1. PRESENTED BY
DR.MAYANK SHARMA
GOVT MEDICAL,KOTA

2.  SYSTEMIC BACTERIAL INFECTIONS IN
NEONATES IS KNOWN AS NEONATAL
SEPSIS(NNS).
 NNS IS THE MOST COMMON MORBIDITIES
SEEN AT THE COMMUNITY AND FACILITY
LEVEL.
 IT INCORPORATES
PNEUMONIA,MENINGITIS,
GASTROENTRITIS AND POLYNEPHRITIS.

3.  ESCHERICHIA COLI,STAPHYLOCOCCUS
AUREUS AND KLEBSIELLA SP.
ARERESPONSIBLE FOR MOST CASES OF
NNS.
 OTHERS ARE
ADENOVIRUS,ENTEROVIRUS,TORCH,TRIC
HOMONIASIS,SYPHILIS,GONORRHOEA.
 CH.PNEUMONAE,H.INFLUENZAE,SPECIES
OF BACTEROIDES AND CLOSTRIDIUM
HAVE BEEN FOUND WITH NNS.

4.  NNS IS OF TWO TYPES:-
 1 EARLY NNS(LESS THAN 72 HOURS AFTER
BIRTH).
 2 LATE NNS(GREATER THAN 72 HOURS AND
WITHIN 90 DAYS OF BIRTH).

5. EARLY NSS LATE NNS
1 WITHIN 72 HOURS. 1 FROM 72 HOURS TO 90 DAYS.
2 CAUSED BY ORGANISM PRESENT IN 2 CAUSED BY ORGANISM PRESENT IN
MATERNAL GUT. THE EXTERNAL ENVIORMENT.
3 PREDISPOSING FACTORS:-
A. LBW A.LBW
B.PROLONG RUPTURE OF B.LACK OF BREAT FEEDING,POOR
.MEMBRANES,PROLONGED LABOR. CORD CARE
C. FOUL SMELLING C. SUPERFICIAL INFECTION.
LIQUOR,ASPIRATION OF MECONIUM.
D.MULTIPLE PERVAGINUM D.ASPIRATION OF FEEDS,DISRUPTION
EXAMINATION. OF SKIN INTEGRITY WITH NEEDLE
PRICKS,USE OF IV FLUIDS.

6.  NEONATAL IMMUNE SYSTEM IS LESS
DEVELOPED.
 PMNs ARE DEFICIENT IN CHEMOTAXIS AND
KILLING CAPACITY.
 THEY ARE LESS DEFORMABLE.
 CAPACITY OF NEONATAL PMNs FOR
PHAGOCYTOSIS ARE REDUCED.

7.  FINALLY PMN RESERVES ARE EASILY
DEPLETED.
 MACROPGHAGE CHEMOTAXIS IS
IMPAIRED.
 THERE NUMBER IS ALSO DECREASED.
 CYTOKININ PRODUCTION IS DECREASED.

8.  POPULATION OF T-CELLS IN NEONATES
ALSO IMMATURE.
 B-CEEL STIMULATION AND
PROLIFERATION ALSO DECREASED.
 ALL THESE REASONS LEAD TO NNS.