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Juvenile Rheumatoid Arthritis
Definition - JRA ,[object Object]
JUVENILE RHEUMATOID ARTHRITIS American College of Rheumatology Revised Criteria ,[object Object],[object Object],[object Object],[object Object]
JUVENILE RHEUMATOID ARTHRITIS Epidemiology ,[object Object],[object Object],[object Object],[object Object]
Clinical Manifestations of JRA
Symptoms and Types ,[object Object],[object Object],[object Object]
[object Object],[object Object]
[object Object],[object Object]
ILAR Proposed Classification Criteria ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
JUVENILE RHEUMATOID ARTHRITIS Laboratory Studies: Pauciarticular Disease ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
JUVENILE RHEUMATOID ARTHRITIS Clinical features: systemic disease ,[object Object],[object Object],[object Object],[object Object]
JUVENILE RHEUMATOID ARTHRITIS Laboratory studies: systemic disease ,[object Object],[object Object],[object Object],[object Object]
JUVENILE RHEUMATOID ARTHRITIS Extra-articular Manifestations ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Prognosis of JRA ,[object Object],[object Object],[object Object]
[object Object],[object Object],[object Object],Prognosis of JRA
[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],Prognosis of JRA
Before the 1990s … Pyramid Approach   Traditional Approach to the Treatment of JRA Cytotoxic Drugs  Disease Modifying  Anti-Rheumatic Drugs (DMARDs) Intra-Articular/Oral Corticosteroids Non-Steroidal Anti-Inflammatory Drugs (NSAIDs)
[object Object],[object Object],Evolving Treatment of JRA Since the 1990s and into the 2000s…
[object Object],[object Object],[object Object],[object Object],[object Object],Treatments with Indications for JRA
[object Object],Treatments with Indications for JRA
[object Object],[object Object],[object Object],[object Object],Treatments with Indications for JRA
[object Object],[object Object],[object Object],[object Object],Treatments with Indications for JRA
Treatment of JRA ,[object Object],[object Object],[object Object],[object Object],[object Object]
Treatment of JRA ,[object Object],[object Object]
[object Object],[object Object],[object Object],[object Object],[object Object],Treatment of JRA
Treatment of JRA ,[object Object],[object Object],[object Object]
[object Object],[object Object],[object Object],Treatment of JRA ,[object Object],[object Object]
[object Object],[object Object],Treatment of JRA
[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],Treatment of JRA
[object Object],[object Object],[object Object],[object Object],Treatment of JRA in 2008 Modified from Laxer R, Hashkes PJ. Medical Treatment of Juvenile  Idiopathic Arthritis. JAMA, October 5, 2005. Vol 294, No. 13, pp 1671-1684.
[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],Treatment of JRA in 2006 Modified from Laxer R, Hashkes PJ. Medical Treatment of Juvenile  Idiopathic Arthritis. JAMA, October 5, 2005. Vol 294, No. 13, pp 1671-1684.
[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],Treatment of JRA in 2006 Modified from Laxer R, Hashkes PJ. Medical Treatment of Juvenile  Idiopathic Arthritis. JAMA, October 5, 2005. Vol 294, No. 13, pp 1671-1684.

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Juvenile+Rheumatoid+Arthritis+slides

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  • 17. Before the 1990s … Pyramid Approach Traditional Approach to the Treatment of JRA Cytotoxic Drugs Disease Modifying Anti-Rheumatic Drugs (DMARDs) Intra-Articular/Oral Corticosteroids Non-Steroidal Anti-Inflammatory Drugs (NSAIDs)
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Notas do Editor

  1. ADD TRANSITION: UNEMPLOYMENT
  2. VIOXX: 2 to 11 years of age: 0.6 mg/kg to a maximum of 25 mg once daily. Pts < 40 kg, recommended to use 12.5 mg/5 mL suspension. 12 to 17 yrs, 25 mg once daily. Maximum daily dose 25 mg. Adverse Events: Upper/abdominal pain, headache, upper respiratory tract infection, pyrexia, skin/subcutaneous disorders, insomnia, dizziness, elevated hepatic enzymes, edema, pseudoporphyria.
  3. MTX: ADD AE PROFILE LAST BULLET NEEDS TO BE MODIFIED