The Science and Ethics of Life Extension

The Science and Ethics of Life Extension Third Meeting, Winter Quarter Stanford Transhumanism Association January 28, 2005 Michael Jin

Senescence: a fatal disease ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

Part I – Should we seek life extension? Part I S HOULD W E S EEK L IFE E XTENSION ? “ If we are to be destroyed, I am now convinced that it will not be a neutral or malevolent force that will do us in, but one that is benevolent in the extreme, one whose only motivation is to improve us and better our civilization” – Sherwin Nylund

Aubrey de Grey, Cambridge bio-gerontologist, addressing his critics ,[object Object],[object Object]

Defeating aging is a matter of morality, not practicality ,[object Object]

De Grey addresses practical arguments anyway ,[object Object],[object Object],[object Object],[object Object],[object Object]

The Human Dignity Argument ,[object Object]

Rebutting Kass’ Human Dignity ,[object Object],[object Object]

The Human Virtue Argument ,[object Object]

Rebutting the virtue argument ,[object Object],[object Object],[object Object],[object Object]

The Laundry List Argument ,[object Object]

Rebutting the Laundry List Argument: What is man? ,[object Object]

Unamuno: What man is not ,[object Object]

Unamuno: What man wants (In three words: To live forever) ,[object Object],[object Object]

Part II – Can we seek life extension? Part II C AN W E S EEK L IFE E XTENSION ? “ Those who hope for no other life are dead even for this” – Johann Wolfgang Von Goethe

Evidence from Calorie Restriction ,[object Object]

CR Theory, “ Caloric Restriction: Explaining the Enigma of Aging ” ,[object Object]

Another Idea (Note: Speculation here, not science.) ,[object Object],[object Object]

CR in Humans? (Fontana et al., 4/19/04, Proc. Natl. Acad. Sci.) Abstract Excerpt: “The CR group were markedly leaner than the comparison group (BMI, 19.6 � 1.9 vs. 25.9 � 3.2; % body fat, 8.7 � 7% vs. 24 � 8%). Total serum cholesterol (Tchol), LDL-cholesterol, Tchol/HDLChol ratio, triglycerides, fasting glucose, fasting insulin, hsCRP, PDFG-AB, systolic and diastolic BP were all markedly lower, while HDL-Chol was higher, in the CR, than in the American diet group… Based on measurements of a range of risk factors, it appears that long-term CR has a powerful protective effect against atherosclerosis.” 30 months on CR, 123lbs, BMI 18.5

The Search for a CR Mimetic: “Have Your Cake…” ,[object Object],[object Object]

Aubrey de Grey’s 7 Point Plan ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]

Aubrey’s Predictions: Milestones ,[object Object],[object Object]

Mainstream Response to de Grey ,[object Object],[object Object]

Part III – What can I do today? Part III W HAT CAN W E DO TODAY? First they ignore you, then they laugh at you, then they fight you, then you win. – Mohandas Gandhi

How much, how fast ,[object Object]

Kick-starting the War on Aging ,[object Object],[object Object]

Diet, Exercise, Supplementation ,[object Object],[object Object],[object Object],[object Object]

Cryonics: Extreme Life Extension ,[object Object],[object Object],[object Object],[object Object]

Michael Shermer on Cryonics: A Secular Pascal’s Wager? ,[object Object]

Why the critics may be wrong ,[object Object],[object Object],[object Object]

The Coming Future ,[object Object]

My Personal Predictions ,[object Object],[object Object],[object Object],[object Object],[object Object]

The Science and Ethics of Life Extension

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