They
work in the same way as the body's own hormones, triggering the ovaries to release eggs.
This method, known as ovulation induction, can sometimes lead to conception after a few months
without further intervention. Possible side effects include premenstrual symptoms such as nausea,
headaches and weight gain.
Such drugs are also used as part of other more complicated treatments, such as in vitro fertilization and
intrauterine insemination (see below). Other drugs - to help control the menstrual cycle or thicken the
lining of the womb to prepare it for pregnancy, for example - may also be used. These can also cause
side effects, such as hot flushes, headaches, nausea and swollen breasts.
There are other methods:
Assisted reproduction treatments
Intrauterine insemination (IUI)
Intrauterine insemination, also known as artificial insemination, involves inserting sperm into the womb
at the time of ovulation using a catheter (a very fine needle or probe). The woman may need to take
fertility drugs to stimulate egg production. The sperm used may be her partner's or donated.
In vitro fertilization (IVF)
Women Eggs and sperm are collected and fertilized in the laboratory before the resulting embryo is
transferred to the womb. The woman takes fertility drugs to stimulate the production of eggs. Once
these are mature, they're collected by the doctor, using ultrasound to guide the collecting tube. The
man produces a sperm sample, which is prepared before being put with the eggs in a Petri dish and left
for a few days to see if fertilization takes place. If a healthy embryo develops, this is placed in the womb
using a catheter (a very fine needle or probe). Usually, no more than one or two are placed. Any
remaining embryos suitable for freezing may be stored for future use. The sperm and/or eggs used may
be the couple's own or donated.
Intracytoplasmic sperm injection (ICSI)
When a man has less sperm that are good for fertilization then A single sperm is injected into the
cytoplasm or centre of a single egg. This is then transferred to the womb using the same process as IVF.
Why it's used: to treat male factor infertility, such as low sperm count or poor motility (mobility or
movement) or abnormally shaped sperm. ICSI may also be used following previous unsuccessful
2. attempts at fertilization using IVF and when sperm has been retrieved directly from the epididymis or
the testicles (see 'Sperm extraction', below).
Success rate: as for IVF, about 25 per cent per cycle, sometimes more.
Gamete intrafallopian transfer (GIFT)
What is it? Gametes - eggs and sperm - are collected as for IVF. Instead of mixing sperm and eggs
together in the laboratory, they're immediately transferred to one of the woman's fallopian tubes so
fertilization takes place inside the body. Only a few clinics offer this in the UK.
Why it's used: unexplained infertility.
Success rate: lower than IVF, but it’s difficult to be certain as sometimes it’s offered to couples for whom
IVF has already failed.
Sperm extraction
What is it? A small operation that removes sperm from the epididymis (the tube where sperm mature in
the man's body) or the testicles (where sperm cells are made) for use in ICSI or another treatment.
There are several different methods of sperm extraction like:
PESA (percutaneous epididymal sperm aspiration) involves guiding a small needle into the epididymis to
draw out fluid containing sperm.
TESE (testicular sperm extraction) MESA (microsurgical sperm aspiration) uses a small needle to extract
mature sperm from the epididymis.
Why it's used: when a man can't produce sperm - for example, after a vasectomy or failed reversal.
Success rate: when used in ICSI, about 25 per cent per cycle.
Embryo freezing
What is it? The HFEA stipulates that (with certain strict exceptions) only two embryos may be
transferred to the womb at a time in fertility treatments. However, because IVF often creates more
embryos than can be transferred in a single cycle, most clinics will freeze any remaining healthy embryos
for use in future IVF treatments, with the patients' consent.
Why it's used: to avoid the need for further fresh IVF cycles involving invasive processes of egg
stimulation and collection.
Success rate: normally only 60 per cent of embryos survive the freeze/thaw process and those that do
survive have a lower rate of implantation and so a lower pregnancy rate than fresh embryos.