FUSF Presentation giving at the Celebration of Science conference.

1. Focused Ultrasound

2. Disclosure
InSightec board member and shareholder

3. 3
Focused Ultrasound
New, revolutionary, noninvasive therapeutic technology
Alternative or adjunct
 Surgery
 Radiation therapy
 Drug delivery
Early stage, MR 25 years ago, additional R&D
As important to therapy as MR is to diagnoses
Transform treatment of a variety of serious medical disorders
 Benign and malignant tumors
 Metastatic cancer
 Parkinson’s disease & epilepsy
 Back pain, hypertension
Real today, infancy

4. Essential Tremor

5. Essential Tremor

6. Essential Tremor

7. Essential Tremor

8. Functional Testing
Before Procedure After Procedure

9. Thalamic Lesion Created to Treat Essential Tremor

10. Uterine Fibroid Treatment
Pre-treatment MR scan of fibroid

11. Uterine Fibroid Treatment Comparison
Hysterectomy Focused Ultrasound
Major surgery Noninvasive, no incision
General anesthesia Conscious sedation
Painful Minimal discomfort
Hospitalization Outpatient
6 weeks recovery 1 day recovery
Side effects No side effects
No more children Preserved fertility

12. Uterine Fibroid Treatment
Pre-treatment 9 months post-treatment
Nine months after treatment, the fibroid has been absorbed

13. Breast Cancer
Pre treatment 2 weeks post treatment

14. What is Focused Ultrasound?

15. Marriage of Two Breakthrough Technologies
Focused Ultrasound: therapy
 Treat tissue deep in body
• Noninvasively
• Accurately and precisely
Magnetic Resonance (MR) or Ultrasound (US) Imaging
 Identify and target tissue to be treated
 Guide and control treatment in real time
 Immediate confirmation of effectiveness

16. Focused Ultrasound
Analogous to a magnifying glass focusing rays of the sun…

17. Focused Ultrasound
Multiple intersecting
beams of ultrasound
 Focused with extreme
accuracy
 Point: 1 mm diameter
 Deep in body
Individual beams pass harmlessly
through tissue
Point of convergence: profound effect
Adjacent tissue unaffected

18. Effects at Focal Point
Destroy tissue: thermal ablation, cavitation
Deliver drugs
Dissolve clots: sonothrombolysis
Radiation sensitization
Drug activity enhancement
Coagulate blood vessels
Amplification of cancer biomarkers
Immunomodulation
Neuromodulation
Vasodilation
Variety of effects, variety of disorders
Abundant research opportunities

19. Destroy Tissue: Thermal Ablation
Heating any tissue to 130 F (56 C) for one second
Destroys any tissue, normal or abnormal.

20. Focal Drug Delivery
Deliver drugs in high concentrations
 Precisely where needed
 Minimizing systemic toxicity
Drugs
 Chermotherapeutic agents
 Antibotics
 Genes
 Growth factors

21. Drugs contained in microbubbles released by ultrasound
only at the target 1/5

22. Drugs contained in microbubbles released by ultrasound
only at the target 2/5

23. Drugs contained in microbubbles released by ultrasound
only at the target 3/5

24. Drugs contained in microbubbles released by ultrasound
only at the target 4/5

25. Drugs contained in microbubbles released by ultrasound
only at the target 5/5

26. Focused Ultrasound Procedure
Steps in procedure
 Targeting
 Planning
 Treating
 Confirming

27. Procedure: Targeting
Structures
to be avoided
Region to
be treated

28. Procedure: Planning
Automatic planning

29. Procedure: Treatment
Real time guidance
Temperature
measurement

30. FUS Advantages vs Radiation
 Single treatment
 Immediate and verifiable effect
 Greater precision and accuracy
 Real time localization
 No cumulative dose
 No limitations on lesion size
 No limitations on number of treatments
 No secondary tumors
 100% cell death
 Sharp margins

31. Global Development Landscape

32. Imagine the Future: 2020
Advances in technology
 Imaging
 Focused ultrasound
 Focal drug delivery
Undreamed-of applications

33. SNAKE OIL: CURE-ALL
33

34. Limitations: Cannot be used for all conditions
Scoliosis Leukemia
Traumatic Injuries
Lung Tumors

35. Potential Impact, Urgent Need
Technology widely available
 Delay = unnecessary death, disability, suffering
 Countless individuals: friends, family, you!
Focused Ultrasound Foundation
 Shorten time to wide-spread use
 Saving time, saving lives

36. Focused Ultrasound
Foundation
It’s all about the patients