gastrointestinal agents

Gastrointestinal Drugs Anatomy Diseases Therapeutic Agents

GIT Structure & Function ,[object Object],[object Object],[object Object],[object Object]

Esophagus Lower Esophageal Sphincter LES tone Stomach Body Pylorus Delayed Gastric Emptying Duodenum

Electron Micrograph of the small intestine in cross section

Damaged Mucosal Tissue in Peptic Ulcer Disease

GI Transit Time Composition ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

GIT Diseases ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

GERD ,[object Object],[object Object],[object Object],[object Object]

GERD Treatment Non-Drug Drug ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

Therapeutic Agents ~~Antacids ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

Therapeutic Agents ~~ H2 Receptor Antagonists ,[object Object],[object Object],[object Object],[object Object],[object Object]

Proton Pump Inhibitors ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

Remember the neurotransmitters?

Treatment Agents cont. ,[object Object],[object Object],[object Object],[object Object],[object Object]

Antidiarrheals ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

Constipation ~~ Therapeutic Agents ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

Constipation Agents cont. ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

Anatomy of Vomiting Chemo Receptor Trigger Zone Vomiting Center Smell Center Sight Center Vestibular Stimulation GI tract Skeletal Muscle Dopamine, Serotonin, Opiate Receptors

Mechanisms Underlying Nausea and Vomiting

Antiemetics~ OTC Rx ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

Eaten Alive – Parasites and their Human Hosts

Parasites Schistosoma mansoni (6,650 x electron micrograph) Large worm is male with female's head projecting from a middle fold. Permanant mating position 300 eggs/day released

...the larvae head for the nearest snail host

...they gobble up whole cell debris...

Even when potent drugs are found, parasites refuse to surrender.

Therapeutic Management ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

Malaria ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

Irritable Bowel Syndrome ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

Summary Slide ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

Summary Slide (cont.) ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

gastrointestinal agents

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gastrointestinal agents