Chapter 4 Immunologic System

Immunologic system Tianjin general hospital JiangLihong

[object Object],[object Object]

Characteristics of the immunologic system ,[object Object],[object Object],[object Object],[object Object]

Immunodeficiency diseases ,[object Object],[object Object]

Classification ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

Classification ,[object Object],[object Object],[object Object],[object Object]

Weight of thymus gland ,[object Object],[object Object],[object Object],[object Object]

Weight of spleen ,[object Object],[object Object],[object Object]

Nonspecific defense mechanisms ,[object Object],[object Object]

[object Object],Physical Cellular Humoral Skin Mucous membranes Mucociliary system Phagocytic cells Neutrophils Macrophages Monocytes Eosinophils Reticuloendothelial system Lysosomes Interferon Complement Lactoferrin lymphokines

Character of nonspecific immunity in children ,[object Object]

Components and characters of nonspecific immunity Thin,damaged easily Physical barrier Skin and mucosa 35-70%of that of adult 60%of content for adult Kill bacteria Complement properdin Low gastric acidity,fail to destroy bacteria,low lactic acid from skin Kill bacteria Tissue fluid:gastric juice,lactic acid from skin Penetration,meningitis,intrauterine infection barrier Blood-brain barrier placental barrier Perfect after 34w GA phagocytosis Macrophage Imperfect,infection diffuse easily Filtration Lymph nodes Characters in children Function Components

Specific immunity ,[object Object],[object Object]

Specific immune mechanisms ,[object Object],[object Object]

Specific Cellular Immunity ,[object Object],[object Object]

T-cell functions ,[object Object],[object Object],[object Object],[object Object]

Characteristics of T-cell in children ,[object Object],[object Object]

Specific Humoral Immunity ,[object Object],[object Object],[object Object]

The 5 major classes of immunoglobulins ,[object Object],[object Object],[object Object],[object Object],[object Object]

IgG ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

IgM ,[object Object],[object Object],[object Object]

IgA ,[object Object],[object Object],[object Object],[object Object]

IgD ,[object Object],[object Object],[object Object],[object Object],[object Object]

IgE ,[object Object],[object Object],[object Object]

IgE ,[object Object],[object Object]

Classification ,[object Object],[object Object],[object Object],[object Object],[object Object]

Primary immunodeficincy disease common manifestation

Recurrent infection and chronic infection ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

Autoimmunologic disease and lymphoma ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

Congenital hypogammaglobulinemia ,[object Object],[object Object],[object Object],[object Object],[object Object]

Congenital hypogammaglobulinemia ,[object Object],[object Object],[object Object]

Infant transient hypogammaglobulinemia ,[object Object],[object Object],[object Object],[object Object],[object Object]

Selective IgA deficiency ,[object Object],[object Object],[object Object]

Congenital thymus dysplasia ,[object Object]

Congenital thymus dysplasia ,[object Object],[object Object],[object Object],[object Object]

Treatment of PID ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

HIV(human immunodeficiency virus) ,[object Object],[object Object],[object Object]

Transmission route to children ,[object Object],[object Object],[object Object],[object Object]

Reduction of vertical transmission of HIV ,[object Object],[object Object],[object Object]

HIV-infected children ,[object Object],[object Object],[object Object],[object Object],[object Object]

Treatment-antivirus ,[object Object],[object Object],[object Object]

PROTEINASE INHIBITOR ,[object Object],[object Object],[object Object]

NRIT(nucleoside reverse transcriptase inhibitor) ,[object Object],[object Object],[object Object]

NNRIT(nonnucleoside reverse transcriptase) ,[object Object],[object Object],[object Object],[object Object],[object Object]

Questions ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

Chapter 4 Immunologic System

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Chapter 4 Immunologic System